Detailed information for compound 1438658

Basic information

Technical information
  • TDR Targets ID: 1438658
  • Name: 5-methyl-N-(4-methylphenyl)-2-(5-methylthioph en-2-yl)imidazo[3,2-a]pyridin-3-amine
  • MW: 333.45 | Formula: C20H19N3S
  • H donors: 1 H acceptors: 1 LogP: 6.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Nc1c(nc2n1c(C)ccc2)c1ccc(s1)C
  • InChi: 1S/C20H19N3S/c1-13-7-10-16(11-8-13)21-20-19(17-12-9-15(3)24-17)22-18-6-4-5-14(2)23(18)20/h4-12,21H,1-3H3
  • InChiKey: DBINJLYGWDRSDQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-methyl-N-(4-methylphenyl)-2-(5-methyl-2-thienyl)imidazo[3,2-a]pyridin-3-amine
  • 5-methyl-N-(4-methylphenyl)-2-(5-methyl-2-thienyl)-3-imidazo[3,2-a]pyridinamine
  • [5-methyl-2-(5-methyl-2-thienyl)imidazo[3,2-a]pyridin-3-yl]-(4-methylphenyl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, liver and RBC Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, liver and RBC 574 aa 524 aa 36.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0257 0.1995 0.1995
Entamoeba histolytica protein kinase, putative 0.0495 0.4255 0.4205
Echinococcus granulosus cyclin dependent kinase 1 0.0586 0.5121 0.4961
Brugia malayi intracellular kinase 0.0698 0.6185 0.6185
Brugia malayi serine/threonine kinase 12 0.0082 0.0336 0.0336
Echinococcus multilocularis dual specificity 0.0495 0.4255 0.4164
Trichomonas vaginalis CMGC family protein kinase 0.0698 0.6185 1
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0336 0.0543
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0034 0.0055
Schistosoma mansoni lipoxygenase 0.0242 0.1856 0.1589
Entamoeba histolytica hypothetical protein 0.1099 1 1
Giardia lamblia Kinase, CMGC GSK 0.0698 0.6185 1
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0482 0.4135 0.4135
Chlamydia trachomatis pyruvate kinase 0.0081 0.0318 0.5
Loa Loa (eye worm) pyruvate kinase 0.0081 0.0318 0.0318
Leishmania major protein kinase, putative 0.0082 0.0336 0.0019
Loa Loa (eye worm) AUR protein kinase 0.0082 0.0336 0.0336
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0586 0.5121 0.5121
Mycobacterium ulcerans pyruvate kinase 0.0081 0.0318 0.5
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0698 0.6185 0.6125
Echinococcus granulosus casein kinase i 0.0482 0.4135 0.3943
Trypanosoma cruzi casein kinase, putative 0.0482 0.4135 0.3943
Entamoeba histolytica protein kinase, putative 0.0082 0.0336 0.0252
Echinococcus multilocularis pyruvate kinase 0.0081 0.0318 0.0164
Echinococcus multilocularis pyruvate kinase 0.0081 0.0318 0.0164
Echinococcus granulosus casein kinase I alpha 0.0482 0.4135 0.3943
Brugia malayi serine/threonine-protein kinase 6 0.0082 0.0336 0.0336
Entamoeba histolytica protein kinase, putative 0.1099 1 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.1099 1 1
Brugia malayi Protein kinase domain containing protein 0.0586 0.5121 0.5121
Giardia lamblia Aurora kinase 0.0082 0.0336 0.0031
Entamoeba histolytica protein kinase domain containing protein 0.1099 1 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0698 0.6185 0.606
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0082 0.0336 0.0019
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0257 0.1995 0.1733
Schistosoma mansoni serine/threonine protein kinase 0.0482 0.4135 0.3943
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1099 1 1
Echinococcus multilocularis casein kinase I alpha 0.0482 0.4135 0.4042
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0081 0.0318 0.5
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0586 0.5121 0.5121
Echinococcus multilocularis casein kinase I alpha 0.0482 0.4135 0.4042
Trichomonas vaginalis CMGC family protein kinase 0.0586 0.5121 0.828
Echinococcus multilocularis dual specificity 0.1099 1 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0698 0.6185 0.606
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0495 0.4255 0.671
Trypanosoma brucei protein kinase, putative 0.0698 0.6185 0.606
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0698 0.6185 0.606
Trichomonas vaginalis CMGC family protein kinase 0.0495 0.4255 0.6879
Schistosoma mansoni serine/threonine protein kinase 0.1099 1 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0586 0.5121 0.4961
Echinococcus multilocularis aurora kinase A 0.0082 0.0336 0.0182
Trypanosoma cruzi cdc2-related kinase 3 0.0586 0.5121 0.4961
Echinococcus multilocularis dual specificity 0.0495 0.4255 0.4164
Entamoeba histolytica protein kinase, putative 0.0698 0.6185 0.6152
Plasmodium falciparum serine/threonine protein kinase, putative 0.0082 0.0336 0.0031
Entamoeba histolytica protein kinase , putative 0.0082 0.0336 0.0252
Echinococcus multilocularis protein kinase shaggy 0.0698 0.6185 0.6125
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0482 0.4135 0.3943
Trichomonas vaginalis CMGC family protein kinase 0.0495 0.4255 0.6879
Trypanosoma cruzi casein kinase, putative 0.0482 0.4135 0.3943
Echinococcus multilocularis casein kinase i 0.0482 0.4135 0.4042
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.0318 0.0514
Loa Loa (eye worm) pyruvate kinase 0.0081 0.0318 0.0318
Echinococcus multilocularis dual specificity 0.0495 0.4255 0.4164
Entamoeba histolytica cell division protein kinase 2, putative 0.0586 0.5121 0.5079
Onchocerca volvulus 0.0454 0.3868 0.6253
Loa Loa (eye worm) hypothetical protein 0.0056 0.0086 0.0086
Echinococcus multilocularis cyclin dependent kinase 0.0586 0.5121 0.5044
Giardia lamblia Kinase, CMGC DYRK 0.0495 0.4255 0.671
Brugia malayi serine/threonine protein kinase 6 0.0082 0.0336 0.0336
Schistosoma mansoni protein kinase 0.0482 0.4135 0.3943
Entamoeba histolytica protein kinase domain containing protein 0.0698 0.6185 0.6152
Echinococcus multilocularis casein kinase I delta 0.0482 0.4135 0.4042
Trypanosoma cruzi casein kinase, putative 0.0482 0.4135 0.3943
Trypanosoma brucei aurora B kinase 0.0082 0.0336 0.0019
Entamoeba histolytica protein kinase, putative 0.0082 0.0336 0.0252
Schistosoma mansoni lipoxygenase 0.0169 0.1163 0.0873
Leishmania major casein kinase, putative 0.0482 0.4135 0.3943
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0257 0.1995 0.1733
Echinococcus granulosus dual specificity 0.1099 1 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0586 0.5121 0.5121
Echinococcus multilocularis cyclin dependent kinase 1 0.0586 0.5121 0.5044
Trypanosoma cruzi cdc2-related kinase 3 0.0586 0.5121 0.4961
Plasmodium vivax casein kinase 1, putative 0.0482 0.4135 0.6506
Trypanosoma brucei cdc2-related kinase 3 0.0586 0.5121 0.4961
Plasmodium vivax glycogen synthase kinase 3, putative 0.0698 0.6185 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0586 0.5121 0.4961
Echinococcus granulosus cyclin dependent kinase 0.0586 0.5121 0.4961
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0698 0.6185 0.6185
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0352 0.0352
Echinococcus granulosus cyclin dependent kinase 5 0.0586 0.5121 0.4961
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0336 0.0543
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0586 0.5121 0.8187
Trypanosoma brucei cdc2-related kinase 1 0.0586 0.5121 0.4961
Giardia lamblia Kinase, CMGC CDK 0.0586 0.5121 0.8187
Giardia lamblia Kinase, CMGC CDK 0.0586 0.5121 0.8187
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0698 0.6185 0.606
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0698 0.6185 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0721 0.0721
Brugia malayi cell division control protein 2 homolog 0.0586 0.5121 0.5121
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.1099 1 1
Toxoplasma gondii aurora kinase 0.0082 0.0336 0.0031
Brugia malayi hypothetical protein 0.0123 0.0721 0.0721
Brugia malayi Pyruvate kinase, M2 isozyme 0.0081 0.0318 0.0318
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0495 0.4255 0.4066
Plasmodium vivax protein kinase Crk2 0.0586 0.5121 0.8187
Echinococcus granulosus dual specificity 0.0495 0.4255 0.4066
Trichomonas vaginalis CK1 family protein kinase 0.0482 0.4135 0.6686
Echinococcus granulosus chromobox protein 1 0.0084 0.0352 0.0035
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0082 0.0336 0.0031
Trichomonas vaginalis CMGC family protein kinase 0.0495 0.4255 0.6879
Schistosoma mansoni chromobox protein 0.0084 0.0352 0.0035
Entamoeba histolytica protein kinase domain containing protein 0.0082 0.0336 0.0252
Trypanosoma cruzi cdc2-related kinase 1 0.0586 0.5121 0.4961
Echinococcus multilocularis casein kinase I delta 0.0482 0.4135 0.4042
Loa Loa (eye worm) pyruvate kinase-PB 0.0056 0.0086 0.0086
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0698 0.6185 0.6185
Entamoeba histolytica protein kinase, putative 0.1099 1 1
Trichomonas vaginalis CK1 family protein kinase 0.0482 0.4135 0.6686
Trichomonas vaginalis pyruvate kinase, putative 0.0081 0.0318 0.0514
Trichomonas vaginalis CMGC family protein kinase 0.0586 0.5121 0.828
Entamoeba histolytica protein kinase domain containing protein 0.0495 0.4255 0.4205
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0586 0.5121 0.4961
Schistosoma mansoni serine/threonine protein kinase 0.0495 0.4255 0.4066
Schistosoma mansoni chromobox protein 0.0084 0.0352 0.0035
Plasmodium falciparum glycogen synthase kinase 3 0.0698 0.6185 1
Giardia lamblia Kinase, CK1 Casein kinase 0.0482 0.4135 0.6506
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0242 0.1856 0.1589
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0336 0.0543
Echinococcus granulosus dual specificity 0.0495 0.4255 0.4066
Brugia malayi Heterochromatin protein 1 0.0084 0.0352 0.0352
Echinococcus multilocularis cyclin dependent kinase 1 0.0586 0.5121 0.5044
Echinococcus granulosus casein kinase I delta 0.0482 0.4135 0.3943
Brugia malayi Pyruvate kinase, muscle isozyme 0.0081 0.0318 0.0318
Echinococcus granulosus aurora kinase A 0.0082 0.0336 0.0019
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0034 0.0055
Entamoeba histolytica protein kinase domain containing protein 0.0698 0.6185 0.6152
Echinococcus granulosus protein kinase shaggy 0.0698 0.6185 0.606
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0257 0.1995 0.1868
Schistosoma mansoni serine/threonine protein kinase 0.0586 0.5121 0.4961
Brugia malayi casein kinase 1, delta 0.0482 0.4135 0.4135
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0336 0.0019
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0082 0.0336 0.0182
Entamoeba histolytica cell division protein kinase 2, putative 0.0586 0.5121 0.5079
Echinococcus granulosus dual specificity 0.0495 0.4255 0.4066
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0482 0.4135 0.4135
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.0318 0.0514
Loa Loa (eye worm) hypothetical protein 0.0123 0.0721 0.0721
Trichomonas vaginalis CMGC family protein kinase 0.0495 0.4255 0.6879
Loa Loa (eye worm) hypothetical protein 0.0558 0.4854 0.4854
Toxoplasma gondii casein kinase I 0.0482 0.4135 0.6506
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0242 0.1856 0.1727
Loa Loa (eye worm) AUR protein kinase 0.0082 0.0336 0.0336
Echinococcus multilocularis chromobox protein 1 0.0084 0.0352 0.0198
Trypanosoma cruzi casein kinase, putative 0.0482 0.4135 0.3943
Loa Loa (eye worm) hypothetical protein 0.0081 0.0318 0.0318
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0352 0.0568
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0034 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0336 0.0543
Schistosoma mansoni protein kinase 0.0082 0.0336 0.0019
Trypanosoma cruzi cdc2-related kinase 1 0.0586 0.5121 0.4961
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0495 0.4255 0.4066
Giardia lamblia Kinase, CMGC GSK 0.0698 0.6185 1
Loa Loa (eye worm) hypothetical protein 0.1071 0.9732 0.9732
Entamoeba histolytica casein kinase, putative 0.0482 0.4135 0.4085
Echinococcus multilocularis casein kinase I alpha 0.0482 0.4135 0.4042
Entamoeba histolytica casein kinase 1, putative 0.0482 0.4135 0.4085
Trypanosoma cruzi casein kinase, putative 0.0482 0.4135 0.3943
Trichomonas vaginalis CMGC family protein kinase 0.0698 0.6185 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0586 0.5121 0.5044
Trichomonas vaginalis pyruvate kinase, putative 0.0081 0.0318 0.0514
Trichomonas vaginalis CMGC family protein kinase 0.0495 0.4255 0.6879
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0082 0.0336 0.0252
Onchocerca volvulus 0.0482 0.4135 0.6686
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1099 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0495 0.4255 0.6879
Echinococcus granulosus casein kinase I delta 0.0482 0.4135 0.3943
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0495 0.4255 0.4255
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0082 0.0336 0.0252
Trichomonas vaginalis CMGC family protein kinase 0.0586 0.5121 0.828
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0482 0.4135 0.4135
Mycobacterium leprae Probable pyruvate kinase PykA 0.0081 0.0318 0.5
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0082 0.0336 0.0252
Loa Loa (eye worm) hypothetical protein 0.1071 0.9732 0.9732
Echinococcus granulosus casein kinase I alpha 0.0482 0.4135 0.3943
Trichomonas vaginalis CK1 family protein kinase 0.0482 0.4135 0.6686
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0454 0.3868 0.3666
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.1099 1 1
Trypanosoma cruzi aurora B kinase, putative 0.0082 0.0336 0.0019
Plasmodium falciparum casein kinase 1 0.0482 0.4135 0.6506
Echinococcus granulosus casein kinase I alpha 0.0482 0.4135 0.3943
Loa Loa (eye worm) pyruvate kinase 0.0081 0.0318 0.0318
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.0318 0.0514
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0495 0.4255 0.4255
Plasmodium falciparum protein kinase 5 0.0586 0.5121 0.8187
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0495 0.4255 0.4066
Echinococcus granulosus chromobox protein 1 0.0084 0.0352 0.0035
Loa Loa (eye worm) AUR protein kinase 0.0082 0.0336 0.0336
Onchocerca volvulus 0.0698 0.6185 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.0352 0.0198
Brugia malayi casein kinase I 0.0482 0.4135 0.4135
Schistosoma mansoni serine/threonine protein kinase 0.0586 0.5121 0.4961
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0352 0.0568
Trypanosoma brucei casein kinase I, isoform 2 0.0482 0.4135 0.3943

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.1905 uM PUBCHEM_BIOASSAY: Secondary LDH Assay for Activators of Human Pyruvate Kinase M2 isoform: for Probe SAR. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.5702 um PUBCHEM_BIOASSAY: Secondary LDH Assay for Activators of Human Reticulocyte Pyruvate Kinase: for Probe SAR. (Class of assay: confirmatory) [Related pubchem assays: 2095, 1631 ] ChEMBL. No reference
Potency (functional) = 16.3433 um PUBCHEM_BIOASSAY: Secondary LDH Assay for Activators of Human Liver Pyruvate Kinase: for Probe SAR. (Class of assay: confirmatory) [Related pubchem assays: 1540, 2576, 2535, 2095, 1751, 2536, 2533, 2562, 2534, 1631 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.0856 uM PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase: for Probe SAR. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 36.5881 um PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1634, 1631, 1379 ] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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