TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 230.349 | Formula: C15H22N2
H donors: 0 H acceptors: 0 LogP: 3.36 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C/C=C(/CN1CCN(CC1)c1ccccc1)\C
InChi: 1S/C15H22N2/c1-3-14(2)13-16-9-11-17(12-10-16)15-7-5-4-6-8-15/h3-8H,9-13H2,1-2H3/b14-3+
InChiKey: OTIKVFFRQRTXKP-LZWSPWQCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Rac GTPase activating protein 1	0.0115	0.0958	0.0958
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0004	0.0004
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0242	0.2555	0.4213
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.004	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0958	0.1579
Loa Loa (eye worm)	hypothetical protein	0.004	0.0004	0.0006
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0377	0.2803
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.004	0.0004	0.0004
Echinococcus multilocularis	serine threonine protein kinase	0.0565	0.6621	0.6621
Schistosoma mansoni	retinoic acid receptor RXR	0.004	0.0004	0.0004
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.004	0.0004	0.0004
Echinococcus multilocularis	RNA directed DNA polymerase	0.0406	0.4612	0.4612
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.004	0.0004	0.0004
Mycobacterium leprae	conserved hypothetical protein	0.0039	0	0.5
Schistosoma mansoni	hypothetical protein	0.0053	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0958	0.1579
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0	0.5
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.068	0.8074	0.8074
Brugia malayi	jmjC domain containing protein	0.0058	0.0242	0.0382
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.004	0.0004	0.0004
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0142	0.1293	0.1293
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0162	0.1548	0.1548
Brugia malayi	diacylglycerol kinase	0.0115	0.0958	0.1513
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.004	0.0004	0.0004
Brugia malayi	Pleckstrin Homology Domain	0.0119	0.101	0.1595
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.004	0.0004	0.0006
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0201	0.0201
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0201	0.0201
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0123	0.1049	0.1049
Schistosoma mansoni	serine/threonine protein kinase	0.0415	0.4727	0.4727
Schistosoma mansoni	lozenge	0.0055	0.0201	0.0201
Schistosoma mansoni	jumonji domain containing protein	0.0058	0.0242	0.0242
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.004	0.0004	0.0004
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0004	0.0004
Schistosoma mansoni	unc-13 (munc13)	0.0133	0.1179	0.1179
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0201	0.0201
Echinococcus multilocularis	myotubularin protein 13	0.0119	0.101	0.101
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0142	0.1293	0.1293
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0115	0.0958	0.1579
Brugia malayi	Protein kinase domain containing protein	0.0119	0.1002	0.1583
Schistosoma mansoni	steroid hormone receptor ad4bp	0.004	0.0004	0.0004
Toxoplasma gondii	hypothetical protein	0.0174	0.1698	1
Brugia malayi	p70 ribosomal S6 kinase beta	0.0142	0.1293	0.2042
Echinococcus granulosus	lysine specific demethylase 5A	0.0058	0.0242	0.0242
Brugia malayi	Protein kinase domain containing protein	0.0142	0.1293	0.2042
Loa Loa (eye worm)	hypothetical protein	0.0421	0.4813	0.7937
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.027	0.2901	0.4784
Echinococcus multilocularis	microtubule associated protein 2	0.0833	1	1
Schistosoma mansoni	serine/threonine kinase	0.0142	0.1293	0.1293
Brugia malayi	RhoGAP domain containing protein	0.0115	0.0958	0.1513
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0133	0.1179	0.1179
Loa Loa (eye worm)	hypothetical protein	0.004	0.0004	0.0006
Leishmania major	hypothetical protein, conserved	0.0039	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0004	0.0006
Echinococcus granulosus	protein kinase c eta type	0.0115	0.0958	0.0958
Onchocerca volvulus		0.0243	0.2563	0.5072
Echinococcus granulosus	chromobox protein 1	0.0069	0.0377	0.0377
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.1345	1
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0142	0.1293	0.2131
Loa Loa (eye worm)	hypothetical protein	0.028	0.3026	0.499
Echinococcus granulosus	NDR protein kinase	0.0142	0.1293	0.1293
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0142	0.1293	0.2131
Brugia malayi	nuclear receptor NHR-88	0.004	0.0004	0.0006
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0115	0.0958	0.0958
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0142	0.1293	0.2131
Onchocerca volvulus		0.0133	0.1179	0.2334
Plasmodium vivax	hypothetical protein, conserved	0.0039	0	0.5
Onchocerca volvulus		0.0239	0.2511	0.4969
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.004	0.0004	0.0006
Echinococcus granulosus	ecdysone induced protein 78C	0.004	0.0004	0.0004
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0377	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0258	0.2754	0.454
Brugia malayi	Ras association domain family 1 isoform A	0.0115	0.0958	0.1513
Brugia malayi	C1-like domain containing protein	0.0242	0.2555	0.4036
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0142	0.1293	0.2131
Schistosoma mansoni	serine/threonine protein kinase	0.0119	0.1002	0.1002
Echinococcus multilocularis	survival motor neuron protein 1	0.0258	0.2754	0.2754
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0133	0.1179	0.1179
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0119	0.1002	0.1002
Echinococcus multilocularis	protein kinase c eta type	0.0115	0.0958	0.0958
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0242	0.0399
Brugia malayi	Variant SH3 domain containing protein	0.0115	0.0958	0.1513
Schistosoma mansoni	unc-13 (munc13)	0.0133	0.1179	0.1179
Loa Loa (eye worm)	steroid hormone receptor	0.004	0.0004	0.0006
Schistosoma mansoni	atypical protein kinase C	0.0408	0.4644	0.4644
Onchocerca volvulus	Protein ultraspiracle homolog	0.004	0.0004	0.0008
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0251	0.2665	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.028	0.3026	0.499
Trichomonas vaginalis	AGC family protein kinase	0.0142	0.1293	0.9611
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0242	0.0242
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0004	0.0006
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0142	0.1293	0.1293
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.004	0.0004	0.0006
Schistosoma mansoni	protein kinase C mu	0.0242	0.2555	0.2555
Mycobacterium ulcerans	beta-lactamase	0.0039	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0004	0.0006
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0174	0.1698	0.2799
Echinococcus granulosus	myotubularin protein 13	0.0119	0.101	0.101
Brugia malayi	Heterochromatin protein 1	0.0069	0.0377	0.0596
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0004	0.0004
Echinococcus multilocularis	FTZ F1 alpha	0.004	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1058	0.1745
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.004	0.0004	0.0004
Onchocerca volvulus		0.028	0.3026	0.5989
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0427	0.4878	0.8044
Schistosoma mansoni	serine/threonine protein kinase	0.0142	0.1293	0.1293
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0058	0.0242	0.0242
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0377	0.2803
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0031	0.0062
Schistosoma mansoni	microtubule-associated protein tau	0.0833	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.1345	1
Brugia malayi	protein kinase C3,putative	0.0259	0.2771	0.4378
Schistosoma mansoni	hypothetical protein	0.0123	0.1049	0.1049
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0201	0.0318
Echinococcus granulosus	protein kinase C gamma type	0.0565	0.6621	0.6621
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.004	0.0004	0.0006
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.004	0.0004	0.0004
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0201	0.0201
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0031	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0958	0.1579
Schistosoma mansoni	serine/threonine protein kinase	0.0119	0.1002	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0119	0.101	0.1665
Loa Loa (eye worm)	hypothetical protein	0.0174	0.1698	0.2799
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.004	0.0004	0.0008
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0142	0.1293	0.8276
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.1345	1
Schistosoma mansoni	coup transcription factor	0.004	0.0004	0.0004
Onchocerca volvulus		0.004	0.0004	0.0008
Trichomonas vaginalis	AGC family protein kinase	0.0142	0.1293	0.9611
Loa Loa (eye worm)	hypothetical protein	0.0243	0.2563	0.4226
Mycobacterium leprae	Probable lipase LipE	0.0039	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0146	0.1345	0.9569
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.1345	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0201	0.0201
Brugia malayi	Hr1 repeat family protein	0.0142	0.1293	0.2042
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0142	0.1293	0.1293
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0142	0.1293	0.2131
Brugia malayi	steroid hormone receptor	0.004	0.0004	0.0006
Mycobacterium ulcerans	hypothetical protein	0.0039	0	0.5
Loa Loa (eye worm)	runx1	0.0055	0.0201	0.0332
Mycobacterium ulcerans	lipase LipD	0.0039	0	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.004	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0521	0.6065	1
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.1345	1
Brugia malayi	Nuclear hormone receptor-like 1	0.004	0.0004	0.0006
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0115	0.0958	0.0958
Schistosoma mansoni	serine/threonine protein kinase	0.068	0.8074	0.8074
Echinococcus multilocularis	protein kinase c epsilon type	0.0415	0.4727	0.4727
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0004	0.0006
Brugia malayi	ecdysteroid receptor	0.004	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.004	0.0004	0.0006
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0	0.5
Onchocerca volvulus		0.044	0.5053	1
Echinococcus granulosus	serine:threonine protein kinase N2	0.0142	0.1293	0.1293
Echinococcus granulosus	FTZ F1 alpha	0.004	0.0004	0.0004
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0147	0.1362	1
Echinococcus multilocularis	unc 13 (munc13)	0.0133	0.1179	0.1179
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0242	0.0242
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.004	0.0004	0.0006
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.004	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.004	0.0004	0.0006
Echinococcus multilocularis	protein kinase c iota type	0.0398	0.4514	0.4514
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0004	0.0004
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0115	0.0958	0.0958
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0138	0.1248	0.9281
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0115	0.0958	0.0958
Echinococcus granulosus	Protein kinase C brain isozyme	0.068	0.8074	0.8074
Echinococcus granulosus	Diacylglycerol kinase theta	0.0115	0.0958	0.0958
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0201	0.0201
Echinococcus granulosus	survival motor neuron protein 1	0.0258	0.2754	0.2754
Loa Loa (eye worm)	hypothetical protein	0.0174	0.1698	0.2799
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0146	0.1345	0.2218
Brugia malayi	hypothetical protein	0.044	0.5053	0.7981
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.1345	1
Schistosoma mansoni	chromobox protein	0.0069	0.0377	0.0377
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.004	0.0004	0.0006
Brugia malayi	RhoGEF domain containing protein	0.0115	0.0958	0.1513
Loa Loa (eye worm)	hypothetical protein	0.044	0.5053	0.8331
Schistosoma mansoni	protein kinase C mu	0.0115	0.0958	0.0958
Toxoplasma gondii	AGC kinase	0.0142	0.1293	0.7615
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1058	0.1745
Echinococcus granulosus	protein kinase c epsilon type	0.0415	0.4727	0.4727
Loa Loa (eye worm)	hypothetical protein	0.004	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0958	0.1579
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0415	0.4727	0.7794
Loa Loa (eye worm)	hypothetical protein	0.0174	0.1698	0.2799
Loa Loa (eye worm)	raf kinase	0.0115	0.0958	0.1579
Loa Loa (eye worm)	hypothetical protein	0.004	0.0004	0.0006
Echinococcus granulosus	protein kinase c iota type	0.0398	0.4514	0.4514
Echinococcus multilocularis	Protein lozenge	0.0055	0.0201	0.0201
Trichomonas vaginalis	AGC family protein kinase	0.0142	0.1293	0.9611
Entamoeba histolytica	protein kinase, putative	0.0146	0.1345	0.9569
Echinococcus granulosus	chromobox protein 1	0.0069	0.0377	0.0377
Schistosoma mansoni	serine/threonine protein kinase	0.0142	0.1293	0.1293
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0958	0.1579
Schistosoma mansoni	diacylglycerol kinase theta	0.0115	0.0958	0.0958
Schistosoma mansoni	serine/threonine protein kinase	0.0115	0.0958	0.0958
Brugia malayi	Steroid receptor seven-up type 2	0.004	0.0004	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.004	0.0004	0.0006
Brugia malayi	RhoGAP domain containing protein	0.0115	0.0958	0.1513
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.004	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1179	0.1944
Brugia malayi	protein kinase C II.	0.0415	0.4727	0.7467
Schistosoma mansoni	RAR-like nuclear receptor	0.004	0.0004	0.0004
Entamoeba histolytica	protein kinase, putative	0.0142	0.1293	0.8276
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0142	0.1293	0.1293
Echinococcus granulosus	N chimaerin	0.0115	0.0958	0.0958
Schistosoma mansoni	hypothetical protein	0.0115	0.0958	0.0958
Echinococcus granulosus	raf serine:threonine protein kinase	0.0115	0.0958	0.0958
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0282	0.3053	0.3053
Brugia malayi	jmjC domain containing protein	0.0058	0.0242	0.0382
Onchocerca volvulus		0.0053	0.0168	0.0332
Schistosoma mansoni	serine/threonine protein kinase	0.068	0.8074	0.8074
Echinococcus granulosus	unc 13 munc13	0.0133	0.1179	0.1179
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0406	0.4612	0.4612
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.004	0.0004	0.0006
Brugia malayi	nuclear hormone receptor	0.004	0.0004	0.0006
Schistosoma mansoni	protein kinase C	0.0133	0.1179	0.1179
Schistosoma mansoni	serine/threonine protein kinase	0.0142	0.1293	0.1293
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0242	0.2555	0.4036
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0115	0.0958	0.0958
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0004	0.0006
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0115	0.0958	0.0958
Echinococcus multilocularis	lysine specific demethylase 5A	0.0058	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.044	0.5053	0.8331
Echinococcus multilocularis	N chimaerin	0.0115	0.0958	0.0958
Echinococcus multilocularis	ecdysone induced protein 78C	0.004	0.0004	0.0004
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0142	0.1293	0.2131
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0115	0.0958	0.1579
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0377	0.0377
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.1345	1
Brugia malayi	Protein kinase domain containing protein	0.0142	0.1293	0.2042
Loa Loa (eye worm)	hypothetical protein	0.0406	0.4612	0.7605
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.1345	1
Schistosoma mansoni	survival motor neuron protein	0.0053	0.0168	0.0168
Schistosoma mansoni	diacylglycerol kinase theta	0.0115	0.0958	0.0958
Echinococcus granulosus	serine:threonine protein kinase N2	0.0143	0.131	0.131
Loa Loa (eye worm)	hypothetical protein	0.0239	0.2511	0.414
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.004	0.0004	0.0004
Brugia malayi	photoreceptor-specific nuclear receptor	0.004	0.0004	0.0006
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0115	0.0958	0.1579
Onchocerca volvulus		0.0123	0.1058	0.2095
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0146	0.1345	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0958	0.1579
Brugia malayi	hypothetical protein	0.0258	0.2754	0.435
Brugia malayi	diacylglycerol kinase	0.0115	0.0958	0.1513
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0115	0.0958	0.0958
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0142	0.1293	0.1293
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0142	0.1293	0.1293
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.004	0.0004	0.0004
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0201	0.0332
Echinococcus granulosus	RNA directed DNA polymerase	0.0406	0.4612	0.4612
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0119	0.1002	0.1002
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0053	0.0168	0.0265
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0127	0.1103	0.1818
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0058	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0395	0.4478	0.7384
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.004	0.0004	0.0006
Schistosoma mansoni	vav2	0.0119	0.101	0.101
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0115	0.0958	0.1579
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.0377	0.0622
Brugia malayi	Protein kinase c protein 2	0.0542	0.6331	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.004	0.0004	0.0006
Brugia malayi	Protein kinase domain containing protein	0.0146	0.1345	0.2125
Schistosoma mansoni	thyroid hormone receptor	0.0162	0.1548	0.1548
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0142	0.1293	0.1293
Schistosoma mansoni	thyroid hormone receptor	0.0162	0.1548	0.1548
Loa Loa (eye worm)	hypothetical protein	0.028	0.3026	0.499
Schistosoma mansoni	serine/threonine protein kinase	0.0142	0.1293	0.1293
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0031	0.0231
Schistosoma mansoni	chromobox protein	0.0069	0.0377	0.0377
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0004	0.0006
Onchocerca volvulus	Bile acid receptor homolog	0.004	0.0004	0.0008
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0123	0.1049	0.1049
Schistosoma mansoni	rac gtpase activating protein	0.0115	0.0958	0.0958
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.004	0.0004	0.0006
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.004	0.0004	0.0004
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.004	0.0004	0.0004
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0201	0.0201
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0004	0.0006
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.004	0.0004	0.0006
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.004	0.0004	0.0004
Toxoplasma gondii	diacylglycerol kinase, putative	0.0115	0.0958	0.5641
Loa Loa (eye worm)	hypothetical protein	0.004	0.0004	0.0006

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (binding)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1588143

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1450005