Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FXNA | 0.0133 | 0.0867 | 0.0867 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0144 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0867 | 0.0867 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0867 | 0.0867 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0867 | 0.0867 |
Brugia malayi | nicalin | 0.0133 | 0.0867 | 0.0867 |
Onchocerca volvulus | 0.0116 | 0.0694 | 0.0746 | |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0196 | 0.0196 |
Brugia malayi | leucyl aminopeptidase | 0.0133 | 0.0867 | 0.0867 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.1022 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0354 | 0.0354 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0133 | 0.0867 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0133 | 0.0867 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0133 | 0.0867 | 0.0931 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0133 | 0.0867 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0063 | 0.0144 | 0.0144 |
Echinococcus multilocularis | plexin a4 | 0.0137 | 0.0913 | 0.1519 |
Schistosoma mansoni | plexin | 0.0068 | 0.0196 | 0.0326 |
Echinococcus granulosus | roundabout 2 | 0.0099 | 0.0518 | 0.0862 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0133 | 0.0867 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0078 | 0.0308 | 0.0513 |
Echinococcus granulosus | twitchin | 0.0078 | 0.0308 | 0.0513 |
Loa Loa (eye worm) | plexin A | 0.0137 | 0.0913 | 0.0913 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0196 | 0.0326 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0063 | 0.0144 | 0.024 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0633 | 0.6007 | 0.6451 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0133 | 0.0867 | 0.1443 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0083 | 0.0354 | 0.0588 |
Brugia malayi | plexin A | 0.0137 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0144 | 0.0144 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0133 | 0.0867 | 0.1443 |
Onchocerca volvulus | 0.0133 | 0.0867 | 0.0931 | |
Echinococcus granulosus | defective proboscis extension response | 0.0063 | 0.0144 | 0.024 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.0867 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0063 | 0.0144 | 0.024 |
Echinococcus multilocularis | roundabout 2 | 0.0099 | 0.0518 | 0.0862 |
Schistosoma mansoni | vesicular amine transporter | 0.0063 | 0.0144 | 0.024 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0133 | 0.0867 | 0.1443 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0144 | 0.0144 |
Echinococcus multilocularis | Immunoglobulin | 0.0063 | 0.0144 | 0.024 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0133 | 0.0867 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0144 | 0.0144 |
Leishmania major | hypothetical protein, conserved | 0.0133 | 0.0867 | 0.5 |
Onchocerca volvulus | 0.0927 | 0.9031 | 0.9698 | |
Onchocerca volvulus | Fxna peptidase homolog | 0.0133 | 0.0867 | 0.0931 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0133 | 0.0867 | 0.1443 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0133 | 0.0867 | 0.1443 |
Schistosoma mansoni | cell adhesion molecule | 0.0083 | 0.0354 | 0.0588 |
Brugia malayi | hypothetical protein | 0.0063 | 0.0144 | 0.0144 |
Schistosoma mansoni | nephrin | 0.0078 | 0.0308 | 0.0513 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0133 | 0.0867 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0633 | 0.6007 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0133 | 0.0867 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0133 | 0.0867 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0133 | 0.0867 | 0.1443 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0133 | 0.0867 | 0.1443 |
Brugia malayi | Plexin repeat family protein | 0.0116 | 0.0694 | 0.0694 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0633 | 0.6007 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0133 | 0.0867 | 0.0931 |
Echinococcus granulosus | Immunoglobulin | 0.0063 | 0.0144 | 0.024 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0633 | 0.6007 | 1 |
Echinococcus multilocularis | neuroglian | 0.0078 | 0.0308 | 0.0513 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.6007 | 0.6007 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0955 | 0.9312 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0518 | 0.0518 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0063 | 0.0144 | 0.024 |
Schistosoma mansoni | nicalin (M28 family) | 0.0133 | 0.0867 | 0.1443 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0133 | 0.0867 | 0.1443 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0144 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0694 | 0.0694 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0867 | 0.0867 |
Brugia malayi | Peptidase family M28 containing protein | 0.0633 | 0.6007 | 0.6007 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0133 | 0.0867 | 0.5 |
Schistosoma mansoni | plexin | 0.0116 | 0.0694 | 0.1156 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0063 | 0.0144 | 0.0144 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0133 | 0.0867 | 0.5 |
Echinococcus granulosus | plexin a4 | 0.0137 | 0.0913 | 0.1519 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0133 | 0.0867 | 0.0867 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0144 | 0.0144 |
Leishmania major | glutaminyl cyclase, putative | 0.0133 | 0.0867 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0133 | 0.0867 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0063 | 0.0144 | 0.024 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0133 | 0.0867 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 163 nM | Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation counting | ChEMBL. | 21186123 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.