Detailed information for compound 1432628

Basic information

Technical information
  • TDR Targets ID: 1432628
  • Name: 4-[(2,4-dimethoxyphenyl)amino]-4-oxobut-2-eno ic acid
  • MW: 251.235 | Formula: C12H13NO5
  • H donors: 2 H acceptors: 3 LogP: 0.81 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1NC(=O)/C=C/C(=O)O
  • InChi: 1S/C12H13NO5/c1-17-8-3-4-9(10(7-8)18-2)13-11(14)5-6-12(15)16/h3-7H,1-2H3,(H,13,14)(H,15,16)/b6-5+
  • InChiKey: RZOGENBZVRGYHU-AATRIKPKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-4-[(2,4-dimethoxyphenyl)amino]-4-oxobut-2-enoic acid
  • (E)-4-[(2,4-dimethoxyphenyl)amino]-4-oxo-but-2-enoic acid
  • 4-[(2,4-dimethoxyphenyl)amino]-4-oxo-but-2-enoic acid
  • 4-[(2,4-dimethoxyphenyl)amino]-4-keto-but-2-enoic acid
  • (E)-4-[(2,4-dimethoxyphenyl)amino]-4-keto-but-2-enoic acid
  • 4-(2,4-dimethoxyanilino)-4-oxobut-2-enoic acid
  • Maybridge3_005913
  • MLS000850776
  • IDI1_017300
  • SMR000456793
  • ST5325349

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.077 0.586
Schistosoma mansoni fkbp-rapamycin associated protein 0.0189 0.0326 0.1724
Loa Loa (eye worm) phosphatidylinositol 3 0.0656 0.1677 1
Loa Loa (eye worm) hypothetical protein 0.0323 0.0714 0.4257
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0287 0.2182
Trypanosoma cruzi hypothetical protein, conserved 0.1226 0.3326 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0356 0.0809 0.2431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0332 0.0739 0.5626
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0135 0.0171 0.1305
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0209 0.0386 0.4769
Schistosoma mansoni hypothetical protein 0.0132 0.0163 0.0864
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0135 0.0171 0.0907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0332 0.0739 0.5626
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0208 0.0383 0.4968
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0356 0.0809 0.0809
Echinococcus multilocularis geminin 0.0205 0.0372 0.0372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0334 0.0747 0.5686
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0323 0.0714 0.0714
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0135 0.0171 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0323 0.0714 0.5433
Onchocerca volvulus 0.0114 0.011 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.015 0.0214 0.2648
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0189 0.0326 0.0326
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0133 0.0166 0.05
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.073 0.1891 0.1891
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0356 0.0809 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0356 0.0809 0.6153
Loa Loa (eye worm) hypothetical protein 0.0208 0.0381 0.2271
Leishmania major phosphatidylinositol 3-kinase, putative 0.0321 0.0709 0.1999
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.077 0.586
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0379 0.0877 0.4637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0345 0.0778 0.5919
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0135 0.0171 0.0907
Loa Loa (eye worm) hypothetical protein 0.0189 0.0326 0.1944
Trichomonas vaginalis PIKK family atypical protein kinase 0.021 0.0387 0.2949
Toxoplasma gondii target of rapamycin (TOR), putative 0.0342 0.077 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0273 0.0273
Schistosoma mansoni alpha-glucosidase 0.0169 0.027 0.1429
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.073 0.1891 0.1891
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0135 0.0171 0.1305
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0135 0.0171 0.1305
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0455 0.1095 0.8331
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0379 0.0877 0.6673
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0135 0.0171 0.2227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0345 0.0778 0.5919
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0135 0.0171 0.0171
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0132 0.0163 0.0163
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0201 0.0362 0.2754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0375 0.2854
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0356 0.0809 0.2281
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.0107 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0326 0.2481
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.0383 0.2912
Schistosoma mansoni hypothetical protein 0.0205 0.0372 0.1968
Trichomonas vaginalis PIKK family atypical protein kinase 0.0345 0.0778 0.5919
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0209 0.0386 0.2934
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0135 0.0171 0.0171
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0135 0.0171 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0209 0.0386 0.116
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0356 0.0809 0.0809
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0206 0.0375 0.1983
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0379 0.0877 0.2637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0031 0.0233
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0249 0.05 0.3803
Mycobacterium leprae conserved hypothetical protein 0.0076 0 0.5
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0379 0.0877 0.0877
Mycobacterium tuberculosis Conserved hypothetical protein 0.0076 0 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0189 0.0326 0.2481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0213 0.0395 0.3008
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0206 0.0375 0.1128
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0356 0.0809 1
Toxoplasma gondii FATC domain-containing protein 0.0206 0.0375 0.487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.0426 0.3242
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.0809 0.6153
Echinococcus granulosus geminin 0.0205 0.0372 0.0372
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0456 0.11 0.8371
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0135 0.0171 0.1023
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0135 0.0171 0.0171
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0321 0.0709 0.8764
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0379 0.0877 0.2637
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.073 0.1891 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0333 0.0745 0.444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.0709 0.5393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.077 0.586
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0135 0.0171 0.1305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.077 0.586
Leishmania major phosphatidylinositol kinase related protein, putative 0.0093 0.0049 0.0138
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0349 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.077 0.586
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0209 0.0386 0.2039
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0349 0.0349
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0135 0.0171 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.0362 0.2754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0332 0.0739 0.5627
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3535 1 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0356 0.0809 0.2281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0334 0.0747 0.5686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.077 0.586
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0343 0.0772 0.9543
Entamoeba histolytica hypothetical protein 0.0456 0.11 0.8371
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0189 0.0326 0.0981
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0189 0.0326 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.0709 0.5393
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0097 0.0061 0.0759
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0209 0.0386 0.2934
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0206 0.0375 0.2854
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0323 0.0714 0.0714
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0206 0.0375 0.4638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0332 0.0739 0.5627
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.053 0.1314 0.3952
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0417 0.0986 0.7502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0345 0.0778 0.5919
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0356 0.0809 0.2431
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0356 0.0809 0.6153
Loa Loa (eye worm) phosphatidylinositol 3 0.0133 0.0166 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.0809 0.6153
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0135 0.0171 0.2121
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0135 0.0171 0.1305
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0135 0.0171 0.1305
Giardia lamblia GTOR 0.0356 0.0809 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.021 0.0387 0.2949
Loa Loa (eye worm) acetyltransferase 0.0175 0.0287 0.1709
Trypanosoma cruzi target of rapamycin kinase 3 0.0345 0.0778 0.2339
Loa Loa (eye worm) hypothetical protein 0.0132 0.0163 0.0974
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0287 0.1516
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.053 0.1314 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0356 0.0809 0.4821
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0209 0.0386 0.2934
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0417 0.0986 0.7502
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0219 0.0413 0.5112
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0356 0.0809 0.4276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.0809 0.6153
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0209 0.0386 0.2934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0332 0.0739 0.5627
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.053 0.1314 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0332 0.0739 0.5627
Loa Loa (eye worm) hypothetical protein 0.013 0.0156 0.0929
Echinococcus granulosus serine protein kinase ATM 0.0206 0.0375 0.0375
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0349 0.0349
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0135 0.0171 0.2227
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.02 0.0358 0.2723
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0107 0.0813
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.053 0.1314 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.053 0.1314 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0333 0.0745 0.9208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0232 0.0452 0.3438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.077 0.586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.0709 0.5393
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0132 0.0163 0.0163
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.053 0.1314 0.3952
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0093 0.0049 0.0147
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0345 0.0778 0.2195
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0379 0.0877 0.0877
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0345 0.0778 0.9621
Loa Loa (eye worm) hypothetical protein 0.0208 0.0383 0.2281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.0709 0.5393
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0349 0.2084
Echinococcus multilocularis serine protein kinase ATM 0.0206 0.0375 0.0375
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0349 0.2659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.0809 0.6153
Trichomonas vaginalis PIKK family atypical protein kinase 0.021 0.0387 0.2949
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0135 0.0171 0.0516
Schistosoma mansoni alpha-glucosidase 0.0169 0.027 0.1429
Entamoeba histolytica hypothetical protein 0.0206 0.0375 0.2854
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0209 0.0386 0.2934
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0163 0.1243
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0287 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0333 0.0745 0.5666
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.053 0.1314 1
Brugia malayi FAT domain containing protein 0.0132 0.0163 0.1243
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.013 0.0156 0.0468
Schistosoma mansoni hypothetical protein 0.0205 0.0372 0.1968
Trichomonas vaginalis PIKK family atypical protein kinase 0.0345 0.0778 0.5919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0332 0.0739 0.5626
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0333 0.0745 0.21
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0209 0.0386 0.2934
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0135 0.0171 0.0516
Entamoeba histolytica protein kinase rad3, putative 0.0189 0.0326 0.2481
Echinococcus multilocularis Zinc finger, PHD finger 0.0135 0.0171 0.0171
Leishmania major phosphatidylinositol 3-kinase, putative 0.0135 0.0171 0.0484
Leishmania major hypothetical protein, conserved 0.1302 0.3545 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.647 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.