Detailed information for compound 1469504

Basic information

Technical information
  • TDR Targets ID: 1469504
  • Name: 2-(3-diethylaminopropylamino)-N-(5-methyl-1,2 -oxazol-3-yl)acetamide
  • MW: 268.355 | Formula: C13H24N4O2
  • H donors: 2 H acceptors: 2 LogP: 1.01 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCNCC(=O)Nc1noc(c1)C)CC
  • InChi: 1S/C13H24N4O2/c1-4-17(5-2)8-6-7-14-10-13(18)15-12-9-11(3)19-16-12/h9,14H,4-8,10H2,1-3H3,(H,15,16,18)
  • InChiKey: REYQXKJNEBTFNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3-diethylaminopropylamino)-N-(5-methylisoxazol-3-yl)acetamide
  • 2-(3-diethylaminopropylamino)-N-(5-methyl-3-isoxazolyl)acetamide
  • 2-(3-diethylaminopropylamino)-N-(5-methyl-1,2-oxazol-3-yl)ethanamide
  • 2-(3-Diethylamino-propylamino)-N-(5-methyl-isoxazol-3-yl)-acetamide
  • ASN 08270369

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0052 0.0129 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.1088 0.4097 0.3989
Trichomonas vaginalis CAMK family protein kinase 0.2629 1 1
Schistosoma mansoni nephrin 0.0057 0.0148 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0037 0.0072 0.5
Brugia malayi serine/threonine-protein kinase 6 0.0065 0.018 0.0109
Loa Loa (eye worm) AUR protein kinase 0.0065 0.018 0.018
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0037 0.0072 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0129 0.0129
Leishmania major protein kinase, putative 0.0065 0.018 0.0109
Onchocerca volvulus Tyrosine kinase homolog 0.0298 0.1073 0.0041
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0352 0.1277 0.1277
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0055 0.0142 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.2629 1 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.2629 1 1
Brugia malayi Fibronectin type III domain containing protein 0.0052 0.0129 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0129 0.0057
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0065 0.018 0.5
Echinococcus multilocularis neuroglian 0.0057 0.0148 0.0077
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.2629 1 1
Echinococcus multilocularis Immunoglobulin 0.0052 0.0129 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0037 0.0072 0.5
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0052 0.0129 0.0057
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.0142 0.0071
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0058 0.0153 0.0082
Leishmania major cytochrome p450-like protein 0.0055 0.0142 0.0071
Loa Loa (eye worm) AUR protein kinase 0.0065 0.018 0.018
Schistosoma mansoni vesicular amine transporter 0.0052 0.0129 0.0057
Echinococcus granulosus aurora kinase A 0.0065 0.018 0.0109
Loa Loa (eye worm) hypothetical protein 0.0052 0.0129 0.0129
Mycobacterium leprae putative cytochrome p450 0.0037 0.0072 0.5
Echinococcus granulosus twitchin 0.0067 0.0187 0.0117
Loa Loa (eye worm) hypothetical protein 0.0063 0.0172 0.0172
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0022 0.0013 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0037 0.0072 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0142 0.0142
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0037 0.0072 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0129 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.2629 1 1
Trypanosoma brucei aurora B kinase 0.0065 0.018 0.0109
Echinococcus granulosus roundabout 2 0.0063 0.0172 0.0101
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.0142 0.0071
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0052 0.0129 0.0057
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0037 0.0072 0.5
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.1025 0.3854 0.381
Trypanosoma cruzi polo-like protein kinase, putative 0.2629 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0037 0.0072 0.5
Plasmodium falciparum serine/threonine protein kinase, putative 0.0065 0.018 0.5
Onchocerca volvulus Serine\/threonine kinase homolog 0.2629 1 1
Echinococcus granulosus neuroglian 0.0057 0.0148 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0037 0.0072 0.5
Trichomonas vaginalis CAMK family protein kinase 0.1088 0.4097 0.3989
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0037 0.0072 0.5
Echinococcus granulosus Immunoglobulin 0.0052 0.0129 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.2629 1 1
Loa Loa (eye worm) cytochrome P450 0.0037 0.0072 0.0072
Trypanosoma cruzi aurora B kinase, putative 0.0065 0.018 0.0109
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0037 0.0072 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0052 0.0129 0.0129
Trypanosoma cruzi polo-like protein kinase, putative 0.2629 1 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0065 0.018 0.0109
Mycobacterium leprae Conserved hypothetical protein 0.0037 0.0072 0.5
Trichomonas vaginalis CAMK family protein kinase 0.2629 1 1
Echinococcus multilocularis Immunoglobulin 0.0052 0.0129 0.0057
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0037 0.0072 0.5
Schistosoma mansoni cell adhesion molecule 0.0058 0.0153 0.0082
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0037 0.0072 0.5
Trichomonas vaginalis CAMK family protein kinase 0.2629 1 1
Giardia lamblia Kinase, PLK 0.2629 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.2629 1 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0037 0.0072 0.5
Toxoplasma gondii aurora kinase 0.0065 0.018 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0037 0.0072 0.5
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0037 0.0072 0.5
Brugia malayi serine/threonine kinase 12 0.0065 0.018 0.0109
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0037 0.0072 0.5
Trichomonas vaginalis CAMK family protein kinase 0.2629 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0352 0.1277 0.1214
Trypanosoma brucei cytochrome P450, putative 0.0055 0.0142 0.0071
Brugia malayi Cytochrome P450 family protein 0.0117 0.0377 0.0308
Schistosoma mansoni kinase 0.2566 0.9757 0.9756
Brugia malayi hypothetical protein 0.0052 0.0129 0.0057
Loa Loa (eye worm) hypothetical protein 0.0052 0.0129 0.0129
Echinococcus granulosus defective proboscis extension response 0.0052 0.0129 0.0057
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0142 0.0142
Loa Loa (eye worm) AUR protein kinase 0.0065 0.018 0.018
Echinococcus multilocularis roundabout 2 0.0063 0.0172 0.0101
Brugia malayi Cytochrome P450 family protein 0.0055 0.0142 0.0071
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0037 0.0072 0.5
Trichomonas vaginalis CAMK family protein kinase 0.2629 1 1
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.1025 0.3854 0.381
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0037 0.0072 0.5
Schistosoma mansoni serine/threonine protein kinase 0.2629 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.018 0.0109
Schistosoma mansoni protein kinase 0.0065 0.018 0.0109
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0037 0.0072 0.5
Trypanosoma brucei polo-like protein kinase 0.2629 1 1
Brugia malayi serine/threonine protein kinase 6 0.0065 0.018 0.0109
Loa Loa (eye worm) CYP4Cod1 0.0055 0.0142 0.0142
Brugia malayi Cytochrome P450 family protein 0.0055 0.0142 0.0071
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0065 0.018 0.0109
Loa Loa (eye worm) hypothetical protein 0.0052 0.0129 0.0129
Echinococcus granulosus serine:threonine protein kinase PLK1 0.2629 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0117 0.0377 0.0377
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0037 0.0072 0.5
Echinococcus multilocularis aurora kinase A 0.0065 0.018 0.0109

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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