TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.691 | Formula: C27H40O2Si
H donors: 1 H acceptors: 1 LogP: 7.71 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@]2(O)C#C[Si](CC)(CC)CC)C
InChi: 1S/C27H40O2Si/c1-6-30(7-2,8-3)18-17-27(28)16-14-25-24-11-9-20-19-21(29-5)10-12-22(20)23(24)13-15-26(25,27)4/h10,12,19,23-25,28H,6-9,11,13-16H2,1-5H3/t23-,24-,25+,26+,27-/m1/s1
InChiKey: RHBLVLSCNRVHSE-IONQDRQYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0499	0.049
Echinococcus granulosus	neurogenic locus notch protein	0.0043	0.0067	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0124	0.0096
Giardia lamblia	High cysteine membrane protein EGF-like	0.0062	0.0198	1
Schistosoma mansoni	notch	0.0593	0.3895	0.5894
Echinococcus multilocularis	notch	0.018	0.1023	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0198	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0156	0.0129
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0075	0.0287	0.3351
Trypanosoma brucei	Aph-1 protein, putative	0.038	0.2414	0.5
Brugia malayi	EGF-like domain containing protein	0.0043	0.0067	0.0002
Giardia lamblia	Neurogenic locus notch-like protein	0.0062	0.0198	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0067	0.0036
Echinococcus granulosus	fibrillin 1	0.0064	0.0212	0.0147
Brugia malayi	Cadherin domain containing protein	0.0043	0.0067	0.0002
Schistosoma mansoni	hypothetical protein	0.0051	0.0124	0.0087
Echinococcus multilocularis	expressed conserved protein	0.0062	0.0198	0.0133
Brugia malayi	Calcium binding EGF domain containing protein	0.0169	0.0945	0.0926
Brugia malayi	Muscle positioning protein 4	0.0056	0.0156	0.0095
Brugia malayi	EGF-like domain containing protein	0.0043	0.0067	0.0002
Giardia lamblia	High cysteine membrane protein EGF-like	0.0062	0.0198	1
Brugia malayi	EGF-like domain containing protein	0.078	0.5193	0.5404
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0156	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0499	0.049
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0587	0.0582
Echinococcus multilocularis	neurogenic locus notch protein	0.0043	0.0067	0.0002
Onchocerca volvulus	Slit protein homolog	0.0095	0.0425	0.036
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0255	0.1543	0.1485
Loa Loa (eye worm)	notch protein	0.0169	0.0945	0.0958
Echinococcus granulosus	delta-like protein 1	0.0043	0.0067	0.0002
Echinococcus granulosus	protein jagged 1	0.0043	0.0067	0.0002
Toxoplasma gondii	sushi domain (scr repeat) domain-containing protein	0.0137	0.0722	1
Brugia malayi	EGF-like domain containing protein	0.0137	0.0722	0.0691
Echinococcus granulosus	protein jagged 2	0.0043	0.0067	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0067	0.0036
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0976	0.6562	0.6857
Echinococcus granulosus	slit 2 protein	0.0095	0.0425	0.0361
Giardia lamblia	Notch 2, putative	0.0062	0.0198	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0112	0.0546	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0198	0.0174
Echinococcus multilocularis	crumbs 1	0.0062	0.0198	0.0133
Giardia lamblia	High cysteine membrane protein EGF-like	0.0062	0.0198	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0287	0.0267
Onchocerca volvulus		0.0051	0.0124	0.0057
Toxoplasma gondii	notch (dsl) domain-containing protein	0.0137	0.0722	1
Schistosoma mansoni	notch	0.018	0.1023	0.1471
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0043	0.0066	0.0035
Brugia malayi	EGF-like domain containing protein	0.0095	0.0425	0.0378
Echinococcus multilocularis	protein jagged 1	0.0043	0.0067	0.0002
Schistosoma mansoni	slit	0.0095	0.0425	0.055
Echinococcus multilocularis	neural cadherin	0.0043	0.0067	0.0002
Echinococcus granulosus	gamma secretase subunit aph 1	0.0976	0.6562	0.6539
Brugia malayi	gamma-secretase subunit aph-1	0.0976	0.6562	0.6846
Echinococcus granulosus	fibropellin Ia	0.0043	0.0067	0.0002
Giardia lamblia	High cysteine membrane protein EGF-like	0.0062	0.0198	1
Loa Loa (eye worm)	hypothetical protein	0.1406	0.9554	1
Schistosoma mansoni	notch	0.0095	0.0425	0.055
Echinococcus granulosus	hypothetical protein	0.0062	0.0198	0.0133
Loa Loa (eye worm)	Notch2	0.0933	0.6261	0.6541
Echinococcus granulosus	neurogenic locus protein delta	0.0095	0.0425	0.0361
Echinococcus granulosus	crumbs 1	0.0062	0.0198	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0287	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0067	0.0036
Brugia malayi	GCC2 and GCC3 family protein	0.0056	0.0156	0.0095
Echinococcus granulosus	neural cadherin	0.0043	0.0067	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0587	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0215	0.1264	0.1293
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0112	0.0546	0.5
Echinococcus multilocularis	fibrillin 2	0.0064	0.0212	0.0147
Echinococcus multilocularis	conserved hypothetical protein	0.0062	0.0198	0.0133
Echinococcus granulosus	neurogenic locus notch protein 4	0.0105	0.0499	0.0436
Echinococcus multilocularis	protein jagged 2	0.0043	0.0067	0.0002
Onchocerca volvulus		0.0137	0.0722	0.0659
Giardia lamblia	High cysteine membrane protein Group 1	0.0062	0.0198	1
Onchocerca volvulus		0.0095	0.0425	0.036
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0198	0.0174
Giardia lamblia	High cysteine membrane protein EGF-like	0.0062	0.0198	1
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0976	0.6562	1
Onchocerca volvulus	Neurogenic locus notch homolog	0.0137	0.0722	0.0659
Brugia malayi	Calcium binding EGF domain containing protein	0.0169	0.0945	0.0926
Echinococcus multilocularis	fibropellin Ia	0.0043	0.0067	0.0002
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0075	0.0287	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0198	0.0174
Plasmodium vivax	Rh5 interacting protein, putative	0.0062	0.0198	0.5
Schistosoma mansoni	hypothetical protein	0.0137	0.0722	0.1008
Brugia malayi	EGF-like domain containing protein	0.0043	0.0067	0.0002
Brugia malayi	EGF-like domain containing protein	0.0051	0.0124	0.0061
Echinococcus granulosus	fibrillin 2	0.0064	0.0212	0.0147
Plasmodium falciparum	Rh5 interacting protein	0.0062	0.0198	0.5
Brugia malayi	Delta serrate ligand family protein	0.0043	0.0067	0.0002
Echinococcus multilocularis	neurogenic locus protein delta	0.0095	0.0425	0.0361
Giardia lamblia	High cysteine protein	0.0062	0.0198	1
Giardia lamblia	High cysteine membrane protein EGF-like	0.0062	0.0198	1
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0587	0.0582
Echinococcus multilocularis	fibrillin 1	0.0064	0.0212	0.0147
Toxoplasma gondii	microneme protein MIC12	0.0126	0.0644	0.8812
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0105	0.0499	0.0436
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0118	0.0587	0.055
Giardia lamblia	Hypothetical protein	0.0062	0.0198	1
Brugia malayi	hypothetical protein	0.0215	0.1264	0.1263
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0499	0.049
Toxoplasma gondii	EGF family domain-containing protein	0.0051	0.0124	0.0866
Giardia lamblia	High cysteine protein	0.0062	0.0198	1
Giardia lamblia	High cysteine membrane protein Group 2	0.0062	0.0198	1
Trypanosoma cruzi	Aph-1 protein, putative	0.038	0.2414	0.5
Onchocerca volvulus		0.0137	0.0722	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0425	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0287	0.0267
Giardia lamblia	High cysteine membrane protein Group 1	0.0062	0.0198	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0722	0.0724
Brugia malayi	Calcium binding EGF domain containing protein	0.0075	0.0287	0.0233
Onchocerca volvulus	Putative cubilin	0.0056	0.0156	0.0089
Onchocerca volvulus		0.0118	0.0587	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0425	0.0412
Brugia malayi	Cadherin domain containing protein	0.0043	0.0067	0.0002
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0043	0.0067	0.0002
Trypanosoma cruzi	Aph-1 protein, putative	0.038	0.2414	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0046	0.0089	0.0033
Echinococcus granulosus	neurogenic locus notch protein	0.147	0.9999	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0067	0.0036
Echinococcus multilocularis	glioma pathogenesis protein	0.0062	0.0198	0.0133
Schistosoma mansoni	notch	0.0064	0.0212	0.0223
Echinococcus multilocularis	neurogenic locus notch protein	0.147	0.9999	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0945	0.0958
Echinococcus granulosus	protein jagged 2	0.0043	0.0067	0.0002
Brugia malayi	notch-like transmembrane receptor	0.1406	0.9554	1
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0976	0.6562	0.6539
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0067	0.0036
Toxoplasma gondii	microneme protein MIC8	0.0051	0.0124	0.0866
Brugia malayi	EGF-like domain containing protein	0.0043	0.0067	0.0002
Loa Loa (eye worm)	transmembrane cell adhesion receptor mua-3	0.0126	0.0644	0.0642
Echinococcus granulosus	sodium channel protein	0.0112	0.0546	0.0484
Giardia lamblia	High cysteine membrane protein EGF-like	0.0062	0.0198	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0945	0.0958
Echinococcus granulosus	protein jagged 1	0.0043	0.0067	0.0002
Echinococcus multilocularis	neurogenic locus protein delta	0.0043	0.0067	0.0002
Echinococcus granulosus	expressed conserved protein	0.0062	0.0198	0.0133
Echinococcus granulosus	notch	0.018	0.1023	0.0963
Echinococcus multilocularis	sodium channel protein	0.0112	0.0546	0.0484
Giardia lamblia	High cysteine membrane protein EGF-like	0.0062	0.0198	1
Brugia malayi	EGF-like domain containing protein	0.0043	0.0067	0.0002
Echinococcus multilocularis	slit 2 protein	0.0095	0.0425	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0067	0.0036
Echinococcus multilocularis	protein jagged 1	0.0043	0.0067	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0067	0.0036
Trichomonas vaginalis	nucleolar phosphoprotein p130, putative	0.0062	0.0198	1
Schistosoma mansoni	voltage-gated potassium channel	0.0046	0.0089	0.0033
Brugia malayi	sulfakinin receptor protein	0.0215	0.1264	0.1263
Brugia malayi	Calcium binding EGF domain containing protein	0.0056	0.0156	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0425	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0198	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0198	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0856	0.0865
Toxoplasma gondii	sushi domain (scr repeat) domain-containing protein	0.0137	0.0722	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1627655

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1473373