Detailed information for compound 1474442

Basic information

Technical information
  • TDR Targets ID: 1474442
  • Name: N-(4-chloro-3-nitrophenyl)-2-pyridin-1-ium-1- ylacetamide
  • MW: 292.698 | Formula: C13H11ClN3O3+
  • H donors: 1 H acceptors: 3 LogP: 2.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C[n+]1ccccc1)Nc1ccc(c(c1)[N+](=O)[O-])Cl
  • InChi: 1S/C13H10ClN3O3/c14-11-5-4-10(8-12(11)17(19)20)15-13(18)9-16-6-2-1-3-7-16/h1-8H,9H2/p+1
  • InChiKey: QBWYFZLGPAHJPH-UHFFFAOYSA-O  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-chloro-3-nitro-phenyl)-2-pyridin-1-ium-1-yl-acetamide
  • N-(4-chloro-3-nitrophenyl)-2-(1-pyridin-1-iumyl)acetamide
  • N-(4-chloro-3-nitro-phenyl)-2-pyridin-1-ium-1-yl-ethanamide
  • BAS 01248458
  • ZINC04902532

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.006 0.1088 0.6106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Echinococcus multilocularis biogenic amine (5HT) receptor 0.006 0.1088 0.1054
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0026 0.0403 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Echinococcus granulosus fmrfamide receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.006 0.1088 0.1344
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0758 0.2622
Echinococcus granulosus beta hexosaminidase subunit alpha 0.0243 0.4856 0.4837
Schistosoma mansoni Smad4 0.001 0.0068 0.003
Schistosoma mansoni opsin-like receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus peptide allatostatin:somatostatin 0.006 0.1088 0.1054
Onchocerca volvulus 0.006 0.1088 0.6106
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.006 0.1088 0.6106
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni biogenic amine receptor 0.006 0.1088 0.1054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0758 0.1032
Entamoeba histolytica hypothetical protein 0.0035 0.0586 0.0246
Echinococcus multilocularis orexin receptor type 2 0.006 0.1088 0.1054
Entamoeba histolytica beta-N-acetylhexosaminidase, beta subunit 0.0389 0.7853 1
Trichomonas vaginalis beta-hexosaminidase, putative 0.0243 0.4856 1
Echinococcus granulosus neuropeptide receptor A26 0.006 0.1088 0.1054
Echinococcus multilocularis g protein coupled receptor 0.006 0.1088 0.1054
Brugia malayi beta-lactamase 0.0043 0.0758 0.0922
Brugia malayi G-protein coupled receptor 0.006 0.1088 0.1344
Schistosoma mansoni amine GPCR 0.006 0.1088 0.1054
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.006 0.1088 0.1344
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Schistosoma mansoni biogenic amine receptor 0.006 0.1088 0.1054
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.1088 0.1054
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi gonadotropin-releasing hormone receptor 2 0.006 0.1088 0.1344
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0758 0.2622
Loa Loa (eye worm) melatonin receptor type 1A 0.006 0.1088 0.1344
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0396 0.0459
Schistosoma mansoni hypothetical protein 0.006 0.1088 0.1054
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.1088 0.1054
Brugia malayi neuropeptide F receptor 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0068 0.003
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.1088 0.1344
Schistosoma mansoni neuropeptide receptor 0.006 0.1088 0.1054
Echinococcus granulosus neuropeptide Y receptor 0.006 0.1088 0.1054
Brugia malayi Serotonin receptor 0.006 0.1088 0.1344
Giardia lamblia Kinase, PLK 0.0092 0.1757 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.1088 0.1054
Echinococcus multilocularis neuropeptide receptor 0.006 0.1088 0.1054
Schistosoma mansoni opsin-like receptor 0.006 0.1088 0.1054
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.006 0.1088 0.1054
Brugia malayi beta-lactamase family protein 0.0043 0.0758 0.0922
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0758 0.1561
Onchocerca volvulus 0.006 0.1088 0.6106
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0028 0.0432 0.2296
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Echinococcus granulosus alpha 1A adrenergic receptor 0.006 0.1088 0.1054
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1757 0.1818
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0396 0.0459
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0396 0.0459
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Mycobacterium tuberculosis Conserved protein 0.0043 0.0758 0.1032
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0068 0.0039
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0758 1
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0396 0.0459
Brugia malayi Smad1 0.001 0.0068 0.0039
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.1088 0.1054
Toxoplasma gondii cell division protein CDC48AP 0.0017 0.0205 0.1424
Echinococcus granulosus neuropeptide FF receptor 2 0.006 0.1088 0.1054
Entamoeba histolytica hypothetical protein 0.0035 0.0586 0.0246
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0396 0.2087
Echinococcus granulosus cpg binding protein 0.0037 0.0618 0.0583
Brugia malayi CXXC zinc finger family protein 0.0035 0.0578 0.0691
Echinococcus multilocularis somatostatin receptor 0.006 0.1088 0.1054
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Echinococcus granulosus thyrotropin releasing hormone receptor 0.006 0.1088 0.1054
Brugia malayi ORL1-like opioid receptor 0.006 0.1088 0.1344
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1757 1
Onchocerca volvulus 0.006 0.1088 0.6106
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.006 0.1088 0.1344
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0758 0.0922
Mycobacterium ulcerans lipase LipD 0.0043 0.0758 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.006 0.1088 0.1054
Schistosoma mansoni growth hormone secretagogue receptor 0.006 0.1088 0.1054
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0758 1
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni biogenic amine receptor 0.006 0.1088 0.1054
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.1088 0.1054
Giardia lamblia AAA family ATPase 0.0017 0.0205 0.0974
Onchocerca volvulus 0.006 0.1088 0.6106
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0578 0.0691
Schistosoma mansoni cpg binding protein 0.0035 0.0578 0.0542
Brugia malayi G-protein coupled receptor 0.006 0.1088 0.1344
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0389 0.7853 1
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0389 0.7853 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0758 0.2622
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus allatostatin A receptor 0.006 0.1088 0.1054
Trichomonas vaginalis beta-hexosaminidase, putative 0.009 0.172 0.3542
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Echinococcus granulosus g-protein coupled receptor 0.006 0.1088 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Schistosoma mansoni amine GPCR 0.006 0.1088 0.1054
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0086 0.0049
Trichomonas vaginalis beta-hexosaminidase, putative 0.0243 0.4856 1
Echinococcus granulosus g protein coupled receptor 0.006 0.1088 0.1054
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0758 0.1032
Schistosoma mansoni neuropeptide f receptor 76f 0.006 0.1088 0.1054
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0011 0.01 0.0063
Onchocerca volvulus Hexosaminidase D homolog 0.009 0.172 0.9784
Onchocerca volvulus 0.006 0.1088 0.6106
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Trichomonas vaginalis esterase, putative 0.0043 0.0758 0.1561
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0243 0.4856 1
Brugia malayi Serotonin receptor 0.006 0.1088 0.1344
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0758 0.0723
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0396 0.2087
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1757 0.1726
Schistosoma mansoni myosin xvIII 0.006 0.1088 0.1054
Echinococcus granulosus neuropeptides capa receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2824 0.3565
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0011 0.01 0.0063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0027 0.0056
Echinococcus multilocularis beta hexosaminidase subunit beta 0.0389 0.7853 0.7845
Loa Loa (eye worm) hypothetical protein 0.0016 0.0198 0.0206
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0026 0.0403 0.4833
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0026 0.0403 0.0367
Echinococcus multilocularis dro:myosuppressin receptor 0.006 0.1088 0.1054
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.1088 0.1054
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0758 0.1032
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0758 0.1032
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.1088 0.1054
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1757 0.22
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Loa Loa (eye worm) TYRA-2 protein 0.006 0.1088 0.1344
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Echinococcus multilocularis G protein coupled receptor 139 0.006 0.1088 0.1054
Echinococcus multilocularis neuropeptide receptor A26 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Onchocerca volvulus 0.006 0.1088 0.6106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Echinococcus multilocularis g-protein coupled receptor 0.006 0.1088 0.1054
Onchocerca volvulus 0.006 0.1088 0.6106
Echinococcus multilocularis g protein coupled receptor 0.006 0.1088 0.1054
Schistosoma mansoni beta-hexosaminidase B 0.0389 0.7853 0.7845
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Brugia malayi G protein-coupled receptor 0.006 0.1088 0.1344
Echinococcus granulosus neuropeptide receptor 0.006 0.1088 0.1054
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Onchocerca volvulus Peroxidase homolog 0.0026 0.0396 0.2087
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.1088 0.1054
Echinococcus multilocularis Smad4 0.001 0.0068 0.003
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1757 1
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0083 0.0059
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Loa Loa (eye worm) hypothetical protein 0.018 0.3567 0.4516
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0011 0.01 0.008
Schistosoma mansoni peroxidasin 0.0026 0.0396 0.036
Schistosoma mansoni hypothetical protein 0.0494 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0396 0.0459
Schistosoma mansoni amine GPCR 0.006 0.1088 0.1054
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0389 0.7853 1
Echinococcus multilocularis sex peptide receptor 0.006 0.1088 0.1054
Schistosoma mansoni neuropeptide receptor 0.006 0.1088 0.1054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Onchocerca volvulus 0.0026 0.0396 0.2087
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0396 0.2087
Brugia malayi RE15519p 0.006 0.1088 0.1344
Echinococcus granulosus neuropeptide s receptor 0.006 0.1088 0.1054
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0758 0.1032
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.006 0.1088 0.1054
Echinococcus granulosus Smad4 0.001 0.0068 0.003
Onchocerca volvulus 0.0043 0.0758 0.4191
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0758 0.1032
Onchocerca volvulus 0.0026 0.0396 0.2087
Loa Loa (eye worm) beta-lactamase 0.0043 0.0758 0.0922
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni smad1 5 8 and 0.001 0.0068 0.003
Loa Loa (eye worm) VCP protein 0.0011 0.01 0.008
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0028 0.0432 0.089
Echinococcus granulosus orexin receptor type 2 0.006 0.1088 0.1054
Brugia malayi putative neuropeptide receptor 0.006 0.1088 0.1344
Echinococcus multilocularis neuropeptide receptor 0.006 0.1088 0.1054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Echinococcus multilocularis tachykinin peptides receptor 99D 0.006 0.1088 0.1054
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.006 0.1088 0.1344
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1214 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0586 0.0551
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Brugia malayi Dopamine receptor protein 2 0.006 0.1088 0.1344
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.1088 0.1054
Brugia malayi hypothetical protein 0.0026 0.0396 0.0459
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0396 0.0459
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.1088 0.1054
Trypanosoma brucei polo-like protein kinase 0.0092 0.1757 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.006 0.1088 0.1054
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Brugia malayi MH2 domain containing protein 0.0144 0.2824 0.3565
Schistosoma mansoni peroxidasin 0.0026 0.0396 0.036
Onchocerca volvulus 0.0043 0.0758 0.4191
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0758 0.1032
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.006 0.1088 0.1054
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Toxoplasma gondii ABC1 family protein 0.0043 0.0758 0.6125
Schistosoma mansoni hypothetical protein 0.006 0.1088 0.1054
Echinococcus granulosus neuropeptide Y receptor 0.006 0.1088 0.1054
Schistosoma mansoni smad1 5 8 and 0.001 0.0068 0.003
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.009 0.172 0.2153
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0086 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0802 0.1652
Schistosoma mansoni neuropeptide receptor 0.006 0.1088 0.1054
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0758 0.0723
Schistosoma mansoni opsin-like receptor 0.006 0.1088 0.1054
Brugia malayi G protein-coupled receptor F59B2.13 0.006 0.1088 0.1344
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Echinococcus granulosus g protein coupled receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi Peroxidasin 0.0026 0.0396 0.0459
Echinococcus granulosus 7tm_1 domain containing protein 0.006 0.1088 0.1054
Brugia malayi larval opioid receptor 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Echinococcus granulosus 7TM GPCR rhodopsin 0.006 0.1088 0.1054
Entamoeba histolytica beta-N-acetylhexosaminidase, alpha subunit 0.0389 0.7853 1
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0028 0.0432 0.0396
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0068 0.003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis peroxidasin 0.0026 0.0396 0.036
Brugia malayi MH2 domain containing protein 0.001 0.0068 0.0039
Onchocerca volvulus 0.006 0.1088 0.6106
Echinococcus multilocularis muscleblind protein 1 0.018 0.3567 0.3543
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.1088 0.1054
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0028 0.0432 0.0396
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.1088 0.1054
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0068 0.003
Echinococcus granulosus smad 0.001 0.0068 0.003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0758 0.0723
Onchocerca volvulus 0.006 0.1088 0.6106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Mycobacterium ulcerans beta-lactamase 0.0043 0.0758 1
Onchocerca volvulus 0.0035 0.0578 0.3141
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1757 0.1726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.006 0.1088 0.1054
Echinococcus granulosus neuropeptides capa receptor 0.006 0.1088 0.1054
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Mycobacterium tuberculosis Conserved protein 0.0043 0.0758 0.1032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.1088 0.1054
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0758 0.0922
Brugia malayi Dopamine receptor protein 1 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) vesicle-fusing ATPase 0.0016 0.0198 0.0206
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0086 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0027 0.0056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi vesicle-fusing ATPase 0.0016 0.0198 0.0206
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0586 0.0551
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.1088 0.1054
Onchocerca volvulus 0.006 0.1088 0.6106
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Onchocerca volvulus 0.006 0.1088 0.6106
Onchocerca volvulus Neuropeptide F receptor homolog 0.006 0.1088 0.6106
Brugia malayi Blistered cuticle protein 3 0.0026 0.0396 0.0459
Schistosoma mansoni amine GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi hypothetical protein 0.0035 0.0586 0.0702
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.1088 0.1054
Brugia malayi Tachykinin-like peptides receptor 99D 0.006 0.1088 0.1344
Echinococcus multilocularis smad 0.001 0.0068 0.003
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Loa Loa (eye worm) Smad1 0.001 0.0068 0.0039
Brugia malayi follicle stimulating hormone receptor 0.006 0.1088 0.1344
Schistosoma mansoni smad1 5 8 and 0.001 0.0068 0.003
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni alpha-1 adrenergic receptor 0.006 0.1088 0.1054
Echinococcus multilocularis allatostatin A receptor 0.006 0.1088 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi Muscleblind-like protein 0.018 0.3567 0.4516
Echinococcus granulosus serotonin receptor 0.006 0.1088 0.1054
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0758 0.1561
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2824 0.3565
Onchocerca volvulus 0.006 0.1088 0.6106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1757 0.22
Echinococcus multilocularis fmrfamide receptor 0.006 0.1088 0.1054
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.006 0.1088 0.1054
Echinococcus multilocularis muscleblind protein 0.018 0.3567 0.3543
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.006 0.1088 0.1344
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0586 0.0551
Entamoeba histolytica hypothetical protein 0.0035 0.0586 0.0246
Schistosoma mansoni hypothetical protein 0.0035 0.0586 0.0551
Brugia malayi putative neuropeptide receptor NPR1 0.006 0.1088 0.1344
Onchocerca volvulus 0.006 0.1088 0.6106
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni adenoreceptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0068 0.003
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1757 1
Echinococcus multilocularis serotonin receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0396 0.0459
Brugia malayi valosin containing protein 0.0016 0.0198 0.0206
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.1088 0.1054
Echinococcus granulosus G protein coupled receptor 139 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Onchocerca volvulus 0.0026 0.0396 0.2087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Brugia malayi GnHR receptor homolog 0.006 0.1088 0.1344
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0043 0.0005
Leishmania major hypothetical protein, conserved 0.0043 0.0758 0.2622
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.006 0.1088 0.1054
Loa Loa (eye worm) glycosyl hydrolase family 20 0.0389 0.7853 1
Loa Loa (eye worm) hypothetical protein 0.009 0.172 0.2153
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) follicle stimulating hormone receptor 0.006 0.1088 0.1344
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0017 0.0205 0.1424
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1375 0.1343
Onchocerca volvulus Peroxidase homolog 0.0026 0.0396 0.2087
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.1088 0.1054
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.009 0.172 0.2153
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1757 1
Echinococcus granulosus g protein coupled receptor 0.006 0.1088 0.1054
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0396 0.2087
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Entamoeba histolytica hypothetical protein 0.0035 0.0586 0.0246
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0758 0.1561
Echinococcus granulosus muscleblind protein 0.018 0.3567 0.3543
Schistosoma mansoni cpg binding protein 0.0037 0.0618 0.0583
Echinococcus multilocularis g protein coupled receptor 0.006 0.1088 0.1054
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.006 0.1088 0.1054
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0043 0.0005
Echinococcus multilocularis serotonin receptor 0.006 0.1088 0.1054
Echinococcus granulosus beta hexosaminidase subunit beta 0.0389 0.7853 0.7845
Loa Loa (eye worm) hypothetical protein 0.009 0.172 0.2153
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.1088 0.1054
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.5565 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0758 0.1561
Trichomonas vaginalis beta-hexosaminidase, putative 0.0243 0.4856 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.006 0.1088 0.1054
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0396 0.0459
Brugia malayi neuropeptide F receptor 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Schistosoma mansoni beta-hexosaminidase B 0.0389 0.7853 0.7845
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0758 1
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.1088 0.1054
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.006 0.1088 0.1054
Onchocerca volvulus 0.006 0.1088 0.6106
Echinococcus granulosus tachykinin peptides receptor 99D 0.006 0.1088 0.1054
Schistosoma mansoni smad 0.001 0.0068 0.003
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0068 0.003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0068 0.0039
Brugia malayi sulfakinin receptor protein 0.006 0.1088 0.1344
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Brugia malayi Dopamine receptor 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0043 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0043 0.0005
Schistosoma mansoni amine GPCR 0.006 0.1088 0.1054
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Toxoplasma gondii cell division protein CDC48CY 0.0028 0.0432 0.3356
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Schistosoma mansoni cpg binding protein 0.0037 0.0618 0.0583
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0396 0.0459
Echinococcus granulosus peroxidasin 0.0026 0.0396 0.036
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0396 0.0459
Brugia malayi beta-lactamase family protein 0.0043 0.0758 0.0922
Echinococcus granulosus neuropeptide receptor 0.006 0.1088 0.1054
Schistosoma mansoni peptide (allatostatin)-like receptor 0.006 0.1088 0.1054
Mycobacterium ulcerans hypothetical protein 0.0043 0.0758 1
Mycobacterium leprae Probable lipase LipE 0.0043 0.0758 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.1088 0.1054
Echinococcus multilocularis neuropeptide s receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis cpg binding protein 0.0037 0.0618 0.0583
Mycobacterium tuberculosis Conserved protein 0.0043 0.0758 0.1032
Schistosoma mansoni neuropeptide receptor 0.006 0.1088 0.1054
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1757 0.1726
Echinococcus granulosus dro:myosuppressin receptor 0.006 0.1088 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.006 0.1088 0.1054
Echinococcus granulosus hypothetical protein 0.006 0.1088 0.1054
Onchocerca volvulus 0.006 0.1088 0.6106
Echinococcus granulosus somatostatin receptor 0.006 0.1088 0.1054
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0028 0.0432 0.0396
Brugia malayi AKH receptor 0.006 0.1088 0.1344
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.006 0.1088 0.1054
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.1088 0.1054
Onchocerca volvulus 0.006 0.1088 0.6106
Onchocerca volvulus 0.0043 0.0758 0.4191
Brugia malayi Melatonin receptor type 1A 0.006 0.1088 0.1344
Schistosoma mansoni kinase 0.0047 0.0827 0.0793
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.1088 0.1054
Echinococcus multilocularis beta hexosaminidase subunit alpha 0.0243 0.4856 0.4837
Loa Loa (eye worm) hypothetical protein 0.018 0.3567 0.4516
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0043 0.0005
Brugia malayi MH1 domain containing protein 0.001 0.0068 0.0039
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi MH2 domain containing protein 0.001 0.0068 0.0039
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0802 0.1652
Echinococcus multilocularis neuropeptide FF receptor 2 0.006 0.1088 0.1054
Trichomonas vaginalis helicase, putative 0.0008 0.0027 0.0056
Schistosoma mansoni hypothetical protein 0.006 0.1088 0.1054
Schistosoma mansoni histamine h1 receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.006 0.1088 0.1054
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0758 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0758 0.0723
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.006 0.1088 0.1344
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0758 0.1561
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Brugia malayi MH1 domain containing protein 0.001 0.0068 0.0039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.1088 0.1344
Schistosoma mansoni hypothetical protein 0.006 0.1088 0.1054
Echinococcus granulosus sex peptide receptor 0.006 0.1088 0.1054
Echinococcus multilocularis fmrfamide receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.006 0.1088 0.1344

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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