TDR Targets

Basic information

Technical information

TDR Targets ID: 1455073
Name: 1-(5-chloro-2-methylphenyl)-4-[1-[1-(furan-2- ylmethyl)tetrazol-5-yl]butyl]piperazine hydro chloride
MW: 451.393 | Formula: C21H28Cl2N6O
H donors: 0 H acceptors: 3 LogP: 4.8 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(c1nnnn1Cc1ccco1)N1CCN(CC1)c1cc(Cl)ccc1C.Cl
InChi: 1S/C21H27ClN6O.ClH/c1-3-5-19(21-23-24-25-28(21)15-18-6-4-13-29-18)26-9-11-27(12-10-26)20-14-17(22)8-7-16(20)2;/h4,6-8,13-14,19H,3,5,9-12,15H2,1-2H3;1H
InChiKey: BTLRQWTVQRIMPM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(5-chloro-2-methyl-phenyl)-4-[1-[1-(2-furylmethyl)tetrazol-5-yl]butyl]piperazine hydrochloride
1-(5-chloro-2-methylphenyl)-4-[1-[1-(2-furylmethyl)-5-tetrazolyl]butyl]piperazine hydrochloride
1-(5-chloro-2-methyl-phenyl)-4-[1-[1-(furan-2-ylmethyl)-1,2,3,4-tetrazol-5-yl]butyl]piperazine hydrochloride
1-(5-Chloro-2-methyl-phenyl)-4-[1-(1-furan-2-ylmethyl-1H-tetrazol-5-yl)-butyl]-piperazine
MLS000070880
SMR000005004

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calcium channel, voltage-dependent, T type, alpha 1H subunit	Starlite/ChEMBL	No references
Homo sapiens	thyroid stimulating hormone receptor	Starlite/ChEMBL	No references
Homo sapiens	neuropeptide S receptor 1	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	arachidonate 15-lipoxygenase	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Brugia malayi	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_129328	All targets in OG5_129328
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129328	All targets in OG5_129328
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	Get druggable targets OG5_129328	All targets in OG5_129328
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Echinococcus granulosus	arachidonate 5 lipoxygenase	arachidonate 15-lipoxygenase	662 aa	590 aa	23.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.004	0.0045
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0029	0.003
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Schistosoma mansoni	cpg binding protein	0.0035	0.0417	0.0467
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase, putative	0.0052	0.0667	1
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0028	0.0313	0.0351
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0786	0.1299
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0191	0.0238
Onchocerca volvulus		0.0028	0.0313	0.4696
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0052	0.0667	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.0561	0.0927
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.0313
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0028	0.0313	0.039
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0029	0.003
Brugia malayi	follicle stimulating hormone receptor	0.0283	0.4002	0.6615
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0561	0.0581
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0028	0.0313	0.0518
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0158	0.2199	0.2199
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0191	0.0238
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0029	0.003
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0667	0.0747
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Entamoeba histolytica	anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative	0.0052	0.0667	0.0379
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0158	0.2199	0.2742
Schistosoma mansoni	hypothetical protein	0.0494	0.7058	0.7904
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.2928	0.3034
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0417	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0158	0.2199	0.2199
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0191	0.0214
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0028	0.0313	0.0313
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.7058	0.8802
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0561	0.07
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.0052	0.0667	0.0747
Schistosoma mansoni	hypothetical protein	0.0024	0.026	0.0291
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0313	0.0351
Trypanosoma brucei	FAD dependent oxidoreductase, putative	0.0052	0.0667	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0029	0.003
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.0313
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0561	0.8415
Onchocerca volvulus		0.0028	0.0313	0.4696
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0029	0.003
Loa Loa (eye worm)	hypothetical protein	0.0041	0.051	0.0571
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.051	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0623	0.893	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0561	0.0561
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.0561	0.07
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0052	0.0667	1
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.0623	0.893	1
Schistosoma mansoni	cpg binding protein	0.0037	0.0445	0.0499
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0786	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0024	0.026	0.0291
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0029	0.003
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0313	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 20	0.0052	0.0667	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0028	0.0313	0.0313
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.0052	0.0667	0.1102
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0028	0.0313	0.0351
Onchocerca volvulus		0.0028	0.0313	0.4696
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0028	0.0313	0.0351
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.0052	0.0667	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0067	0.0879	0.1097
Onchocerca volvulus		0.0028	0.0313	0.4696
Loa Loa (eye worm)	doublecortin family protein	0.0024	0.026	0.0291
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0029	0.003
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0667	0.0747
Echinococcus multilocularis	cpg binding protein	0.0037	0.0445	0.0555
Echinococcus multilocularis	neuropeptide receptor A26	0.056	0.8019	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.026	0.0324
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0028	0.0313	0.4696
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0191	0.0191
Schistosoma mansoni	protein tyrosine phosphatase	0.0028	0.0313	0.0351
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.0052	0.0667	0.0667
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Schistosoma mansoni	fad oxidoreductase	0.0052	0.0667	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Onchocerca volvulus		0.0028	0.0313	0.4696
Onchocerca volvulus		0.0028	0.0313	0.4696
Schistosoma mansoni	pcd6 interacting protein-related	0.0028	0.0313	0.0351
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0028	0.0313	0.039
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0028	0.0313	0.0313
Onchocerca volvulus		0.0028	0.0313	0.4696
Onchocerca volvulus		0.0028	0.0313	0.4696
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0673	0.965	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Echinococcus granulosus	Polycystic kidney disease protein	0.0024	0.026	0.026
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0158	0.2199	0.2742
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0028	0.0313	0.0313
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0313	0.0351
Echinococcus granulosus	neuropeptide receptor A26	0.056	0.8019	0.8019
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Leishmania major	hypothetical protein, conserved	0.0052	0.0667	1
Echinococcus granulosus	GPCR family 2	0.0019	0.0191	0.0191
Toxoplasma gondii	FAD-dependent glycerol-3-phosphate dehydrogenase	0.0052	0.0667	0.7704
Echinococcus granulosus	cpg binding protein	0.0037	0.0445	0.0445
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0424	0.6049	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0024	0.026	0.0324
Echinococcus multilocularis	neuropeptide s receptor	0.056	0.8019	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0028	0.0313	0.039
Trypanosoma brucei	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0052	0.0667	1
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.0052	0.0667	0.0747
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.039
Onchocerca volvulus		0.0028	0.0313	0.4696
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0028	0.0313	0.039
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0028	0.0313	0.039
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0028	0.0313	0.039
Onchocerca volvulus		0.0028	0.0313	0.4696
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.026	0.026
Echinococcus multilocularis	RUN	0.0024	0.026	0.0324
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0028	0.0313	0.0351
Schistosoma mansoni	fad oxidoreductase	0.0052	0.0667	0.0747
Onchocerca volvulus		0.0028	0.0313	0.4696
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0052	0.0667	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Schistosoma mansoni	hypothetical protein	0.0019	0.0191	0.0214
Onchocerca volvulus		0.0028	0.0313	0.4696
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0865	1
Trichomonas vaginalis	pten, drome, putative	0.0028	0.0313	0.0324
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Brugia malayi	hypothetical protein	0.0028	0.0313	0.0518
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.039
Echinococcus multilocularis		0.0028	0.0313	0.039
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.039
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0028	0.0313	0.0351
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.026	0.0324
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.007	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0214	0.3013	0.3374
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Onchocerca volvulus	4.1 G protein, putative homolog	0.0028	0.0313	0.4696
Onchocerca volvulus		0.0028	0.0313	0.4696
Brugia malayi	hypothetical protein	0.0024	0.026	0.0429
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0028	0.0313	0.4696
Schistosoma mansoni	rab6-interacting	0.0024	0.026	0.0291
Echinococcus multilocularis	hypothetical protein	0.0028	0.0313	0.039
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0191	0.0315
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0068	0.0113
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Plasmodium vivax	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0052	0.0667	1
Brugia malayi	Protein-tyrosine phosphatase	0.0028	0.0313	0.0518
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.0052	0.0667	0.0831
Brugia malayi	RE18450p	0.0052	0.0667	0.1102
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0029	0.003
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0028	0.0313	0.0518
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.0052	0.0667	0.1102
Onchocerca volvulus		0.0028	0.0313	0.4696
Brugia malayi	Doublecortin family protein	0.0024	0.026	0.0429
Schistosoma mansoni	lipoxygenase	0.0067	0.0879	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Onchocerca volvulus		0.0028	0.0313	0.4696
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0028	0.0313	0.0351
Brugia malayi	Protein-tyrosine phosphatase 1	0.0028	0.0313	0.0518
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Onchocerca volvulus		0.0028	0.0313	0.4696
Onchocerca volvulus	Putative fad oxidoreductase	0.0052	0.0667	1
Trypanosoma brucei	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0052	0.0667	1
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.0673	0.965	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0979	0.1096
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Schistosoma mansoni	loxhd1	0.0024	0.026	0.0291
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0028	0.0313	0.039
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.0313
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.026	0.026
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.039
Brugia malayi	hypothetical protein	0.0028	0.0313	0.0518
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0424	0.6049	0.6773
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0029	0.003
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0052	0.0667	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0029	0.003
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0028	0.0313	0.0313
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0424	0.6049	0.6049
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0028	0.0313	0.0351
Onchocerca volvulus		0.0028	0.0313	0.4696
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0028	0.0313	0.0351
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.004	0.004
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0028	0.0313	0.4696
Onchocerca volvulus		0.0028	0.0313	0.4696
Leishmania major	glycerol-3-phosphate dehydrogenase-like protein	0.0052	0.0667	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0028	0.0313	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0024	0.026	0.0291
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0029	0.003
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Onchocerca volvulus		0.0028	0.0313	0.4696
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.0313
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.7058	0.7058
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0158	0.2199	0.3635
Schistosoma mansoni	hypothetical protein	0.0019	0.0191	0.0214
Brugia malayi	Protein-tyrosine phosphatase	0.0028	0.0313	0.0518
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0067	0.0879	0.0879
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0313	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Brugia malayi	cDNA sequence BC016226	0.0052	0.0667	0.1102
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.0561	0.0266
Schistosoma mansoni	protein tyrosine phosphatase	0.0028	0.0313	0.0351
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.0313
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0561	0.8415
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0052	0.0667	0.5
Schistosoma mansoni	protein tyrosine phosphatase	0.0028	0.0313	0.0351
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.0561	0.7012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Onchocerca volvulus		0.0028	0.0313	0.4696
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0786	0.088
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0028	0.0313	0.039
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0028	0.0313	0.039
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0191	0.0191
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0028	0.0313	0.0351
Toxoplasma gondii	hypothetical protein	0.0052	0.0667	0.7704
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0158	0.2199	0.2462
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.0313
Onchocerca volvulus		0.0028	0.0313	0.4696
Schistosoma mansoni	lipoxygenase	0.0024	0.026	0.0291
Onchocerca volvulus		0.0024	0.026	0.3893
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0571	0.8179	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0561	0.0628
Schistosoma mansoni	NAD dehydrogenase	0.0052	0.0667	0.0747
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0028	0.0313	0.039
Schistosoma mansoni	polycystin 1-related	0.0024	0.026	0.0291
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0561	0.8415
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0313	0.0351
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0424	0.6049	0.7544
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0052	0.0667	1
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.007	0.0079
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0214	0.3013	0.4981
Schistosoma mansoni	d-amino acid oxidase	0.0623	0.893	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0028	0.0313	0.0351
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0029	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0561	0.0581
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0028	0.0313	0.0351
Leishmania major	hypothetical protein, conserved	0.0052	0.0667	1
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0191	0.0238
Brugia malayi	hypothetical protein	0.0024	0.026	0.0429
Onchocerca volvulus		0.0028	0.0313	0.4696
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.039
Brugia malayi	hypothetical protein	0.0028	0.0313	0.0518
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.004	0.005
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0029	0.003
Onchocerca volvulus	Dimethylglycine dehydrogenase, mitochondrial homolog	0.0052	0.0667	1
Trichomonas vaginalis	helicase, putative	0.0008	0.0029	0.003
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0424	0.6049	0.6773
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0052	0.0667	0.0379
Schistosoma mansoni	hypothetical protein	0.0019	0.0191	0.0214
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.0052	0.0667	0.0667
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.0313
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0029	0.003
Onchocerca volvulus		0.0024	0.026	0.3893
Schistosoma mansoni	hypothetical protein	0.0041	0.051	0.0571
Leishmania major	tyrosine specific protein phosphatase, putative	0.0028	0.0313	0.4696
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Onchocerca volvulus		0.0035	0.0417	0.6251
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0191	0.0214
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial	0.0052	0.0667	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.007	0.007
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0417	0.0467
Trypanosoma cruzi	FAD dependent oxidoreductase, putative	0.0052	0.0667	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0561	0.07
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.0561	0.8415
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0191	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Brugia malayi	hypothetical protein	0.0028	0.0313	0.0518
Echinococcus granulosus	neuropeptide s receptor	0.056	0.8019	0.8019
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0667	0.0747
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.004	0.005
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0561	0.0561
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0028	0.0313	0.0313
Onchocerca volvulus	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog	0.0052	0.0667	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.039
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0623	0.893	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0313	0.0313
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0351
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Onchocerca volvulus		0.0028	0.0313	0.4696
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.0561	0.0561
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.0561	0.0628
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0029	0.003
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0052	0.0667	1
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0028	0.0313	0.039
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Loa Loa (eye worm)	hypothetical protein	0.006	0.0786	0.088
Brugia malayi	hypothetical protein	0.0028	0.0313	0.0518
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0029	0.003
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.0052	0.0667	0.0831
Echinococcus granulosus	RUN	0.0024	0.026	0.026
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0028	0.0313	0.039
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0313	0.0351
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0028	0.0313	0.0351
Plasmodium falciparum	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0052	0.0667	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0029	0.003
Schistosoma mansoni	hypothetical protein	0.0019	0.0191	0.0214
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0028	0.0313	0.4696
Schistosoma mansoni	cpg binding protein	0.0037	0.0445	0.0499
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0313	0.0518
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0561	0.0581
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0158	0.2199	0.2462
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0028	0.0313	0.4696
Schistosoma mansoni	rab6-interacting	0.0024	0.026	0.0291
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0028	0.0313	0.039
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0283	0.4002	0.4481
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.0561	0.0628

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	0.728 uM	PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channel. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID493021, AID493022, AID493023, AID493041, AID504579, AID504584, AID504619, AID504628]	ChEMBL.	No reference
Potency (functional)	= 0.631 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 0.7079 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 0.7943 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 0.7943 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 1.5849 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1423898

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1455073