Detailed information for compound 1474764

Basic information

Technical information
  • TDR Targets ID: 1474764
  • Name: (5R,6S)-3-(1,9-dimethylpyrido[2,3-b]indol-1-i um-6-yl)-6-(1-hydroxyethyl)-7-oxo-1-azabicycl o[3.2.0]hept-2-ene-2-carboxylic acid
  • MW: 392.428 | Formula: C22H22N3O4+
  • H donors: 2 H acceptors: 4 LogP: 2.02 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]([C@H]1C(=O)N2[C@@H]1CC(=C2C(=O)O)c1ccc2c(c1)c1ccc[n+](c1n2C)C)O
  • InChi: 1S/C22H21N3O4/c1-11(26)18-17-10-14(19(22(28)29)25(17)21(18)27)12-6-7-16-15(9-12)13-5-4-8-23(2)20(13)24(16)3/h4-9,11,17-18,26H,10H2,1-3H3/p+1/t11-,17-,18-/m1/s1
  • InChiKey: DDWQDIKZDBWFQK-HWOJHCLVSA-O  


Substructure search Similarity search

Network

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Synonyms

  • (5R,6S)-3-(1,9-dimethyl-6-pyrido[2,3-b]indol-1-iumyl)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-3-(1,9-dimethylpyrido[2,3-b]indol-1-ium-6-yl)-6-(1-hydroxyethyl)-7-keto-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 0.2171 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0166 0.007
Trichomonas vaginalis beta-hexosaminidase, putative 0.0228 0.4617 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1387 0.1793
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0078 0.1387 0.4288
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Schistosoma mansoni cathepsin B (C01 family) 0.0024 0.0236 0.0236
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0639 0.1768
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.2171 0.4668
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0129 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.102 0.3054
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0236 0.0263
Echinococcus multilocularis cathepsin b 0.0157 0.3082 0.3082
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0236 0.0263
Schistosoma mansoni ap endonuclease 0.0019 0.0114 0.0114
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.102 0.1306
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0541 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0024 0.0236 0.0591
Giardia lamblia Encystation-specific protease 0.0024 0.0236 0.1213
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0024 0.0236 0.0263
Schistosoma mansoni hypothetical protein 0.0479 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0812 0.0812
Schistosoma mansoni cathepsin F (C01 family) 0.0115 0.2171 0.2171
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0115 0.2171 0.4668
Echinococcus multilocularis dnaJ subfamily B 0.0479 1 1
Brugia malayi RNA, U transporter 1 0.0082 0.1473 0.1908
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0357 0.1182
Brugia malayi cathepsin Z-like cysteine proteinase 0.0024 0.0236 0.0263
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0277 0.0539
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0494 0.0607
Loa Loa (eye worm) hypothetical protein 0.0078 0.1387 0.1793
Toxoplasma gondii cathepsin B 0.0065 0.1116 0.4402
Giardia lamblia Cathepsin L precursor 0.0024 0.0236 0.1213
Onchocerca volvulus 0.0078 0.1387 0.5946
Onchocerca volvulus 0.0115 0.2171 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0166 0.0252
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0212 0.0398
Schistosoma mansoni importin beta-1 0.0029 0.033 0.033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0812 0.0812
Schistosoma mansoni inositol monophosphatase 0.0043 0.0639 0.0639
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 0.2171 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0236 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.1116 0.2367
Brugia malayi CXXC zinc finger family protein 0.0066 0.1124 0.1444
Plasmodium falciparum serine repeat antigen 8 0.0024 0.0236 0.0591
Entamoeba histolytica cysteine proteinase, putative 0.0115 0.2171 0.2761
Leishmania major cathepsin L-like protease 0.0115 0.2171 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0061 0.0061
Loa Loa (eye worm) fibroinase 0.0115 0.2171 0.2835
Echinococcus granulosus cathepsin b 0.0157 0.3082 0.3082
Echinococcus granulosus snurportin 1 0.0308 0.6331 0.6331
Entamoeba histolytica cysteine proteinase 1, putative 0.0061 0.102 0.1216
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0166 0.0252
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0812 0.1029
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0236 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 0.2171 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 0.2171 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0024 0.0236 0.1213
Loa Loa (eye worm) hypothetical protein 0.0029 0.033 0.0388
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.102 0.2159
Onchocerca volvulus Cathepsin L homolog 0.0115 0.2171 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0236 0.0448
Brugia malayi Cathepsin L-like precursor 0.0115 0.2171 0.2835
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0024 0.0236 0.0163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.2171 0.4668
Loa Loa (eye worm) hypothetical protein 0.0037 0.0494 0.0607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0236 0.0236
Entamoeba histolytica cysteine protease, putative 0.0024 0.0236 0.0163
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0812 0.1029
Brugia malayi Importin beta-1 subunit 0.0029 0.033 0.0388
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0277 0.0539
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0024 0.0236 0.0591
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.3082 0.3082
Giardia lamblia Cathepsin B precursor 0.0024 0.0236 0.1213
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0115 0.2171 1
Onchocerca volvulus 0.0115 0.2171 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0024 0.0236 0.0591
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0147 0.0147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0812 0.0812
Giardia lamblia Cathepsin L precursor 0.0024 0.0236 0.1213
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0541 0.5
Leishmania major cathepsin L-like protease 0.0115 0.2171 1
Entamoeba histolytica cysteine protease, putative 0.0024 0.0236 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0639 1
Brugia malayi Cathepsin L-like precursor 0.0115 0.2171 0.2835
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.2171 0.4668
Echinococcus multilocularis cysteine protease 0.0115 0.2171 0.2171
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0277 0.0539
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.102 0.102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Echinococcus multilocularis cathepsin L cysteine protease 0.0115 0.2171 0.2171
Leishmania major cathepsin L-like protease 0.0115 0.2171 1
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.102 0.3054
Plasmodium vivax vivapain-2 0.0115 0.2171 1
Loa Loa (eye worm) cysteine protease 0.0115 0.2171 0.2835
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.239 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0357 0.1182
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.102 0.2159
Echinococcus granulosus beta hexosaminidase subunit alpha 0.0228 0.4617 0.4617
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0142 0.0139
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.102 0.1216
Loa Loa (eye worm) inositol-1 0.0043 0.0639 0.0799
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0024 0.0236 0.1213
Brugia malayi Cathepsin L-like precursor 0.0078 0.1387 0.1793
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0639 0.255
Brugia malayi hypothetical protein 0.003 0.0357 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0024 0.0236 0.0263
Loa Loa (eye worm) ctsf protein 0.0115 0.2171 0.2835
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0065 0.1116 0.3376
Toxoplasma gondii preprocathepsin c precursor, putative 0.0024 0.0236 0.0534
Schistosoma mansoni cathepsin F (C01 family) 0.0115 0.2171 0.2171
Echinococcus granulosus cathepsin L 0.0024 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Plasmodium vivax unspecified product 0.0037 0.0494 0.1848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0812 0.0812
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0061 0.0061
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0024 0.0236 0.0591
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Brugia malayi Cathepsin L-like precursor 0.0115 0.2171 0.2835
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.3082 0.3082
Brugia malayi Cathepsin L-like cysteine proteinase 0.0078 0.1387 0.1793
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0166 0.0171
Giardia lamblia Cathepsin L-like protease 0.0024 0.0236 0.1213
Loa Loa (eye worm) glycosyl hydrolase family 20 0.0365 0.7565 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0024 0.0236 0.0591
Plasmodium falciparum serine repeat antigen 6 0.0024 0.0236 0.0591
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0037 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0115 0.2171 0.6932
Giardia lamblia Cathepsin B precursor 0.0024 0.0236 0.1213
Entamoeba histolytica cysteine protease, putative 0.0115 0.2171 0.2761
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Echinococcus multilocularis cathepsin L 0.0024 0.0236 0.0236
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0024 0.0236 0.0591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Trypanosoma cruzi cruzipain precursor, putative 0.0037 0.0494 0.1281
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.1387 0.1708
Trichomonas vaginalis beta-hexosaminidase, putative 0.0228 0.4617 1
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0639 0.0639
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0024 0.0236 0.0591
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0236 0.0236
Onchocerca volvulus Cathepsin F homolog 0.0115 0.2171 1
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0639 0.1327
Schistosoma mansoni beta-hexosaminidase B 0.0365 0.7565 0.7565
Loa Loa (eye worm) hypothetical protein 0.0085 0.1533 0.1987
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0115 0.2171 0.4668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1387 0.2957
Schistosoma mansoni cpg binding protein 0.0066 0.1124 0.1124
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0024 0.0236 0.0236
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0024 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0024 0.0236 0.0263
Leishmania major cysteine peptidase A (CPA) 0.0115 0.2171 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0166 0.0519
Onchocerca volvulus Hexosaminidase D homolog 0.0085 0.1533 0.6701
Entamoeba histolytica beta-N-acetylhexosaminidase, alpha subunit 0.0365 0.7565 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0639 0.0704
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0365 0.7565 1
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Loa Loa (eye worm) hypothetical protein 0.0037 0.0494 0.0607
Loa Loa (eye worm) cathepsin B 0.0065 0.1116 0.1433
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0024 0.0236 0.0591
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Giardia lamblia Cathepsin L precursor 0.0024 0.0236 0.1213
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0024 0.0236 0.0591
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0639 0.2305
Echinococcus granulosus cathepsin l cysteine peptidase 0.0115 0.2171 0.2171
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Echinococcus multilocularis cpg binding protein 0.007 0.1205 0.1205
Brugia malayi Cathepsin L-like precursor 0.0037 0.0494 0.0607
Onchocerca volvulus 0.0115 0.2171 1
Echinococcus granulosus cysteine protease 0.0061 0.102 0.102
Brugia malayi Cathepsin L-like precursor 0.0078 0.1387 0.1793
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.6331 0.8361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 0.2171 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0236 0.0448
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0114 0.0102
Schistosoma mansoni beta-hexosaminidase B 0.0365 0.7565 0.7565
Plasmodium falciparum importin beta, putative 0.0029 0.033 0.1048
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0166 0.0175
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0157 0.3082 0.3082
Echinococcus multilocularis cathepsin b 0.0157 0.3082 0.3082
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0024 0.0236 0.0591
Trypanosoma cruzi cysteine protease, putative 0.0061 0.102 0.3054
Entamoeba histolytica cysteine proteinase, putative 0.0115 0.2171 0.2761
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.2171 0.4668
Schistosoma mansoni ap endonuclease 0.0019 0.0114 0.0114
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0115 0.2171 0.2835
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0236 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 0.2171 1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.033 0.033
Echinococcus granulosus cathepsin L cysteine proteinase 0.0115 0.2171 0.2171
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0639 0.0639
Giardia lamblia Cathepsin B precursor 0.0065 0.1116 1
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0115 0.2171 0.2835
Loa Loa (eye worm) hypothetical protein 0.003 0.0357 0.0425
Onchocerca volvulus 0.0115 0.2171 1
Plasmodium vivax vivapain-1 0.0061 0.102 0.4405
Trichomonas vaginalis beta-hexosaminidase, putative 0.0228 0.4617 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0236 0.0448
Trypanosoma brucei cysteine peptidase C (CPC) 0.0065 0.1116 0.4869
Leishmania major cathepsin L-like protease 0.0115 0.2171 1
Echinococcus multilocularis beta hexosaminidase subunit beta 0.0365 0.7565 0.7565
Schistosoma mansoni cathepsin C 0.0024 0.0236 0.0236
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0639 0.1327
Schistosoma mansoni inositol monophosphatase 0.0043 0.0639 0.0639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0639 0.1327
Giardia lamblia Cathepsin L precursor 0.0024 0.0236 0.1213
Leishmania major cathepsin L-like protease 0.0115 0.2171 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0024 0.0236 0.0263
Echinococcus granulosus cathepsin L cysteine protease 0.0061 0.102 0.102
Giardia lamblia Cathepsin L precursor 0.0024 0.0236 0.1213
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0024 0.0236 0.0263
Plasmodium vivax vivapain-3 0.0061 0.102 0.4405
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0114 0.0114
Echinococcus multilocularis cathepsin L cysteine protease 0.0115 0.2171 0.2171
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0024 0.0236 0.1213
Leishmania major cathepsin L-like protease 0.0115 0.2171 1
Trichomonas vaginalis beta-hexosaminidase, putative 0.0085 0.1533 0.3276
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0277 0.0539
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.2171 0.4668
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Plasmodium falciparum serine repeat antigen 9 0.0024 0.0236 0.0591
Plasmodium vivax importin-beta 2, putative 0.0029 0.033 0.1048
Leishmania major cathepsin L-like protease 0.0115 0.2171 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0115 0.2171 0.2171
Plasmodium falciparum serine repeat antigen 4 0.0024 0.0236 0.0591
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0115 0.2171 0.2171
Trypanosoma cruzi major cysteine proteinase, putative 0.0024 0.0236 0.041
Echinococcus granulosus cathepsin l1 0.0115 0.2171 0.2171
Echinococcus granulosus cpg binding protein 0.007 0.1205 0.1205
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0024 0.0236 0.0448
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0114 0.0183
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0357 0.1182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.2171 0.4668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 0.2171 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.3082 0.4045
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0024 0.0236 0.0163
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.033 0.1048
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0065 0.1116 0.4869
Brugia malayi fibroinase precursor 0.0024 0.0236 0.0263
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0114 0.0102
Schistosoma mansoni cpg binding protein 0.007 0.1205 0.1205
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.1116 0.1116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0812 0.0812
Trypanosoma cruzi cruzipain precursor, putative 0.0115 0.2171 0.6932
Entamoeba histolytica cysteine protease, putative 0.0024 0.0236 0.0163
Schistosoma mansoni hypothetical protein 0.0308 0.6331 0.6331
Echinococcus granulosus geminin 0.0171 0.339 0.339
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0037 0.0037
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.102 0.102
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0639 0.1768
Brugia malayi cathepsin L-like precursor 0.0078 0.1387 0.1793
Plasmodium falciparum cysteine proteinase falcipain 1 0.0061 0.102 0.4405
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0277 0.0539
Plasmodium falciparum serine repeat antigen 1 0.0024 0.0236 0.0591
Loa Loa (eye worm) histone methyltransferase 0.002 0.0147 0.0146
Entamoeba histolytica beta-N-acetylhexosaminidase, beta subunit 0.0365 0.7565 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0105 0.0164
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0365 0.7565 1
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0085 0.1533 0.1987
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0357 0.1068
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0166 0.0166
Echinococcus multilocularis beta hexosaminidase subunit alpha 0.0228 0.4617 0.4617
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0024 0.0236 0.0236
Trypanosoma cruzi cysteine peptidase, putative 0.0115 0.2171 0.6932
Plasmodium falciparum serine repeat antigen 2 0.0024 0.0236 0.0591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 0.2171 1
Brugia malayi Cathepsin L-like precursor 0.0115 0.2171 0.2835
Echinococcus multilocularis geminin 0.0171 0.339 0.339
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0277 0.0539
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.2711 0.2711
Onchocerca volvulus 0.0115 0.2171 1
Echinococcus multilocularis cathepsin L 0.0061 0.102 0.102
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0024 0.0236 0.0236
Plasmodium falciparum cysteine proteinase falcipain 3 0.0115 0.2171 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0024 0.0236 0.041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0812 0.0812
Brugia malayi Papain family cysteine protease containing protein 0.0115 0.2171 0.2835
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0228 0.4617 1
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.102 0.1216
Giardia lamblia Hypothetical protein 0.0024 0.0236 0.1213
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.102 0.1216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0236 0.0448
Plasmodium vivax unspecified product 0.0024 0.0236 0.0591
Brugia malayi cathepsin F-like cysteine proteinase 0.0037 0.0494 0.0607
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.1124 0.1444
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.3082 0.3082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0024 0.0236 0.0591
Leishmania major hypothetical protein, conserved 0.003 0.0357 0.1182
Brugia malayi hypothetical protein 0.0019 0.0128 0.012
Trypanosoma cruzi cysteine peptidase, putative 0.0115 0.2171 0.6932
Leishmania major GTP-binding protein, putative 0.0021 0.0166 0.0252
Entamoeba histolytica cysteine protease, putative 0.0024 0.0236 0.0163
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0639 0.255
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.102 0.1306
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0024 0.0236 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Echinococcus multilocularis cysteine protease 0.0115 0.2171 0.2171
Brugia malayi cathepsin B-like cysteine proteinase 0.0157 0.3082 0.4045
Brugia malayi cathepsin F-like cysteine proteinase 0.0024 0.0236 0.0263
Plasmodium vivax unspecified product 0.0061 0.102 0.4405
Giardia lamblia Cysteine protease 0.0024 0.0236 0.1213
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0166 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0236 0.0448
Entamoeba histolytica hypothetical protein 0.0024 0.0236 0.0163
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0212 0.0398
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0639 1
Echinococcus granulosus cathepsin b 0.0157 0.3082 0.3082
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0024 0.0236 0.0591
Loa Loa (eye worm) hypothetical protein 0.0037 0.0494 0.0607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0236 0.0448
Onchocerca volvulus 0.0066 0.1124 0.4591
Onchocerca volvulus 0.0115 0.2171 1
Giardia lamblia Cathepsin L precursor 0.0024 0.0236 0.1213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.102 0.4405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 0.2171 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0236 0.0448
Giardia lamblia Cysteine protease 0.0024 0.0236 0.1213
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0114 0.0114
Plasmodium vivax serine-repeat antigen (SERA) 0.0024 0.0236 0.0591
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0037 0.0037
Brugia malayi cathepsin Z-like cysteine proteinase 0.0024 0.0236 0.0263
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0085 0.1533 0.1987
Plasmodium vivax vivapain-2 0.0115 0.2171 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0061 0.102 0.3054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Leishmania major cathepsin L-like protease 0.0115 0.2171 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0166 0.0171
Trichomonas vaginalis ran, putative 0.0021 0.0166 0.0296
Trypanosoma cruzi cysteine peptidase, putative 0.0115 0.2171 0.6932
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0277 0.0539
Echinococcus granulosus cathepsin L 0.0061 0.102 0.102
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0357 0.1182
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0212 0.0332
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0115 0.2171 0.2835
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0277 0.0539
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0236 0.0236
Echinococcus granulosus importin subunit beta 1 0.0029 0.033 0.033
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0236 0.0263
Entamoeba histolytica cysteine proteinase 2 0.0061 0.102 0.1216
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0357 0.0819
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0024 0.0236 0.0448
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0494 0.1281
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0166 0.0175
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.102 0.102
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0037 0.0494 0.0607
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0157 0.3082 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0061 0.0061
Plasmodium falciparum serine repeat antigen 3 0.0024 0.0236 0.0591
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0024 0.0236 0.1213
Schistosoma mansoni ran 0.0021 0.0166 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0236 0.0448
Toxoplasma gondii cathepsin CPC2 0.0024 0.0236 0.0534
Echinococcus granulosus beta hexosaminidase subunit beta 0.0365 0.7565 0.7565
Giardia lamblia Cathepsin L-like protease 0.0024 0.0236 0.1213
Brugia malayi cathepsin L precursor 0.0024 0.0236 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 0.2171 1
Schistosoma mansoni cpg binding protein 0.007 0.1205 0.1205
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0114 0.0183
Leishmania major importin beta-1 subunit, putative 0.0023 0.0212 0.0478
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Toxoplasma gondii cathepsin CPL 0.0115 0.2171 0.904
Brugia malayi Cathepsin L-like precursor 0.0115 0.2171 0.2835
Brugia malayi Cathepsin L-like precursor 0.0115 0.2171 0.2835
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0236 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.2171 0.4668
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0365 0.7565 1
Entamoeba histolytica hypothetical protein 0.0023 0.0212 0.0132
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0061 0.0061
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.033 0.0948
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0115 0.2171 1
Schistosoma mansoni cathepsin s 0.0037 0.0494 0.0494
Schistosoma mansoni hypothetical protein 0.0171 0.339 0.339
Giardia lamblia Cysteine protease 0.0024 0.0236 0.1213
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0357 0.0819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1387 0.2957
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0061 0.0061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0812 0.0812
Plasmodium falciparum serine repeat antigen 7 0.0024 0.0236 0.0591
Schistosoma mansoni hypothetical protein 0.0171 0.339 0.339
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0236 0.0448
Giardia lamblia Cathepsin B precursor 0.0024 0.0236 0.1213
Giardia lamblia Cathepsin B precursor 0.0024 0.0236 0.1213
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0024 0.0236 0.0448
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0212 0.0398
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.1387 0.1387
Entamoeba histolytica cysteine protease, putative 0.0024 0.0236 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0236 0.0448
Loa Loa (eye worm) hypothetical protein 0.0078 0.1387 0.1793
Schistosoma mansoni cathepsin S (C01 family) 0.0024 0.0236 0.0236
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.102 0.3054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.2171 0.4668
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0166 0.0166
Giardia lamblia Hypothetical protein 0.0024 0.0236 0.1213
Schistosoma mansoni ran 0.0021 0.0166 0.0166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.2171 0.4668
Giardia lamblia Cathepsin B precursor 0.0024 0.0236 0.1213
Toxoplasma gondii cathepsin CPC1 0.0024 0.0236 0.0534
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0115 0.2171 1
Giardia lamblia Cathepsin B precursor 0.0065 0.1116 1
Echinococcus granulosus cathepsin l1 0.0078 0.1387 0.1387
Giardia lamblia Cathepsin B precursor 0.0065 0.1116 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0024 0.0236 0.0591
Plasmodium falciparum serine repeat antigen 5 0.0024 0.0236 0.0591
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0129 0.0215
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.033 0.1048
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Entamoeba histolytica cysteine protease, putative 0.0061 0.102 0.1216
Giardia lamblia Cysteine protease 0.0024 0.0236 0.1213
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0166 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.102 0.4405
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.102 0.1216
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0024 0.0236 0.0591
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0114 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0147 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0236 0.0448
Onchocerca volvulus Cathepsin L homolog 0.0115 0.2171 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.2171 0.4668
Onchocerca volvulus 0.0115 0.2171 1
Brugia malayi Inositol-1 0.0043 0.0639 0.0799
Loa Loa (eye worm) hypothetical protein 0.0085 0.1533 0.1987
Entamoeba histolytica cysteine protease, putative 0.0024 0.0236 0.0163
Echinococcus multilocularis snurportin 1 0.0308 0.6331 0.6331

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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