Detailed information for compound 1427139

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 384.431 | Formula: C23H20N4O2
  • H donors: 2 H acceptors: 4 LogP: 3.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)c1nnc(c2c1cccc2)Nc1ccc(cc1)C(=O)N(C)C
  • InChi: 1S/C23H20N4O2/c1-27(2)23(29)16-7-11-17(12-8-16)24-22-20-6-4-3-5-19(20)21(25-26-22)15-9-13-18(28)14-10-15/h3-14,28H,1-2H3,(H,24,26)
  • InChiKey: VSCUPIFQOMIRKF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.203 0.6108
Schistosoma mansoni ap endonuclease 0.0023 0.0159 0.0317
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0207 0.045
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0051 0.0048
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0285 0.2857 1
Trichomonas vaginalis helicase, putative 0.0008 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0012 0.0051 0.0103
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0159 0.0404
Schistosoma mansoni hypothetical protein 0.0019 0.0121 0.0242
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0036 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2144 0.645
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0207 0.0711
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0282 0.0725
Schistosoma mansoni ras GTP exchange factor 0.0008 0.0004 0.0008
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0036 0.0032
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0036 0.0032
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0036 0.0083
Echinococcus granulosus cpg binding protein 0.0037 0.0302 0.0597
Brugia malayi hypothetical protein 0.004 0.0336 0.0865
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0336 0.0663
Entamoeba histolytica hypothetical protein 0.004 0.0336 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0036 0.0032
Brugia malayi hypothetical protein 0.0011 0.0036 0.0083
Echinococcus granulosus DNA topoisomerase 1 0.0381 0.384 0.7668
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0004 0.0008
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0036 0.0083
Entamoeba histolytica hypothetical protein 0.004 0.0336 1
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5007 0.5005
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0004 0.0008
Schistosoma mansoni cpg binding protein 0.0037 0.0302 0.0604
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.203 0.6108
Schistosoma mansoni dishevelled 0.0011 0.0036 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3134 0.9434
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3134 0.9434
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.203 0.6108
Schistosoma mansoni cpg binding protein 0.0037 0.0302 0.0604
Echinococcus multilocularis cpg binding protein 0.0037 0.0302 0.0299
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.3134 0.8158
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0682 0.1362
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3134 0.9434
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0014 0.001
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.0096 0.0909 0.3173
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0006 0.0006
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0036 0.0083
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0285 0.2857 1
Schistosoma mansoni DNA topoisomerase type I 0.0381 0.384 0.767
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3134 0.9434
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3134 0.9434
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0008 0.0004 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0159 0.0543
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0036 0.0071
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0545 0.1409
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0207 0.0711
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0083
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0036 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0545 0.1409
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3134 0.9434
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0159 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0034 0.0079
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0036 0.0146
Schistosoma mansoni hypothetical protein 0.0019 0.0121 0.0242
Plasmodium vivax topoisomerase I, putative 0.0381 0.384 1
Mycobacterium ulcerans glutaminase 0.033 0.3321 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0494 0.5007 1
Toxoplasma gondii DNA topoisomerase I, putative 0.0381 0.384 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.0006
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0336 0.067
Loa Loa (eye worm) DNA topoisomerase I 0.0381 0.384 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0014 0.001
Onchocerca volvulus 0.0011 0.0036 0.0146
Entamoeba histolytica hypothetical protein 0.004 0.0336 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0004 0.0008
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0159 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.0006
Brugia malayi N-terminal motif family protein 0.0218 0.2168 0.5641
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.3134 0.8158
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0159 0.0467
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2144 0.645
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5007 1
Leishmania major DNA topoisomerase type IB small subunit 0.0096 0.0909 0.2781
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.203 0.6108
Brugia malayi DNA topoisomerase I 0.0381 0.384 1
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0096 0.0909 0.2781
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0159 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0336 0.0332
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0121 0.0306
Leishmania major hypothetical protein, conserved 0.0027 0.0207 0.0177
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0036 0.0071
Schistosoma mansoni hypothetical protein 0.004 0.0336 0.067
Brugia malayi DIX domain containing protein 0.0011 0.0036 0.0083
Schistosoma mansoni hypothetical protein 0.0019 0.0121 0.0242
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0207 0.013
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0006 0.0006
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0159 0.031
Trichomonas vaginalis glutaminase, putative 0.033 0.3321 1
Schistosoma mansoni ap endonuclease 0.0023 0.0159 0.0317
Entamoeba histolytica hypothetical protein 0.004 0.0336 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0121 0.0117
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.2168 1
Schistosoma mansoni DNA topoisomerase type I 0.0285 0.2857 0.5705
Brugia malayi glutaminase DH11.1 0.033 0.3321 0.8647
Toxoplasma gondii exonuclease III APE 0.0023 0.0159 0.0324
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0159 0.5
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0036 0.0083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.0006
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0036 0.0032
Schistosoma mansoni glutaminase 0.033 0.3321 0.6634
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0159 0.0543
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.203 0.6108
Echinococcus multilocularis GPCR, family 2 0.0019 0.0121 0.0117
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0159 0.467
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0306
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.203 0.9364
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0036 0.0083
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0083
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0159 0.0155
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0349 0.0898
Schistosoma mansoni dishevelled 0.0011 0.0036 0.0071
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0529
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.0006
Leishmania major DNA topoisomerase IB, large subunit 0.0285 0.2857 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0051 0.0095
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0121 0.0234
Plasmodium falciparum topoisomerase I 0.0381 0.384 1
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0036 0.0063
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0083
Brugia malayi hypothetical protein 0.0027 0.0207 0.0529
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0121 0.0306
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0036 0.0063
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0159 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0207 0.013
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.203 0.6108
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0036 0.0063
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0207 0.0177
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0014 0.0028
Loa Loa (eye worm) hypothetical protein 0.0218 0.2168 0.5641
Echinococcus granulosus GPCR family 2 0.0019 0.0121 0.0234
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0036 0.0063
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0601 0.1487
Schistosoma mansoni hypothetical protein 0.0041 0.0349 0.0696
Onchocerca volvulus 0.0035 0.0282 0.1285
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0121 0.0234
Loa Loa (eye worm) glutaminase 2 0.033 0.3321 0.8647
Echinococcus multilocularis DNA topoisomerase 1 0.0381 0.384 0.3838
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0121 0.0306
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0036 0.0071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0545 0.1409
Loa Loa (eye worm) glutaminase 0.033 0.3321 0.8647
Schistosoma mansoni dep domain containing protein 0.0011 0.0036 0.0071
Brugia malayi hypothetical protein 0.0018 0.0107 0.0269
Loa Loa (eye worm) hypothetical protein 0.006 0.0545 0.1409
Schistosoma mansoni hypothetical protein 0.0019 0.0121 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.0006
Schistosoma mansoni DNA topoisomerase type I 0.0285 0.2857 0.5705
Brugia malayi hypothetical protein 0.0011 0.0036 0.0083
Loa Loa (eye worm) hypothetical protein 0.0041 0.0349 0.0898
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0006 0.0006
Brugia malayi CXXC zinc finger family protein 0.0035 0.0282 0.0725
Schistosoma mansoni cpg binding protein 0.0035 0.0282 0.0563
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0036 0.0032
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0036 0.0063
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0121 0.0117
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0036 0.0063
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0207 0.013
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0159 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.203 0.6108

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.9466 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 42.5615 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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