Detailed information for compound 1469316

Basic information

Technical information
  • TDR Targets ID: 1469316
  • Name: 1-[2-(hydroxymethyl)piperidin-1-yl]-3-[(2-met hoxyphenyl)methoxy]propan-2-ol
  • MW: 309.401 | Formula: C17H27NO4
  • H donors: 2 H acceptors: 2 LogP: 1.19 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1CCCCN1CC(COCc1ccccc1OC)O
  • InChi: 1S/C17H27NO4/c1-21-17-8-3-2-6-14(17)12-22-13-16(20)10-18-9-5-4-7-15(18)11-19/h2-3,6,8,15-16,19-20H,4-5,7,9-13H2,1H3
  • InChiKey: PFDOMIHOTPTBDC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(hydroxymethyl)-1-piperidyl]-3-[(2-methoxyphenyl)methoxy]propan-2-ol
  • 1-[2-(hydroxymethyl)-1-piperidinyl]-3-[(2-methoxyphenyl)methoxy]propan-2-ol
  • 1-(2-methoxybenzyl)oxy-3-(2-methylol-1-piperidyl)propan-2-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.0104 0.006
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0037 0.0044 0.5
Trichomonas vaginalis CAMK family protein kinase 0.309 1 1
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.1049 0.3345 0.3316
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0037 0.0044 0.5
Schistosoma mansoni serine/threonine protein kinase 0.309 1 1
Echinococcus granulosus twitchin 0.0068 0.0148 0.0104
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0068 0.0146 0.5
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0037 0.0044 0.5
Brugia malayi serine/threonine kinase 12 0.0068 0.0146 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.309 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0104 0.0104
Leishmania major cytochrome p450-like protein 0.0055 0.0104 0.006
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0068 0.0146 0.0102
Echinococcus granulosus serine:threonine protein kinase PLK1 0.309 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0093 0.0093
Brugia malayi Cytochrome P450 family protein 0.0116 0.0303 0.026
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0037 0.0044 0.5
Echinococcus multilocularis aurora kinase A 0.0068 0.0146 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0037 0.0044 0.5
Trypanosoma brucei polo-like protein kinase 0.309 1 1
Echinococcus multilocularis Immunoglobulin 0.0052 0.0093 0.0049
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0037 0.0044 0.5
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0037 0.0044 0.5
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0058 0.0113 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.309 1 1
Giardia lamblia Kinase, PLK 0.309 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.309 1 1
Loa Loa (eye worm) cytochrome P450 0.0037 0.0044 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0037 0.0044 0.5
Toxoplasma gondii aurora kinase 0.0068 0.0146 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0037 0.0044 0.5
Brugia malayi serine/threonine protein kinase 6 0.0068 0.0146 0.0102
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.309 1 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0037 0.0044 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.035 0.1065 0.1065
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0104 0.0104
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.0303 0.0303
Schistosoma mansoni kinase 0.2828 0.9146 0.9142
Loa Loa (eye worm) hypothetical protein 0.0052 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0052 0.0093 0.0093
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0093 0.0049
Brugia malayi Cytochrome P450 family protein 0.0055 0.0104 0.006
Echinococcus granulosus aurora kinase A 0.0068 0.0146 0.0102
Echinococcus multilocularis roundabout 2 0.0063 0.0129 0.0085
Brugia malayi hypothetical protein 0.0052 0.0093 0.0049
Trypanosoma brucei cytochrome P450, putative 0.0055 0.0104 0.006
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0037 0.0044 0.5
Trichomonas vaginalis CAMK family protein kinase 0.309 1 1
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0146 0.0146
Echinococcus granulosus roundabout 2 0.0063 0.0129 0.0085
Loa Loa (eye worm) CYP4Cod1 0.0055 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0052 0.0093 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0037 0.0044 0.5
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.1049 0.3345 0.3316
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0037 0.0044 0.5
Schistosoma mansoni cell adhesion molecule 0.0058 0.0113 0.0069
Schistosoma mansoni protein kinase 0.0068 0.0146 0.0102
Trypanosoma cruzi polo-like protein kinase, putative 0.309 1 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.309 1 1
Echinococcus multilocularis neuroglian 0.0057 0.0109 0.0065
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0037 0.0044 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0037 0.0044 0.5
Trichomonas vaginalis CAMK family protein kinase 0.1311 0.42 0.4114
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0052 0.0093 0.0049
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0037 0.0044 0.5
Trichomonas vaginalis CAMK family protein kinase 0.309 1 1
Brugia malayi serine/threonine-protein kinase 6 0.0068 0.0146 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0037 0.0044 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0129 0.0129
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0052 0.0093 0.0049
Trypanosoma cruzi polo-like protein kinase, putative 0.309 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0146 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.1311 0.42 0.4114
Brugia malayi Fibronectin type III domain containing protein 0.0052 0.0093 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.309 1 1
Echinococcus granulosus neuroglian 0.0057 0.0109 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0037 0.0044 0.5
Leishmania major protein kinase, putative 0.0068 0.0146 0.0102
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0068 0.0146 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0037 0.0044 0.5
Trypanosoma brucei aurora B kinase 0.0068 0.0146 0.0102
Echinococcus multilocularis Immunoglobulin 0.0052 0.0093 0.0049
Brugia malayi Immunoglobulin I-set domain containing protein 0.035 0.1065 0.1025
Onchocerca volvulus Tyrosine kinase homolog 0.0297 0.0892 0.0034
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.309 1 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.309 1 1
Brugia malayi Cytochrome P450 family protein 0.0055 0.0104 0.006
Echinococcus granulosus defective proboscis extension response 0.0052 0.0093 0.0049
Schistosoma mansoni vesicular amine transporter 0.0052 0.0093 0.0049
Trypanosoma cruzi aurora B kinase, putative 0.0068 0.0146 0.0102
Schistosoma mansoni nephrin 0.0057 0.0109 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.309 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0093 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0037 0.0044 0.5
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0052 0.0093 0.0049
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0055 0.0104 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0113 0.0113
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.0104 0.006
Echinococcus granulosus Immunoglobulin 0.0052 0.0093 0.0049
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0146 0.0146
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0146 0.0146
Plasmodium falciparum serine/threonine protein kinase, putative 0.0068 0.0146 0.5
Mycobacterium leprae putative cytochrome p450 0.0037 0.0044 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0063 0.0129 0.0129
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0037 0.0044 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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