Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0167 | 0.253 | 0.372 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.253 | 0.372 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.014 | 0.0261 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0704 | 0.1456 |
Trypanosoma cruzi | Vps23 core domain containing protein, putative | 0.0022 | 0.0227 | 0.7496 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0163 | 0.0016 |
Entamoeba histolytica | tumor susceptibility gene 101 protein, putative | 0.0047 | 0.0619 | 0.4928 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0163 | 0.0309 |
Loa Loa (eye worm) | glutaminase 2 | 0.0306 | 0.4734 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0198 | 0.0035 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0259 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0303 | 0.4695 | 0.6902 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0211 | 0.161 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0283 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.033 | 0.017 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0436 | 0.6802 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0017 | 0.0025 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.033 | 0.0665 |
Brugia malayi | hypothetical protein | 0.0069 | 0.0967 | 0.2015 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0393 | 0.0578 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0303 | 0.4695 | 0.9918 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0637 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0443 | 0.0903 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.014 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0671 | 0.1386 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0259 | 0.7182 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0198 | 0.0292 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.0393 | 0.0578 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0637 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0198 | 0.029 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0259 | 0.0097 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0028 | 0.0023 |
Loa Loa (eye worm) | glutaminase | 0.0306 | 0.4734 | 1 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0017 | 0.0025 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0198 | 0.029 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0704 | 0.1456 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0198 | 0.029 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.033 | 0.0486 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0283 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0259 | 0.0512 |
Mycobacterium ulcerans | glutaminase | 0.0306 | 0.4734 | 0.4646 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.014 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0283 | 0.0563 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0259 | 0.0097 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0198 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0198 | 0.1204 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0259 | 0.0097 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0211 | 0.0412 |
Schistosoma mansoni | smad | 0.0009 | 0.0017 | 0.0025 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0259 | 0.1743 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.014 | 0.0261 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.0365 | 0.0739 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0245 | 0.8303 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.014 | 0.0206 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.1162 | 0.2428 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0259 | 0.1743 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0283 | 0.0122 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0065 | 0.091 | 0.1338 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0198 | 0.6159 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0211 | 0.0227 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0393 | 0.0578 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.006 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0443 | 0.0903 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0259 | 0.0113 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0259 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0163 | 0.0309 |
Schistosoma mansoni | tsg101-related | 0.0057 | 0.0785 | 0.1154 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.033 | 0.0486 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0259 | 0.1743 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.033 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0704 | 0.1456 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0259 | 0.0512 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0283 | 0.0122 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0283 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0259 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0436 | 0.6802 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0704 | 0.1456 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0637 | 1 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.0671 | 0.0986 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0163 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0163 | 0.0309 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0211 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0083 | 0.1194 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0259 | 0.0512 |
Echinococcus granulosus | dnaJ subfamily B | 0.0436 | 0.6802 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0198 | 0.0035 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0017 | 0.0025 |
Echinococcus granulosus | smad | 0.0009 | 0.0017 | 0.0025 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0283 | 0.8226 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0245 | 0.0393 |
Brugia malayi | glutaminase DH11.1 | 0.0306 | 0.4734 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0967 | 0.2015 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0637 | 1 | 1 |
Schistosoma mansoni | tsg101-related | 0.0057 | 0.0785 | 0.1154 |
Echinococcus granulosus | tumor protein p63 | 0.0341 | 0.5286 | 0.7771 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0083 | 0.1194 | 1 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0211 | 0.0311 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.014 | 0.0206 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0211 | 0.6777 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0211 | 0.0321 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0198 | 0.0383 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0211 | 0.0049 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.19 | 0.3992 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0365 | 0.0537 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0283 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0283 | 0.0122 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.0393 | 0.0578 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0211 | 0.5575 |
Schistosoma mansoni | glutaminase | 0.0306 | 0.4734 | 0.6959 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.014 | 0.0206 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0017 | 0.0025 |
Brugia malayi | hypothetical protein | 0.0016 | 0.014 | 0.026 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0017 | 0.0025 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.08 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0017 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.033 | 0.0665 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0637 | 1 | 1 |
Schistosoma mansoni | ran | 0.0021 | 0.0211 | 0.0311 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.006 | 0.0088 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.033 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0163 | 0.0309 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.003 | 0.0027 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.014 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0259 | 0.0512 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0259 | 0.0097 |
Trichomonas vaginalis | hypothetical protein | 0.0033 | 0.0409 | 0.0745 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.19 | 0.3992 |
Echinococcus multilocularis | tumor protein p63 | 0.0341 | 0.5286 | 0.7771 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.014 | 0.0261 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0259 | 0.0113 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0283 | 0.1411 |
Echinococcus multilocularis | geminin | 0.0167 | 0.253 | 0.372 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.253 | 0.372 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.014 | 0.0206 |
Schistosoma mansoni | tsg101-related | 0.0047 | 0.0619 | 0.091 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0443 | 0.0651 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0637 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0259 | 0.0512 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.033 | 0.2204 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.003 | 0.0044 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0198 | 0.0383 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0017 | 0.0025 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0198 | 0.0292 |
Trichomonas vaginalis | glutaminase, putative | 0.0306 | 0.4734 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.014 | 0.0206 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0259 | 0.7182 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0259 | 0.7182 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0245 | 0.1623 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0083 | 0.1194 | 1 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0017 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.014 | 0.0206 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0198 | 0.6159 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0017 | 0.0025 |
Echinococcus granulosus | snurportin 1 | 0.0303 | 0.4695 | 0.6902 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0211 | 0.6777 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0083 | 0.1194 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.014 | 0.0206 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.003 | 0.0044 |
Echinococcus multilocularis | tumor susceptibility gene 101 protein | 0.0069 | 0.0967 | 0.1422 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0211 | 0.0412 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0259 | 0.5 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0245 | 0.0393 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0198 | 0.0035 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0211 | 0.0049 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0211 | 0.1325 |
Onchocerca volvulus | 0.005 | 0.0671 | 1 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0259 | 0.0097 |
Echinococcus multilocularis | smad | 0.0009 | 0.0017 | 0.0025 |
Echinococcus granulosus | tumor susceptibility gene 101 protein | 0.0069 | 0.0967 | 0.1422 |
Echinococcus multilocularis | snurportin 1 | 0.0303 | 0.4695 | 0.6902 |
Trypanosoma brucei | Vps23 core domain containing protein, putative | 0.0022 | 0.0227 | 0.6166 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0637 | 1 | 1 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0211 | 0.0311 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.19 | 0.3992 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0017 | 0.0025 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0259 | 0.0097 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0017 | 0.0025 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.033 | 0.017 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0259 | 0.0512 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0083 | 0.1194 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.006 | 0.0088 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0245 | 0.5583 |
Leishmania major | hypothetical protein, conserved | 0.0022 | 0.0227 | 0.3482 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.014 | 0.0206 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0198 | 0.029 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0245 | 0.0393 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.0365 | 0.0739 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.033 | 1 |
Onchocerca volvulus | 0.0031 | 0.0365 | 0.259 | |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0198 | 0.5066 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0198 | 0.0051 |
Schistosoma mansoni | ran | 0.0021 | 0.0211 | 0.0311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.