Detailed information for compound 1461402

Basic information

Technical information
  • TDR Targets ID: 1461402
  • Name: 2-morpholin-4-ylquinoline
  • MW: 214.263 | Formula: C13H14N2O
  • H donors: 0 H acceptors: 1 LogP: 2.27 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O1CCN(CC1)c1ccc2c(n1)cccc2
  • InChi: 1S/C13H14N2O/c1-2-4-12-11(3-1)5-6-13(14-12)15-7-9-16-10-8-15/h1-6H,7-10H2
  • InChiKey: HKSKLECHCQBNJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-morpholinoquinoline
  • Oprea1_659757
  • ST5446333

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0214
Schistosoma mansoni inositol monophosphatase 0.0045 0.0202 0.0189
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0104 0.0175
Entamoeba histolytica hypothetical protein 0.0072 0.0541 0.0891
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.012 0.1139 0.1127
Loa Loa (eye worm) hypothetical protein 0.0134 0.1318 0.3079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.025 0.0458
Loa Loa (eye worm) hypothetical protein 0.0049 0.0261 0.0585
Schistosoma mansoni coup transcription factor 0.0254 0.2809 0.2799
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.012 0.1139 0.1127
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.025 0.056
Brugia malayi Tnks protein 0.0056 0.0346 0.0642
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.049 0.1125
Echinococcus granulosus nuclear receptor 2DBD gamma 0.012 0.1139 0.1139
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0346 0.099
Schistosoma mansoni nuclear receptor nhr-48 0.012 0.1139 0.1127
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0156 0.0494
Brugia malayi hypothetical protein 0.0134 0.1318 0.2519
Brugia malayi Inositol-1 0.0045 0.0202 0.0365
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0254 0.2809 0.2809
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0104 0.0104
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.037 0.425 0.4243
Schistosoma mansoni steroid hormone receptor ad4bp 0.0254 0.2809 0.2799
Brugia malayi conserved hypotetical protein 0.012 0.1139 0.2174
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0346 0.099
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0134 0.1318 0.1318
Loa Loa (eye worm) tnks protein 0.0056 0.0346 0.0785
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0254 0.2809 0.2809
Loa Loa (eye worm) hypothetical protein 0.0134 0.1318 0.3079
Loa Loa (eye worm) hypothetical protein 0.037 0.425 1
Brugia malayi Steroid receptor seven-up type 2 0.0254 0.2809 0.5397
Brugia malayi hypothetical protein 0.0134 0.1318 0.2519
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0254 0.2809 0.5397
Onchocerca volvulus 0.0037 0.0104 0.0309
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0423 0.041
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0346 0.099
Schistosoma mansoni RAR-like nuclear receptor 0.0254 0.2809 0.2799
Brugia malayi Nuclear hormone receptor E75 0.012 0.1139 0.2174
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.012 0.0065
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.006 0.009
Brugia malayi ecdysone receptor 0.012 0.1139 0.2174
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0254 0.2809 0.2799
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0254 0.2809 0.2809
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0254 0.2809 0.5397
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0334 0.0321
Brugia malayi WGR domain containing protein 0.0446 0.5193 1
Brugia malayi beta-lactamase 0.0037 0.0104 0.0175
Echinococcus granulosus poly ADP ribose polymerase 1 0.0446 0.5193 0.5193
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0446 0.5193 0.5186
Schistosoma mansoni hypothetical protein 0.0033 0.006 0.0047
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.012 0.1139 0.2174
Entamoeba histolytica hypothetical protein 0.0056 0.0346 0.0509
Onchocerca volvulus 0.0254 0.2809 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.012 0.1139 0.4017
Loa Loa (eye worm) hypothetical protein 0.0254 0.2809 0.6598
Toxoplasma gondii ABC1 family protein 0.0037 0.0104 0.0173
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0104 0.0091
Brugia malayi RNA binding protein 0.0062 0.0423 0.0791
Schistosoma mansoni chromobox protein 0.0068 0.049 0.0477
Echinococcus granulosus poly (ADP ribose) polymerase 0.0072 0.0541 0.0541
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0086 0.0086
Loa Loa (eye worm) RNA binding protein 0.0062 0.0423 0.0967
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0446 0.5193 0.5186
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi MH2 domain containing protein 0.0119 0.1125 0.2147
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0254 0.2809 0.2809
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0254 0.2809 0.5397
Loa Loa (eye worm) nuclear receptor NHR-67 0.012 0.1139 0.2657
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.2562 1
Schistosoma mansoni nuclear receptor 0.012 0.1139 0.1127
Echinococcus granulosus thyroid hormone receptor alpha 0.012 0.1139 0.1139
Echinococcus multilocularis tankyrase 0.0056 0.0346 0.0333
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0151 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0254 0.2809 0.5397
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0254 0.2809 0.5397
Onchocerca volvulus 0.0037 0.0104 0.0309
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0156 0.0212
Onchocerca volvulus 0.004 0.0151 0.0477
Schistosoma mansoni retinoic acid receptor RXR 0.0254 0.2809 0.2799
Trichomonas vaginalis chromobox protein, putative 0.0068 0.049 0.1579
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0453 0.5274 1
Brugia malayi nuclear hormone receptor 0.012 0.1139 0.2174
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0423 0.041
Leishmania major hypothetical protein, conserved 0.0049 0.0261 1
Loa Loa (eye worm) inositol-1 0.0045 0.0202 0.0446
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.012 0.1139 0.1127
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0346 0.099
Echinococcus granulosus poly (ADP ribose) polymerase 0.0072 0.0541 0.0541
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0423 0.0791
Loa Loa (eye worm) hypothetical protein 0.0254 0.2809 0.6598
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0346 0.099
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0261 0.0379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0254 0.2809 0.6598
Loa Loa (eye worm) beta-lactamase 0.0037 0.0104 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0346 0.099
Brugia malayi nuclear hormone receptor family member nhr-6 0.012 0.1139 0.2174
Brugia malayi beta-lactamase family protein 0.0037 0.0104 0.0175
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0254 0.2809 0.2799
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0254 0.2809 0.5397
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0254 0.2809 0.6598
Echinococcus multilocularis ecdysone induced protein 78C 0.0254 0.2809 0.2799
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0202 0.0401
Entamoeba histolytica zinc finger protein, putative 0.0056 0.0346 0.0509
Loa Loa (eye worm) hypothetical protein 0.0033 0.006 0.011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0254 0.2809 0.2799
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0423 0.041
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.037 0.425 1
Schistosoma mansoni thyroid hormone receptor 0.0254 0.2809 0.2799
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0214
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0202 0.5
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0423 0.0967
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0202 0.0236
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0214
Onchocerca volvulus 0.012 0.1139 0.4017
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0334 0.0321
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0334 0.0757
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0134 0.1318 0.1306
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0104 0.0091
Loa Loa (eye worm) hypothetical protein 0.0254 0.2809 0.6598
Trypanosoma brucei poly(adp-ribose) polymerase 0.037 0.425 1
Schistosoma mansoni nuclear hormone receptor 0.012 0.1139 0.1127
Schistosoma mansoni nuclear hormone receptor 0.012 0.1139 0.1127
Brugia malayi Nuclear hormone receptor-like 1 0.0134 0.1318 0.2519
Echinococcus granulosus Nuclear hormone receptor HR96 0.012 0.1139 0.1139
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0086 0.0073
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0144 0.0163
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1125 0.2625
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0254 0.2809 0.2809
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0202 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0254 0.2809 0.5397
Loa Loa (eye worm) steroid hormone receptor 0.0254 0.2809 0.6598
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0261 0.5
Echinococcus granulosus poly (ADP ribose) polymerase 0.0118 0.111 0.111
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0423 0.041
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.012 0.1139 0.1139
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0254 0.2809 0.2799
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.012 0.1139 0.1127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0254 0.2809 0.6598
Brugia malayi Heterochromatin protein 1 0.0068 0.049 0.092
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.025 0.0458
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Entamoeba histolytica hypothetical protein 0.0056 0.0346 0.0509
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0202 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.012 0.0065
Schistosoma mansoni chromobox protein 0.0068 0.049 0.0477
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2547 1
Brugia malayi WGR domain containing protein 0.037 0.425 0.818
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0254 0.2809 0.5397
Brugia malayi hypothetical protein 0.0032 0.0044 0.0059
Loa Loa (eye worm) hypothetical protein 0.0254 0.2809 0.6598
Echinococcus granulosus chromobox protein 1 0.0068 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0254 0.2809 0.2799
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.037 0.425 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0134 0.1318 0.3079
Brugia malayi photoreceptor-specific nuclear receptor 0.0254 0.2809 0.5397
Echinococcus granulosus nuclear receptor nhr 48 0.012 0.1139 0.1139
Loa Loa (eye worm) nuclear hormone receptor 0.012 0.1139 0.2657
Brugia malayi hypothetical protein 0.012 0.1139 0.2174
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0254 0.2809 0.2799
Brugia malayi orphan nuclear receptor NR2E1 0.012 0.1139 0.2174
Echinococcus multilocularis nuclear receptor nhr 48 0.012 0.1139 0.1127
Onchocerca volvulus Bile acid receptor homolog 0.0254 0.2809 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0104 0.0214
Echinococcus granulosus FTZ F1 alpha 0.0254 0.2809 0.2809
Loa Loa (eye worm) hypothetical protein 0.0134 0.1318 0.3079
Loa Loa (eye worm) hypothetical protein 0.0048 0.025 0.056
Echinococcus granulosus tankyrase 0.0056 0.0346 0.0346
Trichomonas vaginalis chromobox protein, putative 0.0068 0.049 0.1579
Echinococcus granulosus ecdysone induced protein 78C 0.0254 0.2809 0.2809
Brugia malayi Cytochrome P450 family protein 0.0049 0.0252 0.046
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Schistosoma mansoni thyroid hormone receptor 0.0254 0.2809 0.2799
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0423 0.0967
Schistosoma mansoni nuclear receptor 0.012 0.1139 0.1127
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0254 0.2809 0.2809
Echinococcus multilocularis Nuclear hormone receptor HR96 0.012 0.1139 0.1127
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Brugia malayi Nuclear hormone receptor E75 0.012 0.1139 0.2174
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0261 0.5
Onchocerca volvulus 0.0233 0.2547 0.906
Echinococcus multilocularis chromobox protein 1 0.0068 0.049 0.0477
Brugia malayi ecdysteroid receptor 0.0254 0.2809 0.5397
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0202 1
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0254 0.2809 0.2799
Brugia malayi Nuclear hormone receptor-like 1 0.0134 0.1318 0.2519
Brugia malayi chromobox protein homolog 3 0.0038 0.012 0.0206
Schistosoma mansoni hypothetical protein 0.0035 0.0086 0.0073
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0214
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1125 0.2625
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0254 0.2809 0.5397
Brugia malayi beta-lactamase family protein 0.0037 0.0104 0.0175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0334 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0254 0.2809 0.5397
Brugia malayi Nuclear hormone receptor-like 1 0.0254 0.2809 0.5397
Echinococcus multilocularis FTZ F1 alpha 0.0254 0.2809 0.2799
Brugia malayi nuclear receptor NHR-88 0.0254 0.2809 0.5397
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.012 0.1139 0.4017
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0011
Brugia malayi nuclear receptor NHR-88 0.012 0.1139 0.2174
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0254 0.2809 0.5397
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0202 0.0401
Echinococcus granulosus Nuclear hormone receptor HR96 0.012 0.1139 0.1139
Loa Loa (eye worm) DR-78 0.012 0.1139 0.2657
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0254 0.2809 0.2809
Brugia malayi hypothetical protein 0.0035 0.0086 0.0141
Onchocerca volvulus Protein ultraspiracle homolog 0.0254 0.2809 1
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0214
Loa Loa (eye worm) hypothetical protein 0.0254 0.2809 0.6598
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0128 0.1239 0.1228
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0202 0.0359
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0202 0.0189
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0261 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0334 0.0334
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0254 0.2809 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0202 0.6247
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0254 0.2809 0.6598
Loa Loa (eye worm) hypothetical protein 0.0134 0.1318 0.3079
Brugia malayi tailless protein 0.012 0.1139 0.2174
Brugia malayi hypothetical protein 0.012 0.1139 0.2174
Brugia malayi nuclear receptor RXR 0.012 0.1139 0.2174
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0261 0.0379
Echinococcus multilocularis thyroid hormone receptor alpha 0.0254 0.2809 0.2799
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0254 0.2809 0.2799
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Loa Loa (eye worm) hypothetical protein 0.0254 0.2809 0.6598
Echinococcus granulosus poly (ADP ribose) polymerase 0.019 0.2003 0.2003
Brugia malayi TAR-binding protein 0.0062 0.0423 0.0791
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.012 0.1139 0.1127
Brugia malayi nuclear hormone receptor family member odr-7 0.012 0.1139 0.2174
Brugia malayi Pre-SET motif family protein 0.0205 0.2195 0.4212
Loa Loa (eye worm) hypothetical protein 0.012 0.1139 0.2657
Brugia malayi steroid hormone receptor 0.0254 0.2809 0.5397
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0253 0.2789 0.655
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2195 0.5148
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0254 0.2809 0.2799
Schistosoma mansoni nuclear hormone receptor 0.0254 0.2809 0.2799
Schistosoma mansoni inositol monophosphatase 0.0045 0.0202 0.0189
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0104 0.0091
Echinococcus multilocularis Nuclear hormone receptor HR96 0.012 0.1139 0.1127
Loa Loa (eye worm) hypothetical protein 0.0254 0.2809 0.6598
Loa Loa (eye worm) hypothetical protein 0.0254 0.2809 0.6598
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0423 0.041
Schistosoma mansoni poly [ADP-ribose] polymerase 0.037 0.425 0.4243
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0261 0.0379
Brugia malayi nuclear receptor NHR-67 0.012 0.1139 0.2174
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0254 0.2809 0.5397
Schistosoma mansoni zinc finger protein 0.012 0.1139 0.1127
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0254 0.2809 0.5397
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0254 0.2809 0.2799
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0252
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0013 0.0013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0254 0.2809 0.2799
Echinococcus granulosus tar DNA binding protein 0.0062 0.0423 0.0423
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0086 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0423 0.041
Schistosoma mansoni tankyrase 0.0056 0.0346 0.0333
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0202 0.0401
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0446 0.5193 1
Brugia malayi nuclear hormone receptor 0.0254 0.2809 0.5397
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0134 0.1318 0.3079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0254 0.2809 0.6598
Brugia malayi hypothetical protein 0.0049 0.0261 0.0478
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0254 0.2809 0.2799
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0346 0.099
Echinococcus granulosus chromobox protein 1 0.0068 0.049 0.049
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0334 0.062
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0261 0.0471
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0104 0.3664
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0202 0.0236
Loa Loa (eye worm) hypothetical protein 0.0265 0.2945 0.692
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0134 0.1318 0.1306
Brugia malayi nuclear receptor RXR 0.0134 0.1318 0.2519
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0314 0.3552 0.3544
Entamoeba histolytica hypothetical protein 0.0056 0.0346 0.0509
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0334 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0346 0.099
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0134 0.1318 0.1306
Echinococcus granulosus poly adp ribose polymerase 2 0.037 0.425 0.425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0334 0.0321
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0252 0.0562
Echinococcus granulosus WGR domain containing protein 0.019 0.2003 0.2003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0254 0.2809 0.6598
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.012 0.0365
Echinococcus multilocularis chromobox protein 1 0.0068 0.049 0.0477
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0144 1
Onchocerca volvulus Tankyrase homolog 0.0056 0.0346 0.1175
Loa Loa (eye worm) nuclear receptor nhr-7B 0.012 0.1139 0.2657
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0202 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0254 0.2809 0.6598
Onchocerca volvulus 0.012 0.1139 0.4017
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0156 0.0212
Onchocerca volvulus 0.0037 0.0104 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0346 0.099
Entamoeba histolytica hypothetical protein 0.0056 0.0346 0.0509
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antagonist activity at rat cannabinoid CB1 receptor in Wistar rat cerebellar membranes at 10 uM by [35S]GTPgammaS binding assay ChEMBL. 21215643
Activity (functional) = 7 % Agonist activity at human recombinant cannabinoid CB2 receptor expressed in CHO cells at 10 uM by [35S]GTPgammaS binding assay ChEMBL. 21215643

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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