TDR Targets

Basic information

Technical information

TDR Targets ID: 1476616
Name: 1-[bis(4-chlorophenyl)methoxy]-3-(3,4-dihydro -1H-isoquinolin-2-yl)propan-2-ol
MW: 442.378 | Formula: C25H25Cl2NO2
H donors: 1 H acceptors: 1 LogP: 5.47 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(CN1CCc2c(C1)cccc2)COC(c1ccc(cc1)Cl)c1ccc(cc1)Cl
InChi: 1S/C25H25Cl2NO2/c26-22-9-5-19(6-10-22)25(20-7-11-23(27)12-8-20)30-17-24(29)16-28-14-13-18-3-1-2-4-21(18)15-28/h1-12,24-25,29H,13-17H2
InChiKey: XIRMZNKBAGVWMK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0059	0.015
Schistosoma mansoni	hypothetical protein	0.0293	0.1257	0.322
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0069	0.0178
Brugia malayi	Pax transcription factor protein 2	0.0245	0.1021	0.262
Echinococcus granulosus	lactate dehydrogenase a	0.0832	0.3897	0.9982
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0059	0.015
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0312	0.135	0.3465
Leishmania major	malate dehydrogenase, putative	0.0832	0.3897	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0069	0.0178
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0128	0.045	0.1152
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.0313	0.0802
Onchocerca volvulus		0.0182	0.0717	0.7021
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Echinococcus multilocularis	protein patched	0.0043	0.0034	0.0086
Echinococcus granulosus	L lactate dehydrogenase B chain	0.0832	0.3897	0.9982
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.135	0.9599
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0824	0.3859	0.9884
Echinococcus multilocularis	Niemann Pick C1 protein	0.0143	0.0523	0.1341
Treponema pallidum	replicative DNA helicase (dnaB)	0.0467	0.2108	0.5
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0125	0.0322
Echinococcus granulosus	lactate dehydrogenase protein	0.0832	0.3897	0.9982
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.011	0.036	0.0925
Echinococcus granulosus	tumor protein p63	0.0343	0.1505	0.3855
Trypanosoma brucei	malate dehydrogenase-related	0.0323	0.1407	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0025	0.0064
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Echinococcus multilocularis	lactate dehydrogenase a	0.0832	0.3897	0.9982
Schistosoma mansoni	hypothetical protein	0.0041	0.0026	0.0066
Brugia malayi	CHE-14 protein	0.0043	0.0034	0.0086
Schistosoma mansoni	hypothetical protein	0.0041	0.0026	0.0066
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.3904	1
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Mycobacterium tuberculosis	RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].	0.1612	0.7715	0.7715
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0034	0.0086
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.011	0.036	0.036
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0323	0.1407	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0717	0.1839
Trichomonas vaginalis	malate dehydrogenase, putative	0.0158	0.0595	0.4227
Schistosoma mansoni	thyroid hormone receptor	0.015	0.056	0.1434
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0125	0.0321
Echinococcus multilocularis	geminin	0.0205	0.0825	0.2114
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0081	0.0207
Schistosoma mansoni	malate dehydrogenase	0.0832	0.3897	0.9982
Echinococcus granulosus	malate dehydrogenase	0.0323	0.1407	0.3604
Onchocerca volvulus	Huntingtin homolog	0.0125	0.0433	0.424
Schistosoma mansoni	hypothetical protein	0.0037	0.0002	0.0006
Onchocerca volvulus	Glucosylceramidase homolog	0.0205	0.0825	0.8083
Echinococcus granulosus	Niemann Pick C1 protein	0.0143	0.0523	0.1341
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.011	0.036	0.036
Trypanosoma brucei	trypanothione reductase	0.0048	0.0059	0.0416
Echinococcus multilocularis	L lactate dehydrogenase	0.0509	0.2314	0.5926
Loa Loa (eye worm)	pax transcription factor protein 2	0.0245	0.1021	0.262
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.135	0.9599
Plasmodium falciparum	L-lactate dehydrogenase	0.0832	0.3897	1
Trichomonas vaginalis	malate dehydrogenase, putative	0.0158	0.0595	0.4227
Leishmania major	glycosomal malate dehydrogenase	0.0323	0.1407	0.361
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0317	0.0813
Echinococcus multilocularis	expressed conserved protein	0.0094	0.0284	0.0726
Brugia malayi	Probable malate dehydrogenase, mitochondrial precursor	0.0323	0.1407	0.361
Schistosoma mansoni	L-lactate dehydrogenase	0.0323	0.1407	0.3604
Leishmania major	trypanothione reductase	0.0048	0.0059	0.015
Echinococcus granulosus	neuropeptide s receptor	0.0566	0.2596	0.6648
Onchocerca volvulus	Huntingtin homolog	0.0125	0.0433	0.424
Entamoeba histolytica	malate dehydrogenase, putative	0.0323	0.1407	0.3606
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.011	0.036	0.1278
Brugia malayi	Malate dehydrogenase, cytoplasmic	0.0323	0.1407	0.361
Trypanosoma brucei	glycosomal malate dehydrogenase	0.0323	0.1407	1
Echinococcus granulosus	cytosolic malate dehydrogenase	0.0323	0.1407	0.3604
Toxoplasma gondii	lactate dehydrogenase LDH1	0.0832	0.3897	1
Toxoplasma gondii	malate dehydrogenase MDH	0.0832	0.3897	1
Mycobacterium leprae	PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase	0.0467	0.2108	0.7483
Brugia malayi	lactate dehydrogenase.	0.0832	0.3897	1
Echinococcus multilocularis	X box binding protein 1	0.0293	0.1257	0.322
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0122	0.042	0.149
Leishmania major	cytosolic malate dehydrogenase	0.0323	0.1407	0.361
Schistosoma mansoni	thyroid hormone receptor	0.015	0.056	0.1434
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.011	0.036	0.036
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0034	0.0086
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0825	0.5866
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Schistosoma mansoni	patched 1	0.0043	0.0034	0.0086
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0125	0.0125
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0059	0.0059
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0125	0.0595
Schistosoma mansoni	Replicative DNA helicase	0.0467	0.2108	0.5401
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0433	0.1111
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0034	0.0086
Schistosoma mansoni	hypothetical protein	0.0041	0.0026	0.0066
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0125	0.0321
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0231	0.0953	0.0953
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0059	0.015
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0125	0.0595
Echinococcus multilocularis	transcription factor eb	0.011	0.036	0.0923
Toxoplasma gondii	lactate dehydrogenase LDH2	0.0832	0.3897	1
Entamoeba histolytica	heat shock transcription factor, putative	0.0101	0.0317	0.0807
Leishmania major	malate dehydrogenase, putative	0.0323	0.1407	0.361
Echinococcus granulosus	expressed conserved protein	0.0094	0.0284	0.0726
Schistosoma mansoni	malate dehydrogenase	0.0323	0.1407	0.3604
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0034	0.0238
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.011	0.036	0.036
Trypanosoma cruzi	malate dehydrogenase, putative	0.0323	0.1407	1
Schistosoma mansoni	hypothetical protein	0.0128	0.045	0.1152
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0122	0.042	0.042
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.0313	0.0804
Echinococcus granulosus	lactate dehydrogenase a	0.0832	0.3897	0.9982
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0034	0.0086
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0118	0.0303
Leishmania major	malate dehydrogenase	0.0323	0.1407	0.361
Brugia malayi	hypothetical protein	0.0125	0.0433	0.1111
Echinococcus multilocularis	tumor protein p63	0.0343	0.1505	0.3855
Plasmodium falciparum	malate dehydrogenase	0.0832	0.3897	1
Plasmodium falciparum	lactate dehydrogenase, putative	0.0323	0.1407	0.3512
Entamoeba histolytica	malate dehydrogenase, putative	0.0832	0.3897	1
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0323	0.1407	1
Giardia lamblia	Malate dehydrogenase	0.0323	0.1407	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.135	0.9599
Plasmodium vivax	lactate dehydrogenase	0.0832	0.3897	1
Loa Loa (eye worm)	twinkle helicase	0.0133	0.0476	0.1222
Echinococcus granulosus	cytosolic malate dehydrogenase	0.0323	0.1407	0.3604
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0118	0.0303
Mycobacterium tuberculosis	Probable reductase	0.011	0.036	0.036
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.0879	0.625
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0125	0.0322
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0125	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0832	0.3897	1
Echinococcus granulosus	X box binding protein 1	0.0293	0.1257	0.322
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0059	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0358	0.0918
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.135	0.9599
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0118	0.0303
Mycobacterium tuberculosis	Probable malate dehydrogenase Mdh	0.0323	0.1407	0.1407
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.0313	0.0802
Brugia malayi	HSF-type DNA-binding domain containing protein	0.0101	0.0317	0.0813
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0323	0.1407	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.0879	0.625
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.135	0.9599
Brugia malayi	hypothetical protein	0.0182	0.0717	0.1839
Echinococcus multilocularis	thyroid hormone receptor alpha	0.015	0.056	0.1434
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0825	0.5866
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Echinococcus multilocularis	lactate dehydrogenase protein	0.0832	0.3897	0.9982
Schistosoma mansoni	hypothetical protein	0.0205	0.0825	0.2114
Mycobacterium leprae	PROBABLE MALATE DEHYDROGENASE MDH	0.0323	0.1407	0.4993
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.3904	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.135	0.9599
Trypanosoma cruzi	mitochondrial malate dehydrogenase, putative	0.0323	0.1407	1
Chlamydia trachomatis	replicative DNA helicase	0.0467	0.2108	1
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0323	0.1407	1
Brugia malayi	hypothetical protein	0.0037	0.0002	0.0006
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0825	0.5866
Loa Loa (eye worm)	hypothetical protein	0.006	0.0118	0.0303
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0059	0.015
Trypanosoma cruzi	malate dehydrogenase, putative	0.0323	0.1407	1
Leishmania major	mitochondrial malate dehydrogenase	0.0323	0.1407	0.361
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0323	0.1407	1
Schistosoma mansoni	hypothetical protein	0.0205	0.0825	0.2114
Echinococcus multilocularis	lactate dehydrogenase a	0.0832	0.3897	0.9982
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0323	0.1407	1
Echinococcus granulosus	L lactate dehydrogenase	0.0509	0.2314	0.5926
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0025	0.0064
Mycobacterium tuberculosis	Probable oxidoreductase	0.0122	0.042	0.042
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0125	0.0321
Trypanosoma brucei	cytosolic malate dehydrogenase	0.0323	0.1407	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.0313	0.0804
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0002	0.0006
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.0313	0.0798
Schistosoma mansoni	L-lactate dehydrogenase	0.0832	0.3897	0.9982
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0825	0.5866
Entamoeba histolytica	malate dehydrogenase,cytoplasmic, putative	0.0323	0.1407	0.3606
Plasmodium vivax	lactate/malate dehydrogenase, putative	0.0323	0.1407	0.361
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0825	0.5866
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0002	0.0006
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0063	0.0162
Echinococcus multilocularis	cytosolic malate dehydrogenase	0.0323	0.1407	0.3604
Schistosoma mansoni	malate dehydrogenase	0.0323	0.1407	0.3604
Trypanosoma brucei	mitochondrial malate dehydrogenase	0.0323	0.1407	1
Wolbachia endosymbiont of Brugia malayi	malate dehydrogenase	0.0832	0.3897	1
Echinococcus multilocularis	L lactate dehydrogenase B chain	0.0832	0.3897	0.9982
Echinococcus multilocularis	neuropeptide s receptor	0.0566	0.2596	0.6648
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0433	0.1111
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0323	0.1407	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0034	0.0086
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0312	0.135	0.3465
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Entamoeba histolytica	heat shock transcription factor, putative	0.0101	0.0317	0.0807
Echinococcus granulosus	geminin	0.0205	0.0825	0.2114
Echinococcus multilocularis	malate dehydrogenase	0.0323	0.1407	0.3604
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0122	0.042	0.042
Onchocerca volvulus		0.0245	0.1021	1
Trichomonas vaginalis	malate dehydrogenase, putative	0.0323	0.1407	1
Echinococcus granulosus	malate dehydrogenase	0.0323	0.1407	0.3604
Entamoeba histolytica	heat shock transcription factor, putative	0.0101	0.0317	0.0807
Onchocerca volvulus	Heat shock factor protein 2 homolog	0.0101	0.0317	0.3102
Echinococcus granulosus	transcription factor eb	0.011	0.036	0.0923
Mycobacterium leprae	Conserved hypothetical protein	0.0612	0.2818	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0059	0.015
Mycobacterium ulcerans	malate dehydrogenase	0.0323	0.1407	0.6672
Loa Loa (eye worm)	malate dehydrogenase	0.0323	0.1407	0.361
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0059	0.015
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0825	0.5866
Mycobacterium tuberculosis	Probable dehydrogenase	0.011	0.036	0.036
Schistosoma mansoni	hypothetical protein	0.0041	0.0026	0.0066
Onchocerca volvulus		0.005	0.0069	0.0679
Echinococcus multilocularis	malate dehydrogenase	0.0323	0.1407	0.3604
Echinococcus multilocularis	lactate dehydrogenase a	0.0832	0.3897	0.9982
Schistosoma mansoni	hypothetical protein	0.0041	0.0025	0.0063
Echinococcus multilocularis	cytosolic malate dehydrogenase	0.0323	0.1407	0.3604
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0125	0.0321
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0825	0.5866
Brugia malayi	Thioredoxin reductase	0.0048	0.0059	0.015
Echinococcus multilocularis	neuropeptide receptor A26	0.0566	0.2596	0.6648
Loa Loa (eye worm)	malate dehydrogenase	0.0323	0.1407	0.361
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0109	0.0358	0.0918
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0102	0.0321	0.0822
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0323	0.1407	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0128	0.045	0.1152
Plasmodium vivax	malate dehydrogenase, putative	0.0832	0.3897	1
Brugia malayi	glutathione reductase	0.0048	0.0059	0.015
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.3904	1
Echinococcus granulosus	neuropeptide receptor A26	0.0566	0.2596	0.6648
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0002	0.0006
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0059	0.015
Mycobacterium ulcerans	replicative DNA helicase DnaB	0.0467	0.2108	1
Schistosoma mansoni	malate dehydrogenase	0.0323	0.1407	0.3604

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1619397

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1476616