Detailed information for compound 1463341

Basic information

Technical information
  • TDR Targets ID: 1463341
  • Name: 4-(5,5-dimethyl-3-morpholin-4-yl-1-cyclohex-2 -enylidene)morpholin-4-ium
  • MW: 279.398 | Formula: C16H27N2O2+
  • H donors: 0 H acceptors: 0 LogP: 0.58 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1(C)CC(=CC(=[N+]2CCOCC2)C1)N1CCOCC1
  • InChi: 1S/C16H27N2O2/c1-16(2)12-14(17-3-7-19-8-4-17)11-15(13-16)18-5-9-20-10-6-18/h11H,3-10,12-13H2,1-2H3/q+1
  • InChiKey: GIJYIOLGBVKZFU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(5,5-dimethyl-3-morpholino-1-cyclohex-2-enylidene)morpholin-4-ium
  • Oprea1_514736

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.0268
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0032 0.0268 0.0268
Brugia malayi metallopeptidase family M24 containing protein 0.0058 0.0863 0.0863
Loa Loa (eye worm) initiation factor 2-associated protein 0.047 1 1
Schistosoma mansoni cytochrome P450 reductase 0.0032 0.0268 0.0268
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0058 0.0863 0.0612
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.047 1 1
Echinococcus multilocularis FACT complex subunit SPT16 0.0058 0.0863 0.0863
Giardia lamblia Methionine aminopeptidase 0.047 1 1
Trypanosoma brucei methionine aminopeptidase 2, putative 0.047 1 1
Echinococcus multilocularis xaa Pro dipeptidase 0.0058 0.0863 0.0863
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0032 0.0268 0.0081
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0058 0.0863 0.0688
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0058 0.0863 0.5
Plasmodium vivax peptidase, putative 0.0058 0.0863 0.0688
Echinococcus granulosus FACT complex subunit SPT16 0.0058 0.0863 0.0863
Trypanosoma cruzi aminopeptidase P1, putative 0.0058 0.0863 0.0612
Brugia malayi flavodoxin family protein 0.0032 0.0268 0.0268
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0058 0.0863 0.0688
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.047 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0058 0.0863 0.0612
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0058 0.0863 0.0688
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0032 0.0268 0.0081
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0058 0.0863 0.0863
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0058 0.0863 0.0688
Schistosoma mansoni peptidase 0.0058 0.0863 0.0863
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0058 0.0863 0.0688
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0058 0.0863 0.0688
Loa Loa (eye worm) hypothetical protein 0.0058 0.0863 0.0863
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0058 0.0863 0.0612
Leishmania major methionine aminopeptidase 2, putative 0.047 1 1
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0058 0.0863 0.0863
Loa Loa (eye worm) FAD binding domain-containing protein 0.0032 0.0268 0.0268
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0058 0.0863 0.0688
Treponema pallidum methionine aminopeptidase (map) 0.0058 0.0863 0.5
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0058 0.0863 0.0612
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.047 1 1
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0058 0.0863 0.0863
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0058 0.0863 0.0688
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0058 0.0863 0.0688
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0058 0.0863 0.0612
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0058 0.0863 0.0863
Mycobacterium ulcerans methionine aminopeptidase 0.0058 0.0863 1
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0058 0.0863 0.0612
Giardia lamblia Xaa-Pro dipeptidase 0.0058 0.0863 0.0688
Loa Loa (eye worm) DNA-binding protein 0.0058 0.0863 0.0863
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0058 0.0863 0.0612
Loa Loa (eye worm) methionine aminopeptidase type I 0.0058 0.0863 0.0863
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0058 0.0863 0.5
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0058 0.0863 0.0688
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.047 1 1
Toxoplasma gondii methionine aminopeptidase 2, putative 0.047 1 1
Echinococcus multilocularis xaa Pro dipeptidase 0.0058 0.0863 0.0863
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0058 0.0863 0.0612
Echinococcus granulosus methionine aminopeptidase type I 0.0058 0.0863 0.0863
Trypanosoma brucei methionine aminopeptidase, putative 0.0058 0.0863 0.0612
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0058 0.0863 1
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0058 0.0863 0.0612
Treponema pallidum aminopeptidase P 0.0058 0.0863 0.5
Mycobacterium ulcerans aminopeptidase 0.0058 0.0863 1
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0058 0.0863 0.0863
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0058 0.0863 0.0612
Brugia malayi FAD binding domain containing protein 0.0032 0.0268 0.0268
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0058 0.0863 0.0863
Plasmodium falciparum aminopeptidase P 0.0058 0.0863 0.0612
Plasmodium vivax FACT complex subunit SPT16, putative 0.0058 0.0863 0.0688
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0058 0.0863 0.0863
Echinococcus multilocularis methionine aminopeptidase, type I 0.0058 0.0863 0.0863
Echinococcus granulosus xaa Pro dipeptidase 0.0058 0.0863 0.0863
Plasmodium vivax methionine aminopeptidase 2, putative 0.047 1 1
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0058 0.0863 0.0688
Trypanosoma cruzi aminopeptidase P, putative 0.0058 0.0863 0.0612
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0058 0.0863 0.0688
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0058 0.0863 0.5
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0058 0.0863 0.0612
Leishmania major hypothetical protein, conserved 0.0058 0.0863 0.0688
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0058 0.0863 0.0863
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0058 0.0863 0.0688
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0058 0.0863 0.0688
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0032 0.0268 0.0268
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0058 0.0863 0.0612
Echinococcus granulosus methionyl aminopeptidase 2 0.047 1 1
Echinococcus multilocularis Proliferation associated protein 2G4 0.0058 0.0863 0.0863
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0058 0.0863 0.0688
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0058 0.0863 0.0612
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.047 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0058 0.0863 0.0612
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0058 0.0863 0.0612
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0058 0.0863 0.0863
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0058 0.0863 0.0863
Brugia malayi Methionine aminopeptidase protein type I 0.0058 0.0863 0.0863
Echinococcus multilocularis methionyl aminopeptidase 2 0.047 1 1
Leishmania major transcription factor-like protein 0.0058 0.0863 0.0688
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.047 1 1
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0058 0.0863 0.0688
Brugia malayi metallopeptidase family M24 containing protein 0.0058 0.0863 0.0863
Mycobacterium ulcerans dipeptidase 0.0058 0.0863 1
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0058 0.0863 0.5
Trichomonas vaginalis sulfite reductase, putative 0.0032 0.0268 0.0081
Plasmodium falciparum methionine aminopeptidase 2 0.047 1 1
Echinococcus multilocularis xaa pro aminopeptidase 0.0058 0.0863 0.0863
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0058 0.0863 0.0688
Brugia malayi metallopeptidase family M24 containing protein 0.0058 0.0863 0.0863
Leishmania major p450 reductase, putative 0.0032 0.0268 0.0081
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0058 0.0863 0.0863
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0032 0.0268 0.0268
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0058 0.0863 0.5
Chlamydia trachomatis methionine aminopeptidase 0.0058 0.0863 1
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0058 0.0863 0.0612
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0058 0.0863 0.5
Trypanosoma brucei Metallopeptidase family M24, putative 0.0058 0.0863 0.0612
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0058 0.0863 0.0863
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0058 0.0863 0.5
Entamoeba histolytica methionine aminopeptidase, putative 0.047 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0058 0.0863 0.0612
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0058 0.0863 0.5
Echinococcus granulosus xaa Pro dipeptidase 0.0058 0.0863 0.0863
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0058 0.0863 0.0863
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.047 1 1
Echinococcus granulosus xaa pro aminopeptidase 0.0058 0.0863 0.0863
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.047 1 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0058 0.0863 0.0863
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0058 0.0863 0.0688
Mycobacterium tuberculosis Dipeptidase PepE 0.0058 0.0863 0.5
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0058 0.0863 0.0612
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0058 0.0863 0.0863
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0058 0.0863 0.0688
Chlamydia trachomatis aminopeptidase P 0.0058 0.0863 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0863 0.0863
Mycobacterium ulcerans dipeptidase PepE 0.0058 0.0863 1
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0058 0.0863 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.047 1 1
Echinococcus granulosus Proliferation associated protein 2G4 0.0058 0.0863 0.0863
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0032 0.0268 0.0268
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0058 0.0863 0.0612
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0058 0.0863 0.0612
Giardia lamblia Xaa-Pro dipeptidase 0.0058 0.0863 0.0688
Loa Loa (eye worm) hypothetical protein 0.0058 0.0863 0.0863

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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