Detailed information for compound 1442905

Basic information

Technical information
  • TDR Targets ID: 1442905
  • Name: 1-(4-fluorophenyl)-2-[2-(trifluoromethyl)benz imidazol-1-yl]ethanone
  • MW: 322.257 | Formula: C16H10F4N2O
  • H donors: 0 H acceptors: 2 LogP: 3.97 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(=O)Cn1c2ccccc2nc1C(F)(F)F
  • InChi: 1S/C16H10F4N2O/c17-11-7-5-10(6-8-11)14(23)9-22-13-4-2-1-3-12(13)21-15(22)16(18,19)20/h1-8H,9H2
  • InChiKey: SWQMAGHRNVLUOP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-fluorophenyl)-2-[2-(trifluoromethyl)-1-benzimidazolyl]ethanone
  • 1-(4-fluorophenyl)-2-[2-(trifluoromethyl)-1H-1,3-benzimidazol-1-yl]-1-ethanone
  • MLS000546587
  • SMR000179985
  • 2R-1569
  • ZINC01384061

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0273 0.4791
Schistosoma mansoni nAChR subunit 0.0119 0.0097 0.0086
Loa Loa (eye worm) hypothetical protein 0.0547 0.1326 0.2075
Echinococcus granulosus heat shock protein 90 0.0138 0.0153 0.0153
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0139 0.0156 0.0199
Schistosoma mansoni opsin-like receptor 0.0139 0.0156 0.0164
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Schistosoma mansoni neuropeptide receptor 0.0139 0.0156 0.0164
Brugia malayi PAN domain containing protein 0.016 0.0215 0.0293
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0371 0.0821 0.1266
Trypanosoma brucei C-8 sterol isomerase, putative 0.0371 0.0821 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0256 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0335 0.0718 0.11
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Brugia malayi neuropeptide F receptor 0.0139 0.0156 0.0199
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0119 0.0097 0.0104
Onchocerca volvulus 0.016 0.0215 0.2663
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0112 0.0078 0.0001
Schistosoma mansoni heat shock protein 0.0138 0.0153 0.0161
Brugia malayi brahma associated protein 60 kDa 0.0111 0.0076 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0503 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.0156 0.0164
Echinococcus multilocularis jun protein 0.0099 0.0041 0.0041
Echinococcus multilocularis g-protein coupled receptor 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0139 0.0156 0.0199
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Brugia malayi SWIB/MDM2 domain containing protein 0.0111 0.0076 0.007
Schistosoma mansoni heat shock protein 0.0138 0.0153 0.0161
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Echinococcus granulosus biogenic amine 5HT receptor 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus multilocularis nmda type glutamate receptor 0.0115 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0116 0.009 0.0093
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Brugia malayi neuropeptide F receptor 0.0139 0.0156 0.0199
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0119 0.0097 0.0104
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.0181 0.0239
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0139 0.0156 0.0156
Toxoplasma gondii heat shock protein 90, putative 0.0138 0.0153 0.0115
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0119 0.0097 0.0104
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0547 0.1326 0.1326
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1195 0.3184 0.3184
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0139 0.0156 0.0199
Echinococcus granulosus ecdysone induced protein 78C 0.0096 0.0032 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0247 0.4195
Echinococcus granulosus dro:myosuppressin receptor 0.0139 0.0156 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0247 0.4195
Echinococcus multilocularis heat shock protein 0.0138 0.0153 0.0153
Brugia malayi G protein-coupled receptor 0.0139 0.0156 0.0199
Onchocerca volvulus 0.0119 0.0097 0.0945
Brugia malayi hypothetical protein 0.0139 0.0156 0.0199
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0119 0.0097 0.0097
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0139 0.0156 0.0156
Brugia malayi putative neuropeptide receptor NPR1 0.0139 0.0156 0.0199
Loa Loa (eye worm) PAN domain-containing protein 0.016 0.0215 0.0293
Echinococcus granulosus FTZ F1 alpha 0.0096 0.0032 0.0032
Schistosoma mansoni integrin alpha 0.0148 0.0181 0.0197
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Brugia malayi Serotonin receptor 0.0139 0.0156 0.0199
Schistosoma mansoni brg-1 associated factor 0.0111 0.0076 0.0058
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0256 0.049 0.049
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0139 0.0156 0.0156
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0144 0.0171 0.0171
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Loa Loa (eye worm) heat shock protein 90 0.0138 0.0153 0.0195
Trypanosoma cruzi heat shock protein 85, putative 0.0125 0.0116 0.051
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0139 0.0156 0.0156
Echinococcus multilocularis glycine receptor subunit beta 0.0119 0.0097 0.0097
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0167 0.0237 0.0237
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0119 0.0097 0.0086
Loa Loa (eye worm) LGC-31 protein 0.0119 0.0097 0.0104
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Echinococcus multilocularis neuropeptide receptor A26 0.0643 0.1601 0.1601
Toxoplasma gondii hypothetical protein 0.016 0.0215 0.0205
Toxoplasma gondii PAN/Apple domain-containing protein 0.016 0.0215 0.0205
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0119 0.0097 0.0086
Echinococcus multilocularis neuropeptide FF receptor 2 0.0139 0.0156 0.0156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.0156 0.0164
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0119 0.0097 0.0097
Trypanosoma brucei heat shock protein 90, putative 0.0138 0.0153 0.1013
Brugia malayi Melatonin receptor type 1A 0.0139 0.0156 0.0199
Schistosoma mansoni amine GPCR 0.0139 0.0156 0.0164
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0119 0.0097 0.0104
Brugia malayi latrophilin 2 splice variant baaae 0.1077 0.2844 0.4507
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0096 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0547 0.1326 0.1711
Schistosoma mansoni biogenic amine (5HT) receptor 0.0139 0.0156 0.0164
Loa Loa (eye worm) G-protein coupled receptor 0.0139 0.0156 0.0199
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0119 0.0097 0.0097
Brugia malayi hypothetical protein 0.0139 0.0156 0.0199
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.3573 1 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0106 0.0061 0.0047
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0167 0.0237 0.213
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.0032 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Brugia malayi RE15519p 0.0139 0.0156 0.0199
Echinococcus multilocularis g protein coupled receptor 0.0139 0.0156 0.0156
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0119 0.0097 0.0086
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0119 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus granulosus serotonin receptor 0.0139 0.0156 0.0156
Toxoplasma gondii hypothetical protein 0.016 0.0215 0.0205
Echinococcus multilocularis FTZ F1 alpha 0.0096 0.0032 0.0032
Brugia malayi Endoplasmin precursor 0.0138 0.0153 0.0195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.0156 0.0164
Onchocerca volvulus 0.0139 0.0156 0.1813
Echinococcus multilocularis nAChR subunit 0.0119 0.0097 0.0097
Brugia malayi PAN domain containing protein 0.016 0.0215 0.0293
Loa Loa (eye worm) G-protein coupled receptor 0.0139 0.0156 0.0199
Echinococcus multilocularis sex peptide receptor 0.0139 0.0156 0.0156
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0112 0.0078 0.0001
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.0078 0.0073
Trichomonas vaginalis heat shock protein, putative 0.0138 0.0153 0.2088
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Loa Loa (eye worm) PAN domain-containing protein 0.016 0.0215 0.0293
Echinococcus granulosus jun protein 0.0099 0.0041 0.0041
Echinococcus granulosus tachykinin peptides receptor 99D 0.0139 0.0156 0.0156
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Echinococcus multilocularis somatostatin receptor 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0112 0.0078 0.0074
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) hypothetical protein 0.2272 0.6271 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0167 0.0237 0.2131
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) hypothetical protein 0.0167 0.0237 0.0328
Mycobacterium leprae conserved hypothetical protein 0.0164 0.0228 1
Echinococcus multilocularis neuropeptide s receptor 0.0643 0.1601 0.1601
Echinococcus multilocularis endoplasmin 0.0125 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0139 0.0156 0.0164
Onchocerca volvulus 0.0111 0.0076 0.0635
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0099 0.0041 0.0041
Plasmodium falciparum heat shock protein 90 0.0138 0.0153 1
Toxoplasma gondii heat shock protein HSP90 0.0138 0.0153 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0139 0.0156 0.0156
Toxoplasma gondii transporter, cation channel family protein 0.0167 0.0237 0.0237
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0335 0.0718 0.0907
Brugia malayi Cation transporter family protein 0.0119 0.0097 0.0104
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0139 0.0156 0.0164
Toxoplasma gondii PAN domain-containing protein 0.2481 0.6871 1
Onchocerca volvulus 0.0119 0.0097 0.0945
Toxoplasma gondii microneme protein MIC17C 0.016 0.0215 0.0205
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0139 0.0156 0.0164
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0119 0.0097 0.0104
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Trypanosoma brucei heat shock protein, putative 0.0138 0.0153 0.1013
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0111 0.0076 0.0076
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0139 0.0156 0.0199
Echinococcus granulosus SWI:SNF matrix associated 0.0111 0.0076 0.0076
Loa Loa (eye worm) adenylyl cyclase 3 0.0143 0.0166 0.0215
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0111 0.0076 0.0076
Echinococcus multilocularis g protein coupled receptor 0.0139 0.0156 0.0156
Echinococcus granulosus 7TM GPCR rhodopsin 0.0139 0.0156 0.0156
Brugia malayi hypothetical protein 0.0139 0.0156 0.0199
Echinococcus granulosus sex peptide receptor 0.0139 0.0156 0.0156
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0119 0.0097 0.0097
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0139 0.0156 0.0164
Brugia malayi G protein-coupled receptor F59B2.13 0.0139 0.0156 0.0199
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1624 0.4413 0.7023
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Onchocerca volvulus 0.016 0.0215 0.2663
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.0032 0.0032
Onchocerca volvulus 0.0139 0.0156 0.1813
Echinococcus granulosus heat shock protein 90 0.0125 0.0116 0.0116
Schistosoma mansoni growth hormone secretagogue receptor 0.0139 0.0156 0.0164
Entamoeba histolytica heat shock protein 90, putative 0.0138 0.0153 0.5531
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0167 0.0237 0.0237
Schistosoma mansoni amine GPCR 0.0139 0.0156 0.0164
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0361 0.0791 0.1216
Loa Loa (eye worm) hypothetical protein 0.0112 0.0078 0.0073
Schistosoma mansoni endoplasmin 0.0138 0.0153 0.0161
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Brugia malayi Tachykinin-like peptides receptor 99D 0.0139 0.0156 0.0199
Echinococcus multilocularis fmrfamide receptor 0.0139 0.0156 0.0156
Echinococcus multilocularis allatostatin A receptor 0.0275 0.0544 0.0544
Echinococcus granulosus nAChR subunit 0.0119 0.0097 0.0097
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1183 0.3149 0.3149
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0167 0.0237 0.2982
Schistosoma mansoni hypothetical protein 0.0207 0.035 0.0421
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Schistosoma mansoni apoptosis regulator bax 0.0361 0.0791 0.1003
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0167 0.0237 0.027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.0156 0.0164
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Schistosoma mansoni hypothetical protein 0.0547 0.1326 0.1711
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0097 0.0104
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0361 0.0791 0.1003
Echinococcus granulosus 7tm_1 domain containing protein 0.0139 0.0156 0.0156
Trypanosoma cruzi heat shock protein 85, putative 0.0138 0.0153 0.1014
Schistosoma mansoni biogenic amine receptor 0.0139 0.0156 0.0164
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Brugia malayi hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) integrin alpha pat-2 0.0228 0.041 0.0607
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0503 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0111 0.0076 0.007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0097 0.0104
Trypanosoma cruzi Heat shock protein 83, putative 0.0138 0.0153 0.1014
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Echinococcus granulosus tm gpcr rhodopsin 0.1183 0.3149 0.3149
Echinococcus granulosus endoplasmin 0.0125 0.0116 0.0116
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0139 0.0156 0.0199
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Plasmodium vivax heat shock protein 86, putative 0.0138 0.0153 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0139 0.0156 0.0199
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Treponema pallidum heat shock protein 90 0.0125 0.0116 0.5
Schistosoma mansoni hypothetical protein 0.0139 0.0156 0.0164
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Brugia malayi Dopamine receptor protein 1 0.0139 0.0156 0.0199
Brugia malayi hypothetical protein 0.0139 0.0156 0.0199
Echinococcus granulosus glycine receptor subunit beta 0.0119 0.0097 0.0097
Onchocerca volvulus 0.0139 0.0156 0.1813
Loa Loa (eye worm) neuropeptide F receptor 0.0139 0.0156 0.0199
Toxoplasma gondii microneme protein MIC17A 0.016 0.0215 0.0205
Echinococcus multilocularis SWI:SNF matrix associated 0.0111 0.0076 0.0076
Loa Loa (eye worm) bone morphogenic protein 6 0.0124 0.0113 0.013
Echinococcus multilocularis GPCR, family 2 0.0547 0.1326 0.1326
Echinococcus multilocularis neuropeptide Y receptor 0.0139 0.0156 0.0156
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.0032 0.0032
Brugia malayi hypothetical protein 0.0139 0.0156 0.0199
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.0156 0.0164
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Schistosoma mansoni hypothetical protein 0.1077 0.2844 0.3716
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0256 0.049 0.049
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0247 0.4195
Schistosoma mansoni opsin-like receptor 0.0139 0.0156 0.0164
Onchocerca volvulus 0.0139 0.0156 0.1813
Loa Loa (eye worm) hypothetical protein 0.016 0.0215 0.0293
Giardia lamblia Heat shock protein HSP 90-alpha 0.0138 0.0153 1
Brugia malayi larval opioid receptor 0.0139 0.0156 0.0199
Echinococcus granulosus neuropeptides capa receptor 0.0139 0.0156 0.0156
Echinococcus granulosus GPCR family 2 0.0547 0.1326 0.1326
Echinococcus multilocularis neuropeptide receptor 0.0139 0.0156 0.0156
Onchocerca volvulus Putative nachr subunit 0.0256 0.049 0.6682
Loa Loa (eye worm) calcium channel 0.0167 0.0237 0.0328
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0167 0.0237 0.027
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0119 0.0097 0.0097
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0119 0.0097 0.0104
Brugia malayi Cation transporter family protein 0.0119 0.0097 0.0104
Toxoplasma gondii PAN domain-containing protein 0.016 0.0215 0.0205
Loa Loa (eye worm) hypothetical protein 0.0527 0.1268 0.1982
Echinococcus granulosus peptide allatostatin:somatostatin 0.0139 0.0156 0.0156
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0139 0.0156 0.0156
Echinococcus granulosus tm gpcr rhodopsin 0.0139 0.0156 0.0156
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0335 0.0718 0.0907
Onchocerca volvulus 0.0119 0.0097 0.0945
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0097 0.0104
Schistosoma mansoni histamine h1 receptor 0.0139 0.0156 0.0164
Schistosoma mansoni neuropeptide F-like receptor 0.0139 0.0156 0.0164
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0096 0.0032 0.0032
Schistosoma mansoni glutamate receptor NMDA 0.0273 0.0539 0.067
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Onchocerca volvulus 0.0139 0.0156 0.1813
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Trypanosoma brucei heat shock protein, putative 0.0138 0.0153 0.1013
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0167 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Onchocerca volvulus 0.016 0.0215 0.2663
Brugia malayi G-protein coupled receptor 0.0139 0.0156 0.0199
Schistosoma mansoni hypothetical protein 0.0139 0.0156 0.0164
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Toxoplasma gondii PAN domain-containing protein 0.016 0.0215 0.0205
Schistosoma mansoni hypothetical protein 0.0361 0.0791 0.1003
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0256 0.049 0.0735
Echinococcus granulosus glycine receptor subunit alpha 1 0.0119 0.0097 0.0097
Echinococcus granulosus g-protein coupled receptor 0.0139 0.0156 0.0156
Toxoplasma gondii PAN domain-containing protein 0.2481 0.6871 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.026 0.0503 0.0756
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0167 0.0237 0.0237
Trichomonas vaginalis heat shock protein, putative 0.0125 0.0116 0.1241
Onchocerca volvulus 0.0139 0.0156 0.1813
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0273 0.4791
Echinococcus granulosus glutamate NMDA receptor subunit 0.0273 0.0539 0.0539
Echinococcus granulosus nmda type glutamate receptor 0.0115 0.0087 0.0087
Plasmodium vivax endoplasmin, putative 0.0138 0.0153 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus granulosus G protein coupled receptor 139 0.0139 0.0156 0.0156
Echinococcus granulosus fmrfamide receptor 0.0139 0.0156 0.0156
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0503 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Schistosoma mansoni biogenic amine receptor 0.0139 0.0156 0.0164
Onchocerca volvulus 0.0139 0.0156 0.1813
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0247 0.4195
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0096 0.0032 0.0032
Onchocerca volvulus 0.016 0.0215 0.2663
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0139 0.0156 0.0164
Trypanosoma cruzi heat shock protein 90, putative 0.0125 0.0116 0.051
Onchocerca volvulus 0.016 0.0215 0.2663
Brugia malayi hypothetical protein 0.0964 0.2521 0.3989
Trichomonas vaginalis heat shock protein, putative 0.0125 0.0116 0.1241
Brugia malayi Serotonin receptor 0.0139 0.0156 0.0199
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Brugia malayi PAN domain containing protein 0.016 0.0215 0.0293
Chlamydia trachomatis DNA topoisomerase I 0.0111 0.0076 0.5
Trypanosoma cruzi heat shock protein 85, putative 0.0138 0.0153 0.1014
Schistosoma mansoni neuropeptide receptor 0.0139 0.0156 0.0164
Mycobacterium ulcerans hypothetical protein 0.0164 0.0228 1
Schistosoma mansoni nAChR subunit 0.0119 0.0097 0.0086
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0139 0.0156 0.0156
Echinococcus granulosus neuropeptide receptor A26 0.0643 0.1601 0.1601
Loa Loa (eye worm) hypothetical protein 0.016 0.0215 0.0293
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) hypothetical protein 0.0206 0.0346 0.0504
Brugia malayi Caveolin-1 0.0527 0.1268 0.1982
Echinococcus multilocularis sodium channel protein 0.0633 0.1571 0.1571
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.026 0.0503 0.0756
Brugia malayi phosphoinositide-dependent protein kinase I 0.0106 0.0061 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Brugia malayi Dopamine receptor protein 2 0.0139 0.0156 0.0199
Entamoeba histolytica hypothetical protein, conserved 0.0164 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0256 0.049 0.0735
Echinococcus granulosus voltage dependent calcium channel 0.0167 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0167 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0119 0.0097 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0503 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0119 0.0097 0.0097
Brugia malayi PAN domain containing protein 0.016 0.0215 0.0293
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0633 0.1571 0.1571
Toxoplasma gondii microneme protein, putative 0.016 0.0215 0.0205
Echinococcus multilocularis neuropeptide receptor 0.0139 0.0156 0.0156
Echinococcus multilocularis orexin receptor type 2 0.0139 0.0156 0.0156
Trypanosoma brucei heat shock protein, putative 0.0138 0.0153 0.1013
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0139 0.0156 0.0164
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus multilocularis SWI:SNF matrix associated 0.0111 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Chlamydia trachomatis SWIB complex protein 0.0111 0.0076 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0139 0.0156 0.0164
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0119 0.0097 0.0104
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0139 0.0156 0.0164
Onchocerca volvulus 0.0256 0.049 0.6682
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0139 0.0156 0.0164
Brugia malayi Dopamine receptor 0.0139 0.0156 0.0199
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0115 0.0087 0.0087
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0119 0.0097 0.0097
Onchocerca volvulus 0.0139 0.0156 0.1813
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0167 0.0237 0.0237
Schistosoma mansoni nAChR subunit 0.0119 0.0097 0.0086
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0139 0.0156 0.0164
Trypanosoma brucei heat shock protein 90, putative 0.0138 0.0153 0.1013
Echinococcus multilocularis ecdysone induced protein 78C 0.0096 0.0032 0.0032
Onchocerca volvulus 0.016 0.0215 0.2663
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0119 0.0097 0.0104
Echinococcus multilocularis integrin alpha 3 0.0113 0.0082 0.0082
Trypanosoma cruzi heat shock protein 85, putative 0.0138 0.0153 0.1014
Onchocerca volvulus 0.016 0.0215 0.2663
Echinococcus granulosus sodium channel protein 0.0633 0.1571 0.1571
Loa Loa (eye worm) PAN domain-containing protein 0.016 0.0215 0.0293
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Loa Loa (eye worm) PAN domain-containing protein 0.016 0.0215 0.0293
Trypanosoma brucei heat shock protein, putative 0.0138 0.0153 0.1013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0139 0.0156 0.0164
Brugia malayi PAN domain containing protein 0.016 0.0215 0.0293
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0097 0.0104
Loa Loa (eye worm) latrophilin receptor protein 2 0.0547 0.1326 0.2075
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus granulosus somatostatin receptor 0.0139 0.0156 0.0156
Schistosoma mansoni nAChR subunit 0.0119 0.0097 0.0086
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0125 0.0116 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0275 0.0544 0.0677
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Echinococcus multilocularis fmrfamide receptor 0.0139 0.0156 0.0156
Echinococcus granulosus biogenic amine 5HT receptor 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus multilocularis g protein coupled receptor 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus granulosus neuropeptide FF receptor 2 0.0139 0.0156 0.0156
Schistosoma mansoni endoplasmin 0.0138 0.0153 0.0161
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1195 0.3184 0.3184
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0119 0.0097 0.0097
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0061 0.0039
Brugia malayi Transforming growth factor beta like domain containing protein 0.0124 0.0113 0.013
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.0247 0.313
Brugia malayi PAN domain containing protein 0.016 0.0215 0.0293
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0503 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Schistosoma mansoni myosin xvIII 0.0139 0.0156 0.0164
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0273 0.0539 0.0539
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0119 0.0097 0.0104
Brugia malayi excitatory GABA receptor EXP-1A 0.0119 0.0097 0.0104
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0256 0.049 0.0606
Schistosoma mansoni hypothetical protein 0.0547 0.1326 0.1711
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0547 0.1326 0.1326
Echinococcus granulosus neuropeptide receptor 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Schistosoma mansoni neuropeptide receptor 0.0139 0.0156 0.0164
Mycobacterium tuberculosis Conserved protein 0.0164 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0119 0.0097 0.0104
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0139 0.0156 0.0199
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0256 0.049 0.0606
Loa Loa (eye worm) hypothetical protein 0.0256 0.049 0.0735
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0139 0.0156 0.0156
Brugia malayi bZIP transcription factor family protein 0.0099 0.0041 0.0015
Echinococcus granulosus neuropeptide s receptor 0.0643 0.1601 0.1601
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0119 0.0097 0.0104
Loa Loa (eye worm) hypothetical protein 0.016 0.0215 0.0293
Onchocerca volvulus 0.0139 0.0156 0.1813
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Schistosoma mansoni protein kinase 0.0144 0.0171 0.0184
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0167 0.0237 0.0328
Echinococcus multilocularis SWI:SNF matrix associated 0.0111 0.0076 0.0076
Trypanosoma brucei heat shock protein, putative 0.0138 0.0153 0.1013
Onchocerca volvulus 0.0139 0.0156 0.1813
Echinococcus granulosus voltage dependent calcium channel 0.0167 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Schistosoma mansoni nAChR subunit 0.0119 0.0097 0.0086
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0361 0.0791 0.0791
Schistosoma mansoni amine GPCR 0.0139 0.0156 0.0164
Echinococcus granulosus glycine receptor subunit beta 0.0119 0.0097 0.0097
Onchocerca volvulus 0.0139 0.0156 0.1813
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0139 0.0156 0.0164
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0112 0.0078 0.0001
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0361 0.0791 0.0791
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0097 0.0104
Brugia malayi PAN domain containing protein 0.016 0.0215 0.0293
Loa Loa (eye worm) hypothetical protein 0.0361 0.0791 0.1216
Loa Loa (eye worm) hypothetical protein 0.0167 0.0237 0.0328
Loa Loa (eye worm) hypothetical protein 0.0275 0.0544 0.0821
Loa Loa (eye worm) endoplasmin 0.0138 0.0153 0.0195
Echinococcus multilocularis heat shock protein 90 0.0125 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0099 0.0041 0.0041
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0633 0.1571 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0119 0.0097 0.0104
Onchocerca volvulus 0.0335 0.0718 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0125 0.0116 0.0116
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0139 0.0156 0.0156
Toxoplasma gondii microneme protein MIC4 0.016 0.0215 0.0205
Schistosoma mansoni hypothetical protein 0.0547 0.1326 0.1711
Trichomonas vaginalis heat shock protein, putative 0.0125 0.0116 0.1241
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Schistosoma mansoni amine GPCR 0.0139 0.0156 0.0164
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0139 0.0156 0.0156
Schistosoma mansoni serine-type protease inhibitor 0.2735 0.7598 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0139 0.0156 0.0156
Echinococcus granulosus glycine receptor subunit alpha 1 0.0119 0.0097 0.0097
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0139 0.0156 0.1813
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0119 0.0097 0.0097
Trypanosoma brucei heat shock protein, putative 0.0138 0.0153 0.1013
Loa Loa (eye worm) apoptosis regulator protein 0.0361 0.0791 0.1216
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0096 0.0032 0.0032
Onchocerca volvulus Neuropeptide F receptor homolog 0.0139 0.0156 0.1813
Onchocerca volvulus 0.0139 0.0156 0.1813
Schistosoma mansoni hypothetical protein 0.0361 0.0791 0.1003
Echinococcus granulosus hypothetical protein 0.0139 0.0156 0.0156
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0112 0.0078 0.0001
Schistosoma mansoni adenoreceptor 0.0139 0.0156 0.0164
Loa Loa (eye worm) hypothetical protein 0.0371 0.0821 0.1266
Echinococcus granulosus alpha 1A adrenergic receptor 0.0139 0.0156 0.0156
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0256 0.049 0.049
Schistosoma mansoni protein kinase 0.0144 0.0171 0.0184
Echinococcus multilocularis neuropeptides capa receptor 0.0139 0.0156 0.0156
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.0228 1
Brugia malayi PAN domain containing protein 0.016 0.0215 0.0293
Echinococcus multilocularis voltage dependent calcium channel 0.0167 0.0237 0.0237
Onchocerca volvulus 0.016 0.0215 0.2663
Echinococcus multilocularis glycine receptor subunit beta 0.0119 0.0097 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0503 1
Schistosoma mansoni opsin-like receptor 0.0139 0.0156 0.0164
Echinococcus granulosus integrin alpha 3 0.0113 0.0082 0.0082
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0119 0.0097 0.0104
Onchocerca volvulus 0.016 0.0215 0.2663
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0096 0.0032 0.0032
Echinococcus granulosus heat shock protein 0.0138 0.0153 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0247 0.4195
Onchocerca volvulus 0.0139 0.0156 0.1813
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Echinococcus granulosus g protein coupled receptor 0.0139 0.0156 0.0156
Trypanosoma brucei RNA helicase, putative 0.0207 0.035 0.3658
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) ACC-1 protein 0.0119 0.0097 0.0104
Schistosoma mansoni protein kinase 0.0144 0.0171 0.0184
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0256 0.049 0.049
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0144 0.0171 0.0171
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0119 0.0097 0.0086
Onchocerca volvulus 0.016 0.0215 0.2663
Echinococcus granulosus allatostatin A receptor 0.0275 0.0544 0.0544
Echinococcus multilocularis heat shock protein 90 0.0138 0.0153 0.0153
Loa Loa (eye worm) TYRA-2 protein 0.0139 0.0156 0.0199
Schistosoma mansoni serine-type protease inhibitor 0.2735 0.7598 1
Loa Loa (eye worm) hypothetical protein 0.016 0.0215 0.0293
Schistosoma mansoni hypothetical protein 0.0111 0.0076 0.0058
Echinococcus granulosus neuropeptide Y receptor 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0139 0.0156 0.0156
Brugia malayi Trypsin family protein 0.0335 0.0718 0.11
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0125 0.0116 0.0253
Loa Loa (eye worm) PAN domain-containing protein 0.016 0.0215 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0076 0.0325
Toxoplasma gondii PAN domain-containing protein 0.016 0.0215 0.0205
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0139 0.0156 0.0199
Echinococcus multilocularis G protein coupled receptor 139 0.0139 0.0156 0.0156
Toxoplasma gondii subtilisin SUB12 0.016 0.0215 0.0205
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.0156 0.0164
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0139 0.0156 0.0164
Schistosoma mansoni amine GPCR 0.0139 0.0156 0.0164
Trypanosoma brucei Heat shock protein 83, putative 0.0138 0.0153 0.1013
Loa Loa (eye worm) melatonin receptor type 1A 0.0139 0.0156 0.0199
Schistosoma mansoni neuropeptide f receptor 76f 0.0139 0.0156 0.0164
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0139 0.0156 0.0199
Brugia malayi GnHR receptor homolog 0.0139 0.0156 0.0199
Brugia malayi PAN domain containing protein 0.016 0.0215 0.0293
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0124 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0165 0.0229 0.0316
Loa Loa (eye worm) hypothetical protein 0.1077 0.2844 0.4507
Brugia malayi hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0256 0.049 0.0735
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Schistosoma mansoni hypothetical protein 0.0139 0.0156 0.0164
Onchocerca volvulus 0.016 0.0215 0.2663
Trypanosoma brucei heat shock protein, putative 0.0138 0.0153 0.1013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0139 0.0156 0.0156
Brugia malayi sulfakinin receptor protein 0.0964 0.2521 0.3989
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Echinococcus granulosus orexin receptor type 2 0.0139 0.0156 0.0156
Brugia malayi ORL1-like opioid receptor 0.0139 0.0156 0.0199
Entamoeba histolytica heat shock protein 90, putative 0.0138 0.0153 0.5531
Toxoplasma gondii 1,3(4)-beta-glucanase 0.016 0.0215 0.0205
Echinococcus multilocularis G-protein coupled receptor, putative 0.0139 0.0156 0.0156
Onchocerca volvulus 0.0139 0.0156 0.1813
Toxoplasma gondii microneme protein MIC17B 0.016 0.0215 0.0205
Loa Loa (eye worm) hypothetical protein 0.016 0.0215 0.0293
Echinococcus multilocularis voltage dependent calcium channel 0.0167 0.0237 0.0237
Schistosoma mansoni voltage-gated cation channel 0.0167 0.0237 0.027
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0139 0.0156 0.0156
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0126 0.0118 0.0138
Brugia malayi brahma associated protein 60 kDa 0.0111 0.0076 0.007
Brugia malayi Calcitonin receptor-like protein seb-1 0.1624 0.4413 0.7023
Brugia malayi hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) ACC-1 protein 0.0119 0.0097 0.0104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Schistosoma mansoni biogenic amine (5HT) receptor 0.0139 0.0156 0.0164
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Loa Loa (eye worm) hypothetical protein 0.0256 0.049 0.0735
Echinococcus multilocularis dro:myosuppressin receptor 0.0139 0.0156 0.0156
Echinococcus granulosus tm gpcr rhodopsin 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0964 0.2521 0.3989
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0106 0.0061 0.0061
Echinococcus granulosus neuropeptides capa receptor 0.0139 0.0156 0.0156
Brugia malayi follicle stimulating hormone receptor 0.0139 0.0156 0.0199
Echinococcus granulosus g protein coupled receptor 0.0139 0.0156 0.0156
Brugia malayi Latrophilin receptor protein 2 0.0547 0.1326 0.2075
Leishmania major C-8 sterol isomerase-like protein 0.0371 0.0821 0.4979
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0167 0.0237 0.0237
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0247 0.4195
Brugia malayi G-protein coupled receptor 0.0139 0.0156 0.0199
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0139 0.0156 0.0199
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Leishmania major heat shock protein 83-1 0.0138 0.0153 0.0504
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0096 0.0032 0.0032
Schistosoma mansoni alpha-1 adrenergic receptor 0.0139 0.0156 0.0164
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0247 0.4195
Echinococcus multilocularis thyroid hormone receptor alpha 0.0096 0.0032 0.0032
Brugia malayi Cation transporter family protein 0.0256 0.049 0.0735
Loa Loa (eye worm) hypothetical protein 0.016 0.0215 0.0293
Onchocerca volvulus 0.0139 0.0156 0.1813
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0371 0.0821 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.019 0.0301 0.0431
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0124 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Onchocerca volvulus 0.0258 0.0496 0.6766
Schistosoma mansoni hypothetical protein 0.0361 0.0791 0.1003
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0119 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0199
Toxoplasma gondii hypothetical protein 0.0112 0.0078 0.0004
Brugia malayi AKH receptor 0.0139 0.0156 0.0199
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Loa Loa (eye worm) brahma associated protein 0.0111 0.0076 0.007
Onchocerca volvulus 0.0256 0.049 0.6682
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0106 0.0061 0.0047
Loa Loa (eye worm) neuropeptide F receptor 0.0139 0.0156 0.0199
Schistosoma mansoni nAChR subunit 0.0119 0.0097 0.0086
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0126 0.0118 0.0138
Brugia malayi PAN domain containing protein 0.016 0.0215 0.0293
Brugia malayi putative neuropeptide receptor 0.0139 0.0156 0.0199
Echinococcus granulosus glycine receptor subunit alpha 1 0.0119 0.0097 0.0097
Brugia malayi heat shock protein 90 0.0138 0.0153 0.0195
Echinococcus granulosus neuropeptide Y receptor 0.0139 0.0156 0.0156
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.0032 0.0032
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0139 0.0156 0.0156
Onchocerca volvulus 0.0139 0.0156 0.1813
Schistosoma mansoni hypothetical protein 0.0111 0.0076 0.0058
Onchocerca volvulus 0.0256 0.049 0.6682
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.0156 0.0164
Echinococcus multilocularis serotonin receptor 0.0139 0.0156 0.0156
Echinococcus granulosus g protein coupled receptor 0.0139 0.0156 0.0156
Onchocerca volvulus 0.0275 0.0544 0.7463
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0097 0.0104
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0547 0.1326 0.2075
Loa Loa (eye worm) hypothetical protein 0.0119 0.0097 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.0156 0.0164
Echinococcus granulosus neuropeptide receptor 0.0139 0.0156 0.0156
Brugia malayi hypothetical protein 0.0139 0.0156 0.0199
Schistosoma mansoni neuropeptide receptor 0.0139 0.0156 0.0164
Schistosoma mansoni hypothetical protein 0.0111 0.0076 0.0058
Loa Loa (eye worm) voltage-dependent calcium channel 0.0167 0.0237 0.0328
Trypanosoma cruzi heat shock protein 90, putative 0.0138 0.0153 0.1014
Trypanosoma brucei heat shock protein, putative 0.0138 0.0153 0.1013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0096 0.0032 0.0032
Schistosoma mansoni biogenic amine receptor 0.0139 0.0156 0.0164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.0156 0.0164
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0119 0.0097 0.0104
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0106 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0106 0.0061 0.0047
Echinococcus multilocularis neuropeptide Y receptor 0.0139 0.0156 0.0156
Toxoplasma gondii PAN domain-containing protein 0.016 0.0215 0.0205
Loa Loa (eye worm) hypothetical protein 0.016 0.0215 0.0293
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.2272 0.6271 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0096 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0335 0.0718 0.11
Mycobacterium ulcerans hypothetical protein 0.0164 0.0228 1
Echinococcus multilocularis serotonin receptor 0.0139 0.0156 0.0156
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0256 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0096 0.0033 0.0002
Schistosoma mansoni nAChR subunit 0.0119 0.0097 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0156 0.0156
Echinococcus multilocularis neuropeptides capa receptor 0.0139 0.0156 0.0156
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0112 0.0078 0.0001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0096 0.0032 0.0032
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0139 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0112 0.0078 0.0074
Schistosoma mansoni neuropeptide F-like receptor 0.0139 0.0156 0.0164

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.584893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.548133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (functional) > 100 uM PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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