Detailed information for compound 1463345

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 159.186 | Formula: C6H13N3O2
  • H donors: 1 H acceptors: 2 LogP: 1.74 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=[N+](/N1CCCCC1C)\[O-]
  • InChi: 1S/C6H13N3O2/c1-6-4-2-3-5-8(6)9(11)7-10/h6,10H,2-5H2,1H3/b9-7-
  • InChiKey: OZWNUIRZWJIERI-CLFYSBASSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.004 0.072 0.0364
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0325 1 1
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.003 0.0369 0.0113
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Plasmodium vivax proliferation-associated protein 2g4, putative 0.004 0.072 0.0473
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.004 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.004 0.072 0.072
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Plasmodium vivax methionine aminopeptidase 1c, putative 0.004 0.072 0.0473
Schistosoma mansoni peptidase 0.004 0.072 0.072
Leishmania major methionine aminopeptidase 2, putative 0.0325 1 1
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.004 0.072 0.072
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.004 0.072 0.0364
Treponema pallidum methionine aminopeptidase (map) 0.004 0.072 0.5
Loa Loa (eye worm) FAD binding domain-containing protein 0.003 0.0369 0.0369
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Schistosoma mansoni cytochrome P450 reductase 0.003 0.0369 0.0369
Trypanosoma cruzi Metallopeptidase family M24, putative 0.004 0.072 0.0364
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.003 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.003 0.0369 0.0369
Loa Loa (eye worm) initiation factor 2-associated protein 0.0325 1 1
Brugia malayi metallopeptidase family M24 containing protein 0.004 0.072 0.072
Echinococcus multilocularis FACT complex subunit SPT16 0.004 0.072 0.072
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0325 1 1
Giardia lamblia Methionine aminopeptidase 0.0325 1 1
Echinococcus multilocularis xaa Pro dipeptidase 0.004 0.072 0.072
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0325 1 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.004 0.072 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.003 0.0369 0.0113
Echinococcus granulosus FACT complex subunit SPT16 0.004 0.072 0.072
Plasmodium vivax peptidase, putative 0.004 0.072 0.0473
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Trypanosoma cruzi aminopeptidase P1, putative 0.004 0.072 0.0364
Brugia malayi flavodoxin family protein 0.003 0.0369 0.0369
Echinococcus multilocularis xaa Pro dipeptidase 0.004 0.072 0.072
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.004 0.072 0.5
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0325 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0325 1 1
Trypanosoma brucei methionine aminopeptidase, putative 0.004 0.072 0.0364
Mycobacterium ulcerans methionine aminopeptidase MapB 0.004 0.072 1
Echinococcus granulosus methionine aminopeptidase type I 0.004 0.072 0.072
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.004 0.072 0.0364
Treponema pallidum aminopeptidase P 0.004 0.072 0.5
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.004 0.072 0.072
Mycobacterium ulcerans aminopeptidase 0.004 0.072 1
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.004 0.072 0.072
Plasmodium falciparum aminopeptidase P 0.004 0.072 0.0364
Plasmodium vivax FACT complex subunit SPT16, putative 0.004 0.072 0.0473
Plasmodium falciparum FACT complex subunit SPT16, putative 0.004 0.072 0.0364
Brugia malayi FAD binding domain containing protein 0.003 0.0369 0.0369
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0325 1 1
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.004 0.072 0.072
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.004 0.072 0.0364
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.004 0.072 0.0364
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.004 0.072 0.072
Mycobacterium ulcerans methionine aminopeptidase 0.004 0.072 1
Loa Loa (eye worm) DNA-binding protein 0.004 0.072 0.072
Giardia lamblia Xaa-Pro dipeptidase 0.004 0.072 0.0473
Loa Loa (eye worm) methionine aminopeptidase type I 0.004 0.072 0.072
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.004 0.072 0.0364
Brugia malayi metallopeptidase family M24 containing protein 0.004 0.072 0.072
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0325 1 1
Plasmodium vivax methionine aminopeptidase 1a, putative 0.004 0.072 0.0473
Mycobacterium ulcerans dipeptidase 0.004 0.072 1
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.004 0.072 0.5
Plasmodium falciparum methionine aminopeptidase 2 0.0325 1 1
Trichomonas vaginalis sulfite reductase, putative 0.003 0.0369 0.0113
Echinococcus multilocularis xaa pro aminopeptidase 0.004 0.072 0.072
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Leishmania major p450 reductase, putative 0.003 0.0369 0.0113
Brugia malayi metallopeptidase family M24 containing protein 0.004 0.072 0.072
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.004 0.072 0.5
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.004 0.072 0.072
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.003 0.0369 0.0369
Trypanosoma cruzi Metallopeptidase family M24, putative 0.004 0.072 0.0364
Chlamydia trachomatis methionine aminopeptidase 0.004 0.072 1
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.004 0.072 0.5
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.004 0.072 0.072
Echinococcus granulosus xaa Pro dipeptidase 0.004 0.072 0.072
Plasmodium vivax methionine aminopeptidase 2, putative 0.0325 1 1
Echinococcus multilocularis methionine aminopeptidase, type I 0.004 0.072 0.072
Trypanosoma cruzi aminopeptidase P, putative 0.004 0.072 0.0364
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.004 0.072 0.0364
Leishmania major hypothetical protein, conserved 0.004 0.072 0.0473
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.004 0.072 0.072
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.004 0.072 0.5
Echinococcus multilocularis Proliferation associated protein 2G4 0.004 0.072 0.072
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Echinococcus granulosus NADPH cytochrome P450 reductase 0.003 0.0369 0.0369
Echinococcus granulosus methionyl aminopeptidase 2 0.0325 1 1
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.004 0.072 0.0364
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0325 1 1
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.004 0.072 0.072
Brugia malayi Methionine aminopeptidase protein type I 0.004 0.072 0.072
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.004 0.072 0.072
Leishmania major transcription factor-like protein 0.004 0.072 0.0473
Echinococcus multilocularis methionyl aminopeptidase 2 0.0325 1 1
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.004 0.072 0.0364
Mycobacterium tuberculosis Dipeptidase PepE 0.004 0.072 0.5
Plasmodium vivax methionine aminopeptidase 1b, putative 0.004 0.072 0.0473
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.004 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.004 0.072 0.072
Chlamydia trachomatis aminopeptidase P 0.004 0.072 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0325 1 1
Echinococcus granulosus Proliferation associated protein 2G4 0.004 0.072 0.072
Mycobacterium ulcerans dipeptidase PepE 0.004 0.072 1
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.004 0.072 1
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.003 0.0369 0.0369
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.004 0.072 0.0364
Giardia lamblia Xaa-Pro dipeptidase 0.004 0.072 0.0473
Loa Loa (eye worm) hypothetical protein 0.004 0.072 0.072
Trypanosoma brucei Metallopeptidase family M24, putative 0.004 0.072 0.0364
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.004 0.072 0.072
Entamoeba histolytica methionine aminopeptidase, putative 0.0325 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.004 0.072 0.5
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.004 0.072 0.5
Echinococcus granulosus xaa Pro dipeptidase 0.004 0.072 0.072
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.004 0.072 0.072
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0325 1 1
Echinococcus granulosus xaa pro aminopeptidase 0.004 0.072 0.072
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.004 0.072 0.072
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0325 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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