Detailed information for compound 1433695

Basic information

Technical information
  • TDR Targets ID: 1433695
  • Name: 2-[[2-(furan-2-carbonylamino)-3-furan-2-ylpro p-2-enoyl]amino]-3-methylbutanoic acid
  • MW: 346.335 | Formula: C17H18N2O6
  • H donors: 3 H acceptors: 4 LogP: 2.13 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(C(=O)O)NC(=O)/C(=C\c1ccco1)/NC(=O)c1ccco1)C
  • InChi: 1S/C17H18N2O6/c1-10(2)14(17(22)23)19-15(20)12(9-11-5-3-7-24-11)18-16(21)13-6-4-8-25-13/h3-10,14H,1-2H3,(H,18,21)(H,19,20)(H,22,23)/b12-9+
  • InChiKey: LHCKVTPMAGSYGW-FMIVXFBMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[(E)-2-(furan-2-carbonylamino)-3-furan-2-ylprop-2-enoyl]amino]-3-methylbutanoic acid
  • 2-[[2-(furan-2-carbonylamino)-3-(2-furyl)prop-2-enoyl]amino]-3-methyl-butanoic acid
  • 2-[[(E)-2-(furan-2-carbonylamino)-3-(2-furyl)prop-2-enoyl]amino]-3-methyl-butanoic acid
  • 2-[[3-(2-furyl)-2-[(2-furyl-oxomethyl)amino]-1-oxoprop-2-enyl]amino]-3-methylbutanoic acid
  • 2-[[(E)-3-(2-furyl)-2-[(2-furyl-oxomethyl)amino]-1-oxoprop-2-enyl]amino]-3-methylbutanoic acid
  • 2-[[2-(furan-2-carbonylamino)-3-(2-furyl)acryloyl]amino]-3-methyl-butyric acid
  • 2-[[(E)-2-(furan-2-carbonylamino)-3-(2-furyl)acryloyl]amino]-3-methyl-butyric acid
  • 2-[[(E)-3-furan-2-yl-2-(furan-2-ylcarbonylamino)prop-2-enoyl]amino]-3-methyl-butanoic acid
  • 2-[[3-furan-2-yl-2-(furan-2-ylcarbonylamino)prop-2-enoyl]amino]-3-methyl-butanoic acid
  • BAS 02616911

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0852 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.1037 0.1037
Schistosoma mansoni hypothetical protein 0.035 0.9882 0.9882
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0965 0.1568
Echinococcus granulosus dna polymerase eta 0.0054 0.093 0.151
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0 0.5
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.1278 0.2075
Loa Loa (eye worm) hypothetical protein 0.0066 0.1278 0.1378
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0965 0.1568
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.1278 0.1278
Leishmania major DNA polymerase eta, putative 0.0038 0.0444 0.4775
Echinococcus granulosus geminin 0.0205 0.5482 0.8902
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.1278 0.2075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0965 0.0965
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0965 0.0965
Onchocerca volvulus 0.0144 0.366 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0444 0.4775
Echinococcus multilocularis geminin 0.0205 0.5482 0.8902
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0722 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0852 0.0918
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0852 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0965 0.1568
Loa Loa (eye worm) glutaminase 0.033 0.9276 1
Schistosoma mansoni hypothetical protein 0.0205 0.5482 0.5482
Brugia malayi mbt repeat family protein 0.0058 0.1037 0.1118
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0852 0.1383
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.1037 0.1684
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.4587 0.4945
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.1278 0.2075
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0965 0.1041
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0852 0.0918
Brugia malayi mbt repeat family protein 0.0058 0.1037 0.1118
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0852 1
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.1037 0.1118
Mycobacterium ulcerans glutaminase 0.033 0.9276 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.1037 0.1037
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.1278 0.2075
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0965 0.1041
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.1037 0.1684
Loa Loa (eye worm) glutaminase 2 0.033 0.9276 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0965 0.1568
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0722 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.1037 0.1037
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.093 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.4587 0.4587
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.6158 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.4587 0.7449
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.1037 0.1684
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.6158 1
Schistosoma mansoni DNA polymerase eta 0.0054 0.093 0.093
Schistosoma mansoni glutaminase 0.033 0.9276 0.9276
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0722 0.5
Trichomonas vaginalis glutaminase, putative 0.033 0.9276 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.1037 0.1684
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.093 0.1003
Echinococcus multilocularis dna polymerase eta 0.0054 0.093 0.151
Leishmania major DNA polymerase eta, putative 0.0054 0.093 1
Loa Loa (eye worm) acetyltransferase 0.0175 0.4587 0.4945
Loa Loa (eye worm) MBCTL1 0.0066 0.1278 0.1378
Brugia malayi glutaminase DH11.1 0.033 0.9276 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.093 1
Schistosoma mansoni hypothetical protein 0.0205 0.5482 0.5482
Loa Loa (eye worm) hypothetical protein 0.0058 0.1037 0.1118
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.4439 0.7208
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.1278 0.1378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0965 0.0965
Loa Loa (eye worm) hypothetical protein 0.0054 0.093 0.1003

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0052 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9935 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485292] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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