Detailed information for compound 1463345

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 159.186 | Formula: C6H13N3O2
  • H donors: 1 H acceptors: 2 LogP: 1.74 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=[N+](/N1CCCCC1C)\[O-]
  • InChi: 1S/C6H13N3O2/c1-6-4-2-3-5-8(6)9(11)7-10/h6,10H,2-5H2,1H3/b9-7-
  • InChiKey: OZWNUIRZWJIERI-CLFYSBASSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi FAD binding domain containing protein 0.003 0.0369 0.0369
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.004 0.072 0.072
Mycobacterium tuberculosis Dipeptidase PepE 0.004 0.072 0.5
Plasmodium vivax peptidase, putative 0.004 0.072 0.0473
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.004 0.072 0.5
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.004 0.072 0.0364
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.003 0.0369 0.0369
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0325 1 1
Echinococcus granulosus NADPH cytochrome P450 reductase 0.003 0.0369 0.0369
Echinococcus multilocularis FACT complex subunit SPT16 0.004 0.072 0.072
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.003 0.0369 0.0369
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0325 1 1
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.004 0.072 0.072
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Plasmodium vivax methionine aminopeptidase 2, putative 0.0325 1 1
Plasmodium vivax FACT complex subunit SPT16, putative 0.004 0.072 0.0473
Echinococcus granulosus FACT complex subunit SPT16 0.004 0.072 0.072
Chlamydia trachomatis aminopeptidase P 0.004 0.072 1
Leishmania major methionine aminopeptidase 2, putative 0.0325 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Trypanosoma brucei Metallopeptidase family M24, putative 0.004 0.072 0.0364
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.004 0.072 0.5
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0325 1 1
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.004 0.072 0.072
Mycobacterium ulcerans dipeptidase PepE 0.004 0.072 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Loa Loa (eye worm) methionine aminopeptidase type I 0.004 0.072 0.072
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.004 0.072 0.072
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.004 0.072 0.5
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.004 0.072 0.072
Plasmodium vivax proliferation-associated protein 2g4, putative 0.004 0.072 0.0473
Echinococcus multilocularis xaa pro aminopeptidase 0.004 0.072 0.072
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Trypanosoma cruzi aminopeptidase P, putative 0.004 0.072 0.0364
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0325 1 1
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.004 0.072 0.0364
Giardia lamblia Xaa-Pro dipeptidase 0.004 0.072 0.0473
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.004 0.072 0.072
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.004 0.072 0.5
Schistosoma mansoni cytochrome P450 reductase 0.003 0.0369 0.0369
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.004 0.072 1
Brugia malayi metallopeptidase family M24 containing protein 0.004 0.072 0.072
Leishmania major p450 reductase, putative 0.003 0.0369 0.0113
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.004 0.072 0.5
Schistosoma mansoni peptidase 0.004 0.072 0.072
Loa Loa (eye worm) FAD binding domain-containing protein 0.003 0.0369 0.0369
Trypanosoma cruzi aminopeptidase P1, putative 0.004 0.072 0.0364
Loa Loa (eye worm) DNA-binding protein 0.004 0.072 0.072
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.004 0.072 0.072
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.004 0.072 0.072
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.003 0.0369 0.0113
Plasmodium vivax methionine aminopeptidase 1b, putative 0.004 0.072 0.0473
Leishmania major transcription factor-like protein 0.004 0.072 0.0473
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0325 1 1
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.004 0.072 0.5
Echinococcus multilocularis Proliferation associated protein 2G4 0.004 0.072 0.072
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Giardia lamblia Methionine aminopeptidase 0.0325 1 1
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0325 1 1
Mycobacterium ulcerans dipeptidase 0.004 0.072 1
Plasmodium falciparum FACT complex subunit SPT16, putative 0.004 0.072 0.0364
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.004 0.072 0.5
Echinococcus multilocularis xaa Pro dipeptidase 0.004 0.072 0.072
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.004 0.072 0.0364
Treponema pallidum aminopeptidase P 0.004 0.072 0.5
Brugia malayi Methionine aminopeptidase protein type I 0.004 0.072 0.072
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.004 0.072 0.072
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0325 1 1
Loa Loa (eye worm) initiation factor 2-associated protein 0.0325 1 1
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0325 1 1
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.004 0.072 0.072
Brugia malayi flavodoxin family protein 0.003 0.0369 0.0369
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.003 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.004 0.072 0.072
Trypanosoma cruzi Metallopeptidase family M24, putative 0.004 0.072 0.0364
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0325 1 1
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.004 0.072 0.0364
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.004 0.072 0.072
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Treponema pallidum methionine aminopeptidase (map) 0.004 0.072 0.5
Trichomonas vaginalis sulfite reductase, putative 0.003 0.0369 0.0113
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Echinococcus granulosus Proliferation associated protein 2G4 0.004 0.072 0.072
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.004 0.072 0.0473
Echinococcus granulosus methionyl aminopeptidase 2 0.0325 1 1
Echinococcus granulosus xaa Pro dipeptidase 0.004 0.072 0.072
Mycobacterium ulcerans methionine aminopeptidase 0.004 0.072 1
Brugia malayi metallopeptidase family M24 containing protein 0.004 0.072 0.072
Entamoeba histolytica methionine aminopeptidase, putative 0.0325 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.072 0.072
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0325 1 1
Mycobacterium ulcerans methionine aminopeptidase MapB 0.004 0.072 1
Echinococcus granulosus xaa Pro dipeptidase 0.004 0.072 0.072
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.004 0.072 0.072
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.004 0.072 0.0364
Plasmodium vivax methionine aminopeptidase 1c, putative 0.004 0.072 0.0473
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.004 0.072 0.0364
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.004 0.072 0.072
Giardia lamblia Xaa-Pro dipeptidase 0.004 0.072 0.0473
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.004 0.072 0.0364
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.004 0.072 0.072
Trypanosoma brucei methionine aminopeptidase, putative 0.004 0.072 0.0364
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.004 0.072 0.0473
Plasmodium falciparum methionine aminopeptidase 2 0.0325 1 1
Chlamydia trachomatis methionine aminopeptidase 0.004 0.072 1
Loa Loa (eye worm) hypothetical protein 0.004 0.072 0.072
Trypanosoma cruzi Metallopeptidase family M24, putative 0.004 0.072 0.0364
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.003 0.0369 0.0113
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.004 0.072 0.072
Echinococcus multilocularis xaa Pro dipeptidase 0.004 0.072 0.072
Echinococcus multilocularis methionyl aminopeptidase 2 0.0325 1 1
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.004 0.072 0.5
Mycobacterium ulcerans aminopeptidase 0.004 0.072 1
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.004 0.072 0.0364
Plasmodium falciparum aminopeptidase P 0.004 0.072 0.0364
Echinococcus granulosus methionine aminopeptidase type I 0.004 0.072 0.072
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.004 0.072 0.0364
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.004 0.072 0.0364
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.004 0.072 0.0364
Leishmania major hypothetical protein, conserved 0.004 0.072 0.0473
Plasmodium vivax methionine aminopeptidase 1a, putative 0.004 0.072 0.0473
Brugia malayi metallopeptidase family M24 containing protein 0.004 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.003 0.0369 0.0369
Echinococcus granulosus xaa pro aminopeptidase 0.004 0.072 0.072
Echinococcus multilocularis methionine aminopeptidase, type I 0.004 0.072 0.072
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0325 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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