Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | multiple endocrine neoplasia I | No references | |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0009 | 0.0018 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0039 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0039 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0314 | 0.0448 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0048 | 0.0452 | 0.0407 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0262 | 0.2649 | 0.523 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0334 | 0.0578 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0039 | 1 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0048 | 0.0452 | 0.0696 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0314 | 0.0624 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0048 | 0.0452 | 0.0696 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0048 | 0.0452 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0039 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0334 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0548 | 0.5575 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0048 | 0.0452 | 0.0407 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.0712 | 0.1418 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0039 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0452 | 0.0696 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0039 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0068 | 0.0044 |
Brugia malayi | Choline O-acetyltransferase | 0.0048 | 0.0452 | 0.0699 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0039 | 1 |
Onchocerca volvulus | 0.0048 | 0.0452 | 1 | |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.0632 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0048 | 0.0452 | 0.0899 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0048 | 0.0452 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0048 | 0.0452 | 0.0699 |
Onchocerca volvulus | 0.0048 | 0.0452 | 1 | |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0048 | 0.0452 | 0.0699 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0039 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0262 | 0.2649 | 0.2615 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0048 | 0.0452 | 0.0814 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0262 | 0.2649 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0039 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0548 | 0.5575 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0039 | 1 |
Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.5023 | 1 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.5023 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.0452 | 1 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0048 | 0.0452 | 0.0899 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0068 | 0.0022 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0039 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0048 | 0.0452 | 0.0699 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0334 | 0.0665 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0039 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 0.5023 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0334 | 0.0665 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0046 | 0.0092 |
Echinococcus granulosus | choline O acetyltransferase | 0.0048 | 0.0452 | 0.0814 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0262 | 0.2649 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0048 | 0.0452 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0039 | 1 |
Onchocerca volvulus | 0.0048 | 0.0452 | 1 | |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0314 | 0.0446 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0039 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0039 | 1 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0048 | 0.0452 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0039 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0048 | 0.0452 | 0.0696 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0039 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0048 | 0.0452 | 0.5 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0262 | 0.2649 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1078 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.