TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.529 | Formula: C25H28N6O
H donors: 1 H acceptors: 3 LogP: 3.99 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)CN1C(=O)C(C)Nc2c1c(ncn2)N1CCN(CC1)c1ccccc1
InChi: 1S/C25H28N6O/c1-18-8-10-20(11-9-18)16-31-22-23(28-19(2)25(31)32)26-17-27-24(22)30-14-12-29(13-15-30)21-6-4-3-5-7-21/h3-11,17,19H,12-16H2,1-2H3,(H,26,27,28)
InChiKey: ULQZHSAABXMSBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0164	0.1301	0.1298
Echinococcus granulosus	lysine specific demethylase 5A	0.0081	0.0567	0.0562
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0017	0.0006	0.00000016246
Mycobacterium tuberculosis	Probable reductase	0.0224	0.1839	0.8837
Mycobacterium tuberculosis	Probable dehydrogenase	0.0224	0.1839	0.8837
Giardia lamblia	PHD finger protein 15	0.0067	0.0443	1
Schistosoma mansoni	lamin	0.0031	0.0126	0.0121
Schistosoma mansoni	phd/f-box containing protein	0.0021	0.0044	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0866	0.7517	0.8259
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0101	0.0751	0.0746
Echinococcus multilocularis	Ankyrin	0.0017	0.0007	0.0001
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0047	0.0025
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0164	0.1301	0.143
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0156	0.1155
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0034	0.0156	0.5
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0218	0.1783	0.1781
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0156	0.2083
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0034	0.0156	0.015
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0022	0.0047	0.0034
Echinococcus granulosus	intermediate filament protein	0.0031	0.0126	0.0121
Onchocerca volvulus		0.0054	0.0334	0.0236
Plasmodium falciparum	thioredoxin reductase	0.0098	0.0724	0.9623
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0156	0.1155
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0027	0.0089	0.0083
Schistosoma mansoni	hypothetical protein	0.0022	0.0047	0.0041
Loa Loa (eye worm)	glutathione reductase	0.0098	0.0724	0.0795
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0156	0.2083
Brugia malayi	Neurabin protein 1	0.0101	0.0751	0.076
Brugia malayi	Pre-SET motif family protein	0.0129	0.0997	0.101
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0101	0.0751	0.0825
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0017	0.0006	0.00000016246
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0129	0.0997	0.0993
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0156	0.1155
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0101	0.0751	0.0835
Trypanosoma brucei	trypanothione reductase	0.0098	0.0724	0.5544
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0751	0.0825
Leishmania major	trypanothione reductase	0.0098	0.0724	1
Brugia malayi	jmjC domain containing protein	0.0021	0.0044	0.0045
Onchocerca volvulus		0.0101	0.0751	0.0707
Echinococcus multilocularis	lamin	0.0031	0.0126	0.0121
Entamoeba histolytica	zinc finger protein, putative	0.0164	0.1301	0.5
Schistosoma mansoni	lamin	0.0031	0.0126	0.0121
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0021	0.0044	0.0038
Brugia malayi	jmjC domain containing protein	0.0081	0.0567	0.0574
Schistosoma mansoni	sarm1	0.0101	0.0751	0.0745
Schistosoma mansoni	jumonji domain containing protein	0.0021	0.0044	0.0038
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0129	0.0997	0.0992
Schistosoma mansoni	phosphatidylserine receptor	0.0021	0.0044	0.0038
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0098	0.0724	0.2985
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0034	0.0156	0.1168
Plasmodium vivax	glutathione reductase, putative	0.0098	0.0724	0.7134
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0034	0.0156	0.015
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0034	0.0156	0.0886
Echinococcus multilocularis	lysine specific demethylase 5A	0.0081	0.0567	0.0562
Trypanosoma cruzi	trypanothione reductase, putative	0.0098	0.0724	0.5544
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0025	0.0076	0.0076
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0129	0.0997	0.0992
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0218	0.1783	0.1781
Trichomonas vaginalis	conserved hypothetical protein	0.0164	0.1301	0.1452
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0129	0.0997	0.0992
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0021	0.0044	0.0295
Brugia malayi	PHD-finger family protein	0.0022	0.0047	0.0047
Trichomonas vaginalis	ankyrin, putative	0.0017	0.0006	0.00000016246
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0224	0.1839	0.8837
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.0006	0.00000016246
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0034	0.0156	0.5
Echinococcus granulosus	tankyrase	0.1145	0.9986	1
Onchocerca volvulus	Alhambra homolog	0.0067	0.0443	0.0359
Echinococcus granulosus	SAM domain containing protein	0.0101	0.0751	0.0746
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0034	0.0156	0.2083
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0156	0.1155
Schistosoma mansoni	hypothetical protein	0.0067	0.0443	0.0437
Echinococcus granulosus	stromal interaction molecule 1	0.0101	0.0751	0.0746
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0021	0.0044	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.0751	0.0835
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0017	0.0006	0.00000016246
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0126	0.0139
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0164	0.1301	1
Echinococcus multilocularis	lamin dm0	0.0031	0.0126	0.0121
Plasmodium falciparum	phd finger protein, putative	0.0067	0.0443	0.5647
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0047	0.0051
Echinococcus granulosus	liprin beta 1	0.0101	0.0751	0.0746
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0022	0.0047	0.0314
Trypanosoma cruzi	trypanothione reductase, putative	0.0034	0.0156	0.1155
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0019	0.0024	0.002
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0101	0.0751	0.0746
Entamoeba histolytica	hypothetical protein	0.0164	0.1301	0.5
Brugia malayi	hypothetical protein	0.0101	0.0751	0.076
Brugia malayi	intermediate filament protein	0.0031	0.0126	0.0128
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0156	0.1155
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0164	0.1301	0.1296
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0099	0.0729	0.0725
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0164	0.1301	0.1298
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0034	0.0156	0.0157
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.0006	0.00000016246
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0034	0.0156	0.015
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0022	0.0047	0.0019
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0021	0.0044	0.0295
Onchocerca volvulus		0.0101	0.0751	0.0707
Brugia malayi	hypothetical protein	0.0101	0.0751	0.076
Loa Loa (eye worm)	PHD-finger family protein	0.0067	0.0443	0.0487
Schistosoma mansoni	hypothetical protein	0.0101	0.0751	0.0745
Toxoplasma gondii	NADPH-glutathione reductase	0.0034	0.0156	0.0886
Plasmodium falciparum	glutathione reductase	0.0034	0.0156	0.1576
Treponema pallidum	NADH oxidase	0.0034	0.0156	0.5
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0126	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0164	0.1301	0.143
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0044	0.0049
Echinococcus granulosus	Sterile alpha motif SAM	0.0101	0.0751	0.0746
Mycobacterium tuberculosis	Probable oxidoreductase	0.0249	0.206	1
Schistosoma mansoni	jumonji domain containing protein	0.0173	0.1387	0.1382
Echinococcus granulosus	liprin alpha 2	0.0101	0.0751	0.0746
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0164	0.1301	0.1296
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0101	0.0751	0.7413
Onchocerca volvulus		0.0129	0.0997	0.0987
Trichomonas vaginalis	multiple ankyrin repeats single kh domain protein, putative	0.0017	0.0006	0.00000016246
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0034	0.0156	0.1168
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0126	0.0139
Echinococcus multilocularis	tumor protein p63	0.0371	0.3136	0.3137
Schistosoma mansoni	hypothetical protein	0.0101	0.0751	0.0745
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0156	0.1155
Brugia malayi	WGR domain containing protein	0.0164	0.1301	0.1317
Trichomonas vaginalis	glutathione reductase, putative	0.0034	0.0156	0.0168
Echinococcus multilocularis	jumonji domain containing protein	0.0093	0.0674	0.0669
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0249	0.206	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0034	0.0156	0.1155
Echinococcus granulosus	tumor protein p63	0.0371	0.3136	0.3137
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0081	0.0567	0.0561
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.0007	0.0002
Brugia malayi	jmjC domain containing protein	0.0021	0.0044	0.0045
Schistosoma mansoni	cellular tumor antigen P53	0.0054	0.0334	0.0329
Echinococcus granulosus	thioredoxin glutathione reductase	0.0099	0.0729	0.0725
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.0156	0.1155
Toxoplasma gondii	PHD-finger domain-containing protein	0.0067	0.0443	0.3174
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0156	0.5
Plasmodium falciparum	glutathione reductase	0.0098	0.0724	0.9623
Brugia malayi	coiled-coil like protein 1	0.0101	0.0751	0.076
Entamoeba histolytica	hypothetical protein	0.0164	0.1301	0.5
Brugia malayi	Patatin-like phospholipase family protein	0.0017	0.0006	0.0006
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0101	0.0751	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0751	0.0825
Trichomonas vaginalis	mercuric reductase, putative	0.0034	0.0156	0.0168
Echinococcus multilocularis	phd:f box containing protein	0.0021	0.0044	0.0038
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0034	0.0156	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.0006	0.00000016246
Trichomonas vaginalis	conserved hypothetical protein	0.0164	0.1301	0.1452
Echinococcus granulosus	lysine specific demethylase 6a	0.0021	0.0044	0.0038
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0017	0.0006	0.00000016246
Plasmodium falciparum	thioredoxin reductase	0.0034	0.0156	0.1576
Echinococcus multilocularis	musashi	0.0031	0.0126	0.0121
Echinococcus granulosus	JmjC domain containing protein 4	0.0021	0.0044	0.0038
Brugia malayi	Thioredoxin reductase	0.0098	0.0724	0.0733
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0156	0.1155
Toxoplasma gondii	thioredoxin reductase	0.0098	0.0724	0.5408
Toxoplasma gondii	PHD-finger domain-containing protein	0.0022	0.0047	0.0019
Trichomonas vaginalis	ankyrin, putative	0.0017	0.0007	0.0002
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0017	0.0006	0.00000016246
Echinococcus granulosus	lamin	0.0031	0.0126	0.0121
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.0006	0.00000016246
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0018	0.001	0.0004
Brugia malayi	Pre-SET motif family protein	0.0901	0.7824	0.7921
Echinococcus multilocularis	tankyrase	0.1145	0.9986	1
Echinococcus granulosus	Ankyrin	0.0017	0.0006	0.00000014519
Echinococcus granulosus	histone lysine methyltransferase setb	0.0129	0.0997	0.0993
Loa Loa (eye worm)	tnks protein	0.1045	0.9102	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0156	0.5
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0249	0.206	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0081	0.0567	0.0623
Brugia malayi	jmjC domain containing protein	0.0021	0.0044	0.0045
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0901	0.7824	0.8596
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0101	0.0751	0.5621
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0044	0.0049
Echinococcus granulosus	phd:f box containing protein	0.0021	0.0044	0.0038
Onchocerca volvulus	Tankyrase homolog	0.1028	0.895	1
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0164	0.1301	1
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0164	0.1301	0.1298
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.0751	0.0835
Brugia malayi	Tnks protein	0.1133	0.9877	1
Brugia malayi	jmjC domain containing protein	0.0218	0.1783	0.1805
Trichomonas vaginalis	conserved hypothetical protein	0.0164	0.1301	0.1452
Entamoeba histolytica	hypothetical protein	0.0164	0.1301	0.5
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0034	0.0156	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0164	0.1301	0.1452
Trichomonas vaginalis	conserved hypothetical protein	0.0164	0.1301	0.1452
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0034	0.0156	0.1155
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0021	0.0044	0.0038
Echinococcus multilocularis	liprin beta 1	0.0101	0.0751	0.0746
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0034	0.0156	0.1576
Loa Loa (eye worm)	jmjC domain-containing protein	0.0021	0.0044	0.0049
Echinococcus multilocularis	lysine specific demethylase 6a	0.0021	0.0044	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0164	0.1301	0.1452
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0017	0.0006	0.00000016246
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0101	0.0751	0.076
Echinococcus multilocularis	JmjC domain containing protein 4	0.0021	0.0044	0.0038
Echinococcus granulosus	PHD finger protein rhinoceros	0.0067	0.0443	0.0438
Schistosoma mansoni	protein phosphatase 2C	0.0021	0.0044	0.0038
Onchocerca volvulus		0.1027	0.8939	0.9988
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0129	0.0997	0.0993
Plasmodium vivax	SET domain protein, putative	0.0129	0.0997	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0137	0.107	0.1176
Plasmodium vivax	thioredoxin reductase, putative	0.0098	0.0724	0.7134
Trichomonas vaginalis	conserved hypothetical protein	0.0164	0.1301	0.1452
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0017	0.0008	0.0002
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0156	0.1155
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0334	0.0367
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0224	0.1839	0.8837
Brugia malayi	AF-10 protein	0.0022	0.0047	0.0047
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0129	0.0997	0.7582
Brugia malayi	WGR domain containing protein	0.0164	0.1301	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0997	0.1096
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0224	0.1839	0.8837
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0164	0.1301	0.5
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0067	0.0443	0.0438
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0022	0.0047	0.0314
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0129	0.0997	0.0992
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.0006	0.00000016246
Entamoeba histolytica	hypothetical protein	0.0164	0.1301	0.5
Brugia malayi	Liprin-alpha 2	0.0101	0.0751	0.076
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0751	0.0825
Echinococcus multilocularis	stromal interaction molecule 1	0.0101	0.0751	0.0746
Toxoplasma gondii	PHD-finger domain-containing protein	0.0067	0.0443	0.3174
Brugia malayi	jmjC domain containing protein	0.0021	0.0044	0.0045
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0164	0.1301	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0034	0.0156	0.1576
Echinococcus multilocularis	jumonji domain containing 1A	0.0021	0.0044	0.0038
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0224	0.1839	0.8837
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0126	0.0139
Brugia malayi	F/Y-rich N-terminus family protein	0.0027	0.0089	0.009
Trichomonas vaginalis	set domain proteins, putative	0.1025	0.8925	1
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0164	0.1301	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0864	0.0949
Leishmania major	hypothetical protein, conserved	0.0021	0.0044	0.0532
Trichomonas vaginalis	conserved hypothetical protein	0.0164	0.1301	0.1452
Loa Loa (eye worm)	jmjC domain-containing protein	0.0021	0.0044	0.0049
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.0006	0.00000016246
Brugia malayi	Bromodomain containing protein	0.0067	0.0443	0.0449
Plasmodium falciparum	tyrosine kinase-like protein	0.0101	0.0751	1
Echinococcus granulosus	peregrin	0.0067	0.0443	0.0438
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0034	0.0156	0.2083
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0249	0.206	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0081	0.0567	0.0561
Echinococcus granulosus	poly adp ribose polymerase 2	0.0164	0.1301	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0751	0.0825
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0017	0.0006	0.00000016246
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0034	0.0156	0.3421
Echinococcus multilocularis	peregrin	0.0067	0.0443	0.0438
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0124	0.0955	0.0951
Echinococcus granulosus	jumonji domain containing protein	0.0093	0.0674	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0007	0.0008
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0021	0.0044	0.0295
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.0156	0.1155
Brugia malayi	PHD-finger family protein	0.0067	0.0443	0.0449
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0126	0.0128
Plasmodium vivax	hypothetical protein, conserved	0.0067	0.0443	0.4186
Schistosoma mansoni	hypothetical protein	0.0101	0.0751	0.0745
Loa Loa (eye worm)	thioredoxin reductase	0.0098	0.0724	0.0795
Loa Loa (eye worm)	hypothetical protein	0.003	0.0122	0.0133
Schistosoma mansoni	hypothetical protein	0.0101	0.0751	0.0745
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.0751	0.0835
Loa Loa (eye worm)	jmjC domain-containing protein	0.0021	0.0044	0.0049
Echinococcus multilocularis	SAM domain containing protein	0.0101	0.0751	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0751	0.0825
Echinococcus multilocularis	liprin alpha 2	0.0101	0.0751	0.0746
Echinococcus granulosus	jumonji domain containing 1A	0.0021	0.0044	0.0038
Plasmodium falciparum	protein kinase, putative	0.0101	0.0751	1
Brugia malayi	glutathione reductase	0.0098	0.0724	0.0733
Echinococcus granulosus	lamin dm0	0.0031	0.0126	0.0121
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0164	0.1301	1
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.0751	0.0835
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0025	0.0076	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0164	0.1301	0.1452
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0101	0.0751	0.0745
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0067	0.0443	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0443	0.0487

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1617349

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1478979