Detailed information for compound 1478983

Basic information

Technical information
  • TDR Targets ID: 1478983
  • Name: 1-(4-cyclopentylpiperazin-1-yl)-2-(phenoxy)et hanone
  • MW: 288.385 | Formula: C17H24N2O2
  • H donors: 0 H acceptors: 1 LogP: 2.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)C1CCCC1)COc1ccccc1
  • InChi: 1S/C17H24N2O2/c20-17(14-21-16-8-2-1-3-9-16)19-12-10-18(11-13-19)15-6-4-5-7-15/h1-3,8-9,15H,4-7,10-14H2
  • InChiKey: TXRXTOWGZZQOCS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-cyclopentyl-1-piperazinyl)-2-(phenoxy)ethanone
  • Oprea1_181216
  • BAS 04057428
  • STK146775

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0093 0.0745 0.0817
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0773 0.0848
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0053
Brugia malayi jmjC domain containing protein 0.0021 0.005 0.0051
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.0474 0.3401
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0169 0.1301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0169 0.1301
Trichomonas vaginalis multiple ankyrin repeats single kh domain protein, putative 0.0016 0.00000013679 0.00000018554
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0169 0.5
Echinococcus multilocularis musashi 0.003 0.014 0.014
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.015 0.1296 0.1298
Plasmodium falciparum tyrosine kinase-like protein 0.0093 0.0745 0.9614
Onchocerca volvulus 0.0093 0.0745 0.0687
Entamoeba histolytica hypothetical protein 0.015 0.1296 0.5
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0773 0.5966
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0169 0.0229
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0018 0.0019 0.0026
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.015 0.1296 1
Echinococcus granulosus intermediate filament protein 0.003 0.014 0.014
Brugia malayi intermediate filament protein 0.003 0.014 0.0142
Entamoeba histolytica zinc finger protein, putative 0.015 0.1296 0.5
Echinococcus multilocularis lysine specific demethylase 6a 0.0021 0.005 0.005
Plasmodium falciparum glutathione reductase 0.0096 0.0773 1
Echinococcus granulosus phd:f box containing protein 0.0021 0.005 0.005
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0474 0.5677
Loa Loa (eye worm) hypothetical protein 0.0065 0.0474 0.0519
Trichomonas vaginalis ankyrin, putative 0.0016 0.00000013679 0.00000018554
Loa Loa (eye worm) hypothetical protein 0.0093 0.0745 0.0817
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0745 0.1011
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0169 0.1301
Echinococcus multilocularis peregrin 0.0065 0.0474 0.0474
Plasmodium falciparum glutathione reductase 0.0033 0.0169 0.164
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0779 0.078
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0169 0.1301
Schistosoma mansoni hypothetical protein 0.0065 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.015 0.1296 0.1423
Echinococcus multilocularis liprin alpha 2 0.0093 0.0745 0.0746
Plasmodium vivax tyrosine kinase-like protein, putative 0.0093 0.0745 0.9315
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0363 0.0363
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0053 0.0034
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0005 0.0006
Echinococcus multilocularis tumor protein p63 0.0364 0.3367 0.3372
Echinococcus granulosus lysine specific demethylase 5A 0.0078 0.0605 0.0606
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0169 0.164
Brugia malayi coiled-coil like protein 1 0.0093 0.0745 0.0754
Trichomonas vaginalis conserved hypothetical protein 0.015 0.1296 0.1758
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0169 0.5
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0169 0.0171
Echinococcus granulosus jumonji domain containing protein 0.009 0.0719 0.072
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0243 0.2194 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0169 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0745 0.1011
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.00000013679 0.00000018554
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0098 0.0796 0.0797
Echinococcus granulosus tumor protein p63 0.0364 0.3367 0.3372
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.014 0.0152
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0169 0.2181
Echinococcus multilocularis liprin beta 1 0.0093 0.0745 0.0746
Schistosoma mansoni jumonji domain containing protein 0.0169 0.1476 0.1476
Mycobacterium tuberculosis Probable oxidoreductase 0.0243 0.2194 1
Schistosoma mansoni hypothetical protein 0.0093 0.0745 0.0745
Trichomonas vaginalis conserved hypothetical protein 0.015 0.1296 0.1758
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0093 0.0745 0.1011
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.015 0.1296 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0169 0.2181
Loa Loa (eye worm) hypothetical protein 0.003 0.014 0.0152
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0169 0.1301
Brugia malayi jmjC domain containing protein 0.0021 0.005 0.0051
Plasmodium falciparum thioredoxin reductase 0.0033 0.0169 0.164
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0745 0.1011
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0016 0.00000013679 0.00000018554
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0093 0.0745 0.0746
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0095 0.0761 0.0763
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0169 0.5
Plasmodium vivax SET domain protein, putative 0.0098 0.0796 1
Brugia malayi Pre-SET motif family protein 0.0098 0.0796 0.0806
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0093 0.0745 0.0817
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0169 0.5
Schistosoma mansoni phosphatidylserine receptor 0.0021 0.005 0.005
Brugia malayi hypothetical protein 0.0093 0.0745 0.0754
Brugia malayi Neurabin protein 1 0.0093 0.0745 0.0754
Loa Loa (eye worm) hypothetical protein 0.0053 0.0363 0.0397
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.0087 0.0088
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0169 0.5
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0169 0.1301
Echinococcus granulosus lamin dm0 0.003 0.014 0.014
Schistosoma mansoni phd/f-box containing protein 0.0021 0.005 0.005
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0093 0.0745 0.0746
Echinococcus multilocularis Ankyrin 0.0016 0.0001 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0169 0.1301
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0212 0.1897 0.19
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0169 0.0952
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0169 0.0952
Entamoeba histolytica hypothetical protein 0.015 0.1296 0.5
Echinococcus multilocularis jumonji domain containing 1A 0.0021 0.005 0.005
Mycobacterium tuberculosis Probable dehydrogenase 0.0218 0.1958 0.8837
Leishmania major hypothetical protein, conserved 0.0021 0.005 0.0646
Brugia malayi Pre-SET motif family protein 0.0684 0.6459 0.6539
Echinococcus multilocularis lamin 0.003 0.014 0.014
Echinococcus granulosus PHD finger protein rhinoceros 0.0065 0.0474 0.0474
Loa Loa (eye worm) jmjC domain-containing protein 0.0078 0.0605 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.015 0.1296 0.1758
Mycobacterium tuberculosis Probable reductase 0.0218 0.1958 0.8837
Trichomonas vaginalis unc-44 ankyrins, putative 0.0016 0.00000013679 0.00000018554
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0218 0.1958 0.8837
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0016 0.00000013679 0.00000018554
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0056
Echinococcus multilocularis tankyrase 0.1049 0.9986 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0169 0.1301
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0016 0.00000013679 0.00000018554
Brugia malayi jmjC domain containing protein 0.0212 0.1897 0.1921
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0796 0.0796
Entamoeba histolytica hypothetical protein 0.015 0.1296 0.5
Echinococcus granulosus lysine specific demethylase 6a 0.0021 0.005 0.005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0083 0.0085
Echinococcus granulosus histone lysine methyltransferase setb 0.0098 0.0796 0.0797
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0169 0.1301
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0093 0.0745 0.0745
Echinococcus multilocularis lysine specific demethylase 5A 0.0078 0.0605 0.0606
Schistosoma mansoni hypothetical protein 0.0093 0.0745 0.0745
Brugia malayi jmjC domain containing protein 0.0078 0.0605 0.0613
Echinococcus multilocularis lamin dm0 0.003 0.014 0.014
Schistosoma mansoni protein phosphatase 2C 0.0021 0.005 0.005
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0169 0.0169
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0093 0.0745 0.5579
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0053 0.0405
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0098 0.0796 0.0797
Echinococcus multilocularis JmjC domain containing protein 4 0.0021 0.005 0.005
Loa Loa (eye worm) glutathione reductase 0.0096 0.0773 0.0848
Schistosoma mansoni lamin 0.003 0.014 0.014
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0773 0.9689
Trichomonas vaginalis conserved hypothetical protein 0.015 0.1296 0.1758
Brugia malayi glutathione reductase 0.0096 0.0773 0.0783
Schistosoma mansoni sarm1 0.0093 0.0745 0.0745
Echinococcus granulosus JmjC domain containing protein 4 0.0021 0.005 0.005
Schistosoma mansoni lip-related protein (liprin) alpha 0.0093 0.0745 0.0745
Brugia malayi PHD-finger family protein 0.0065 0.0474 0.048
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0169 0.5
Echinococcus granulosus Ankyrin 0.0016 0.00000013679 0.00000013699
Echinococcus multilocularis jumonji domain containing protein 0.009 0.0719 0.072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0796 0.0796
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.015 0.1296 0.1423
Loa Loa (eye worm) hypothetical protein 0.0093 0.0745 0.0817
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0169 0.3559
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0605 0.0605
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0243 0.2194 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0065 0.0474 0.0474
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0053 0.002
Brugia malayi WGR domain containing protein 0.015 0.1296 0.1312
Plasmodium vivax glutathione reductase, putative 0.0096 0.0773 0.9689
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0745 0.1011
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0065 0.0474 0.0474
Trichomonas vaginalis unc-44 ankyrins, putative 0.0016 0.00000013679 0.00000018554
Schistosoma mansoni poly [ADP-ribose] polymerase 0.015 0.1296 0.1296
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.005 0.0053
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.005 0.0386
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.015 0.1296 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0169 0.1301
Schistosoma mansoni jumonji domain containing protein 0.0021 0.005 0.005
Onchocerca volvulus 0.078 0.7387 0.8227
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0087 0.0087
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.014 0.0142
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0218 0.1958 0.8837
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.0474 0.3401
Echinococcus granulosus liprin beta 1 0.0093 0.0745 0.0746
Toxoplasma gondii thioredoxin reductase 0.0096 0.0773 0.5804
Echinococcus multilocularis SAM domain containing protein 0.0093 0.0745 0.0746
Echinococcus granulosus poly adp ribose polymerase 2 0.015 0.1296 0.1298
Trichomonas vaginalis ankyrin, putative 0.0016 0.0001 0.0002
Leishmania major trypanothione reductase 0.0096 0.0773 1
Trichomonas vaginalis conserved hypothetical protein 0.015 0.1296 0.1758
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0779 0.078
Trypanosoma brucei poly(adp-ribose) polymerase 0.015 0.1296 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0083 0.0085
Loa Loa (eye worm) PHD-finger family protein 0.0065 0.0474 0.0519
Brugia malayi Bromodomain containing protein 0.0065 0.0474 0.048
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0093 0.0745 0.0754
Loa Loa (eye worm) hypothetical protein 0.0093 0.0745 0.0817
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0146
Onchocerca volvulus 0.0093 0.0745 0.0687
Brugia malayi jmjC domain containing protein 0.0021 0.005 0.0051
Trypanosoma brucei trypanothione reductase 0.0096 0.0773 0.5966
Echinococcus granulosus SAM domain containing protein 0.0093 0.0745 0.0746
Echinococcus granulosus liprin alpha 2 0.0093 0.0745 0.0746
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.005 0.0053
Brugia malayi Thioredoxin reductase 0.0096 0.0773 0.0783
Schistosoma mansoni hypothetical protein 0.0093 0.0745 0.0745
Loa Loa (eye worm) intermediate filament protein 0.003 0.014 0.0152
Echinococcus granulosus peregrin 0.0065 0.0474 0.0474
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0773 0.2985
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0169 0.1301
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0021 0.0053 0.002
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.00000013679 0.00000018554
Schistosoma mansoni intermediate filament proteins 0.003 0.014 0.014
Onchocerca volvulus Alhambra homolog 0.0065 0.0474 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.015 0.1296 0.1758
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0212 0.1897 0.19
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.015 0.1296 1
Brugia malayi Tnks protein 0.1038 0.9878 1
Schistosoma mansoni poly [ADP-ribose] polymerase 0.015 0.1296 0.1296
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0169 0.1589
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0053 0.0035
Echinococcus granulosus Sterile alpha motif SAM 0.0093 0.0745 0.0746
Onchocerca volvulus Tankyrase homolog 0.0942 0.8949 1
Brugia malayi WGR domain containing protein 0.015 0.1296 0.1312
Trichomonas vaginalis conserved hypothetical protein 0.015 0.1296 0.1758
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0243 0.2194 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0169 0.1301
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0684 0.6459 0.7097
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0021 0.005 0.0386
Echinococcus granulosus stromal interaction molecule 1 0.0093 0.0745 0.0746
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0053 0.0405
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0605 0.0605
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.00000013679 0.00000018554
Schistosoma mansoni lamin 0.003 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.0873
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0016 0.0003 0.0004
Loa Loa (eye worm) tnks protein 0.0958 0.9101 1
Echinococcus granulosus tankyrase 0.1049 0.9986 1
Trichomonas vaginalis set domain proteins, putative 0.0779 0.7373 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.00000013679 0.00000018554
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.005 0.005
Brugia malayi hypothetical protein 0.0093 0.0745 0.0754
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0169 0.0229
Brugia malayi Liprin-alpha 2 0.0093 0.0745 0.0754
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0016 0.00000013679 0.00000018554
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0004 0.0005
Brugia malayi AF-10 protein 0.0021 0.0053 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0169 0.1301
Echinococcus granulosus lamin 0.003 0.014 0.014
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0001 0.0002
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0021 0.005 0.005
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0169 0.1589
Brugia malayi jmjC domain containing protein 0.0021 0.005 0.0051
Echinococcus granulosus poly ADP ribose polymerase 1 0.015 0.1296 0.1298
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.00000013679 0.00000018554
Plasmodium falciparum thioredoxin reductase 0.0096 0.0773 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0004 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0169 0.2181
Plasmodium falciparum protein kinase, putative 0.0093 0.0745 0.9614
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0218 0.1958 0.8837
Trichomonas vaginalis conserved hypothetical protein 0.015 0.1296 0.1758
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.005 0.0386
Plasmodium falciparum phd finger protein, putative 0.0065 0.0474 0.586
Onchocerca volvulus 0.0098 0.0796 0.0745
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.015 0.1296 0.1298
Loa Loa (eye worm) hypothetical protein 0.0111 0.0921 0.101
Onchocerca volvulus 0.0053 0.0363 0.0253
Schistosoma mansoni hypothetical protein 0.0021 0.0053 0.0053
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0218 0.1958 0.8837
Entamoeba histolytica hypothetical protein 0.015 0.1296 0.5
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0169 0.2181
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.00000013679 0.00000018554
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0796 0.0796
Loa Loa (eye worm) jmjC domain-containing protein 0.0134 0.114 0.1251
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0098 0.0796 0.599
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0098 0.0796 0.0796
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0093 0.0745 0.0745
Giardia lamblia PHD finger protein 15 0.0065 0.0474 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.005 0.0053
Loa Loa (eye worm) hypothetical protein 0.0794 0.7516 0.8257
Echinococcus multilocularis phd:f box containing protein 0.0021 0.005 0.005
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0016 0.00000013679 0.00000018554
Trichomonas vaginalis conserved hypothetical protein 0.015 0.1296 0.1758
Echinococcus multilocularis stromal interaction molecule 1 0.0093 0.0745 0.0746
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0053
Echinococcus granulosus jumonji domain containing 1A 0.0021 0.005 0.005
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0169 0.164
Loa Loa (eye worm) hypothetical protein 0.0093 0.0745 0.0817
Treponema pallidum NADH oxidase 0.0033 0.0169 0.5
Echinococcus multilocularis poly (ADP ribose) polymerase 0.015 0.1296 0.1298
Brugia malayi PHD-finger family protein 0.0021 0.0053 0.0053

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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