TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 299.197 | Formula: C10H10F5N3O2
H donors: 2 H acceptors: 3 LogP: 2.73 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC1CC(n2c(N1)cc(n2)C(=O)O)C(C(F)(F)F)(F)F
InChi: 1S/C10H10F5N3O2/c1-4-2-6(9(11,12)10(13,14)15)18-7(16-4)3-5(17-18)8(19)20/h3-4,6,16H,2H2,1H3,(H,19,20)
InChiKey: PLAYSRYCRLUCFT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutaminase	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	estrogen receptor 1	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed), beta	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Mycobacterium tuberculosis	Conserved hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania major	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania braziliensis	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania donovani	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania mexicana	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma congolense	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma brucei gambiense	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	polymerase (DNA directed), beta	335 aa	303 aa	32.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0152	0.0245	0.0245
Trichomonas vaginalis	conserved hypothetical protein	0.0335	0.1342	0.3282
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0427	0.1887	0.4615
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0527	0.2485	0.6079
Loa Loa (eye worm)	phosphatidylinositol 3	0.0124	0.0079	0.0193
Trichomonas vaginalis	PIKK family atypical protein kinase	0.057	0.2747	0.6718
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0302	0.1143	0.2797
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1784	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0152	0.0245	0.06
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0152	0.0245	0.0834
Trichomonas vaginalis	conserved hypothetical protein	0.0224	0.0678	0.1657
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0795	0.4088	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0527	0.2485	0.6079
Schistosoma mansoni	hypothetical protein	0.0224	0.0678	0.0678
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0152	0.0245	0.0245
Mycobacterium ulcerans	glutaminase	0.033	0.1309	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0149	0.0228	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0268	0.0939	0.2297
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0302	0.1143	0.1143
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0235	0.0743	0.1818
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0379	0.1602	0.3918
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0302	0.1143	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0479	0.1172
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0152	0.0245	0.06
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0651	0.3228	0.7897
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0363	0.1506	0.1506
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0379	0.16	0.3914
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0527	0.2485	0.6079
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.1516	0.1516
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0507	0.2365	0.2365
Loa Loa (eye worm)	glutaminase 2	0.033	0.1309	0.3203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0603	0.2942	0.7196
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0651	0.3228	0.7897
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0603	0.2942	0.7196
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0866	0.4512	0.4512
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0152	0.0245	0.06
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0302	0.1143	0.1143
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0124	0.0079	0.0079
Entamoeba histolytica	hypothetical protein	0.0423	0.1867	0.5784
Loa Loa (eye worm)	phosphatidylinositol 3	0.0795	0.4088	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0507	0.2365	0.7326
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0359	0.1483	0.1483
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0795	0.4088	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0782	0.4014	0.9818
Onchocerca volvulus		0.0111	0	0.5
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.028	0.1009	0.3124
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0152	0.0245	0.06
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0235	0.0743	0.2302
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0651	0.3228	0.3228
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0613	0.3	0.7337
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0613	0.3	0.7337
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0365	0.1516	0.3709
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0335	0.1342	0.4561
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0651	0.3228	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0613	0.3	0.7337
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0152	0.0245	0.0245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0613	0.3	0.7337
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0613	0.3001	0.7339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0575	0.2772	0.6779
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0224	0.0678	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0195	0.0476
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0651	0.3228	0.3228
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0224	0.0678	0.0678
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.057	0.2747	0.8508
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0152	0.0245	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0363	0.1506	0.3685
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0651	0.3228	0.7897
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0152	0.0245	0.0245
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0187	0.0457	0.1117
Toxoplasma gondii	FATC domain-containing protein	0.0302	0.1143	0.3887
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0302	0.1143	0.1143
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0396	0.1701	0.5268
Trichomonas vaginalis	glutaminase, putative	0.033	0.1309	0.3203
Giardia lamblia	GTOR	0.0651	0.3228	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0795	0.4088	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0507	0.2365	0.5785
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1784	1	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0507	0.2365	0.5785
Echinococcus multilocularis	serine protein kinase ATM	0.0302	0.1143	0.1143
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0152	0.0245	0.06
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0235	0.0743	0.1818
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0379	0.1602	0.3918
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0235	0.0743	0.0743
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0651	0.3228	0.7897
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0235	0.0743	0.1818
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0565	0.2713	0.6636
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0565	0.2714	0.6638
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0527	0.2485	0.6079
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0613	0.3	0.7337
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0565	0.2713	0.6636
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0374	0.1571	0.3841
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0507	0.2365	0.2365
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1784	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0379	0.16	0.3914
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0651	0.3228	0.3228
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0152	0.0245	0.076
Brugia malayi	glutaminase DH11.1	0.033	0.1309	0.1309
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0565	0.2714	0.6638
Loa Loa (eye worm)	hypothetical protein	0.0268	0.0939	0.2297
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0565	0.2713	0.6636
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0368	0.0368
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0302	0.1143	0.1143
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0235	0.0743	0.2302
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0363	0.1506	0.1506
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0651	0.3228	0.3228
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.1516	0.1516
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0191	0.0479	0.0479
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0651	0.3228	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0302	0.1143	0.2797
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0651	0.3228	0.7897
Leishmania major	mitochondrial DNA polymerase beta	0.0365	0.1516	0.3709
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0603	0.2942	0.7196
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0302	0.1143	0.1143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0603	0.2942	0.7196
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0302	0.1143	0.1143
Entamoeba histolytica	hypothetical protein	0.0302	0.1143	0.3542
Brugia malayi	FAT domain containing protein	0.0224	0.0678	0.0678
Onchocerca volvulus		0.0111	0	0.5
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0603	0.2942	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0651	0.3228	0.7897
Loa Loa (eye worm)	hypothetical protein	0.0302	0.1143	0.2797
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0613	0.3001	0.7339
Loa Loa (eye worm)	hypothetical protein	0.0335	0.1342	0.3282
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0173	0.0368	0.09
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0152	0.0245	0.0245
Schistosoma mansoni	glutaminase	0.033	0.1309	0.1309
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0651	0.3228	0.3228
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0368	0.09
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0152	0.0245	0.0245
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0192	0.0484	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0866	0.4512	0.4512
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0194	0.0498	0.1542
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0565	0.2714	0.6638
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0302	0.1143	0.2797
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0296	0.1104	0.342
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0152	0.0245	0.076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0575	0.2772	0.6779
Trichomonas vaginalis	conserved hypothetical protein	0.0191	0.0479	0.1172
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0152	0.0245	0.06
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0651	0.3228	0.7897
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0651	0.3228	0.3228
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0603	0.2942	0.7196
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0302	0.1143	0.1143
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1784	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0235	0.0743	0.1818
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0152	0.0245	0.0245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0191	0.0479	0.1172
Mycobacterium leprae	conserved hypothetical protein	0.0111	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0388	0.1658	0.4055
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0423	0.1867	0.5784
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0152	0.0245	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0603	0.2942	0.7196
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0235	0.0743	0.0743
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0363	0.1506	0.1506
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0152	0.0245	0.06
Loa Loa (eye worm)	phosphatidylinositol 3	0.0651	0.3228	0.7897
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0527	0.2485	0.6079
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0379	0.16	0.3914
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0152	0.0245	0.0245
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0507	0.2365	0.2365
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0603	0.2942	0.7196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0527	0.2485	0.6079
Echinococcus granulosus	serine protein kinase ATM	0.0302	0.1143	0.1143
Entamoeba histolytica	protein kinase rad3, putative	0.0302	0.1143	0.3542
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0507	0.2365	0.5785
Trypanosoma cruzi	target of rapamycin kinase 3	0.0613	0.3001	0.3001
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0152	0.0245	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.0152	0.0245	0.0245
Loa Loa (eye worm)	glutaminase	0.033	0.1309	0.3203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0422	0.1856	0.454
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0866	0.4512	0.4512
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0235	0.0743	0.0743
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0565	0.2714	0.6638
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1784	1	1
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0678	0.1657

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 19.92373 um	PUBCHEM_BIOASSAY: Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 629 (Primary screen preceding this dose response confirmation assay.)]	ChEMBL.	No reference
Potency (functional)	2.2387 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.5113 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference
Potency (binding)	50.1187 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1606765

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1435684