Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0682 | 1 | 1 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0109 | 0.0777 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0682 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0109 | 0.0777 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0109 | 0.0777 | 0.0529 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0262 | 0.0262 |
Mycobacterium tuberculosis | Conserved protein | 0.0109 | 0.0777 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0777 | 0.0777 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0109 | 0.0777 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0109 | 0.0777 | 0.5 |
Brugia malayi | FXNA | 0.0109 | 0.0777 | 0.0777 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0109 | 0.0777 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0777 | 0.0777 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0109 | 0.0777 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0109 | 0.0777 | 0.0529 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0682 | 1 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0109 | 0.0777 | 0.0529 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0109 | 0.0777 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0262 | 0.0262 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0682 | 1 | 1 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0109 | 0.0777 | 0.0529 |
Leishmania major | glutaminyl cyclase, putative | 0.0109 | 0.0777 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0109 | 0.0777 | 0.0529 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0262 | 0.0262 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0682 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0262 | 0.0262 |
Brugia malayi | nicalin | 0.0109 | 0.0777 | 0.0777 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0109 | 0.0777 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0109 | 0.0777 | 0.0777 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0262 | 0.0262 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0777 | 0.0777 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0262 | 0.0262 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0109 | 0.0777 | 0.0529 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0109 | 0.0777 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0109 | 0.0777 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0777 | 0.0777 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0109 | 0.0777 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0109 | 0.0777 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0109 | 0.0777 | 0.0529 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0109 | 0.0777 | 0.5 |
Schistosoma mansoni | nicalin (M28 family) | 0.0109 | 0.0777 | 0.0529 |
Brugia malayi | leucyl aminopeptidase | 0.0109 | 0.0777 | 0.0777 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0109 | 0.0777 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.