Detailed information for compound 1484656

Basic information

Technical information
  • TDR Targets ID: 1484656
  • Name: N-[[2-bromo-5-methoxy-4-(phenylmethoxy)phenyl ]methyl]propan-1-amine hydrochloride
  • MW: 400.738 | Formula: C18H23BrClNO2
  • H donors: 1 H acceptors: 0 LogP: 5.11 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNCc1cc(OC)c(cc1Br)OCc1ccccc1.Cl
  • InChi: 1S/C18H22BrNO2.ClH/c1-3-9-20-12-15-10-17(21-2)18(11-16(15)19)22-13-14-7-5-4-6-8-14;/h4-8,10-11,20H,3,9,12-13H2,1-2H3;1H
  • InChiKey: VYCMMGVYXOSUKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-(benzyloxy)-2-bromo-5-methoxy-benzyl]-propyl-amine hydrochloride
  • SMR000296555
  • MLS000665299
  • N-[4-(benzyloxy)-2-bromo-5-methoxybenzyl]-1-propanamine hydrochloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0003
Brugia malayi RhoGAP domain containing protein 0.0009 0.0003 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0038 0.0038
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0009 0.0003 0.0003
Echinococcus multilocularis signal transduction protein lnk realted 0.0009 0.0003 0.0003
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0014 0.0069 0.1826
Echinococcus multilocularis growth factor receptor bound protein 2 0.0218 0.2667 0.2667
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0024 0.0192 0.5643
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Brugia malayi STAT protein, DNA binding domain containing protein 0.0009 0.0003 0.0003
Onchocerca volvulus Putative organic anion transporter 0.002 0.0151 0.4514
Mycobacterium leprae Probable polyketide synthase Pks1 0.0017 0.0105 0.2589
Mycobacterium ulcerans hypothetical protein 0.0035 0.0335 1
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0038 0.0038
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Loa Loa (eye worm) TK/ABL protein kinase 0.0009 0.0003 0.0003
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0017 0.0105 0.2589
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0335 1
Echinococcus granulosus somatostatin receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0038 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0003 0.0003
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0017 0.0111 0.0111
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Schistosoma mansoni hypothetical protein 0.0014 0.0066 0.0079
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0003 0.0003
Mycobacterium ulcerans hypothetical protein 0.0035 0.0335 1
Brugia malayi hypothetical protein 0.0011 0.0038 0.0038
Echinococcus granulosus agrin 0.0014 0.0069 0.0069
Mycobacterium ulcerans Type I modular polyketide synthase 0.0016 0.0092 0.2188
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0111 0.0111
Trichomonas vaginalis hypothetical protein 0.0388 0.4815 1
Echinococcus granulosus signal transduction protein lnk realted 0.0009 0.0003 0.0003
Echinococcus multilocularis SH2 motif 0.0009 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.1583 0.3287
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0594 0.0594
Schistosoma mansoni amine GPCR 0.0011 0.0038 0.0046
Echinococcus granulosus SH2 domain containing adapter protein F 0.0009 0.0003 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0069
Brugia malayi hypothetical protein 0.0011 0.0038 0.0038
Brugia malayi SH2 domain containing protein 0.0009 0.0003 0.0003
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0254 0.3125 1
Brugia malayi sodium-independent organic anion transporter family protein 0.002 0.0151 0.0151
Brugia malayi SH2 domain containing protein 0.0009 0.0003 0.0003
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0014 0.0069 0.1826
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0017 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0011 0.0038 0.0046
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0011 0.0038 0.1131
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0009 0.0003 0.0082
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0279 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0038 0.0046
Toxoplasma gondii transporter, major facilitator family protein 0.002 0.0151 0.5027
Schistosoma mansoni tensin 0.0009 0.0003 0.0003
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0003 0.0003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0038 0.0046
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0038 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Onchocerca volvulus 0.002 0.0151 0.4514
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0038 0.0038
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0279 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.0111 0.0111
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0017 0.0111 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Echinococcus granulosus GPCR family 2 0.003 0.0273 0.0273
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0038 0.0038
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0038 0.0038
Loa Loa (eye worm) SH2 domain-containing protein 0.0009 0.0003 0.0003
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0038 0.0038
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0038 0.0038
Echinococcus multilocularis tyrosine kinase 0.0009 0.0003 0.0003
Brugia malayi SH2 domain containing protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0038 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0079 0.0079
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0017 0.0111 0.0133
Brugia malayi Variant SH3 domain containing protein 0.0017 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0009 0.0003 0.0082
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0014 0.0069 0.0069
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Src64B 0.0017 0.0111 0.0111
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0016 0.0092 0.2188
Mycobacterium ulcerans putative transglutaminase-like protein 0.0035 0.0335 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0009 0.0003 0.0003
Brugia malayi Protein kinase domain containing protein 0.0009 0.0003 0.0003
Brugia malayi hypothetical protein 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0038 0.0038
Brugia malayi Protein kinase domain containing protein 0.0009 0.0003 0.0003
Schistosoma mansoni SH2A 0.0009 0.0003 0.0003
Loa Loa (eye worm) STAT protein 0.0009 0.0003 0.0003
Schistosoma mansoni adenoreceptor 0.0011 0.0038 0.0046
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0038 0.0038
Brugia malayi Dopamine receptor protein 2 0.0011 0.0038 0.0038
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0013 0.0053 0.0926
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0796 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0009 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.003 0.0273 0.0329
Echinococcus multilocularis serotonin receptor 0.0011 0.0038 0.0038
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0009 0.0003 0.0082
Brugia malayi G protein-coupled receptor 0.0011 0.0038 0.0038
Brugia malayi SH2 domain containing protein 0.0009 0.0003 0.0003
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0066 0.0066
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0105 0.3226
Echinococcus multilocularis expressed protein 0.0014 0.0069 0.0069
Onchocerca volvulus 0.002 0.0151 0.4514
Onchocerca volvulus 0.0011 0.0038 0.1131
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0016 0.0092 0.0092
Schistosoma mansoni tsg101-related 0.0541 0.6767 0.8144
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0009 0.0003 0.0003
Schistosoma mansoni GTPase activating protein 0.0009 0.0003 0.0003
Brugia malayi Dopamine receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Onchocerca volvulus 0.0011 0.0038 0.1131
Brugia malayi larval opioid receptor 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0011 0.0038 0.1131
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0014 0.0069 0.1826
Leishmania major hypothetical protein, conserved 0.0254 0.3125 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0038 0.0038
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0038 0.0038
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0017 0.0111 0.0133
Brugia malayi GnHR receptor homolog 0.0011 0.0038 0.0038
Echinococcus multilocularis 0.0009 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0038 0.0046
Echinococcus granulosus g protein coupled receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Onchocerca volvulus 0.0011 0.0038 0.1131
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0594 0.0594
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0254 0.3125 1
Onchocerca volvulus 0.0011 0.0038 0.1131
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0009 0.0003 0.0003
Brugia malayi cytokine inducible SH2-containing protein 5 0.0009 0.0003 0.0003
Onchocerca volvulus Fatty acid synthase homolog 0.0028 0.0253 0.7565
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0013 0.0056 0.1519
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Schistosoma mansoni vav2 0.0009 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0038 0.0046
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0038 0.0038
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0011 0.0038 0.0046
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0038 0.0038
Echinococcus multilocularis SH2 domain containing protein 7 0.0009 0.0003 0.0003
Schistosoma mansoni tyrosine kinase 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0014 0.0069 0.0069
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0017 0.0105 0.2589
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0016 0.0092 0.2188
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0038 0.0046
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0017 0.0105 0.3008
Echinococcus granulosus tensin 0.0009 0.0003 0.0003
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0038 0.0046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0038 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0038 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0279 0.0892
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus multilocularis N chimaerin 0.0009 0.0003 0.0003
Mycobacterium tuberculosis Long conserved protein 0.0035 0.0335 1
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Schistosoma mansoni neuropeptide receptor 0.0011 0.0038 0.0046
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0013 0.0053 0.0926
Brugia malayi Serotonin receptor 0.0011 0.0038 0.0038
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0038 0.0038
Schistosoma mansoni tsg101-related 0.0663 0.8309 1
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0038 0.0038
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0038 0.0038
Schistosoma mansoni adapter molecule crk 0.0017 0.0111 0.0133
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0038 0.0046
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0038 0.0038
Brugia malayi hypothetical protein 0.002 0.0142 0.0142
Brugia malayi secreted modular calcium-binding protein 1 0.0014 0.0069 0.0069
Brugia malayi hypothetical protein 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0011 0.0038 0.1131
Brugia malayi hypothetical protein 0.0011 0.0038 0.0038
Brugia malayi Protein kinase domain containing protein 0.0009 0.0003 0.0003
Onchocerca volvulus Putative organic anion transporter 0.002 0.0151 0.4514
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0038 0.0038
Brugia malayi prostaglandin transporter 0.002 0.0151 0.0151
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0003 0.0003
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0038 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.1583 0.5066
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.003 0.0272 0.0272
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0038 0.0046
Echinococcus multilocularis NCK adaptor protein 0.0017 0.0111 0.0111
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Conserved protein 0.0035 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0024 0.0192 0.5643
Brugia malayi latrophilin 2 splice variant baaae 0.0065 0.0716 0.0716
Echinococcus granulosus organic anion transporting polypeptide 30B 0.002 0.0151 0.0151
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0011 0.0038 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0009 0.0003 0.0004
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0009 0.0003 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0279 1
Onchocerca volvulus 0.0009 0.0003 0.0082
Echinococcus multilocularis serotonin receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0335 1
Echinococcus multilocularis tensin 0.0009 0.0003 0.0003
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0038 0.0038
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0009 0.0003 0.0003
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0014 0.0069 0.0069
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0011 0.0038 0.1131
Brugia malayi hypothetical protein 0.002 0.0151 0.0151
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0151
Entamoeba histolytica protein kinase, putative 0.0009 0.0003 0.0004
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0017 0.0105 0.2589
Echinococcus granulosus tyrosine protein kinase ABL1 0.0009 0.0003 0.0003
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0003 0.0003
Onchocerca volvulus Putative organic anion transporter 0.002 0.0151 0.4514
Brugia malayi SRC-1 0.0017 0.0111 0.0111
Echinococcus multilocularis GPCR, family 2 0.003 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0151
Brugia malayi hypothetical protein 0.0011 0.0038 0.0038
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0009 0.0003 0.0003
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Hypothetical protein 0.0035 0.0335 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0016 0.0092 0.2188
Brugia malayi Variant SH3 domain containing protein 0.0017 0.0111 0.0111
Onchocerca volvulus 0.0009 0.0003 0.0082
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0038 0.0038
Schistosoma mansoni biogenic amine receptor 0.0011 0.0038 0.0046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0273 0.0273
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0015 0.0086 0.2443
Schistosoma mansoni opsin-like receptor 0.0011 0.0038 0.0046
Echinococcus multilocularis somatostatin receptor 0.0011 0.0038 0.0038
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0017 0.0105 0.2589
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0038 0.0038
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0003 0.0003
Echinococcus granulosus growth factor receptor bound protein 2 0.0218 0.2667 0.2667
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0095 0.1097 0.1097
Onchocerca volvulus 0.002 0.0151 0.4514
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0038 0.0038
Echinococcus granulosus fmrfamide receptor 0.0011 0.0038 0.0038
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0009 0.0003 0.0003
Brugia malayi hypothetical protein 0.003 0.0279 0.0279
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0038 0.0046
Echinococcus granulosus SH2 motif 0.0009 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0133 0.1583 0.2339
Echinococcus granulosus SH2 domain containing protein 7 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Brugia malayi hypothetical protein 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0038 0.0038
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0017 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0011 0.0038 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0594 0.0715
Brugia malayi sodium-independent organic anion transporter family protein 0.002 0.0151 0.0151
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0038 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0273 0.0273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0594 0.0715
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0011 0.0038 0.1131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0038 0.0046
Schistosoma mansoni shc transforming protein 0.0009 0.0003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus granulosus sex peptide receptor 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0035 0.0335 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0016 0.0092 0.263
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0279 0.0892
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0009 0.0003 0.0004
Schistosoma mansoni histamine h1 receptor 0.0011 0.0038 0.0046
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0017 0.0105 0.3008
Toxoplasma gondii type I fatty acid synthase, putative 0.0011 0.0035 0.0493
Schistosoma mansoni tyrosine kinase 0.0017 0.0111 0.0133
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0011 0.0038 0.1131
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Brugia malayi G-protein coupled receptor 0.0011 0.0038 0.0038
Mycobacterium ulcerans polyketide synthase 0.0017 0.0105 0.2589
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Echinococcus multilocularis sex peptide receptor 0.0011 0.0038 0.0038
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0038 0.0038
Brugia malayi Sex muscle abnormal protein 5 0.0218 0.2667 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.1583 0.3287
Echinococcus multilocularis Solute carrier organic anion transporter family 0.002 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0279 0.0892
Mycobacterium ulcerans Type I modular polyketide synthase 0.0016 0.0092 0.2188
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0279 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0038 0.0046
Loa Loa (eye worm) hypothetical protein 0.0796 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0038 0.0038
Brugia malayi Protein kinase domain containing protein 0.0009 0.0003 0.0003
Echinococcus multilocularis follistatin 0.0014 0.0069 0.0069
Echinococcus granulosus tyrosine protein kinase shark 0.0009 0.0003 0.0003
Onchocerca volvulus 0.002 0.0151 0.4514
Brugia malayi Dopamine receptor protein 1 0.0011 0.0038 0.0038
Echinococcus granulosus suppressor of cytokine signaling 7 0.0009 0.0003 0.0003
Entamoeba histolytica SH2 domain containing protein 0.0009 0.0003 0.0004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0038 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0003 0.0003
Trypanosoma brucei RNA helicase, putative 0.0084 0.0956 0.3059
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Mycobacterium ulcerans thioesterase 0.0013 0.0059 0.1111
Schistosoma mansoni hypothetical protein 0.0065 0.0716 0.0861
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0038 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Echinococcus multilocularis SH2 motif 0.0009 0.0003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Brugia malayi sulfakinin receptor protein 0.0011 0.0038 0.0038
Schistosoma mansoni tensin 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Mycobacterium leprae Polyketide synthase Pks13 0.0024 0.0192 0.5382
Trypanosoma cruzi MFS transporter, putative 0.002 0.0151 0.0484
Brugia malayi hypothetical protein 0.0011 0.0038 0.0038
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.003 0.0279 0.0892
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0273 0.0273
Schistosoma mansoni tyrosine kinase 0.0017 0.0111 0.0133
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus granulosus SH2 motif 0.0009 0.0003 0.0003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0038 0.0046
Onchocerca volvulus 0.0009 0.0003 0.0082
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0111 0.0111
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0026 0.0229 0.0229
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0016 0.0092 0.263
Schistosoma mansoni biogenic amine receptor 0.0011 0.0038 0.0046
Echinococcus granulosus Transglutaminase 0.0035 0.0335 0.0335
Schistosoma mansoni growth factor receptor-bound protein 0.0218 0.2667 0.321
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0009 0.0003 0.0003
Onchocerca volvulus 0.0014 0.0069 0.2059
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0011 0.0038 0.1131
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0079 0.2229
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0009 0.0003 0.0003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0594 0.0594
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.0111 0.0111
Schistosoma mansoni amine GPCR 0.0011 0.0038 0.0046
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0038 0.0038
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0009 0.0003 0.0003
Brugia malayi hypothetical protein 0.0011 0.0038 0.0038
Brugia malayi ORL1-like opioid receptor 0.0011 0.0038 0.0038
Schistosoma mansoni neuropeptide receptor 0.0011 0.0038 0.0046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0003 0.0003
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0111 0.0111
Echinococcus granulosus allatostatin A receptor 0.0011 0.0038 0.0038
Echinococcus granulosus hypothetical protein 0.0011 0.0038 0.0038
Trichomonas vaginalis peptide N-glycanase, putative 0.0035 0.0335 0.0695
Brugia malayi Serotonin receptor 0.0011 0.0038 0.0038
Echinococcus granulosus g protein coupled receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0017 0.0111 0.0133
Echinococcus granulosus tyrosine protein kinase Lyn 0.0017 0.0111 0.0111
Brugia malayi SH2 domain containing protein 0.0009 0.0003 0.0003
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0111 0.0133
Brugia malayi SH2 domain containing protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0038 0.0038
Echinococcus granulosus serotonin receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0009 0.0003 0.0003
Echinococcus granulosus tyrosine kinase 0.0009 0.0003 0.0003
Brugia malayi RE15519p 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Schistosoma mansoni biogenic amine receptor 0.0011 0.0038 0.0046
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0038 0.0038
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0009 0.0003 0.0003
Loa Loa (eye worm) sodium-independent organic anion transporter 0.002 0.0151 0.0151
Schistosoma mansoni nck2/grb4 0.0017 0.0111 0.0133
Schistosoma mansoni agrin 0.0014 0.0069 0.0083
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Schistosoma mansoni organic anion transporter 0.002 0.0151 0.0182
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0003 0.0003
Brugia malayi SPARC precursor 0.0014 0.0069 0.0069
Echinococcus granulosus N chimaerin 0.0009 0.0003 0.0003
Onchocerca volvulus 0.0009 0.0003 0.0082
Onchocerca volvulus 0.0011 0.0038 0.1131
Loa Loa (eye worm) SH2 domain-containing protein 0.0009 0.0003 0.0003
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Onchocerca volvulus 0.0009 0.0003 0.0082
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0009 0.0003 0.0003
Schistosoma mansoni amine GPCR 0.0011 0.0038 0.0046
Echinococcus multilocularis agrin 0.0014 0.0069 0.0069
Schistosoma mansoni follistatin 0.0014 0.0069 0.0083
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0017 0.0111 0.0111
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0038 0.0046
Onchocerca volvulus 0.0009 0.0003 0.0082
Onchocerca volvulus 0.0009 0.0003 0.0082
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0151
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0038 0.1131
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0038 0.0046
Schistosoma mansoni growth factor receptor-bound protein 0.0218 0.2667 0.321
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0009 0.0003 0.0003
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0279 0.0279
Echinococcus multilocularis tyrosine protein kinase Blk 0.0009 0.0003 0.0003
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0038 0.0046
Onchocerca volvulus 0.0011 0.0038 0.1131
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0003 0.0003
Brugia malayi neuropeptide F receptor 0.0011 0.0038 0.0038
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0017 0.0111 0.0111
Brugia malayi Latrophilin receptor protein 2 0.003 0.0273 0.0273
Brugia malayi AKH receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0151
Schistosoma mansoni tensin-related 0.0009 0.0003 0.0003
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0014 0.0069 0.0069
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0009 0.0003 0.0003
Echinococcus granulosus hypothetical protein 0.0009 0.0003 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Echinococcus granulosus neuropeptide receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) SRC-1 0.0017 0.0111 0.0111
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0003 0.0003
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0038 0.0038
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0038 0.0038
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0009 0.0003 0.0003
Loa Loa (eye worm) agrin synaptic family protein 0.0014 0.0069 0.0069
Brugia malayi tRNA modification GTPase TrmE family protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Echinococcus granulosus SHC transforming protein 3 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Brugia malayi Melatonin receptor type 1A 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0009 0.0003 0.0082
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0038 0.0046
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0038 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0594 0.0594
Schistosoma mansoni amine GPCR 0.0011 0.0038 0.0046
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0035 0.0335 0.0403
Mycobacterium ulcerans thioesterase TesA 0.0013 0.0059 0.1111
Schistosoma mansoni tensin 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0038 0.1131
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0716 0.0716
Brugia malayi SH2 domain containing protein 0.0009 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0038 0.0046
Mycobacterium ulcerans polyketide synthase Pks13 0.0024 0.0192 0.5382
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0038 0.0046
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0541 0.6767 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0038 0.0038
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.003 0.0273 0.0329
Schistosoma mansoni myosin xvIII 0.0011 0.0038 0.0046
Brugia malayi Calcitonin receptor-like protein seb-1 0.0095 0.1097 0.1097
Echinococcus granulosus expressed conserved protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0038 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.1583 0.5066
Echinococcus multilocularis SH2 motif 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0009 0.0003 0.0082
Brugia malayi hypothetical protein 0.0009 0.0003 0.0003
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0013 0.0053 0.0926
Entamoeba histolytica hypothetical protein 0.0133 0.1583 0.2339
Echinococcus multilocularis Transglutaminase 0.0035 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0111 0.0111
Brugia malayi Thioredoxin family protein 0.0035 0.0335 0.0335
Schistosoma mansoni neuropeptide receptor 0.0011 0.0038 0.0046
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0796 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0038 0.0038
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus granulosus follistatin 0.0014 0.0069 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0594 0.0594
Onchocerca volvulus 0.0011 0.0038 0.1131
Schistosoma mansoni hypothetical protein 0.0084 0.0956 0.115
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Schistosoma mansoni tensin-related 0.0009 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0133 0.1583 0.2339
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.0111
Echinococcus granulosus orexin receptor type 2 0.0011 0.0038 0.0038
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0003 0.0003
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0038 0.0046
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Blk 0.0009 0.0003 0.0003
Onchocerca volvulus 0.0011 0.0038 0.1131
Onchocerca volvulus 0.0011 0.0038 0.1131
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0017 0.0111 0.0111
Schistosoma mansoni suppressor of cytokine signaling 0.0009 0.0003 0.0003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0273 0.0273
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0011 0.0036 0.0913
Mycobacterium tuberculosis Probable thioesterase TesA 0.0013 0.0059 0.1614
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0038 0.0046
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0273
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0038 0.0038
Schistosoma mansoni signal transduction protein lnk-related 0.0009 0.0003 0.0003
Schistosoma mansoni opsin-like receptor 0.0011 0.0038 0.0046
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0013 0.0059 0.1111
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0038 0.0038
Brugia malayi neuropeptide F receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.0111 0.0111
Brugia malayi hypothetical protein 0.0009 0.0003 0.0003
Giardia lamblia Transglutaminase/protease, putative 0.0035 0.0335 0.5
Echinococcus granulosus g protein coupled receptor 0.0011 0.0038 0.0038
Schistosoma mansoni opsin-like receptor 0.0011 0.0038 0.0046
Schistosoma mansoni hypothetical protein 0.003 0.0273 0.0329
Echinococcus granulosus suppressor of cytokine signaling 6 0.0009 0.0003 0.0003
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.0111 0.0111
Echinococcus granulosus Solute carrier organic anion transporter family 0.002 0.0151 0.0151
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0017 0.0111 0.0111
Onchocerca volvulus 0.002 0.0151 0.4514
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0017 0.0105 0.3008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0273 0.0273
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0038 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0038 0.0046
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0069
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0016 0.0092 0.2188
Echinococcus multilocularis SHC transforming protein 3 0.0009 0.0003 0.0003
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0009 0.0003 0.0003
Onchocerca volvulus 0.0009 0.0003 0.0082
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0594 0.0594
Brugia malayi SH2 domain containing protein 0.0009 0.0003 0.0003
Brugia malayi Protein kinase domain containing protein 0.0009 0.0003 0.0003
Schistosoma mansoni suppressor of cytokine signaling 0.0009 0.0003 0.0003
Brugia malayi G-protein coupled receptor 0.0011 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase shark 0.0009 0.0003 0.0003
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0016 0.0092 0.263
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0079 0.0079
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0218 0.2667 0.2667
Schistosoma mansoni organic anion transporter 0.002 0.0151 0.0182
Toxoplasma gondii protease inhibitor PI2 0.0014 0.0069 0.1826
Entamoeba histolytica hypothetical protein 0.0133 0.1583 0.2339
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0015 0.0079 0.2368
Brugia malayi putative neuropeptide receptor 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0027 0.0241 0.7193
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0038 0.0038
Mycobacterium ulcerans transglutaminase family protein 0.0035 0.0335 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0015 0.0086 0.2443
Echinococcus granulosus tyrosine protein kinase Src42A 0.0009 0.0003 0.0003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0038 0.0038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0038 0.0046
Loa Loa (eye worm) fatty acid synthase 0.0016 0.009 0.009
Schistosoma mansoni tsg101-related 0.0663 0.8309 1
Brugia malayi SH2 domain containing protein 0.0009 0.0003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Echinococcus granulosus tyrosine kinase 0.0009 0.0003 0.0003
Onchocerca volvulus 0.0011 0.0038 0.1131
Echinococcus granulosus tyrosine protein kinase Src42A 0.0017 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0151
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0038 0.0038
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0038 0.0038
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0038 0.0038
Giardia lamblia Hypothetical protein 0.0035 0.0335 0.5
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0133 0.1583 0.5066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Loa Loa (eye worm) SH2 domain-containing protein 0.0009 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase Srms 0.0009 0.0003 0.0003
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0014 0.0069 0.0069
Echinococcus multilocularis tensin 0.0009 0.0003 0.0003
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0038 0.0046
Schistosoma mansoni hypothetical protein 0.003 0.0273 0.0329
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0038 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0038 0.0046
Brugia malayi hypothetical protein 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0273 0.0273
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0003 0.0003
Brugia malayi Tensin 0.0009 0.0003 0.0003
Echinococcus granulosus NCK adaptor protein 0.0017 0.0111 0.0111
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0038 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0038 0.0046
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.0111 0.0111
Mycobacterium ulcerans polyketide synthase 0.0016 0.0092 0.2188
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.002 0.0151 0.0151
Echinococcus granulosus neuropeptide receptor 0.0011 0.0038 0.0038
Brugia malayi protein-tyrosine kinase 0.0009 0.0003 0.0003
Brugia malayi sodium-independent organic anion transporter family protein 0.002 0.0151 0.0151
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0038 0.0046
Schistosoma mansoni neuropeptide receptor 0.0011 0.0038 0.0046
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0111 0.0111
Onchocerca volvulus 0.0009 0.0003 0.0082
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0009 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0594 0.0715
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0014 0.0069 0.1826
Brugia malayi hypothetical protein 0.002 0.0151 0.0151
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0095 0.1097 0.1097
Loa Loa (eye worm) TK protein kinase 0.0009 0.0003 0.0003
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0038 0.0038
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0017 0.0111 0.0111
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0095 0.1097 0.1097
Schistosoma mansoni amine GPCR 0.0011 0.0038 0.0046
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0038 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0111 0.0111

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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