Detailed information for compound 1480716

Basic information

Technical information
  • TDR Targets ID: 1480716
  • Name: 2-propan-2-yl-1-prop-2-enylbenzimidazole
  • MW: 200.28 | Formula: C13H16N2
  • H donors: 0 H acceptors: 1 LogP: 3.35 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCn1c(nc2c1cccc2)C(C)C
  • InChi: 1S/C13H16N2/c1-4-9-15-12-8-6-5-7-11(12)14-13(15)10(2)3/h4-8,10H,1,9H2,2-3H3
  • InChiKey: PAHIHSOPHLVJJC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-allyl-2-isopropyl-benzimidazole
  • 1-allyl-2-isopropylbenzimidazole
  • 2-propan-2-yl-1-prop-2-enyl-benzimidazole
  • T5449418
  • 1-Allyl-2-isopropyl-1H-benzoimidazole
  • BAS 10319668
  • AF-399/15337316
  • ZINC00351175

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.046 0.2492 0.7479
Echinococcus granulosus folate receptor beta 0.1707 0.9357 1
Echinococcus multilocularis Major facilitator superfamily, general substrate transporter 0.0613 0.3335 0.3334
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0139 0.0722 0.3341
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0063 0.0842
Schistosoma mansoni ferritin 0.001 0.0014 0.0034
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0014 0.0143
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0106 0.0481
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0182 0.0192
Echinococcus multilocularis cpg binding protein 0.0034 0.0148 0.0145
Loa Loa (eye worm) hypothetical protein 0.0027 0.0106 0.0481
Toxoplasma gondii hypothetical protein 0.042 0.227 1
Schistosoma mansoni hypothetical protein 0.0046 0.0212 0.0628
Entamoeba histolytica hypothetical protein 0.0399 0.2157 1
Schistosoma mansoni apoferritin-2 0.001 0.0014 0.0034
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0069 0.0925
Schistosoma mansoni hypothetical protein 0.0612 0.3331 1
Brugia malayi Reduced folate carrier family protein 0.0206 0.1097 0.5079
Loa Loa (eye worm) hypothetical protein 0.0206 0.1097 0.5079
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.028 0.1287
Trypanosoma brucei Selenophosphate synthetase 2 0.0011 0.0022 1
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0221 0.0234
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0139 0.0722 0.9034
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.0139 0.0722 0.3306
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0069 0.0309
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0063 0.0842
Entamoeba histolytica hypothetical protein 0.026 0.1394 0.6459
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0297 0.1296
Echinococcus granulosus Major facilitator superfamily general substrate transporter 0.0613 0.3335 0.3563
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.028 0.1287
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0399 0.2157 1
Onchocerca volvulus Folate transporter 1 homolog 0.0206 0.1097 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.1097 0.5079
Loa Loa (eye worm) hypothetical protein 0.0058 0.028 0.1287
Mycobacterium tuberculosis Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt 0.0022 0.0082 0.1104
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0399 0.2157 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.1097 0.5079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0105 0.0537 0.2479
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0106 0.0481
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0106 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0015 0.0013
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0399 0.2157 1
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0399 0.2157 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0309
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0399 0.2157 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.1097 0.5079
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0309
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0069 0.0309
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0399 0.2157 1
Trypanosoma cruzi selenophosphate synthetase, putative 0.0011 0.0022 1
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0221 0.0234
Schistosoma mansoni selinide water dikinase 0.0011 0.0022 0.0059
Leishmania major selenophosphate synthetase, putative 0.0011 0.0022 0.1898
Schistosoma mansoni ferritin 0.001 0.0014 0.0034
Plasmodium vivax selenophosphate synthetase, putative 0.0011 0.0022 0.0091
Schistosoma mansoni hypothetical protein 0.0018 0.0061 0.0175
Mycobacterium ulcerans phosphoribosylaminoimidazole synthetase 0.0034 0.0145 0.1786
Schistosoma mansoni cpg binding protein 0.0034 0.0148 0.0435
Schistosoma mansoni hypothetical protein 0.0018 0.0061 0.0175
Schistosoma mansoni ferritin light chain 0.001 0.0014 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0106 0.1301
Onchocerca volvulus 0.0032 0.0138 0.1231
Echinococcus granulosus dnaJ subfamily B 0.046 0.2492 0.2661
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0106 0.0481
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0061 0.0271
Mycobacterium ulcerans hypothetical protein 0.0027 0.0106 0.1301
Schistosoma mansoni cpg binding protein 0.0034 0.0148 0.0435
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0139 0.0722 0.3341
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0139 0.0722 0.9034
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0139 0.0722 0.9034
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0014 0.0143
Wolbachia endosymbiont of Brugia malayi phosphoribosylamine--glycine ligase 0.0153 0.0799 0.3665
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0004 0.0001
Chlamydia trachomatis deoxycytidine triphosphate deaminase 0.0139 0.0722 0.3129
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0399 0.2157 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.1097 0.5079
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.0579 0.173
Loa Loa (eye worm) hypothetical protein 0.0206 0.1097 0.5079
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0063 0.0842
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0014 0.0143
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0106 0.1301
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0399 0.2157 1
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT 0.0153 0.0799 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0106 0.0481
Echinococcus multilocularis folate receptor beta 0.1707 0.9357 0.9357
Entamoeba histolytica hypothetical protein 0.0206 0.1097 0.5079
Echinococcus multilocularis ferritin 0.001 0.0014 0.0011
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0139 0.0722 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.1097 0.5079
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0399 0.2157 1
Schistosoma mansoni ferritin 0.001 0.0014 0.0034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0106 0.1301
Echinococcus granulosus dUTP pyrophosphatase 0.0399 0.2157 0.2303
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.0834
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.0013
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0004 0.0001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0061 0.0058
Entamoeba histolytica hypothetical protein 0.026 0.1394 0.6459
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0179 0.0817
Echinococcus granulosus expressed conserved protein 0.0104 0.0532 0.0566
Brugia malayi folate-like transporter 3 0.0206 0.1097 0.5079
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0221 0.0219
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0105 0.0537 0.2479
Mycobacterium leprae PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) 0.0011 0.0022 0.0247
Toxoplasma gondii selenide, water dikinase 0.0011 0.0022 0.0087
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.0569 0.263
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0004 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.0537 0.0534
Onchocerca volvulus 0.0034 0.0145 0.13
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0069 0.0836
Brugia malayi selenium donor protein 0.0011 0.0022 0.0091
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.0013
Schistosoma mansoni cpg binding protein 0.0032 0.0138 0.0405
Schistosoma mansoni hypothetical protein 0.0046 0.0212 0.0628
Wolbachia endosymbiont of Brugia malayi phosphoribosylaminoimidazole synthetase 0.0034 0.0145 0.0611
Onchocerca volvulus 0.0206 0.1097 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0106 0.1301
Echinococcus multilocularis Niemann Pick C1 protein 0.0158 0.0831 0.0828
Schistosoma mansoni hypothetical protein 0.0018 0.0061 0.0175
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.0569 0.0567
Brugia malayi hypothetical protein 0.004 0.0182 0.0834
Loa Loa (eye worm) reduced folate carrier family protein 0.0206 0.1097 0.5079
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0399 0.2157 0.9501
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0106 1
Trypanosoma cruzi selenophosphate synthetase, putative 0.0011 0.0022 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0182 0.018
Brugia malayi dUTP diphosphatase 0.0399 0.2157 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0015 0.0055
Echinococcus multilocularis GPCR, family 2 0.0018 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0058 0.028 0.1287
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0309
Onchocerca volvulus 0.0206 0.1097 1
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.0569 0.0606
Loa Loa (eye worm) hypothetical protein 0.0027 0.0106 0.0481
Brugia malayi CXXC zinc finger family protein 0.0032 0.0138 0.0625
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0014 0.0158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.0537 0.0571
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0106 0.1301
Echinococcus granulosus selenide water dikinase 0.0011 0.0022 0.0021
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.0834
Loa Loa (eye worm) hypothetical protein 0.0111 0.0569 0.263
Loa Loa (eye worm) selenium donor protein 0.0011 0.0022 0.0091
Onchocerca volvulus 0.0206 0.1097 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0106 0.0481
Schistosoma mansoni hypothetical protein 0.0046 0.0212 0.0628
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.0537 0.0534
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0309
Echinococcus multilocularis protein dispatched 1 0.0054 0.0258 0.0255
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0106 0.0481
Entamoeba histolytica hypothetical protein 0.0399 0.2157 1
Echinococcus multilocularis protein patched 0.0048 0.0221 0.0219
Echinococcus granulosus ferritin 0.001 0.0014 0.0012
Brugia malayi CHE-14 protein 0.0048 0.0221 0.1014
Schistosoma mansoni ferritin 0.001 0.0014 0.0034
Echinococcus multilocularis dnaJ subfamily B 0.046 0.2492 0.249
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0004 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.0206 0.1097 0.5079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0004 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0106 0.1301
Onchocerca volvulus Folate transporter 1 homolog 0.0206 0.1097 1
Onchocerca volvulus 0.0027 0.0106 0.0948
Echinococcus granulosus expressed protein 0.001 0.0014 0.0012
Schistosoma mansoni ferritin light chain 0.001 0.0014 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0537 0.1605
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0106 0.1301
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.0834
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.0569 0.263
Echinococcus granulosus Niemann Pick C1 protein 0.0158 0.0831 0.0885
Plasmodium falciparum selenide water dikinase, putative 0.0011 0.0022 0.0091
Giardia lamblia Hypothetical protein 0.0206 0.1097 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0014 0.0052
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0817
Echinococcus multilocularis expressed conserved protein 0.0104 0.0532 0.053
Wolbachia endosymbiont of Brugia malayi phosphoribosylformylglycinamidine synthase domain-containing protein 0.0011 0.0022 0.0039
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0399 0.2157 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0138 0.0625
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0061 0.0271
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0063 0.0842
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0221 0.1014
Loa Loa (eye worm) hypothetical protein 0.0206 0.1097 0.5079
Schistosoma mansoni hypothetical protein 0.004 0.0182 0.054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0271
Mycobacterium tuberculosis Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) 0.0011 0.0022 0.0273
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0106 0.1301
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0399 0.2157 1
Schistosoma mansoni hypothetical protein 0.0046 0.0212 0.0628
Mycobacterium tuberculosis Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) 0.0034 0.0145 0.1977
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0106 0.0481
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0106 0.1441
Echinococcus granulosus cpg binding protein 0.0034 0.0148 0.0155
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0106 1
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.0834
Onchocerca volvulus 0.0206 0.1097 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.1097 0.5079
Schistosoma mansoni apoferritin-2 0.001 0.0014 0.0034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0337 0.1004
Onchocerca volvulus 0.0027 0.0107 0.0956
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0537 0.1605
Echinococcus multilocularis dUTP pyrophosphatase 0.0399 0.2157 0.2155
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0309
Schistosoma mansoni hypothetical protein 0.004 0.0179 0.0529
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0106 0.1301
Echinococcus multilocularis 0.0011 0.0022 0.002
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0014 0.0158
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0061 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.0537 0.0571
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0061 0.0271
Trichomonas vaginalis ferritin, putative 0.001 0.0014 0.0066
Echinococcus granulosus GPCR family 2 0.0018 0.0061 0.0062
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0106 0.1441
Mycobacterium ulcerans phosphoribosylamine--glycine ligase 0.0153 0.0799 1
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0182 0.054
Onchocerca volvulus Folate transporter 1 homolog 0.0206 0.1097 1
Echinococcus multilocularis expressed protein 0.001 0.0014 0.0011
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0399 0.2157 0.6472
Loa Loa (eye worm) hypothetical protein 0.0048 0.0221 0.1014
Loa Loa (eye worm) dUTP diphosphatase 0.0399 0.2157 1
Schistosoma mansoni patched 1 0.0048 0.0221 0.0656
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) 0.0034 0.0145 0.1786
Schistosoma mansoni hypothetical protein 0.0018 0.0061 0.0175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0537 0.1605
Mycobacterium ulcerans phosphoribosylformylglycinamidine synthase II 0.0011 0.0022 0.0247
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.028 0.1287
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0399 0.2157 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0221 0.1026
Entamoeba histolytica hypothetical protein 0.0139 0.0722 0.3341

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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