Detailed information for compound 14504

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 242.659 | Formula: C10H11ClN2O3
  • H donors: 4 H acceptors: 4 LogP: 1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1O)C(c1ncc[nH]1)O.Cl
  • InChi: 1S/C10H10N2O3.ClH/c13-7-2-1-6(5-8(7)14)9(15)10-11-3-4-12-10;/h1-5,9,13-15H,(H,11,12);1H
  • InChiKey: HLWGCXFNOIPUAN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ets variant gene 4 0.0011 0.0031 0.0029
Schistosoma mansoni nAChR subunit 0.0012 0.0047 0.0062
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.0328
Trichomonas vaginalis beta-hexosaminidase, putative 0.0223 0.2734 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0461 0.0807
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0138 0.1655 0.8293
Echinococcus multilocularis lamin 0.0026 0.0227 0.0225
Loa Loa (eye worm) hypothetical protein 0.0146 0.1753 0.3944
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0461 0.046
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0101 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0371 0.0648
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0017 0.0015
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0047 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0131 0.0387
Schistosoma mansoni hypothetical protein 0.0012 0.0046 0.0059
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0351 0.1327
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0016 0.0101 0.0232
Brugia malayi hypothetical protein 0.0051 0.0541 0.1218
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0227 0.0508
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0047 0.0046
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0351 0.0866
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0031 0.0029
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0101 0.0176
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0017 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0037
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0351 0.035
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0047 0.0081
Trypanosoma brucei telomerase reverse transcriptase 0.0087 0.1004 0.4915
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0027
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0012 0.0046 0.0075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0461 0.1037
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0017 0.0015
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0012 0.0047 0.0046
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0238 0.07
Loa Loa (eye worm) fli-1 protein 0.023 0.2824 0.6355
Schistosoma mansoni hypothetical protein 0.0012 0.0046 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0131 0.0159
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0238 0.0726
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0017 0.0037
Plasmodium falciparum telomerase reverse transcriptase 0.0087 0.1004 0.5456
Schistosoma mansoni cpg binding protein 0.0028 0.0249 0.0467
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0351 0.151
Plasmodium vivax DNA gyrase subunit A, putative 0.0031 0.0292 0.1151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Loa Loa (eye worm) hypothetical protein 0.0051 0.0541 0.1215
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0131 0.0295
Schistosoma mansoni hypothetical protein 0.0011 0.0031 0.0028
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0031 0.0066
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0017 0.0037
Brugia malayi Inositol-1 0.0036 0.0351 0.079
Brugia malayi nuclear receptor NHR-88 0.001 0.0017 0.0037
Schistosoma mansoni hypothetical protein 0.0011 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0083 0.0947 0.2132
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0131 0.034
Entamoeba histolytica hypothetical protein 0.0038 0.0371 0.062
Plasmodium vivax telomerase reverse transcriptase, putative 0.0087 0.1004 0.5456
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0131 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0012 0.0047 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0034
Echinococcus granulosus intermediate filament protein 0.0026 0.0227 0.0396
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0102
Schistosoma mansoni beta-hexosaminidase B 0.0356 0.4443 0.89
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0037
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0541 0.2337
Trichomonas vaginalis DNA topoisomerase II, putative 0.0146 0.1755 0.6282
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0371 0.0369
Schistosoma mansoni hypothetical protein 0.0032 0.0298 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0034
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0131 0.0387
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0087 0.1004 0.4794
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0099 0.1151 0.2872
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0351 0.0614
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0031 0.0069
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0012 0.0047 0.0103
Echinococcus granulosus muscleblind protein 0.0146 0.1753 0.3075
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0146 0.1755 0.1754
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0319 0.3966 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0034
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0298 0.052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0131 0.0387
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0012 0.0047 0.0107
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2839 0.4981
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0012 0.0047 0.0103
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0164 0.1984 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0461 0.0893
Schistosoma mansoni hypothetical protein 0.0032 0.0298 0.0565
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0541 0.2337
Brugia malayi hypothetical protein 0.0295 0.3658 0.8235
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0857 0.0855
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0085 0.0978 1
Brugia malayi nuclear hormone receptor 0.001 0.0017 0.0037
Schistosoma mansoni nAChR subunit 0.0012 0.0047 0.0062
Schistosoma mansoni nAChR subunit 0.0012 0.0047 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0461 0.0807
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0238 0.0726
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0047 0.0062
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0031 0.0066
Loa Loa (eye worm) hypothetical protein 0.0083 0.0947 0.213
Mycobacterium ulcerans DNA gyrase subunit A 0.0031 0.0292 0.1895
Brugia malayi hypothetical protein 0.0033 0.0311 0.0699
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1483 0.3337
Loa Loa (eye worm) hypothetical protein 0.0026 0.0227 0.0508
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0298 0.052
Schistosoma mansoni DNA topoisomerase II 0.0146 0.1755 0.3496
Brugia malayi steroid hormone receptor 0.001 0.0017 0.0037
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0012 0.0047 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0131 0.0387
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0298 0.0296
Echinococcus granulosus dna polymerase eta 0.0019 0.0131 0.0228
Brugia malayi hypothetical protein 0.0038 0.0371 0.0834
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0037
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0238 0.0942
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0031 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0034
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0016 0.0101 0.0232
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0037
Brugia malayi ecdysteroid receptor 0.001 0.0017 0.0037
Schistosoma mansoni intermediate filament proteins 0.0026 0.0227 0.0423
Loa Loa (eye worm) hypothetical protein 0.0101 0.1177 0.2647
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0298 0.067
Trichomonas vaginalis beta-hexosaminidase, putative 0.0223 0.2734 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0047 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0131 0.0387
Giardia lamblia DNA topoisomerase II 0.0138 0.1658 1
Entamoeba histolytica DNA topoisomerase II, putative 0.0146 0.1755 0.381
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0047 0.0081
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.0047 0.0081
Plasmodium vivax DNA gyrase subunit B, putative 0.0085 0.0978 0.53
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0012 0.0047 0.0081
Schistosoma mansoni lamin 0.0026 0.0227 0.0423
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0164 0.1984 1
Brugia malayi Probable DNA topoisomerase II 0.0146 0.1755 0.3951
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0569 0.2827
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0131 0.0159
Loa Loa (eye worm) hypothetical protein 0.0146 0.1753 0.3944
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0047 0.0107
Echinococcus granulosus nAChR subunit 0.0012 0.0047 0.0081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0102
Loa Loa (eye worm) hypothetical protein 0.0059 0.0649 0.1458
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0047 0.0081
Echinococcus multilocularis geminin 0.0342 0.4264 0.4263
Loa Loa (eye worm) hypothetical protein 0.0032 0.0298 0.0667
Schistosoma mansoni hypothetical protein 0.0032 0.0298 0.0565
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0541 0.2659
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0034
Schistosoma mansoni cpg binding protein 0.003 0.0269 0.0508
Plasmodium vivax DNA topoisomerase II, putative 0.0146 0.1755 1
Echinococcus granulosus dnaJ subfamily B 0.0399 0.499 0.8757
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0101 0.01
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0131 0.0295
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0027
Echinococcus granulosus beta hexosaminidase subunit beta 0.0356 0.4443 0.7796
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0541 0.2659
Schistosoma mansoni hypothetical protein 0.0342 0.4264 0.854
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0047 0.0046
Brugia malayi Flap endonuclease-1 0.0027 0.0238 0.0536
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.0047 0.0107
Schistosoma mansoni ets 0.0011 0.0031 0.0028
Loa Loa (eye worm) glycosyl hydrolase family 20 0.0356 0.4443 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0017 0.0034
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0031 0.0052
Schistosoma mansoni hypothetical protein 0.0038 0.0371 0.0712
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0034
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0053 0.0051
Onchocerca volvulus 0.0047 0.0492 0.1204
Echinococcus multilocularis cpg binding protein 0.003 0.0269 0.0268
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0101 0.0233
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0541 0.2659
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0857 0.1501
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.0047 0.0046
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0101 0.01
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0012 0.0047 0.0107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0034
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0017 0.0027
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0351 0.0949
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0012 0.0047 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0131 0.0387
Leishmania major DNA polymerase kappa, putative 0.0019 0.0131 0.0159
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0351 0.1528
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0083 0.0947 0.2132
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0031 0.0066
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0131 0.013
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0131 0.0228
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0116
Loa Loa (eye worm) hypothetical protein 0.0026 0.0221 0.0494
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0047 0.0046
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0047 0.0046
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0541 0.2515
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0857 0.1926
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Brugia malayi intermediate filament protein 0.0026 0.0227 0.0511
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0099 0.1151 0.2872
Schistosoma mansoni nAChR subunit 0.0012 0.0047 0.0062
Trypanosoma brucei DNA topoisomerase ii 0.0164 0.1984 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1483 0.3337
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0034
Echinococcus multilocularis lamin dm0 0.0026 0.0227 0.0225
Brugia malayi Ets-domain containing protein 0.0076 0.0857 0.1928
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.004 0.0408 0.3494
Plasmodium falciparum DNA gyrase subunit B 0.0085 0.0978 0.53
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0015
Echinococcus multilocularis muscleblind protein 0.0146 0.1753 0.1752
Onchocerca volvulus 0.0028 0.0249 0.0588
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0012 0.0047 0.0062
Onchocerca volvulus 0.0026 0.0227 0.0532
Trypanosoma brucei unspecified product 0.0019 0.0131 0.0387
Brugia malayi CXXC zinc finger family protein 0.0028 0.0249 0.056
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0492 0.1107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0131 0.0114
Entamoeba histolytica beta-N-acetylhexosaminidase, alpha subunit 0.0356 0.4443 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0071 0.0156
Loa Loa (eye worm) hypothetical protein 0.0295 0.3658 0.8234
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0085 0.0978 1
Echinococcus granulosus neuropeptide receptor A26 0.0455 0.5698 1
Schistosoma mansoni hypothetical protein 0.0342 0.4264 0.854
Leishmania major hypothetical protein, conserved 0.0051 0.0541 0.2337
Echinococcus granulosus flap endonuclease 1 0.0027 0.0238 0.0415
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0101 0.0001
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0131 0.0387
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0012 0.0047 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0131 0.0387
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0131 0.0387
Loa Loa (eye worm) inositol-1 0.0036 0.0351 0.0787
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0101 0.0233
Brugia malayi Ets-domain containing protein 0.0076 0.0857 0.1928
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Brugia malayi DNA polymerase I family protein 0.0016 0.0101 0.0228
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0031 0.0028
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0101 0.0228
Toxoplasma gondii RNA-directed DNA polymerase 0.0087 0.1004 0.5456
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0101 0.0001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0351 0.0949
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0131 0.0387
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0238 0.0827
Echinococcus granulosus lamin 0.0026 0.0227 0.0396
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0085 0.0978 1
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0031 0.0292 0.2171
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0223 0.2734 1
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.004 0.0408 0.1627
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0034
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0238 0.0237
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0227 0.0511
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.004 0.0408 0.1822
Mycobacterium ulcerans 5'-3' exonuclease 0.004 0.0408 0.3265
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0298 0.0667
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0066
Onchocerca volvulus Hexosaminidase D homolog 0.0083 0.0947 0.2356
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0012 0.0047 0.0103
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0031 0.0052
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0047 0.0103
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0298 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0037
Entamoeba histolytica hypothetical protein 0.0038 0.0371 0.062
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0085 0.0978 0.53
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0047 0.0107
Schistosoma mansoni beta-hexosaminidase B 0.0356 0.4443 0.89
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0017 0.0015
Trypanosoma cruzi DNA topoisomerase II, putative 0.0138 0.1655 0.8253
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0131 0.0292
Echinococcus granulosus dna polymerase kappa 0.0019 0.0131 0.0228
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.004 0.0408 0.1852
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0461 0.0893
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0038 0.0375 0.2292
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0012 0.0047 0.0062
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0057 0.0618 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.0328
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0131 0.0387
Schistosoma mansoni gabp alpha 0.0076 0.0857 0.1689
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0031 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0131 0.0387
Schistosoma mansoni lamin 0.0026 0.0227 0.0423
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0012 0.0047 0.0062
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.004 0.0408 0.1852
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0356 0.4443 1
Brugia malayi isocitrate dehydrogenase 0.0017 0.0101 0.0228
Schistosoma mansoni nAChR subunit 0.0012 0.0047 0.0062
Loa Loa (eye worm) hypothetical protein 0.0069 0.077 0.1731
Echinococcus multilocularis neuropeptide receptor A26 0.0455 0.5698 0.5697
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0047 0.0107
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0146 0.1755 0.3951
Leishmania major telomerase reverse transcriptase, putative 0.0087 0.1004 0.4794
Brugia malayi Muscleblind-like protein 0.0146 0.1753 0.3946
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0238 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0037
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0182 0.0181
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0131 0.0114
Loa Loa (eye worm) hypothetical protein 0.0083 0.0947 0.213
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0057 0.0618 0.5897
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0066
Schistosoma mansoni ets-related 0.0011 0.0031 0.0028
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0101 0.01
Onchocerca volvulus 0.0012 0.0047 0.0078
Echinococcus multilocularis dna polymerase eta 0.0019 0.0131 0.013
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0356 0.4443 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0146 0.1755 0.3951
Brugia malayi excitatory GABA receptor EXP-1A 0.0012 0.0047 0.0107
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.077 0.1733
Plasmodium falciparum DNA gyrase subunit A 0.0031 0.0292 0.1151
Chlamydia trachomatis DNA gyrase subunit B 0.0085 0.0978 1
Schistosoma mansoni hypothetical protein 0.0069 0.077 0.1515
Brugia malayi Fli-1 protein 0.023 0.2824 0.6356
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2839 0.2838
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0047 0.0081
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0047 0.0081
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0017 0.0034
Echinococcus multilocularis twinkle protein, mitochondrial 0.0012 0.0046 0.0045
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0047 0.0062
Brugia malayi Cation transporter family protein 0.0012 0.0047 0.0107
Echinococcus multilocularis protein C ets 2 0.0011 0.0031 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0015
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0031 0.0029
Brugia malayi transcription factor E74 isoform 0.0011 0.0031 0.0069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1177 0.265
Leishmania major DNA topoisomerase ii 0.0138 0.1655 0.8253
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0012 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0047 0.0081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0012 0.0047 0.0081
Plasmodium falciparum DNA topoisomerase 2 0.0146 0.1755 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0101 0.01
Mycobacterium ulcerans DNA gyrase subunit B 0.0085 0.0978 1
Schistosoma mansoni hypothetical protein 0.0032 0.0298 0.0565
Schistosoma mansoni inositol monophosphatase 0.0036 0.0351 0.0673
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0461 0.0893
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0037
Loa Loa (eye worm) hypothetical protein 0.0099 0.1153 0.2592
Onchocerca volvulus 0.0012 0.0047 0.0078
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0053 0.009
Echinococcus multilocularis GPCR, family 2 0.0032 0.0298 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0131 0.0159
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.004 0.0408 0.1627
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0017 0.0015
Echinococcus granulosus GPCR family 2 0.0032 0.0298 0.052
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0541 0.2659
Entamoeba histolytica beta-N-acetylhexosaminidase, beta subunit 0.0356 0.4443 1
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0138 0.1655 0.8293
Treponema pallidum DNA polymerase I (polA) 0.0057 0.0618 0.476
Schistosoma mansoni survival motor neuron protein 0.0047 0.0492 0.0956
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0047 0.0046
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0303 0.2298
Chlamydia trachomatis DNA gyrase subunit B 0.0067 0.075 0.6674
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0031 0.0292 0.1151
Brugia malayi Cation transporter family protein 0.0012 0.0047 0.0107
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0131 0.0159
Trichomonas vaginalis beta-hexosaminidase, putative 0.0083 0.0947 0.3212
Giardia lamblia Telomerase catalytic subunit 0.0087 0.1004 0.5714
Brugia malayi Ets-domain containing protein 0.0011 0.0031 0.0069
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0031 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0037
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0146 0.1755 0.3079
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0017 0.0037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1177 0.2647
Onchocerca volvulus 0.0295 0.3658 0.9221
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0047 0.0081
Schistosoma mansoni elf1 0.0011 0.0031 0.0028
Echinococcus multilocularis neuropeptide s receptor 0.0455 0.5698 0.5697
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0047 0.0107
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0131 0.0069
Schistosoma mansoni hypothetical protein 0.0399 0.499 1
Plasmodium falciparum flap endonuclease 1 0.0027 0.0238 0.0827
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0057 0.0618 0.476
Echinococcus granulosus twinkle protein mitochondrial 0.0012 0.0046 0.0079
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.002 0.0144 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0131 0.0387
Schistosoma mansoni DNA polymerase I 0.0016 0.0101 0.017
Loa Loa (eye worm) LGC-31 protein 0.0012 0.0047 0.0103
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.004 0.0408 0.1627
Schistosoma mansoni ets-related 0.023 0.2824 0.5644
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0047 0.0107
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0017 0.0037
Loa Loa (eye worm) TOPoisomerase family member 0.0146 0.1755 0.3949
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0012 0.0047 0.0107
Echinococcus multilocularis musashi 0.0026 0.0227 0.0225
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0356 0.4443 1
Brugia malayi hypothetical protein 0.0231 0.2839 0.639
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0012 0.0047 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0131 0.0387
Leishmania major DNA polymerase eta, putative 0.0019 0.0131 0.0159
Brugia malayi Telomerase reverse transcriptase 0.0232 0.2853 0.6421
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0031 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0034
Echinococcus multilocularis beta hexosaminidase subunit beta 0.0356 0.4443 0.4442
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0031 0.0066
Brugia malayi Cation transporter family protein 0.0012 0.0047 0.0107
Echinococcus granulosus protein C ets 2 0.0011 0.0031 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0101 0.01
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0238 0.0519
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0351 0.1327
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0047 0.0107
Onchocerca volvulus 0.0012 0.0047 0.0078
Echinococcus granulosus beta hexosaminidase subunit alpha 0.0223 0.2734 0.4798
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0131 0.034
Echinococcus granulosus neuropeptide s receptor 0.0455 0.5698 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0351 0.0949
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0037
Schistosoma mansoni hypothetical protein 0.0047 0.0492 0.0956
Schistosoma mansoni inositol monophosphatase 0.0036 0.0351 0.0673
Entamoeba histolytica hypothetical protein 0.0038 0.0371 0.062
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0017 0.0027
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0012 0.0047 0.0081
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0461 0.1035
Echinococcus multilocularis nAChR subunit 0.0012 0.0047 0.0046
Schistosoma mansoni hypothetical protein 0.0023 0.0182 0.0333
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0182 0.0318
Trichomonas vaginalis beta-hexosaminidase, putative 0.0223 0.2734 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.0047 0.0103
Brugia malayi MH2 domain containing protein 0.0125 0.1483 0.3339
Toxoplasma gondii DNA topoisomerase 2, putative 0.0146 0.1755 1
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0031 0.0052
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0031 0.0029
Echinococcus granulosus cpg binding protein 0.003 0.0269 0.047
Onchocerca volvulus Putative nachr subunit 0.0012 0.0047 0.0078
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0071 0.0159
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0101 0.0225
Schistosoma mansoni cpg binding protein 0.003 0.0269 0.0508
Loa Loa (eye worm) hypothetical protein 0.0065 0.0717 0.161
Trypanosoma cruzi DNA topoisomerase II, putative 0.0138 0.1655 0.8253
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0087 0.1004 0.4794
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1177 0.265
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0238 0.0315
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0131 0.0159
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0047 0.0107
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0131 0.0159
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0047 0.0046
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0027
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0012 0.0047 0.0081
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.499 0.4989
Loa Loa (eye worm) hypothetical protein 0.0016 0.0101 0.0225
Schistosoma mansoni nAChR subunit 0.0012 0.0047 0.0062
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0099 0.1151 0.2872
Echinococcus granulosus FTZ F1 alpha 0.001 0.0017 0.0027
Chlamydia trachomatis DNA polymerase I 0.0057 0.0618 0.476
Entamoeba histolytica hypothetical protein 0.0038 0.0371 0.062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0461 0.046
Echinococcus granulosus geminin 0.0342 0.4264 0.7482
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0131 0.023
Schistosoma mansoni flap endonuclease-1 0.0025 0.0205 0.0378
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Onchocerca volvulus 0.0012 0.0047 0.0078
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Loa Loa (eye worm) twinkle helicase 0.0012 0.0046 0.0101
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0351 0.2597
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0371 0.0712
Loa Loa (eye worm) hypothetical protein 0.0059 0.0649 0.1458
Onchocerca volvulus 0.0012 0.0047 0.0078
Schistosoma mansoni nAChR subunit 0.0012 0.0047 0.0062
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0101 0.017
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0131 0.023
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0031 0.0029
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0031 0.0052
Schistosoma mansoni DNA polymerase eta 0.0019 0.0131 0.023
Mycobacterium ulcerans DNA polymerase I 0.0057 0.0618 0.5753
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0351 0.1327
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0249 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0037
Loa Loa (eye worm) hypothetical protein 0.0099 0.1153 0.2592
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.065 0.1274
Echinococcus multilocularis muscleblind protein 1 0.0146 0.1753 0.1752
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0351 0.0575
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0047 0.0107
Onchocerca volvulus 0.0026 0.0227 0.0532
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0034
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0227 0.0508
Onchocerca volvulus 0.0012 0.0047 0.0078
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0101 0.0001
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0238 0.0827
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0047 0.0062
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0298 0.067
Leishmania major mitochondrial DNA topoisomerase II 0.0164 0.1984 1
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0047 0.0103
Echinococcus multilocularis beta hexosaminidase subunit alpha 0.0223 0.2734 0.2733
Loa Loa (eye worm) hypothetical protein 0.0231 0.2839 0.6388
Echinococcus granulosus lamin dm0 0.0026 0.0227 0.0396
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0012 0.0047 0.0046

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = -4.41 Log concentration that produces maximum response against epinephrine-induced platelet aggregation ChEMBL. 2157007
IC50 (functional) = 3.16 Inhibitory activity against epinephrine-induced platelet aggregation (secondary wave AGG) ChEMBL. 2157007
IC50 (functional) = 3.2 Inhibitory activity against epinephrine-induced platelet aggregation (primary wave AGG) ChEMBL. 2157007
IC50 (functional) = 3.36 Compound was evaluated for stimulatory activity against serotonin secretion (SEC). ChEMBL. 2157007
Log EC50 (functional) = 4.41 Log concentration that produces maximum response against epinephrine-induced platelet aggregation ChEMBL. 2157007
Log IC50 (functional) = 3.16 Inhibitory activity against epinephrine-induced platelet aggregation (secondary wave AGG) ChEMBL. 2157007
Log IC50 (functional) = 3.2 Inhibitory activity against epinephrine-induced platelet aggregation (primary wave AGG) ChEMBL. 2157007
Log IC50 (functional) = 3.36 Compound was evaluated for stimulatory activity against serotonin secretion (SEC). ChEMBL. 2157007

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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