Detailed information for compound 1470554

Basic information

Technical information
  • TDR Targets ID: 1470554
  • Name: AN-465/43369525
  • MW: 291.773 | Formula: C16H18ClNO2
  • H donors: 1 H acceptors: 0 LogP: 3.09 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1ccc(o1)CNCC1CCCO1
  • InChi: 1S/C16H18ClNO2/c17-13-5-3-12(4-6-13)16-8-7-15(20-16)11-18-10-14-2-1-9-19-14/h3-8,14,18H,1-2,9-11H2
  • InChiKey: LGJAXSGTPKDJHN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-{[5-(4-chlorophenyl)-2-furyl]methyl}-N-(tetrahydro-2-furanylmethyl)amine
  • STK283820

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.4121 1 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.004 0 0.5
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.07 0.1617 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.07 0.1617 0.1617
Plasmodium vivax amine transporter, putative 0.07 0.1617 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.07 0.1617 0.1617
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Trypanosoma brucei C-8 sterol isomerase, putative 0.1466 0.3496 0.5
Onchocerca volvulus 0.07 0.1617 0.1617
Loa Loa (eye worm) hypothetical protein 0.07 0.1617 0.1617
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.07 0.1617 0.1617
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.07 0.1617 0.1617
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.07 0.1617 0.1617
Loa Loa (eye worm) hypothetical protein 0.075 0.1739 0.1739
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.07 0.1617 0.1617
Plasmodium falciparum amino acid transporter, putative 0.07 0.1617 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.07 0.1617 0.1617
Loa Loa (eye worm) norepinephrine transporter 0.4121 1 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.07 0.1617 0.1617
Entamoeba histolytica kinesin, putative 0.0198 0.0389 1
Schistosoma mansoni hypothetical protein 0.0043 0.0009 0.0009
Echinococcus granulosus uncharacterized sodium dependent transporter 0.07 0.1617 0.1617
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0304 0.0648 0.0648
Echinococcus granulosus geminin 0.0171 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.07 0.1617 0.1617
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.07 0.1617 0.1617
Loa Loa (eye worm) hypothetical protein 0.0276 0.0579 0.0579
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.07 0.1617 0.1617
Trichomonas vaginalis conserved hypothetical protein 0.004 0 0.5
Brugia malayi MH2 domain containing protein 0.012 0.0197 0.0197
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0009 0.0009
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.4121 1 1
Plasmodium vivax hypothetical protein, conserved 0.07 0.1617 1
Loa Loa (eye worm) serotonin transporter b 0.4121 1 1
Loa Loa (eye worm) hypothetical protein 0.4121 1 1
Loa Loa (eye worm) hypothetical protein 0.1466 0.3496 0.3496
Schistosoma mansoni sodium/chloride dependent transporter 0.4121 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0197 0.0197
Schistosoma mansoni hypothetical protein 0.0041 0.0004 0.0004
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Plasmodium falciparum transporter, putative 0.07 0.1617 1
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0197 0.0197
Brugia malayi Serine carboxypeptidase S28 family protein 0.0182 0.0348 0.0348
Echinococcus multilocularis sodium and chloride dependent glycine 0.07 0.1617 0.1617
Loa Loa (eye worm) hypothetical protein 0.07 0.1617 0.1617
Echinococcus multilocularis serotonin transporter 0.4121 1 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.07 0.1617 0.1617
Loa Loa (eye worm) hypothetical protein 0.07 0.1617 0.1617
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0182 0.0348 0.0348
Onchocerca volvulus 0.07 0.1617 0.1617
Treponema pallidum sodium- and chloride- dependent transporter 0.4121 1 0.5
Brugia malayi Kinesin motor domain containing protein 0.0198 0.0389 0.0389
Echinococcus granulosus uncharacterized sodium dependent transporter 0.07 0.1617 0.1617
Brugia malayi hypothetical protein 0.07 0.1617 0.1617
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.07 0.1617 0.1617
Brugia malayi NNMT/PNMT/TEMT family protein 0.0276 0.0579 0.0579
Schistosoma mansoni hypothetical protein 0.1329 0.3159 0.3159
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0182 0.0348 0.0348
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1466 0.3496 0.3496
Loa Loa (eye worm) solute carrier family 6 member 4 0.4121 1 1
Echinococcus granulosus sodium and chloride dependent glycine 0.07 0.1617 0.1617
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.004 0 0.5
Echinococcus multilocularis geminin 0.0171 0.0321 0.0321
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.07 0.1617 0.1617
Schistosoma mansoni sodium-dependent amino acid transporter 0.07 0.1617 0.1617
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0004 0.0004
Toxoplasma gondii kinesin motor domain-containing protein 0.0198 0.0389 0.2406
Entamoeba histolytica hypothetical protein 0.0043 0.0009 0.0237
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.07 0.1617 0.1617
Schistosoma mansoni hypothetical protein 0.0171 0.0321 0.0321
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.004 0 0.5
Echinococcus multilocularis kinesin family 1 0.1528 0.3646 0.3646
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.006 0.005 0.005
Onchocerca volvulus 0.4121 1 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Brugia malayi hypothetical protein 0.0043 0.0009 0.0009
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.07 0.1617 0.5
Loa Loa (eye worm) hypothetical protein 0.0276 0.0579 0.0579
Loa Loa (eye worm) kinesin-like protein KLP2 0.0198 0.0389 0.0389
Toxoplasma gondii hypothetical protein 0.07 0.1617 1
Entamoeba histolytica hypothetical protein 0.0043 0.0009 0.0237
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.07 0.1617 0.1617
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0009 0.0009
Brugia malayi Sodium:neurotransmitter symporter family protein 0.07 0.1617 0.1617
Brugia malayi hypothetical protein 0.0304 0.0648 0.0648
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0203 0.0203
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Echinococcus granulosus sodium and chloride dependent glycine 0.07 0.1617 0.1617
Schistosoma mansoni hypothetical protein 0.0171 0.0321 0.0321
Echinococcus granulosus kinesin family 1 0.1528 0.3646 0.3646
Entamoeba histolytica hypothetical protein 0.0043 0.0009 0.0237
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.07 0.1617 0.1617
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.07 0.1617 1
Echinococcus granulosus serotonin transporter 0.4121 1 1
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0182 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0182 0.0348 0.0348
Giardia lamblia Kinesin-5 0.0198 0.0389 1
Echinococcus multilocularis expressed protein 0.0387 0.0852 0.0852
Brugia malayi Sodium:neurotransmitter symporter family protein 0.07 0.1617 0.1617
Onchocerca volvulus 0.07 0.1617 0.1617
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.005 0.005
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1466 0.3496 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.0009 0.0237
Toxoplasma gondii hypothetical protein 0.07 0.1617 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.07 0.1617 0.1617
Loa Loa (eye worm) hypothetical protein 0.0182 0.0348 0.0348
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.005 0.005
Onchocerca volvulus 0.0304 0.0648 0.0648
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0 0.5
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.07 0.1617 0.1617
Loa Loa (eye worm) hypothetical protein 0.07 0.1617 0.1617
Echinococcus granulosus expressed protein 0.0387 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0182 0.0348 0.0348
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0276 0.0579 0.0579
Schistosoma mansoni lipoxygenase 0.0086 0.0112 0.0112
Schistosoma mansoni sodium/chloride dependent transporter 0.07 0.1617 0.1617
Loa Loa (eye worm) hypothetical protein 0.4121 1 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0203 0.0203
Schistosoma mansoni lipoxygenase 0.0122 0.0203 0.0203
Leishmania major C-8 sterol isomerase-like protein 0.1466 0.3496 0.5
Schistosoma mansoni sodium/chloride dependent transporter 0.07 0.1617 0.1617
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.07 0.1617 0.1617
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.07 0.1617 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.005 0.005
Schistosoma mansoni kinesin eg-5 0.0198 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.07 0.1617 0.1617

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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