Detailed information for compound 1486127

Basic information

Technical information
  • TDR Targets ID: 1486127
  • Name: 2-[(4-dimethylamino-2-methoxy-5-nitrobenzoyl) amino]ethyl-diethylazanium chloride
  • MW: 374.863 | Formula: C16H27ClN4O4
  • H donors: 1 H acceptors: 3 LogP: 2.69 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)c1cc([N+](=O)[O-])c(cc1OC)N(C)C)CC.Cl
  • InChi: 1S/C16H26N4O4.ClH/c1-6-19(7-2)9-8-17-16(21)12-10-14(20(22)23)13(18(3)4)11-15(12)24-5;/h10-11H,6-9H2,1-5H3,(H,17,21);1H
  • InChiKey: CUHDCJWCMZTSQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(4-dimethylamino-2-methoxy-5-nitro-benzoyl)amino]ethyl-diethyl-ammonium chloride
  • 2-[[(4-dimethylamino-2-methoxy-5-nitrophenyl)-oxomethyl]amino]ethyl-diethylammonium chloride
  • 2-[(4-dimethylamino-2-methoxy-5-nitro-phenyl)carbonylamino]ethyl-diethyl-azanium chloride
  • 89591-51-5
  • 4-Dimethylamino-5-nitro-2-methoxy-N-(2-diethylaminoethyl)benzamide hydrochloride
  • BENZAMIDE, N-(2-(DIETHYLAMINO)ETHYL)-4-(DIMETHYLAMINO)-2-METHOXY-5-NITRO-, MONOH
  • Benzamide, N-(2-(diethylamino)ethyl)-4-(dimethylamino)-2-methoxy-5-nitro-, monohydrochloride
  • Dimethpramide
  • Dimetpramide
  • N-(2-(Diethylamino)ethyl)-4-(dimethylamino)-2-methoxy-5-nitrobenzamide monohydrochloride
  • N-(2-diethylaminoethyl)-4-dimethylamino-2-methoxy-5-nitrobenzamide hydrochloride
  • N-(2-diethylaminoethyl)-4-dimethylamino-2-methoxy-5-nitro-benzamide hydrochloride
  • MLS000710665
  • SMR000280432
  • ST006426

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0621
Schistosoma mansoni alpha-glucosidase 0.0156 0.0615 0.0615
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0146 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0055 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0312 0.1276 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0146 0.0146
Trypanosoma cruzi UDP-galactopyranose mutase 0.0312 0.1276 1
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.237 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0125
Echinococcus granulosus lysine specific histone demethylase 1A 0.0312 0.1276 0.1471
Mycobacterium tuberculosis Possible oxidoreductase 0.0312 0.1276 0.1445
Echinococcus granulosus protoporphyrinogen oxidase 0.2058 0.8678 1
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0146 0.5225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.1999
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0563 0.4395
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0135 0.1069
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0018 0.0117
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0125 0.4457
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0107 0.0815
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0135 0.1038
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.2891 0.2891
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0018 0.0545
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0019 0.0123
Brugia malayi hypothetical protein 0.0312 0.1276 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.2407
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0019 0.0019
Echinococcus multilocularis protoporphyrinogen oxidase 0.237 1 1
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.2891 0.2891
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0106
Mycobacterium ulcerans protoporphyrinogen oxidase 0.237 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0055 0.0026
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0563 0.4395
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0235
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0235
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0125 0.0956
Echinococcus multilocularis lamin 0.003 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0212
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0045 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0118 0.4202
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0125 0.4457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.1999
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0055 0.0026
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0018 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0068 0.2366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.2407
Toxoplasma gondii Alpha-galactosidase 0.0016 0.0023 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.124 0.9711
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0055 0.367
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0146 0.1121
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0018 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0019 0.0572
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0045 0.1548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.2004
Echinococcus granulosus bloom syndrome protein 0.0021 0.0045 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0018 0.0141
Echinococcus multilocularis tumor protein p63 0.0339 0.1392 0.1392
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0312 0.1276 0.125
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0018 0.0545
Schistosoma mansoni amine oxidase 0.0312 0.1276 0.1276
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0055 0.0026
Mycobacterium ulcerans oxidoreductase 0.0312 0.1276 0.125
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0146 0.1121
Onchocerca volvulus 0.003 0.0082 0.0639
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0107 0.0839
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.124 0.9711
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0165 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0006 0.0102
Mycobacterium ulcerans hypothetical protein 0.016 0.0631 0.0603
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.237 1 1
Echinococcus granulosus lamin dm0 0.003 0.0082 0.0094
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0437 0.0437
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0019 0.0123
Trypanosoma cruzi UDP-galactopyranose mutase 0.0312 0.1276 1
Brugia malayi SWIRM domain containing protein 0.0312 0.1276 1
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0082 0.0639
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0023 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0019 0.0572
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0114 0.0437 0.0503
Toxoplasma gondii melibiase subfamily protein 0.0114 0.0437 0.3343
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0312 0.1276 0.1276
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0312 0.1276 0.1276
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0018 0.012
Mycobacterium ulcerans monoamine oxidase 0.0312 0.1276 0.125
Schistosoma mansoni intermediate filament proteins 0.003 0.0082 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0055 0.0435
Mycobacterium tuberculosis Conserved hypothetical protein 0.0312 0.1276 0.1445
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0125 0.0869
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0114 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0235
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0563 0.4526
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0114 0.0437 0.0437
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0631 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0107 0.3793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Mycobacterium tuberculosis Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) 0.2058 0.8678 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0019 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0018 0.0545
Onchocerca volvulus 0.003 0.0082 0.0639
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0055 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0135 0.1038
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0125 0.0125
Mycobacterium ulcerans dehydrogenase 0.0312 0.1276 0.125
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0019 0.0147
Brugia malayi Melibiase family protein 0.0076 0.0276 0.2164
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0018 0.1044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0019 0.0572
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0437 0.0437
Echinococcus multilocularis lamin dm0 0.003 0.0082 0.0082
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0125 0.0144
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0018 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0107 0.3793
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0045 0.0045
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0019 0.0126
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0312 0.1276 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0146 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.2004
Mycobacterium ulcerans hypothetical protein 0.0024 0.0055 0.0026
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0076 0.0276 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0019 0.0572
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0125 0.4457
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0018 0.0545
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0435
Schistosoma mansoni alpha glucosidase 0.004 0.0125 0.0125
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0312 0.1276 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0146 0.1143
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0437 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0107 0.3793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0435
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0125 0.4457
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0016 0.0018
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.0276 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0146 0.5225
Onchocerca volvulus 0.0024 0.0055 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0079 0.2769
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0312 0.1276 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Schistosoma mansoni amine oxidase 0.0312 0.1276 0.1276
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0125 0.0978
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.124 0.9711
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0125 0.853
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0055 0.367
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0055 0.0435
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0034 0.0035
Echinococcus granulosus lysine specific histone demethylase 1A 0.0312 0.1276 0.1471
Schistosoma mansoni lamin 0.003 0.0082 0.0082
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0722 0.0722
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0016 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0055 0.0026
Onchocerca volvulus 0.0105 0.0398 0.3121
Toxoplasma gondii hypothetical protein 0.0049 0.0162 0.1162
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0023 0.0177
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0019 0.0123
Loa Loa (eye worm) intermediate filament protein 0.003 0.0082 0.0639
Plasmodium vivax hypothetical protein, conserved 0.0312 0.1276 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0018 0.0545
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0125 0.853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.124 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0045 0.1548
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0722 0.0722
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0437 0.0437
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0019 0.0019
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.003 0.0005
Loa Loa (eye worm) RecQ helicase 0.0021 0.0045 0.0356
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0146 0.1143
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0018 0.0141
Brugia malayi amine oxidase, flavin-containing family protein 0.0312 0.1276 1
Echinococcus granulosus microtubule associated protein 2 0.0693 0.2891 0.3331
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.003 0.0111
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0135 0.1038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0019 0.0572
Echinococcus granulosus intermediate filament protein 0.003 0.0082 0.0094
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0019 0.0126
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.0722 0.5655
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0055 0.0411
Onchocerca volvulus 0.005 0.0165 0.1293
Trypanosoma brucei glucosidase, putative 0.004 0.0125 0.0984
Echinococcus granulosus lamin 0.003 0.0082 0.0094
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0146 0.1154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0068 0.2366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.2004
Loa Loa (eye worm) hypothetical protein 0.0076 0.0276 0.2164
Plasmodium falciparum protoporphyrinogen oxidase 0.0312 0.1276 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0097 0.0647
Schistosoma mansoni lamin 0.003 0.0082 0.0082
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0125 0.4457
Brugia malayi intermediate filament protein 0.003 0.0082 0.0639
Onchocerca volvulus 0.0312 0.1276 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0125 0.4457
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0146 0.1121
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0026 0.0026
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.0722 0.5655
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0312 0.1276 0.125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.2407
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0082 0.0639
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0175 0.1348
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0125 0.4457
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0045 0.0339
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0055 0.0435
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0125 0.4457
Echinococcus granulosus tumor protein p63 0.0339 0.1392 0.1604
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0107 0.0815
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0125 0.0956
Echinococcus multilocularis musashi 0.003 0.0082 0.0082
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0018 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.1999
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0018 0.0117
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0055 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0107 0.3793
Echinococcus multilocularis 0.0312 0.1276 0.1276
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0055 0.0026
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0146 0.0168
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0312 0.1276 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0125 0.0978
Giardia lamblia GTOR 0.0045 0.0146 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.0165 0.1293
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0055 0.367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0055 0.0034
Toxoplasma gondii histone lysine-specific demethylase 0.0312 0.1276 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0146 0.5225
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0146 0.1121
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0019 0.0123
Schistosoma mansoni alpha-glucosidase 0.0156 0.0615 0.0615
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0125 0.0956
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0312 0.1276 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0235
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Leishmania major UDP-galactopyranose mutase 0.0312 0.1276 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0146 0.1154
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0146 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0107 0.3793
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0019 0.0147
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.003 0.0082 0.0639
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0435
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0055 0.0026
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0034 0.025
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.0722 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0083 0.292
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0125 0.4457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.2004
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0235
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0055 0.0026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0141

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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