TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 325.246 | Formula: C13H10F3N5O2
H donors: 3 H acceptors: 5 LogP: 2.05 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(F)(F)F.Nc1n[nH]c2c1ccc(c2)c1ccncn1
InChi: 1S/C11H9N5.C2HF3O2/c12-11-8-2-1-7(5-10(8)15-16-11)9-3-4-13-6-14-9;3-2(4,5)1(6)7/h1-6H,(H3,12,15,16);(H,6,7)
InChiKey: GAKPSXQMLOSMLK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	3-phosphoinositide dependent protein kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_128785	All targets in OG5_128785
Loa Loa (eye worm)	AGC/PDK1 protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785
Schistosoma japonicum	ko:K06276 3-phosphoinositide dependent protein kinase-1, putative	Get druggable targets OG5_128785	All targets in OG5_128785
Brugia malayi	phosphoinositide-dependent protein kinase I	Get druggable targets OG5_128785	All targets in OG5_128785
Loa Loa (eye worm)	AGC/PDK1 protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_128785	All targets in OG5_128785
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785
Candida albicans	similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade	Get druggable targets OG5_128785	All targets in OG5_128785
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785
Candida albicans	similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade	Get druggable targets OG5_128785	All targets in OG5_128785
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	Get druggable targets OG5_128785	All targets in OG5_128785
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	Get druggable targets OG5_128785	All targets in OG5_128785
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.1154	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0695	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1154	0.1684
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0273	0.0273
Schistosoma mansoni	hypothetical protein	0.0016	0.0695	0.0998
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0273	0.0398
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0044	0.2667	0.3892
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0273	0.0273
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0055	0.3426	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0398
Echinococcus multilocularis	Niemann Pick C1 protein	0.0103	0.6853	0.6853
Schistosoma mansoni	coup transcription factor	0.0011	0.0273	0.0392
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.1154	0.1684
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0059	0.3745	0.3745
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0273	0.0392
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0055	0.3426	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.2058	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0741	0.1082
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0273	0.0398
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0273	0.0392
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0273	0.0392
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.1154	0.1684
Schistosoma mansoni	hypothetical protein	0.0043	0.2554	0.3665
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0398
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.2673	0.3837
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0273	0.0398
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.3426	0.9147
Brugia malayi	Protein kinase domain containing protein	0.0059	0.3745	0.5465
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0741	0.5
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.1154	1
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.3745	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.2673	0.2673
Schistosoma mansoni	patched 1	0.0044	0.2667	0.3828
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.1154	0.1684
Brugia malayi	nuclear hormone receptor	0.0011	0.0273	0.0398
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0055	0.3426	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.1154	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0055	0.3426	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0741	0.6421
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0695	0.1014
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.2673	0.2673
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1154	0.1684
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.1154	0.1684
Echinococcus granulosus	mitogen activated protein kinase 3	0.0055	0.3426	0.3426
Echinococcus granulosus	GPCR family 2	0.0016	0.0695	0.0695
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0273	0.0273
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0273	0.0273
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.3745	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0273	0.0398
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.3233	0.4718
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0273	0.0273
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0273	0.0392
Schistosoma mansoni	hypothetical protein	0.0043	0.2554	0.3665
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0273	0.0392
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0695	0.0695
Schistosoma mansoni	hypothetical protein	0.0043	0.2554	0.3665
Brugia malayi	Niemann-Pick C1 protein precursor	0.0103	0.6853	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0273	0.0273
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0273	0.0273
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0273	0.0398
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0105	0.6967	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0055	0.3426	0.3426
Onchocerca volvulus		0.0011	0.0273	0.2365
Onchocerca volvulus		0.0023	0.1154	1
Giardia lamblia	Kinase, CMGC MAPK	0.0055	0.3426	0.5
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.1154	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0055	0.3426	0.4999
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0273	0.0273
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0741	0.1082
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0055	0.3426	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0273	0.0398
Mycobacterium ulcerans	hypothetical protein	0.0023	0.1154	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0273	0.2365
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0273	0.0273
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.1154	0.3369
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.2673	0.39
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.1154	0.3369
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0273	0.0392
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0273	0.0392
Entamoeba histolytica	protein kinase, putative	0.0059	0.3745	0.5465
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0273	0.0398
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0055	0.3426	1
Echinococcus multilocularis	protein patched	0.0044	0.2667	0.2667
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0273	0.0398
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0273	0.0398
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0273	0.2365
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.3426	0.4917
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.2667	0.7121
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0273	0.0398
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0273	0.0273
Echinococcus granulosus	Niemann Pick C1 protein	0.0103	0.6853	0.6853
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0059	0.3745	0.5465
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0059	0.3745	0.5465
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0741	1
Echinococcus multilocularis	protein dispatched 1	0.005	0.3112	0.3112
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0273	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0398
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.1154	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0273	0.0273
Echinococcus multilocularis	mitogen activated protein kinase	0.0055	0.3426	0.3426
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0273	0.0398
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0695	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0398
Echinococcus multilocularis	Niemann Pick C1 protein	0.0147	1	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2667	0.3892
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0273	0.0273
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.1154	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0273	0.0398
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.3426	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0398
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0273	0.0392
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.1154	0.1684
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0741	0.1082
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0103	0.6853	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0695	0.0695
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.2673	0.3837
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.3233	0.4718
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.1154	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.6853	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0695	0.1014
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0273	0.0398
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.2673	0.39
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0398
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0695	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0398
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0273	0.0398
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0273	0.0398
Schistosoma mansoni	hypothetical protein	0.0016	0.0695	0.0998
Echinococcus multilocularis	sterol regulatory element binding protein	0.0044	0.2667	0.2667
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0675	0.5844
Brugia malayi	ecdysteroid receptor	0.0011	0.0273	0.0398
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0273	0.0392
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0273	0.0273
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.2673	0.3837
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0675	0.5844
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0273	0.0398
Echinococcus granulosus	sterol regulatory element binding protein	0.0044	0.2667	0.2667
Schistosoma mansoni	hypothetical protein	0.0016	0.0695	0.0998
Brugia malayi	MAP kinase sur-1	0.0055	0.3426	0.4999
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.1154	0.1684
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0273	0.0273
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.3426	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.1154	1
Echinococcus granulosus	Protein patched homolog 1	0.0044	0.2667	0.2667
Trypanosoma brucei	protein kinase, putative	0.0055	0.3426	1
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.3426	0.9147
Loa Loa (eye worm)	hypothetical protein	0.0054	0.3375	0.4925
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0695	0.0695
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0741	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.3233	0.4718
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.1154	0.3369
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.1154	1
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.3745	0.5376
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0273	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0052	0.3233	0.4718
Brugia malayi	CHE-14 protein	0.0044	0.2667	0.3892
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0273	0.0273
Schistosoma mansoni	hypothetical protein	0.0043	0.2554	0.3665
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0059	0.3745	0.3745
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0273	0.0392
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0273	0.0398
Schistosoma mansoni	hypothetical protein	0.0016	0.0695	0.0998
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0273	0.0398
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.2673	0.2673
Echinococcus granulosus	expressed conserved protein	0.0097	0.6408	0.6408
Echinococcus granulosus	mitogen activated protein kinase	0.0055	0.3426	0.3426
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.1154	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0273	0.0398
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0675	0.5844
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.3745	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0741	0.6421
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0273	0.0398
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.3426	0.9147
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0059	0.3745	0.5465
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.3426	0.9147
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0675	0.5844
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0273	0.0273
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0273	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0036	0.2058	0.3004
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.2673	0.2673
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0273	0.0398
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0695	0.1014
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.1154	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0741	0.1082
Schistosoma mansoni	hypothetical protein	0.0036	0.2058	0.2955
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1154	0.1684
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0273	0.0392
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0273	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0398
Echinococcus multilocularis	expressed conserved protein	0.0097	0.6408	0.6408
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0273	0.0398
Brugia malayi	steroid hormone receptor	0.0011	0.0273	0.0398
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0273	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0741	0.1082

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.67 uM	Inhibition of human PDK1 preincubated with substrate biotinylated-AKT3 for 30 mins measured after 4 hrs by Scintillation proximity assay	ChEMBL.	24900229

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1688216

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1495375