Detailed information for compound 1431017

Basic information

Technical information
  • TDR Targets ID: 1431017
  • Name: SMR000456503
  • MW: 304.773 | Formula: C10H9ClN2O3S2
  • H donors: 1 H acceptors: 3 LogP: 2.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cn1)NS(=O)(=O)c1ccc(s1)Cl
  • InChi: 1S/C10H9ClN2O3S2/c1-16-9-4-2-7(6-12-9)13-18(14,15)10-5-3-8(11)17-10/h2-6,13H,1H3
  • InChiKey: BHRDCLCQKRWPDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Maybridge3_002910
  • ZINC00157923
  • 5-chloro-N-(6-methoxy-3-pyridinyl)-2-thiophenesulfonamide
  • MLS000850485

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Protein Rev Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Caenorhabditis elegans Protein GLD-1 Starlite/ChEMBL No references
Homo sapiens poly(A) binding protein, cytoplasmic 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania mexicana poly(a) binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma brucei calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Cryptosporidium parvum poly(a)-binding protein fabm, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma congolense calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei gambiense poly(A)-binding protein 1,PABP2 Get druggable targets OG5_126795 All targets in OG5_126795
Candida albicans similar to PolyA Binding Protein Get druggable targets OG5_126795 All targets in OG5_126795
Entamoeba histolytica polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Plasmodium falciparum polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma brucei gambiense polyadenylate-binding protein 1, putative,PABP1 Get druggable targets OG5_126795 All targets in OG5_126795
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei polyadenylate-binding protein 2 Get druggable targets OG5_126795 All targets in OG5_126795
Schistosoma mansoni polyadenylate binding protein Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania braziliensis poly(A)-binding protein 3, putative;with=GeneDB:LmjF25.0080 Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania major poly(A)-binding protein 2 Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania donovani polyadenylate-binding protein 2 Get druggable targets OG5_126795 All targets in OG5_126795
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma congolense polyadenylate-binding protein 1, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania major poly(A)-binding protein 3 Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma brucei gambiense Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi tumor suppressor. Get druggable targets OG5_170288 All targets in OG5_170288
Entamoeba histolytica polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania infantum polyadenylate-binding protein 1, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma brucei polyadenylate-binding protein 1 Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma congolense polyadenylate-binding protein 2 Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma brucei gambiense calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus polyadenylate binding protein Get druggable targets OG5_126795 All targets in OG5_126795
Schistosoma mansoni polyadenylate binding protein Get druggable targets OG5_126795 All targets in OG5_126795
Schistosoma japonicum Embryonic polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania infantum poly(A)-binding protein 3, putative;with=GeneDB:LmjF25.0080 Get druggable targets OG5_126795 All targets in OG5_126795
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania donovani poly(A)-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Schistosoma mansoni polyadenylate binding protein Get druggable targets OG5_126795 All targets in OG5_126795
Toxoplasma gondii polyadenylate binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum calpain-like cysteine peptidase Get druggable targets OG5_130635 All targets in OG5_130635
Trichomonas vaginalis polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania donovani polyadenylate-binding protein 1, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma cruzi calpain cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis poly(A)-binding protein 2, putative;with=GeneDB:LmjF35.4130,poly(A)-binding protein 2, putative Get druggable targets OG5_126795 All targets in OG5_126795
Echinococcus multilocularis polyadenylate binding protein Get druggable targets OG5_126795 All targets in OG5_126795
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Plasmodium vivax polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Giardia lamblia Polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania donovani calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania mexicana poly(A)-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Candida albicans similar to PolyA Binding Protein Get druggable targets OG5_126795 All targets in OG5_126795
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis polyadenylate-binding protein 1, putative Get druggable targets OG5_126795 All targets in OG5_126795
Loa Loa (eye worm) tumor suppressor Get druggable targets OG5_170288 All targets in OG5_170288
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis RNA-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi polyadenylate-binding protein 1 Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma cruzi polyadenylate-binding protein 1, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trichomonas vaginalis poly(A) binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trichomonas vaginalis RNA-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Babesia bovis polyadenylate binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Theileria parva polyadenylate binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trichomonas vaginalis ribonucleoprotein, chloroplast, putative Get druggable targets OG5_126795 All targets in OG5_126795
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126795 All targets in OG5_126795
Neospora caninum hypothetical protein Get druggable targets OG5_126795 All targets in OG5_126795
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Cryptosporidium hominis poly(a)-binding protein fabm Get druggable targets OG5_126795 All targets in OG5_126795
Trichomonas vaginalis nuclear acid binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii polyA binding protein-related Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma brucei variant surface glycoprotein (VSG), putative Get druggable targets OG5_130635 All targets in OG5_130635
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Trypanosoma brucei gambiense calpain-like cysteine peptidase, putative,antigen, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum poly(A)-binding protein 2,poly(a) binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi polyadenylate-binding protein 4 Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei hypothetical protein Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania donovani hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Leishmania infantum hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0043 0.0646 0.0646
Mycobacterium ulcerans beta-lactamase 0.0043 0.0646 0.5
Brugia malayi TAR-binding protein 0.0076 0.1542 0.1542
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.3132 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0646 0.2435
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0646 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1542 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0646 0.5
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.3132 1
Trypanosoma brucei calpain-like protein, putative 0.0135 0.3132 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0646 0.0646
Toxoplasma gondii ABC1 family protein 0.0043 0.0646 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0646 0.5
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.3132 1
Onchocerca volvulus 0.0043 0.0646 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1542 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0646 0.1245
Onchocerca volvulus 0.0043 0.0646 0.5
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.3132 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.3132 1
Brugia malayi RNA binding protein 0.0076 0.1542 0.1542
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0135 0.3132 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0646 0.5
Leishmania major hypothetical protein, conserved 0.0043 0.0646 0.1245
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1542 0.1542
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.3132 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1542 1
Trichomonas vaginalis esterase, putative 0.0043 0.0646 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0646 0.0364
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1542 0.1287
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0646 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0646 0.2435
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0646 0.5
Loa Loa (eye worm) beta-lactamase 0.0043 0.0646 0.0364
Loa Loa (eye worm) hypothetical protein 0.0033 0.0358 0.0068
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1542 0.1287
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1542 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0646 0.0364
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0646 0.5
Echinococcus granulosus tar DNA binding protein 0.0076 0.1542 1
Trypanosoma brucei hypothetical protein 0.0135 0.3132 1
Brugia malayi beta-lactamase 0.0043 0.0646 0.0646
Brugia malayi beta-lactamase family protein 0.0043 0.0646 0.0646
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0646 0.1245
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.3132 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.3132 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1542 1
Onchocerca volvulus 0.0043 0.0646 0.5
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0646 0.0364
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.3132 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.7001 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.3132 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1542 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0646 0.0364
Mycobacterium ulcerans hypothetical protein 0.0043 0.0646 0.5
Trypanosoma brucei calpain, putative 0.0135 0.3132 1
Brugia malayi hypothetical protein 0.0033 0.0358 0.0358
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0646 0.2435
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0358 0.0358
Brugia malayi hypothetical protein 0.003 0.0293 0.0293
Loa Loa (eye worm) tumor suppressor 0.0388 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0646 0.2435
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0293 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0646 0.0364
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0135 0.3132 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0646 0.5
Mycobacterium ulcerans lipase LipD 0.0043 0.0646 0.5
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.3132 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0293 0.5
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.3132 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0646 0.1245
Mycobacterium leprae Probable lipase LipE 0.0043 0.0646 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0646 0.0364
Loa Loa (eye worm) RNA binding protein 0.0076 0.1542 0.1287
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0135 0.3132 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0646 0.0364

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.541 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2280, AID2290, AID2459] ChEMBL. No reference
IC50 (binding) = 6.301 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2290 (Summary (gld-1 inhibitors)), 2280 (Primary screen (gld-1 inhibitors in singlicate))] ChEMBL. No reference
IC50 (functional) = 14.9 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8888 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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