Detailed information for compound 1436452

Basic information

Technical information
  • TDR Targets ID: 1436452
  • Name: 6-chloro-2-ethyl-N-(5,6,7,8-tetrahydronaphtha len-1-yl)-2,3-dihydro-1,4-benzoxazine-4-carbo xamide
  • MW: 370.873 | Formula: C21H23ClN2O2
  • H donors: 1 H acceptors: 1 LogP: 5.38 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1Oc2ccc(cc2N(C1)C(=O)Nc1cccc2c1CCCC2)Cl
  • InChi: 1S/C21H23ClN2O2/c1-2-16-13-24(19-12-15(22)10-11-20(19)26-16)21(25)23-18-9-5-7-14-6-3-4-8-17(14)18/h5,7,9-12,16H,2-4,6,8,13H2,1H3,(H,23,25)
  • InChiKey: APNIBJFBWAPQNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-2-ethyl-N-tetralin-5-yl-2,3-dihydro-1,4-benzoxazine-4-carboxamide
  • 6-chloro-2-ethyl-N-(5-tetralinyl)-2,3-dihydro-1,4-benzoxazine-4-carboxamide
  • E216-5162
  • NCGC00121367-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae conserved hypothetical protein 0.0122 0.0338 0.5
Loa Loa (eye worm) hypothetical protein 0.0184 0.0675 0.1341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0609 0.3004 0.6684
Leishmania major phosphatidylinositol 3-related kinase, putative 0.085 0.4326 1
Entamoeba histolytica protein kinase rad3, putative 0.0328 0.1465 0.3395
Loa Loa (eye worm) phosphatidylinositol 3 0.0122 0.0338 0.0672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0618 0.3055 0.6813
Entamoeba histolytica hypothetical protein 0.0521 0.2523 0.6584
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0174 0.0625 0.0297
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0338 0.1518 0.3556
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0627 0.3106 0.694
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0281 0.1208 0.2181
Loa Loa (eye worm) phosphatidylinositol 3 0.0122 0.0338 0.0672
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0174 0.0625 0.072
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1887 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0797 0.1151
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0159 0.054 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0425 0.1999 0.4166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0618 0.3055 0.6813
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0444 0.2101 0.1824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0569 0.2787 0.6141
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0728 0.3657 0.3435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.3322 0.7481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0328 0.1465 0.2826
Onchocerca volvulus 0.0122 0.0338 0.5
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1086 0.5618 0.5464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.3322 0.7481
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0281 0.1208 0.2181
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0328 0.1465 0.1166
Loa Loa (eye worm) hypothetical protein 0.0281 0.1209 0.2402
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0459 0.2182 0.2182
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0174 0.0625 0.072
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0328 0.1465 0.1166
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0728 0.3657 0.8322
Echinococcus granulosus tumor protein p63 0.0408 0.1904 0.1621
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0174 0.0625 0.0297
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0728 0.3657 0.3435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0425 0.1999 0.4166
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0679 0.339 0.7654
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.3389 0.7651
Loa Loa (eye worm) hypothetical protein 0.0363 0.166 0.3298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0728 0.3657 0.8322
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0521 0.2523 0.6584
Loa Loa (eye worm) phosphatidylinositol 3 0.0122 0.0338 0.0672
Toxoplasma gondii FATC domain-containing protein 0.0328 0.1465 0.3777
Trichomonas vaginalis conserved hypothetical protein 0.0363 0.166 0.3316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0569 0.2787 0.6141
Loa Loa (eye worm) phosphatidylinositol 3 0.098 0.5035 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.085 0.4326 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.085 0.4326 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0174 0.0625 0.0297
Brugia malayi FAT domain containing protein 0.0241 0.0993 0.0993
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0281 0.1208 0.2181
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.0338 0.0338
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0328 0.1465 0.1166
Onchocerca volvulus 0.0122 0.0338 0.5
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0328 0.1465 0.1166
Schistosoma mansoni fkbp-rapamycin associated protein 0.0328 0.1465 0.1166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0473 0.2262 0.4825
Trichomonas vaginalis PIKK family atypical protein kinase 0.0569 0.2787 0.6141
Loa Loa (eye worm) phosphatidylinositol 3 0.085 0.4326 0.8592
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0728 0.3657 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.3389 0.7651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0631 0.3123 0.6982
Brugia malayi MH2 domain containing protein 0.0144 0.046 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.3389 0.7651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.3389 0.7651
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0728 0.3657 0.8322
Echinococcus multilocularis tumor protein p63 0.0408 0.1904 0.1621
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.046 0.0913
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0206 0.0797 0.0475
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0627 0.3106 0.694
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0728 0.3657 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0174 0.0625 0.1242
Loa Loa (eye worm) phosphatidylinositol 3 0.0122 0.0338 0.0672
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0174 0.0625 0.072
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0174 0.0625 0.072
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0444 0.2101 0.1824
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0627 0.3106 0.2864
Trichomonas vaginalis PIKK family atypical protein kinase 0.0171 0.0605 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0728 0.3657 0.8322
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0464 0.2213 0.47
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1887 1 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0609 0.3004 0.8032
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0627 0.3106 0.694
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0328 0.1465 0.1465
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0174 0.0625 0.0962
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0281 0.1208 0.09
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0627 0.3106 0.3106
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0569 0.2787 0.6141
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1887 1 1
Schistosoma mansoni hypothetical protein 0.0241 0.0993 0.0677
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.046 0.0913
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0281 0.1208 0.2181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0728 0.3657 0.8322
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0228 0.0921 0.1755
Loa Loa (eye worm) hypothetical protein 0.0241 0.0993 0.1971
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0444 0.2101 0.2101
Trypanosoma cruzi target of rapamycin kinase 3 0.0679 0.339 0.3159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0618 0.3055 0.6813
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0627 0.3106 0.2864
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0627 0.3106 0.8339
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0281 0.1208 0.09
Entamoeba histolytica hypothetical protein 0.0328 0.1465 0.3395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.3322 0.7481
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.0338 0.0338
Toxoplasma gondii target of rapamycin (TOR), putative 0.0667 0.3322 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.0797 0.1583
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0328 0.1465 0.1166
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0728 0.3657 0.3657
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0328 0.1465 0.2826
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0174 0.0625 0.0865
Leishmania major phosphatidylinositol 3-kinase, putative 0.0174 0.0625 0.072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.3389 0.7651
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0358 0.163 0.3893
Loa Loa (eye worm) phosphatidylinositol 3 0.0728 0.3657 0.7263
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0412 0.1928 0.3987
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0241 0.0993 0.0677
Echinococcus multilocularis serine protein kinase ATM 0.0328 0.1465 0.1166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0438 0.2067 0.4335
Loa Loa (eye worm) hypothetical protein 0.0281 0.1209 0.2402
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0728 0.3657 0.3435
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0728 0.3657 0.8322
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0174 0.0625 1
Echinococcus granulosus serine protein kinase ATM 0.0328 0.1465 0.1166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.3322 0.7481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0425 0.1999 0.4166
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0174 0.0625 0.0297
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1887 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0122 0.0338 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.0993 0.1641
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0728 0.3657 0.8322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0328 0.1465 0.2826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.3322 0.7481
Loa Loa (eye worm) phosphatidylinositol 3 0.0159 0.054 0.1072
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0505 0.2438 0.6327
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0464 0.2213 0.47
Loa Loa (eye worm) phosphatidylinositol kinase 0.0122 0.0338 0.0672
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.022 0.0873 0.134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.3322 0.7481
Giardia lamblia GTOR 0.0728 0.3657 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0174 0.0625 0.0297
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0363 0.166 0.4432
Loa Loa (eye worm) hypothetical protein 0.0444 0.2101 0.4173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0618 0.3054 0.681
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0174 0.0625 0.0962
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0174 0.0625 0.0865
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0728 0.3657 0.3435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0618 0.3055 0.6813
Echinococcus multilocularis Zinc finger, PHD finger 0.0174 0.0625 0.0297
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0174 0.0625 0.0297
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1086 0.5618 0.5464
Loa Loa (eye worm) hypothetical protein 0.0122 0.0338 0.0672
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0281 0.1208 0.1208
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0281 0.1208 0.262
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0174 0.0625 0.0297
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0728 0.3657 0.3435
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0174 0.0625 0.072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0631 0.3123 0.6982
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1086 0.5618 0.5464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0487 0.2335 0.5007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0618 0.3054 0.681
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0241 0.0993 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0797 0.1151
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1887 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.3322 0.7481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0569 0.2787 0.6141
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0174 0.0625 0.0625
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0281 0.1208 0.262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0618 0.3054 0.681
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0328 0.1465 0.1465
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0174 0.0625 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0328 0.1465 0.291
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0679 0.339 0.7654
Leishmania major phosphatidylinositol 3-kinase, putative 0.0569 0.2787 0.6141

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0794 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5012 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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