Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | 0.0054 | 0.0085 | 0.0053 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0085 | 0.0053 |
Loa Loa (eye worm) | AUR protein kinase | 0.0187 | 0.0477 | 0.0477 |
Trichomonas vaginalis | CAMK family protein kinase | 0.3427 | 1 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0187 | 0.0477 | 0.0446 |
Echinococcus multilocularis | aurora kinase A | 0.0187 | 0.0477 | 0.0446 |
Schistosoma mansoni | protein kinase | 0.0187 | 0.0477 | 0.0446 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0036 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0075 | 0.0075 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3427 | 1 | 1 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.1164 | 0.3348 | 0.3327 |
Giardia lamblia | Kinase, PLK | 0.3427 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0036 | 0.0032 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0054 | 0.0085 | 0.0053 |
Loa Loa (eye worm) | AUR protein kinase | 0.0187 | 0.0477 | 0.0477 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0036 | 0.0032 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0187 | 0.0477 | 0.0446 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0036 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.3427 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0187 | 0.0477 | 0.0446 |
Schistosoma mansoni | kinase | 0.3136 | 0.9146 | 0.9143 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0085 | 0.0085 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0054 | 0.0085 | 1 |
Echinococcus granulosus | Immunoglobulin | 0.0051 | 0.0075 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0075 | 0.0075 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0075 | 0.0043 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0343 | 0.0935 | 0.0935 |
Loa Loa (eye worm) | cytochrome P450 | 0.0036 | 0.0032 | 0.0032 |
Trichomonas vaginalis | CAMK family protein kinase | 0.3427 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0187 | 0.0477 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0107 | 0.0107 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.3427 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.3427 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.3427 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.3427 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0036 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0036 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0093 | 0.0093 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0036 | 0.0032 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0051 | 0.0075 | 0.0043 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0036 | 0.0032 | 0.5 |
Trypanosoma brucei | aurora B kinase | 0.0187 | 0.0477 | 0.0446 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0036 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0036 | 0.0032 | 0.5 |
Echinococcus granulosus | twitchin | 0.007 | 0.0131 | 0.0099 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0036 | 0.0032 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0057 | 0.0093 | 0.0061 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0187 | 0.0477 | 0.0446 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.3427 | 1 | 1 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.1164 | 0.3348 | 0.3327 |
Echinococcus granulosus | neuroglian | 0.0055 | 0.0089 | 0.0057 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.3427 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0075 | 0.0075 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0036 | 0.0032 | 0.5 |
Leishmania major | protein kinase, putative | 0.0187 | 0.0477 | 0.0446 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0036 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0036 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.3427 | 1 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0187 | 0.0477 | 0.0446 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0051 | 0.0075 | 0.0043 |
Echinococcus multilocularis | roundabout 2 | 0.0062 | 0.0107 | 0.0075 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.3427 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1455 | 0.4202 | 0.3912 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0036 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0036 | 0.0032 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0051 | 0.0075 | 0.0043 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0036 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0075 | 0.0075 |
Leishmania major | cytochrome p450-like protein | 0.0054 | 0.0085 | 0.0053 |
Echinococcus granulosus | roundabout 2 | 0.0062 | 0.0107 | 0.0075 |
Loa Loa (eye worm) | AUR protein kinase | 0.0187 | 0.0477 | 0.0477 |
Trichomonas vaginalis | CAMK family protein kinase | 0.3427 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0054 | 0.0085 | 0.0085 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0051 | 0.0075 | 0.0043 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0054 | 0.0085 | 0.0053 |
Schistosoma mansoni | cell adhesion molecule | 0.0057 | 0.0093 | 0.0061 |
Echinococcus multilocularis | neuroglian | 0.0055 | 0.0089 | 0.0057 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0036 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0075 | 0.0075 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.3427 | 1 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0051 | 0.0075 | 0.0043 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0187 | 0.0477 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0036 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0036 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0107 | 0.0107 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0187 | 0.0477 | 0.5 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0051 | 0.0075 | 0.0043 |
Toxoplasma gondii | aurora kinase | 0.0187 | 0.0477 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0036 | 0.0032 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0114 | 0.0261 | 0.0261 |
Schistosoma mansoni | nephrin | 0.0055 | 0.0089 | 0.0057 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0187 | 0.0477 | 0.0446 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0051 | 0.0075 | 0.0043 |
Trichomonas vaginalis | CAMK family protein kinase | 0.3427 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1455 | 0.4202 | 0.3912 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0085 | 0.0053 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.3427 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.3427 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0114 | 0.0261 | 0.023 |
Echinococcus granulosus | defective proboscis extension response | 0.0051 | 0.0075 | 0.0043 |
Schistosoma mansoni | vesicular amine transporter | 0.0051 | 0.0075 | 0.0043 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0036 | 0.0032 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0291 | 0.0782 | 0.003 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0343 | 0.0935 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0075 | 0.0075 |
Brugia malayi | serine/threonine kinase 12 | 0.0187 | 0.0477 | 0.0446 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.