Detailed information for compound 149241

Basic information

Technical information
  • TDR Targets ID: 149241
  • Name: N-[2-(2-benzoyl-4-chloro-N-methylanilino)-2-o xoethyl]benzamide
  • MW: 406.862 | Formula: C23H19ClN2O3
  • H donors: 1 H acceptors: 3 LogP: 4.26 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)C(=O)c1ccccc1)N(C(=O)CNC(=O)c1ccccc1)C
  • InChi: 1S/C23H19ClN2O3/c1-26(21(27)15-25-23(29)17-10-6-3-7-11-17)20-13-12-18(24)14-19(20)22(28)16-8-4-2-5-9-16/h2-14H,15H2,1H3,(H,25,29)
  • InChiKey: VIUNGTJYEOBFIE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(2-benzoyl-4-chloro-N-methyl-anilino)-2-oxo-ethyl]benzamide
  • N-[2-[[4-chloro-2-(phenylcarbonyl)phenyl]-methyl-amino]-2-oxo-ethyl]benzamide
  • N-[2-(2-benzoyl-4-chloro-N-methyl-anilino)-2-keto-ethyl]benzamide
  • N-[2-[[2-(benzoyl)-4-chlorophenyl]-methylamino]-2-oxoethyl]benzamide
  • N-[2-[[2-(benzoyl)-4-chloro-phenyl]-methyl-amino]-2-oxo-ethyl]benzamide
  • N-[2-[[4-chloro-2-(oxo-phenylmethyl)phenyl]-methylamino]-2-oxoethyl]benzamide
  • N-[2-[[2-(benzoyl)-4-chloro-phenyl]-methyl-amino]-2-keto-ethyl]benzamide
  • N-[2-[(4-chloro-2-phenylcarbonyl-phenyl)-methyl-amino]-2-oxo-ethyl]benzamide
  • 76337-79-6
  • BRN 5141468
  • Benzamide, N-(2-((2-benzoyl-4-chlorophenyl)methylamino)-2-oxoethyl)-
  • N-(2-((2-Benzoyl-4-chlorophenyl)methylamino)-2-oxoethyl)benzamide
  • 4-Chloro-2-benzoyl-N-methyl-N(sup alpha)-benzoylglycinanilide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0548
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0371 0.0484
Echinococcus multilocularis hypothetical protein 0.0021 0.0111 0.0111
Plasmodium vivax vivapain-2 0.0028 0.0263 0.7748
Brugia malayi nuclear receptor NHR-88 0.0033 0.0371 0.1184
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0371 0.0484
Loa Loa (eye worm) hypothetical protein 0.0031 0.0334 0.0493
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0263 0.0263
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0263 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0371 0.1184
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.0026
Trypanosoma brucei kinesin, putative 0.0021 0.0111 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0371 0.1184
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.004 0.004
Loa Loa (eye worm) ctsf protein 0.0028 0.0263 0.0389
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0371 0.1219
Echinococcus granulosus GPCR family 2 0.0052 0.0765 0.0765
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0371 0.0484
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0111 0.0322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.3133 0.4626
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0371 0.0371
Loa Loa (eye worm) calpain family protein 1 0.007 0.1155 0.1706
Loa Loa (eye worm) hypothetical protein 0.0049 0.0713 0.1053
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0074 0.1231 0.1608
Leishmania major cathepsin L-like protease 0.0028 0.0263 0.1495
Loa Loa (eye worm) hypothetical protein 0.015 0.285 0.4207
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0371 0.0484
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0263 0.0865
Giardia lamblia Cathepsin B precursor 0.0052 0.078 1
Schistosoma mansoni hypothetical protein 0.0335 0.6773 0.8844
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0548
Echinococcus granulosus cathepsin l1 0.002 0.0097 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0263 0.3201
Schistosoma mansoni ran 0.0023 0.0158 0.0207
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0144
Trypanosoma cruzi kinesin, putative 0.0021 0.0111 0.0322
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0111 0.1198
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.015 0.285 0.3721
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0371 0.1184
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.0064
Brugia malayi hypothetical protein 0.0017 0.004 0.0127
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0371 0.0371
Echinococcus multilocularis cathepsin L 0.0017 0.002 0.002
Brugia malayi TAR-binding protein 0.0067 0.1084 0.346
Echinococcus multilocularis cysteine protease 0.0028 0.0263 0.0263
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.002 0.0097 0.0274
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0111 0.0145
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.077 0.2457
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0144
Onchocerca volvulus Huntingtin homolog 0.0129 0.2406 0.7902
Echinococcus granulosus cathepsin l cysteine peptidase 0.0028 0.0263 0.0263
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0111 0.1198
Echinococcus granulosus cysteine protease 0.0017 0.002 0.002
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0111 0.1198
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0111 0.0322
Brugia malayi Cathepsin L-like precursor 0.002 0.0097 0.0311
Schistosoma mansoni hypothetical protein 0.0377 0.7658 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0052 0.078 0.6569
Echinococcus granulosus calpain A 0.0021 0.0111 0.0111
Plasmodium vivax calpain, putative 0.0021 0.0111 0.29
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0371 0.0548
Echinococcus multilocularis calpain A 0.0074 0.1231 0.1231
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0371 0.0484
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0111 0.0322
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.004 0.0052
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0158 0.0158
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.077 0.077
Echinococcus multilocularis calpain family protein 1, d 0.0049 0.0713 0.0713
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1084 0.1084
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0263 0.0263
Brugia malayi Cathepsin L-like precursor 0.0028 0.0263 0.0841
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0263 0.3201
Schistosoma mansoni ran 0.0023 0.0158 0.0207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0263 0.3201
Echinococcus granulosus calpain A 0.0074 0.1231 0.1231
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0208 0.2476
Onchocerca volvulus 0.0028 0.0263 0.0865
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0158 0.4408
Echinococcus granulosus cathepsin l1 0.0028 0.0263 0.0263
Onchocerca volvulus 0.0028 0.0263 0.0865
Plasmodium vivax importin-beta 2, putative 0.0031 0.0334 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0263 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0263 0.3201
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.015 0.285 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0371 0.0371
Brugia malayi cathepsin L-like precursor 0.002 0.0097 0.0311
Leishmania major GTP-binding protein, putative 0.0023 0.0158 0.0465
Brugia malayi Cathepsin L-like precursor 0.0028 0.0263 0.0841
Brugia malayi Cathepsin L-like precursor 0.0028 0.0263 0.0841
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0111 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Brugia malayi hypothetical protein 0.0017 0.004 0.0127
Brugia malayi Cathepsin L-like precursor 0.0028 0.0263 0.0841
Brugia malayi calpain 7 0.0021 0.0111 0.0355
Onchocerca volvulus Huntingtin homolog 0.0129 0.2406 0.7902
Echinococcus granulosus cathepsin L 0.0017 0.002 0.002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0765 0.1129
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0371 0.1184
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0371 0.0484
Brugia malayi Cathepsin L-like precursor 0.0028 0.0263 0.0841
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0111 0.0322
Entamoeba histolytica Ran family GTPase 0.0023 0.0158 0.5689
Onchocerca volvulus 0.0159 0.3045 1
Brugia malayi Importin beta-1 subunit 0.0031 0.0334 0.1067
Brugia malayi calpain family protein 1 0.007 0.1155 0.3688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0111 0.1198
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0371 0.0371
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0334 0.4131
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0334 0.1808
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.004 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0371 0.1184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0111 0.0145
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.004 0.0059
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1084 0.346
Loa Loa (eye worm) hypothetical protein 0.0129 0.2406 0.3552
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0263 0.0865
Giardia lamblia Cathepsin B precursor 0.0052 0.078 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0111 0.0322
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0097 0.3182
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.113 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0548
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0158 0.0234
Leishmania major cathepsin L-like protease 0.0028 0.0263 0.1495
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0548
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0097 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Loa Loa (eye worm) hypothetical protein 0.0163 0.3133 0.4626
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0263 0.3201
Echinococcus granulosus cathepsin b 0.015 0.285 0.285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0371 0.0484
Schistosoma mansoni importin beta-1 0.0031 0.0334 0.0436
Trypanosoma cruzi cruzipain precursor, putative 0.0028 0.0263 0.086
Schistosoma mansoni hypothetical protein 0.0377 0.7658 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0111 0.1198
Onchocerca volvulus 0.0028 0.0263 0.0865
Onchocerca volvulus 0.0033 0.0371 0.1219
Echinococcus granulosus neuropeptide receptor A26 0.0487 1 1
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0111 0.0111
Echinococcus multilocularis GPCR, family 2 0.0052 0.0765 0.0765
Brugia malayi cathepsin B-like cysteine proteinase 0.015 0.285 0.9096
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0548
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0371 0.1184
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.2037 0.6501
Entamoeba histolytica cysteine protease, putative 0.0028 0.0263 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0074 0.1231 0.1608
Echinococcus granulosus cathepsin b 0.015 0.285 0.285
Giardia lamblia Cathepsin B precursor 0.0052 0.078 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0371 0.1184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0371 0.0371
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.113 0.113
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0074 0.1231 0.1231
Toxoplasma gondii cathepsin B 0.0052 0.078 0.6401
Onchocerca volvulus 0.0028 0.0263 0.0865
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0111 0.0145
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0111 0.0322
Echinococcus multilocularis calpain 0.0021 0.0111 0.0111
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0371 0.0484
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0371 0.0548
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0765 0.0765
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0765 0.0765
Echinococcus granulosus cathepsin L cysteine proteinase 0.0028 0.0263 0.0263
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0208 0.0666
Loa Loa (eye worm) calpain family protein 1 0.0049 0.0713 0.1053
Trypanosoma cruzi kinesin, putative 0.0021 0.0111 0.0322
Brugia malayi steroid hormone receptor 0.0033 0.0371 0.1184
Onchocerca volvulus 0.0028 0.0263 0.0865
Brugia malayi MH2 domain containing protein 0.0126 0.2336 0.7457
Onchocerca volvulus 0.002 0.0097 0.032
Brugia malayi nuclear hormone receptor 0.0033 0.0371 0.1184
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0371 0.1184
Loa Loa (eye worm) hypothetical protein 0.007 0.1155 0.1706
Plasmodium vivax vivapain-2 0.0028 0.0263 0.7748
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0263 0.3201
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.015 0.285 0.3721
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0263 0.3201
Schistosoma mansoni hypothetical protein 0.0052 0.0765 0.0999
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.3133 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.077 0.1005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0371 0.0548
Leishmania major cysteine peptidase A (CPA) 0.0028 0.0263 0.1495
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0158 0.0489
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0371 0.0371
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.077 0.077
Echinococcus multilocularis calpain 5 0.0021 0.0111 0.0111
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.0064
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1084 0.1601
Loa Loa (eye worm) fibroinase 0.0028 0.0263 0.0389
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0263 0.0263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0263 0.3201
Loa Loa (eye worm) RNA binding protein 0.0067 0.1084 0.1601
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0208 0.2476
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.0026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0371 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0765 0.2441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0263 0.3201
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0371 0.1184
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0263 0.3201
Onchocerca volvulus 0.0049 0.0713 0.2342
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0263 0.3201
Brugia malayi nuclear receptor RXR 0.0017 0.004 0.0127
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0371 0.1219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.113 0.5
Brugia malayi hypothetical protein 0.0159 0.3045 0.9719
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0371 0.1184
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0028 0.0263 0.7748
Echinococcus multilocularis snurportin 1 0.0335 0.6773 0.6773
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0263 0.3201
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.2336 0.3449
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.2336 0.3449
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0765 0.2441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0263 0.3201
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0111 0.0322
Brugia malayi ecdysteroid receptor 0.0033 0.0371 0.1184
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.113 0.5
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0028 0.0263 0.7748
Schistosoma mansoni hypothetical protein 0.0052 0.0765 0.0999
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0028 0.0263 0.0389
Brugia malayi calpain family protein 1 0.007 0.1155 0.3688
Schistosoma mansoni hypothetical protein 0.0052 0.0765 0.0999
Echinococcus multilocularis cathepsin b 0.015 0.285 0.285
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0371 0.0371
Leishmania major cathepsin L-like protease 0.0028 0.0263 0.1495
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0059
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.113 1
Entamoeba histolytica hypothetical protein 0.0025 0.0208 0.7737
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0371 0.0484
Schistosoma mansoni calpain (C02 family) 0.0021 0.0111 0.0145
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0263 0.086
Echinococcus multilocularis geminin 0.0377 0.7658 0.7658
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0371 0.0548
Leishmania major cathepsin L-like protease 0.0028 0.0263 0.1495
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0371 0.1184
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.113 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0371 0.0371
Entamoeba histolytica protein kinase, putative 0.0021 0.0111 0.3743
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0158 0.0506
Toxoplasma gondii cathepsin CPL 0.0028 0.0263 0.108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0371 0.1184
Echinococcus granulosus snurportin 1 0.0335 0.6773 0.6773
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0371 0.0371
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0052 0.078 0.2688
Trichomonas vaginalis ran, putative 0.0023 0.0158 0.1821
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.004 0.004
Echinococcus granulosus importin subunit beta 1 0.0031 0.0334 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0371 0.0548
Entamoeba histolytica calpain large subunit domain III containing protein 0.0021 0.0111 0.3743
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.0263 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0371 0.1184
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.6773 1
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0263 0.086
Leishmania major cathepsin L-like protease 0.0028 0.0263 0.1495
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.113 0.1476
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0111 0.0111
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0263 0.086
Plasmodium falciparum importin beta, putative 0.0031 0.0334 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.3045 0.4496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1084 0.1416
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0158 0.4408
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0371 0.0371
Onchocerca volvulus 0.0028 0.0263 0.0865
Leishmania major cathepsin L-like protease 0.0028 0.0263 0.1495
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0059
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0371 0.0548
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.007 0.1155 0.1706
Loa Loa (eye worm) cysteine protease 0.0028 0.0263 0.0389
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1084 0.1416
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.077 0.077
Trypanosoma brucei cysteine peptidase C (CPC) 0.0052 0.078 1
Echinococcus granulosus calpain 0.0021 0.0111 0.0111
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0111 0.0322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0263 0.3201
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0371 0.1184
Echinococcus multilocularis cathepsin b 0.015 0.285 0.285
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0052 0.0765 0.0999
Loa Loa (eye worm) hypothetical protein 0.0052 0.0765 0.1129
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0111 0.1198
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0144
Echinococcus granulosus geminin 0.0377 0.7658 0.7658
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0263 1
Brugia malayi calpain 5 0.0021 0.0111 0.0355
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.113 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0158 0.1821
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0263 0.3201
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1084 0.1416
Loa Loa (eye worm) calpain 5 0.0021 0.0111 0.0164
Brugia malayi hypothetical protein 0.0129 0.2406 0.768
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0371 0.1184
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0158 0.0489
Onchocerca volvulus 0.0028 0.0263 0.0865
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Onchocerca volvulus Cathepsin F homolog 0.0028 0.0263 0.0865
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0097 0.1018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0263 0.3201
Brugia malayi Cathepsin L-like cysteine proteinase 0.002 0.0097 0.0311
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0208 0.2476
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0371 0.0484
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0371 0.0371
Echinococcus multilocularis cysteine protease 0.0028 0.0263 0.0263
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.077 0.1005
Loa Loa (eye worm) cathepsin B 0.0052 0.078 0.1152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0097 0.1018
Brugia malayi Cathepsin L-like precursor 0.0028 0.0263 0.0841
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0074 0.1231 0.1231
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0765 0.0765
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1084 0.1416
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0765 0.0765
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1084 0.1416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0263 0.3201
Brugia malayi RNA binding protein 0.0067 0.1084 0.346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0263 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0263 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.078 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0263 0.3201
Loa Loa (eye worm) hypothetical protein 0.0112 0.2037 0.3007
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0334 0.0334
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.007 0.1155 0.1509
Schistosoma mansoni hypothetical protein 0.0112 0.2037 0.266
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0263 0.0344
Loa Loa (eye worm) hypothetical protein 0.0028 0.0263 0.0389
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0263 0.0263
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0548
Loa Loa (eye worm) calpain 0.0021 0.0111 0.0164
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.078 0.1019
Brugia malayi Cathepsin L-like precursor 0.002 0.0097 0.0311
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.077 0.1136
Echinococcus granulosus tar DNA binding protein 0.0067 0.1084 0.1084
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.3133 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.2406 0.3552
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.113 0.1476
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0371 0.0371
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0371 0.0371
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0263 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0371 0.0548
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.004 0.0127
Brugia malayi RNA, U transporter 1 0.0089 0.1561 0.4983
Loa Loa (eye worm) hypothetical protein 0.0049 0.0713 0.1053
Plasmodium falciparum cysteine proteinase falcipain 3 0.0028 0.0263 0.7748
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0263 0.0841
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0371 0.0548
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0371 0.0484
Leishmania major cathepsin L-like protease 0.0028 0.0263 0.1495
Echinococcus multilocularis neuropeptide receptor A26 0.0487 1 1
Trypanosoma brucei antigen, putative 0.0021 0.0111 0.1198
Leishmania major importin beta-1 subunit, putative 0.0025 0.0208 0.0954
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.077 0.1005
Echinococcus multilocularis neuropeptide s receptor 0.0487 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1084 0.1601
Leishmania major cathepsin L-like protease 0.0028 0.0263 0.1495
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0263 1
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0371 0.0371
Echinococcus granulosus calpain 5 0.0021 0.0111 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.004 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0371 0.1184
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Schistosoma mansoni coup transcription factor 0.0033 0.0371 0.0484
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0371 0.0484
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0371 0.1219
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.015 0.285 0.3721
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0334 0.4131
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0371 0.0371
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0371 0.0371
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0263 0.086
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.0026
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.113 0.113
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.077 0.077
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0111 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0263 0.3201
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.015 0.285 0.3721
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0111 0.0322

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 7.6 mg kg-1 Antagonism of pentylenetetrazole-induced convulsion in mice by oral administration. ChEMBL. 6110780
ED50 (functional) = 7.6 mg kg-1 Antagonism of pentylenetetrazole-induced convulsion in mice by oral administration. ChEMBL. 6110780
ED50 (functional) > 100 mg kg-1 Muscle relaxation activity using the rotarod performance test in mice by oral administration. ChEMBL. 6110780
ED50 (functional) > 100 mg kg-1 Muscle relaxation activity using the rotarod performance test in mice by oral administration. ChEMBL. 6110780
LD50 (ADMET) > 1000 mg kg-1 Acute toxicity expressed as LD50 in mice after oral administration. ChEMBL. 6110780
LD50 (ADMET) > 1000 mg kg-1 Acute toxicity expressed as LD50 in mice after oral administration. ChEMBL. 6110780

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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