Detailed information for compound 1482898

Basic information

Technical information
  • TDR Targets ID: 1482898
  • Name: 4-(2-ethoxyphenoxy)-N-(2-methoxy-5-morpholin- 4-ylsulfonylphenyl)butanamide
  • MW: 478.559 | Formula: C23H30N2O7S
  • H donors: 1 H acceptors: 3 LogP: 2.14 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1OCCCC(=O)Nc1cc(ccc1OC)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C23H30N2O7S/c1-3-31-21-7-4-5-8-22(21)32-14-6-9-23(26)24-19-17-18(10-11-20(19)29-2)33(27,28)25-12-15-30-16-13-25/h4-5,7-8,10-11,17H,3,6,9,12-16H2,1-2H3,(H,24,26)
  • InChiKey: NYZJDBHAAWMZAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-ethoxyphenoxy)-N-(2-methoxy-5-morpholinosulfonyl-phenyl)butanamide
  • 4-(2-ethoxyphenoxy)-N-(2-methoxy-5-morpholinosulfonylphenyl)butanamide
  • 4-(2-ethoxyphenoxy)-N-(2-methoxy-5-morpholinosulfonyl-phenyl)butyramide
  • 4-(2-ethoxyphenoxy)-N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)butanamide
  • T5247041

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0468 0.0749
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0216 0.0519
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.0534 0.0854
Brugia malayi hypothetical protein 0.0036 0.0086 0.0304
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0216 0.1764
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0216 0.0803
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.0534 0.2032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0316
Loa Loa (eye worm) hypothetical protein 0.0053 0.0151 0.058
Onchocerca volvulus 0.007 0.0217 0.0672
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0021 0.0075
Brugia malayi hypothetical protein 0.0016 0.0011 0.0012
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0021 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0044 0.1233
Loa Loa (eye worm) hypothetical protein 0.0036 0.0085 0.0329
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0216 0.0203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1128 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0086 0.0136
Brugia malayi intermediate filament protein 0.0029 0.0058 0.0195
Echinococcus multilocularis lamin dm0 0.0029 0.0058 0.009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0056 0.0217
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0183 0.017
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0045 0.0552
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.002 0.0029
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0105 0.0768
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0013 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1128 1
Echinococcus multilocularis integrin alpha ps 0.0032 0.0072 0.0112
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0045 0.127
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0216 1
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0104 0.0247
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0044 0.2382
Schistosoma mansoni ap endonuclease 0.0019 0.002 0.0007
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0045 0.0492
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0044 0.1233
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.002 0.0064
Schistosoma mansoni hypothetical protein 0.0036 0.0087 0.0074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0468 0.1803
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0081
Echinococcus multilocularis GPCR, family 2 0.0017 0.0013 0.0018
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0183 0.0704
Brugia malayi histone deacetylase 3 (HD3) 0.0041 0.0105 0.0377
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0468 0.1779
Echinococcus multilocularis histone deacetylase 1 0.0041 0.0105 0.0166
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1128 1
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0597
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0058 0.0195
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0021 0.0065
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.0525 1
Schistosoma mansoni hypothetical protein 0.0036 0.0086 0.0073
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0045 0.0492
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0121 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0044 0.2776
Brugia malayi MH2 domain containing protein 0.0124 0.042 0.1591
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0183 0.0704
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.0379 0.1434
Echinococcus multilocularis geminin 0.0519 0.1916 0.3073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1128 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0117 0.0394 0.0382
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0597
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0151 0.0551
Schistosoma mansoni integrin alpha-ps 0.0067 0.0204 0.0191
Schistosoma mansoni lamin 0.0029 0.0058 0.0045
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0105 0.0768
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.0518 0.1251
Onchocerca volvulus Phospholipase A2 homolog 0.028 0.101 0.378
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0105 0.4353
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0107 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0013 0.0027
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0105 0.0768
Brugia malayi histone deacetylase 1 (HD1) 0.0041 0.0105 0.0377
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0086 0.0205
Loa Loa (eye worm) TK/EPH protein kinase 0.0091 0.0293 0.1128
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0008 0.003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0045 0.0224
Schistosoma mansoni integrin alpha-ps 0.0035 0.0082 0.0069
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1657 0.623 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0224
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0081
Loa Loa (eye worm) hypothetical protein 0.0118 0.0395 0.1522
Leishmania major histone deacetylase, putative 0.0041 0.0105 0.4353
Toxoplasma gondii histone deacetylase HDAC2 0.0041 0.0105 0.8414
Toxoplasma gondii histone deacetylase HDAC3 0.0041 0.0105 0.8414
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0482 0.1777 0.1766
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0045 0.127
Mycobacterium ulcerans hypothetical protein 0.0025 0.0045 0.0492
Schistosoma mansoni histone deacetylase 0.0041 0.0105 0.0092
Echinococcus granulosus integrin alpha ps 0.0067 0.0204 0.049
Echinococcus granulosus geminin 0.0519 0.1916 0.4643
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.002 0.0078
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.042 0.1616
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0021 0.0077
Onchocerca volvulus Phospholipase A2 homolog 0.0698 0.2597 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0183 0.017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0045 0.0492
Schistosoma mansoni hypothetical protein 0.0519 0.1916 0.1905
Loa Loa (eye worm) hypothetical protein 0.0032 0.0072 0.0275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0468 0.0456
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0468 0.0749
Loa Loa (eye worm) acetyltransferase 0.0154 0.0534 0.2056
Brugia malayi Histone deacetylase 1 0.0041 0.0105 0.0377
Leishmania major histone deacetylase, putative 0.0041 0.0105 0.4353
Loa Loa (eye worm) hypothetical protein 0.0083 0.0263 0.1012
Giardia lamblia Fructose-bisphosphate aldolase 0.0311 0.1128 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0121 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.002 0.0044
Brugia malayi hypothetical protein 0.0025 0.0044 0.0141
Loa Loa (eye worm) histone deacetylase 3 0.0041 0.0105 0.0406
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1128 1
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0104 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0045 0.0144
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0216 1
Echinococcus multilocularis histone deacetylase 3 0.0041 0.0105 0.0166
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.0825 0.3176
Echinococcus multilocularis musashi 0.0029 0.0058 0.009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0045 0.0492
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0086 0.0073
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0174
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0045 0.0224
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0468 0.1131
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0117 0.0394 0.063
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.1128 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0071 0.022 0.0349
Loa Loa (eye worm) hypothetical protein 0.0036 0.0087 0.0335
Brugia malayi Phospholipase A2 family protein 0.0698 0.2597 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0045 0.0224
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.0517 0.1968
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.0525 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0058 0.0224
Echinococcus granulosus lamin dm0 0.0029 0.0058 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0151 0.058
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0013 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0183 0.017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0045 0.0492
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0045 0.0552
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0171
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0406
Loa Loa (eye worm) hypothetical protein 0.0698 0.2597 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.002 0.0048
Brugia malayi RNA binding protein 0.0062 0.0183 0.0676
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0121 0.0913
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0121 0.029
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0045 0.0144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0174
Echinococcus granulosus integrin alpha ps 0.0032 0.0072 0.0169
Plasmodium falciparum histone deacetylase 1 0.0041 0.0105 0.9802
Echinococcus multilocularis lamin 0.0029 0.0058 0.009
Schistosoma mansoni intermediate filament proteins 0.0029 0.0058 0.0045
Brugia malayi ephrin receptor 1 precursor 0.0034 0.0078 0.0273
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0216 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.0534 0.0522
Echinococcus granulosus histone deacetylase 1 0.0041 0.0105 0.0251
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0058 0.0224
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0105 0.0768
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0183 0.017
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0597
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0183 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0468 0.0456
Loa Loa (eye worm) hypothetical protein 0.0113 0.0379 0.1459
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0087 0.0306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1128 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.0525 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0121 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0071 0.022 0.0528
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0216 0.0831
Schistosoma mansoni ap endonuclease 0.0019 0.002 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0045 0.0144
Echinococcus granulosus GPCR family 2 0.0017 0.0013 0.0027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0151 0.0551
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0105 0.0768
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0013 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0468 0.1131
Echinococcus granulosus tar DNA binding protein 0.0062 0.0183 0.0439
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0183 0.029
Schistosoma mansoni hypothetical protein 0.0519 0.1916 0.1905
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0013 0.0027
Onchocerca volvulus 0.0029 0.0058 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1128 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0021 0.0013
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0597
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0044 0.2776
Brugia malayi TAR-binding protein 0.0062 0.0183 0.0676
Echinococcus granulosus lamin 0.0029 0.0058 0.0137
Echinococcus granulosus leukotriene A 4 hydrolase 0.0117 0.0394 0.0952
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0105 0.0768
Echinococcus multilocularis integrin alpha ps 0.0067 0.0204 0.0324
Echinococcus multilocularis integrin alpha ps 0.0067 0.0204 0.0324
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0216 1
Echinococcus granulosus histone deacetylase 3 0.0041 0.0105 0.0251
Echinococcus granulosus integrin alpha 3 0.0115 0.0385 0.0929
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1128 1
Schistosoma mansoni integrin alpha 0.015 0.0517 0.0505
Plasmodium vivax histone deacetylase 1, putative 0.0041 0.0105 0.8414
Loa Loa (eye worm) hypothetical protein 0.028 0.101 0.3888
Echinococcus granulosus Solute carrier family 22 5 0.1101 0.4124 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0183 0.0676
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0117 0.0394 0.1518
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0045 0.0492
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0105 0.0768
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.002 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0174
Loa Loa (eye worm) hypothetical protein 0.007 0.0217 0.0834
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0121 0.0913
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0468 0.0456
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0216 0.0343
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0107 0.0783
Trypanosoma brucei histone deacetylase 1 0.0041 0.0105 0.4353
Giardia lamblia Histone deacetylase 0.0041 0.0105 0.0768
Schistosoma mansoni histone deacetylase 0.0041 0.0105 0.0092
Entamoeba histolytica histone deacetylase, putative 0.0041 0.0105 0.0768
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0045 0.0492
Onchocerca volvulus 0.0029 0.0058 0.0051
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0044 0.2382
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0105 0.0768
Schistosoma mansoni ephrin receptor 0.0071 0.022 0.0207
Loa Loa (eye worm) RNA binding protein 0.0062 0.0183 0.0704
Schistosoma mansoni lamin 0.0029 0.0058 0.0045
Echinococcus granulosus intermediate filament protein 0.0029 0.0058 0.0137
Echinococcus multilocularis integrin alpha 3 0.0115 0.0385 0.0615
Brugia malayi hypothetical protein 0.0105 0.0348 0.1314
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0044 0.1233
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0045 0.127
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.1128 1
Loa Loa (eye worm) histone deacetylase 1 0.0041 0.0105 0.0406
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0105 0.0768
Schistosoma mansoni hypothetical protein 0.0032 0.0072 0.0058
Leishmania major hypothetical protein, conserved 0.0025 0.0044 0.1233
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.042 0.1616
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0107 0.0783
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0013 0.0018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0013 0.005
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0105 0.4353
Treponema pallidum fructose-bisphosphate aldolase 0.0311 0.1128 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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