Detailed information for compound 1471326

Basic information

Technical information
  • TDR Targets ID: 1471326
  • Name: 2-(4-methoxyphenyl)-N-(oxolan-2-ylmethyl)etha namine
  • MW: 235.322 | Formula: C14H21NO2
  • H donors: 1 H acceptors: 0 LogP: 2.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CCNCC1CCCO1
  • InChi: 1S/C14H21NO2/c1-16-13-6-4-12(5-7-13)8-9-15-11-14-3-2-10-17-14/h4-7,14-15H,2-3,8-11H2,1H3
  • InChiKey: WDFUTBBPRRWMBZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-methoxyphenyl)-N-(tetrahydrofuran-2-ylmethyl)ethanamine
  • 2-(4-methoxyphenyl)-N-(2-tetrahydrofuranylmethyl)ethanamine
  • 2-(4-methoxyphenyl)ethyl-(tetrahydrofurfuryl)amine
  • IFLab1_006099
  • AN-329/15537500
  • STK125071
  • BAS 06977832

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi SRC-1 0.0017 0.078 0.078
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.078 0.078
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.078 0.078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0688 0.0688
Schistosoma mansoni tyrosine kinase 0.0017 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0587 0.0587
Schistosoma mansoni tyrosine kinase 0.001 0.011 0.011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0688 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0688 0.0688
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0688 0.0688
Schistosoma mansoni nicalin (M28 family) 0.0019 0.0943 0.0943
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.078 0.078
Mycobacterium tuberculosis Conserved protein 0.0019 0.0943 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0688 0.0688
Loa Loa (eye worm) leucyl aminopeptidase 0.0019 0.0943 0.0943
Loa Loa (eye worm) SRC-1 0.0017 0.078 0.078
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0019 0.0943 0.0943
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0017 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.0116 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0587 0.0587
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0019 0.0943 0.0943
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.078 0.078
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.078 0.078
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0015 0.0587 0.0587
Toxoplasma gondii peptidase, M28 family protein 0.0019 0.0943 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0017 0.078 0.078
Echinococcus granulosus tyrosine protein kinase ABL1 0.001 0.011 0.011
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.0016 0.0688 0.0688
Loa Loa (eye worm) TK protein kinase 0.001 0.011 0.011
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.011 0.011
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0688 0.0688
Schistosoma mansoni tyrosine kinase 0.0017 0.078 0.078
Trypanosoma cruzi glutaminyl cyclase, putative 0.0019 0.0943 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0688 0.0688
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.001 0.011 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0688 0.0688
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0688 0.0688
Onchocerca volvulus Fxna peptidase homolog 0.0019 0.0943 0.0843
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0688 0.0688
Brugia malayi nuclear hormone receptor 0.0016 0.0688 0.0688
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0688 0.0688
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0688 0.0688
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.078 0.078
Brugia malayi SH2 domain containing protein 0.001 0.011 0.011
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0688 0.0688
Echinococcus granulosus tyrosine protein kinase Blk 0.001 0.011 0.011
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0019 0.0943 0.0943
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0688 0.0688
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0688 0.0688
Loa Loa (eye worm) hypothetical protein 0.0019 0.0943 0.0943
Brugia malayi ecdysteroid receptor 0.0016 0.0688 0.0688
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0587 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0688 0.0688
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0116 1 1
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0019 0.0943 0.0943
Brugia malayi Protein kinase domain containing protein 0.001 0.011 0.011
Onchocerca volvulus Glutaminyl cyclase homolog 0.0116 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0017 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.0019 0.0943 0.0943
Leishmania major hypothetical protein, conserved 0.0019 0.0943 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0688 0.0688
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0116 1 1
Schistosoma mansoni tyrosine kinase 0.0017 0.078 0.078
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.011 0.011
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0017 0.078 0.078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0688 0.0688
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0019 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.001 0.011 0.011
Brugia malayi Protein kinase domain containing protein 0.001 0.011 0.011
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0017 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.0016 0.0688 0.0688
Onchocerca volvulus 0.0019 0.0943 0.0843
Echinococcus granulosus c src tyrosine kinase 0.0017 0.078 0.078
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0116 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0688 0.0688
Loa Loa (eye worm) hypothetical protein 0.0019 0.0943 0.0943
Brugia malayi Protein kinase domain containing protein 0.001 0.011 0.011
Schistosoma mansoni coup transcription factor 0.0016 0.0688 0.0688
Trypanosoma cruzi glutaminyl cyclase, putative 0.0019 0.0943 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0943 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0688 0.0688
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0688 0.0688
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.078 0.078
Toxoplasma gondii hypothetical protein 0.0019 0.0943 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0688 0.0688
Schistosoma mansoni adapter molecule crk 0.0015 0.0587 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0688 0.0688
Echinococcus multilocularis tyrosine protein kinase shark 0.001 0.011 0.011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0688 0.0688
Loa Loa (eye worm) TK/ABL protein kinase 0.001 0.011 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0093 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0688 0.0688
Echinococcus multilocularis tyrosine kinase 0.001 0.011 0.011
Brugia malayi Protein kinase domain containing protein 0.001 0.011 0.011
Echinococcus multilocularis tyrosine protein kinase Blk 0.001 0.011 0.011
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.078 0.078
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0943 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.011 0.011
Brugia malayi protein-tyrosine kinase 0.001 0.011 0.011
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0019 0.0943 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0688 0.0688
Echinococcus multilocularis tyrosine protein kinase Srms 0.001 0.011 0.011
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0943 0.0943
Brugia malayi steroid hormone receptor 0.0016 0.0688 0.0688
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0688 0.0688
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0688 0.0688
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0017 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.0016 0.0688 0.0688
Brugia malayi FXNA 0.0019 0.0943 0.0943
Brugia malayi Sex muscle abnormal protein 5 0.0015 0.0587 0.0587
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.011 0.011
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0688 0.0688
Schistosoma mansoni nck2/grb4 0.0015 0.0587 0.0587
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0587 0.0587
Trypanosoma brucei glutaminyl cyclase, putative 0.0019 0.0943 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0688 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0688 0.0688
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0688 0.0688
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0688 0.0688
Brugia malayi nicalin 0.0019 0.0943 0.0943
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0015 0.0587 0.0587
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0688 0.0688
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0688 0.0688
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.011 0.011
Echinococcus granulosus tyrosine kinase 0.001 0.011 0.011
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0587 0.0587
Echinococcus multilocularis tyrosine protein kinase ABL1 0.001 0.011 0.011
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.011 0.011
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0017 0.078 0.078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0688 0.0688
Brugia malayi Protein kinase domain containing protein 0.001 0.011 0.011
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0587 0.0587
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0688 0.0688
Echinococcus granulosus tyrosine protein kinase shark 0.001 0.011 0.011
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0017 0.078 0.078
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0688 0.0585
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.011 0.011
Entamoeba histolytica SH2-protein kinase domain containing protein 0.001 0.011 0.5
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0019 0.0943 0.0943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0688 0.0688
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0688 0.0688
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0943 0.5
Mycobacterium ulcerans hypothetical protein 0.0019 0.0943 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0688 0.0688
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0688 0.0688
Brugia malayi nuclear receptor NHR-88 0.0016 0.0688 0.0688
Onchocerca volvulus Fxna peptidase homolog 0.0019 0.0943 0.0843
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0688 0.0688
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0688 0.0688
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.011 0.011
Brugia malayi SH2 domain containing protein 0.001 0.011 0.011
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0019 0.0943 0.0943
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0688 0.0688
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0019 0.0943 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.078 0.078
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0688 0.0688
Brugia malayi hypothetical protein 0.001 0.011 0.011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0688 0.0688
Schistosoma mansoni tyrosine kinase 0.0017 0.078 0.078
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0587 0.0587
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0688 0.0688
Echinococcus granulosus tyrosine protein kinase Srms 0.001 0.011 0.011
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0688 0.0688
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0688 0.0688
Echinococcus granulosus tyrosine protein kinase Src42A 0.0017 0.078 0.078
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0688 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0688 0.0688
Echinococcus granulosus tyrosine kinase 0.001 0.011 0.011
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.011 0.011
Leishmania major glutaminyl cyclase, putative 0.0019 0.0943 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0688 0.0688
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0688 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0688 0.0688
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0587 0.0587
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0688 0.0688
Echinococcus granulosus tyrosine protein kinase Fps85D 0.001 0.011 0.011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0688 0.0688
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.001 0.011 0.011
Onchocerca volvulus 0.0016 0.0688 0.0585
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0019 0.0943 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0017 0.078 0.078
Schistosoma mansoni tyrosine kinase 0.001 0.011 0.011
Echinococcus granulosus tyrosine protein kinase Lyn 0.0017 0.078 0.078
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.078 0.078
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0688 0.0585
Onchocerca volvulus Fxna peptidase homolog 0.0019 0.0943 0.0843
Echinococcus granulosus NCK adaptor protein 0.0015 0.0587 0.0587
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0688 0.0688
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0688 0.0688
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0587 0.0587
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.011 0.011
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.078 0.078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0688 0.0688
Schistosoma mansoni Fxna peptidase (M28 family) 0.0019 0.0943 0.0943
Brugia malayi leucyl aminopeptidase 0.0019 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0016 0.0688 0.0688

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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