Detailed information for compound 1446015

Basic information

Technical information
  • TDR Targets ID: 1446015
  • Name: 1-(4-ethoxyphenyl)-5-phenyl-3H-imidazole-2-th ione
  • MW: 296.387 | Formula: C17H16N2OS
  • H donors: 0 H acceptors: 1 LogP: 4.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)n1c(S)ncc1c1ccccc1
  • InChi: 1S/C17H16N2OS/c1-2-20-15-10-8-14(9-11-15)19-16(12-18-17(19)21)13-6-4-3-5-7-13/h3-12H,2H2,1H3,(H,18,21)
  • InChiKey: DZEXPJCQBLAYOC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC03434743

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major vacuolar protein sorting-associated protein 4 0.0074 0.0327 0.0334
Giardia lamblia Katanin 0.0074 0.0327 0.0472
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.005 0.004
Plasmodium vivax cell division cycle ATPase, putative 0.0522 0.3494 0.3654
Trypanosoma cruzi katanin, putative 0.0074 0.0327 0.0334
Giardia lamblia Pyruvate kinase 0.004 0.0086 0.0061
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0616 0.0606
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0047 0.0036
Plasmodium falciparum pyruvate kinase 0.004 0.0086 0.0038
Onchocerca volvulus 0.0036 0.0056 0.0006
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.1369 0.9475 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0086 0.0128
Plasmodium vivax pyruvate kinase, putative 0.004 0.0086 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0086 0.0149
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0449 0.0401
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0148 0.0137
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0086 0.008
Schistosoma mansoni cell division control protein 48 aaa family protein 0.1369 0.9475 0.9472
Mycobacterium ulcerans pyruvate kinase 0.004 0.0086 0.0128
Trypanosoma cruzi vacuolar protein sorting-associated protein 4, putative 0.0074 0.0327 0.0334
Loa Loa (eye worm) vps4b-prov protein 0.0074 0.0326 0.0565
Leishmania major katanin, putative,serine peptidase, Clan SJ, family S16, putative 0.0074 0.0327 0.0334
Trypanosoma cruzi katanin, putative 0.0074 0.0327 0.0334
Trypanosoma brucei Valosin-containing protein 0.1369 0.9475 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0228 0.0394
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0103 0.0177
Giardia lamblia AAA family ATPase 0.0864 0.5905 1
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0597 0.4019 0.3989
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0103 0.0092
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0086 0.008
Echinococcus multilocularis pyruvate kinase 0.004 0.0086 0.0076
Leishmania major hypothetical protein, conserved 0.0257 0.1617 0.1697
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.005 0.004
Trypanosoma brucei katanin, putative 0.0074 0.0327 0.0256
Trypanosoma cruzi katanin, putative 0.0074 0.0327 0.0334
Echinococcus multilocularis pyruvate kinase 0.004 0.0086 0.0076
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.005 0.0087
Brugia malayi SAP1 protein 0.0074 0.0326 0.0482
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0056 0.0006
Loa Loa (eye worm) pyruvate kinase 0.004 0.0086 0.0149
Trypanosoma brucei vacuolar protein sorting-associated protein 4, putative 0.0074 0.0327 0.0256
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0056 0.0046
Chlamydia trachomatis pyruvate kinase 0.004 0.0086 0.5
Brugia malayi Pre-SET motif family protein 0.0251 0.1578 0.2664
Trypanosoma cruzi katanin-like protein, putative 0.0074 0.0327 0.0334
Leishmania major pyruvate kinase 0.004 0.0086 0.008
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0341 0.2213 0.2204
Loa Loa (eye worm) ATPase 0.0074 0.0327 0.0565
Loa Loa (eye worm) pyruvate kinase 0.004 0.0086 0.0149
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0056 0.0006
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0864 0.5905 0.5884
Brugia malayi vps4b-prov protein 0.0074 0.0327 0.0482
Echinococcus granulosus peregrin 0.0035 0.005 0.004
Giardia lamblia SKD1 protein 0.0074 0.0327 0.0472
Trichomonas vaginalis skd/vacuolar sorting, putative 0.0074 0.0327 0.0316
Brugia malayi ATPase, AAA family protein 0.0074 0.0327 0.0482
Echinococcus granulosus katanin p60 ATPase containing subunit A1 0.0074 0.0327 0.0316
Echinococcus multilocularis pyruvate kinase 0.0032 0.0026 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.1617 0.1697
Trypanosoma cruzi vesicular transport protein (CDC48 homologue), putative 0.0074 0.0327 0.0334
Loa Loa (eye worm) hypothetical protein 0.0036 0.0056 0.0097
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0086 0.5
Trichomonas vaginalis AAA ATPase, putative 0.0074 0.0327 0.0316
Loa Loa (eye worm) hypothetical protein 0.0035 0.005 0.0087
Toxoplasma gondii cell division protein CDC48AP 0.0864 0.5905 0.5884
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0103 0.0092
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0103 0.0053
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.1369 0.9475 1
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0086 0.0036
Trypanosoma cruzi metalloprotease, putative 0.0074 0.0327 0.0334
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0315 0.0545
Echinococcus multilocularis peregrin 0.0035 0.005 0.004
Brugia malayi Pre-SET motif family protein 0.0036 0.0056 0.001
Trypanosoma brucei vesicular transport protein (CDC48 homologue), putative 0.0074 0.0327 0.0256
Brugia malayi jmjC domain containing protein 0.0115 0.0616 0.0988
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0616 0.0606
Toxoplasma gondii katanin-like family protein 0.0074 0.0327 0.0278
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0056 0.0046
Echinococcus multilocularis katanin p60 ATPase containing subunit A1 0.0074 0.0327 0.0316
Brugia malayi vesicle-fusing ATPase 0.0846 0.5783 1
Loa Loa (eye worm) hypothetical protein 0.0846 0.5783 1
Giardia lamblia SKD1 protein 0.0074 0.0327 0.0472
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.1443 1 1
Trypanosoma cruzi katanin-like protein, putative 0.0074 0.0326 0.0334
Echinococcus multilocularis fidgetin protein 1 0.0074 0.0327 0.0316
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0597 0.4019 0.6923
Echinococcus granulosus fidgetin protein 1 0.0074 0.0327 0.0316
Loa Loa (eye worm) vesicle-fusing ATPase 0.0846 0.5783 1
Trypanosoma brucei katanin, putative 0.0074 0.0327 0.0256
Schistosoma mansoni skd/vacuolar sorting 0.0074 0.0327 0.0278
Entamoeba histolytica ATPase, Vps4 oligomerisation domain containing protein 0.0074 0.0327 0.0345
Trichomonas vaginalis AAA ATPase, putative 0.0074 0.0327 0.0316
Schistosoma mansoni pyruvate kinase 0.004 0.0086 0.0036
Trypanosoma cruzi katanin, putative 0.0074 0.0327 0.0334
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0056 0.0006
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0056 0.0046
Loa Loa (eye worm) pyruvate kinase 0.004 0.0086 0.0149
Entamoeba histolytica cdc48-like protein, putative 0.1369 0.9475 1
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.1617 0.163
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0086 0.0036
Echinococcus granulosus pyruvate kinase 0.004 0.0086 0.0076
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0086 0.0076
Brugia malayi fidgetin protein 0.0074 0.0326 0.0482
Trypanosoma brucei metalloprotease, putative 0.0074 0.0327 0.0256
Schistosoma mansoni pyruvate kinase 0.004 0.0086 0.0036
Brugia malayi jmjC domain containing protein 0.0043 0.0103 0.0091
Trypanosoma cruzi katanin, putative 0.0074 0.0327 0.0334
Trypanosoma brucei katanin, putative 0.0074 0.0327 0.0256
Leishmania major pyruvate kinase 0.004 0.0086 0.008
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1823 0.1814
Plasmodium falciparum vacuolar protein sorting-associated protein 4 0.0074 0.0327 0.0293
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0086 0.0063
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.1443 1 1
Loa Loa (eye worm) VCP protein 0.0597 0.4019 0.695
Schistosoma mansoni hypothetical protein 0.0074 0.0327 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.1617 0.1697
Echinococcus granulosus vacuolar protein sorting associated protein 4A 0.0074 0.0327 0.0316
Giardia lamblia Topoisomerase II 0.0074 0.0327 0.0472
Onchocerca volvulus 0.0286 0.1823 0.1782
Trypanosoma cruzi vacuolar transport protein 4A, putative 0.0074 0.0327 0.0334
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0103 0.0053
Loa Loa (eye worm) fidgetin protein 0.0074 0.0327 0.0565
Toxoplasma gondii cell division protein CDC48CY 0.1443 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1578 0.2728
Echinococcus multilocularis vacuolar protein sorting associated protein 4A 0.0074 0.0327 0.0316
Leishmania major katanin-like protein,serine peptidase, Clan SJ, family S16, putative 0.0074 0.0327 0.0334
Mycobacterium tuberculosis Putative conserved ATPase 0.0864 0.5905 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0056 0.0006
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0086 0.0036
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0086 0.0036
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.1369 0.9475 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0086 0.0063
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.1369 0.9475 1
Trichomonas vaginalis spermatogenesis associated factor, putative 0.1443 1 1
Entamoeba histolytica vacuolar sorting protein-associating protein 4A (VPS4), putative 0.0074 0.0327 0.0345
Schistosoma mansoni cell division control protein 48 aaa family protein 0.1443 1 1
Echinococcus granulosus pyruvate kinase 0.004 0.0086 0.0076
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0086 0.0076
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0148 0.0137
Trichomonas vaginalis spastin, putative 0.0074 0.0327 0.0316
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0597 0.4019 0.4013
Mycobacterium ulcerans ATPase 0.0864 0.5905 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0056 0.0006
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0341 0.2213 0.2204
Trypanosoma cruzi Valosin-containing protein, putative 0.1369 0.9475 1
Trichomonas vaginalis skd/vacuolar sorting, putative 0.0074 0.0327 0.0316
Trypanosoma brucei katanin, putative 0.0074 0.0327 0.0256
Plasmodium vivax SET domain protein, putative 0.0036 0.0056 0.0006
Leishmania major katanin-like protein,serine peptidase, Clan SJ, family S16, putative 0.0074 0.0327 0.0334
Brugia malayi valosin containing protein 0.0846 0.5782 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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