Detailed information for compound 1498049

Basic information

Technical information
  • TDR Targets ID: 1498049
  • Name: [2-(ethyl-phenylamino)-2-oxoethyl] 4-oxo-4-th iophen-2-ylbutanoate
  • MW: 345.413 | Formula: C18H19NO4S
  • H donors: 0 H acceptors: 3 LogP: 2.83 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccccc1)C(=O)COC(=O)CCC(=O)c1cccs1
  • InChi: 1S/C18H19NO4S/c1-2-19(14-7-4-3-5-8-14)17(21)13-23-18(22)11-10-15(20)16-9-6-12-24-16/h3-9,12H,2,10-11,13H2,1H3
  • InChiKey: ZABCEUNEOOLXQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(ethyl-phenyl-amino)-2-oxo-ethyl] 4-oxo-4-(2-thienyl)butanoate
  • 4-oxo-4-(2-thienyl)butanoic acid [2-(ethyl-phenylamino)-2-oxoethyl] ester
  • 4-keto-4-(2-thienyl)butyric acid [2-(ethyl-phenyl-amino)-2-keto-ethyl] ester
  • [2-(ethyl-phenyl-amino)-2-oxo-ethyl] 4-oxo-4-thiophen-2-yl-butanoate
  • ZINC03250049
  • T0509-8896

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE HYDROLASE 0.0993 0.3061 0.5262
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0273 0.0398
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0261 0.0337
Loa Loa (eye worm) hypothetical protein 0.1179 0.3647 0.5308
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0275 0.0798 0.1152
Brugia malayi glutathione reductase 0.0046 0.0076 0.0099
Brugia malayi ADAMTS-like protease 0.0116 0.0297 0.0422
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0275 0.0798 0.219
Loa Loa (eye worm) hypothetical protein 0.0275 0.0798 0.1162
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0034 0.0039 0.0107
Loa Loa (eye worm) hypothetical protein 0.0081 0.0187 0.0272
Entamoeba histolytica hypothetical protein 0.0035 0.0041 1
Loa Loa (eye worm) zinc metallopeptidase 4 0.0067 0.0142 0.0207
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0261 0.0337
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0685 0.2089 1
Echinococcus granulosus disintegrin and metalloproteinase 0.0074 0.0165 0.0152
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0261 0.0337
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0067 0.0142 0.039
Schistosoma mansoni dihydroceramide desaturase 0.0074 0.0165 0.0453
Echinococcus multilocularis lamin dm0 0.0026 0.0013 0.0013
Brugia malayi Reprolysin 0.0027 0.0015 0.0011
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0038 0.0024
Loa Loa (eye worm) glutathione reductase 0.0046 0.0076 0.011
Trypanosoma brucei Polypeptide deformylase 1 0.0685 0.2089 1
Loa Loa (eye worm) hypothetical protein 0.0208 0.0587 0.0855
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0105 0.0092
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0039 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0136 0.0361 0.0525
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0103 0.0254 0.1182
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0013 0.0008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0022 0.0025
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0101 0.025 0.025
Echinococcus multilocularis lamin 0.0026 0.0013 0.0013
Loa Loa (eye worm) angiogenesis inhibito 0.0031 0.0028 0.0041
Schistosoma mansoni hypothetical protein 0.0165 0.045 0.1233
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0039 0.0057
Echinococcus granulosus GPCR family 2 0.0034 0.0039 0.0026
Loa Loa (eye worm) reprolysin 0.0101 0.025 0.0364
Toxoplasma gondii leucyl aminopeptidase LAP 0.0103 0.0254 0.0441
Loa Loa (eye worm) hypothetical protein 0.0203 0.0572 0.0833
Brugia malayi Disintegrin family protein 0.0074 0.0165 0.0229
Loa Loa (eye worm) hypothetical protein 0.0863 0.2651 0.3859
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0057
Mycobacterium ulcerans zinc metalloprotease 0.0275 0.0798 0.1371
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0436 0.1304 0.1292
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0076 0.0121
Schistosoma mansoni neprilysin-2 (M13 family) 0.0139 0.0369 0.1011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0076 0.0076
Plasmodium falciparum M17 leucyl aminopeptidase 0.0103 0.0254 0.0441
Loa Loa (eye worm) hypothetical protein 0.0109 0.0273 0.0398
Loa Loa (eye worm) hypothetical protein 0.0208 0.0587 0.0855
Trypanosoma cruzi Peptide deformylase 2, putative 0.0685 0.2089 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.0038 0.0143
Schistosoma mansoni hypothetical protein 0.0034 0.0039 0.0107
Loa Loa (eye worm) hypothetical protein 0.157 0.4877 0.7099
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0022 0.0022
Loa Loa (eye worm) matrix metalloproteinase 0.0863 0.2651 0.3859
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0027 0.0015 0.0042
Brugia malayi metalloprotease 0.0027 0.0015 0.0011
Schistosoma mansoni lamin 0.0026 0.0013 0.0036
Mycobacterium tuberculosis Probable reductase 0.0105 0.0261 0.0337
Echinococcus granulosus expressed protein 0.0363 0.1074 0.1062
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0436 0.1304 0.1304
Echinococcus multilocularis adam 0.0187 0.0519 0.0519
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0261 0.0337
Mycobacterium ulcerans leucyl aminopeptidase 0.0103 0.0254 0.039
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0139 0.0369 0.1011
Echinococcus granulosus adam 0.0187 0.0519 0.0507
Loa Loa (eye worm) hypothetical protein 0.0203 0.0572 0.0833
Trypanosoma brucei trypanothione reductase 0.0046 0.0076 0.0325
Schistosoma mansoni endothelin-converting enzyme-related 0.0067 0.0142 0.039
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0076 0.0062
Loa Loa (eye worm) peptidase family M1 containing protein 0.0093 0.0224 0.0327
Schistosoma mansoni hypothetical protein 0.0072 0.0157 0.0431
Onchocerca volvulus 0.0136 0.0361 0.0514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0105 0.0141
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0038 0.0143
Brugia malayi ADAM-TS Spacer 1 family protein 0.0254 0.0731 0.1054
Echinococcus granulosus leucine aminopeptidase protein 0.0103 0.0254 0.0241
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0105 0.0153
Echinococcus multilocularis adam 17 protease 0.0747 0.2285 0.2285
Trypanosoma brucei Peptide deformylase 2 0.0685 0.2089 1
Onchocerca volvulus Matrilysin homolog 0.2172 0.6777 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0022 0.0061
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0039 0.0045
Echinococcus multilocularis expressed protein 0.0363 0.1074 0.1074
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.0347 0.0347
Loa Loa (eye worm) matrixin family protein 0.2202 0.687 1
Schistosoma mansoni neprilysin 0.0072 0.0157 0.0431
Loa Loa (eye worm) hypothetical protein 0.0254 0.0731 0.1064
Loa Loa (eye worm) hypothetical protein 0.0101 0.025 0.0364
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0038 0.0143
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0139 0.0369 0.1011
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0685 0.2089 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0022 0.0061
Onchocerca volvulus 0.0863 0.2651 0.39
Plasmodium vivax SET domain protein, putative 0.0029 0.0022 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0022 0.0061
Schistosoma mansoni hypothetical protein 0.0072 0.0157 0.0431
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0038 0.0038
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0067 0.0142 0.039
Plasmodium falciparum glutathione reductase 0.0046 0.0076 0.0121
Echinococcus multilocularis leucine aminopeptidase protein 0.0103 0.0254 0.0254
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0067 0.0142 0.039
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0165 0.0229
Loa Loa (eye worm) hypothetical protein 0.0112 0.0285 0.0414
Loa Loa (eye worm) hypothetical protein 0.0103 0.0256 0.0373
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0273 0.0387
Loa Loa (eye worm) hypothetical protein 0.0085 0.02 0.0291
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0105 0.0105
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0298 0.0082
Plasmodium vivax peptide deformylase, putative 0.1795 0.5588 1
Brugia malayi intermediate filament protein 0.0026 0.0013 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0039 0.0026
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0038 0.0143
Schistosoma mansoni hypothetical protein 0.0072 0.0157 0.0431
Schistosoma mansoni hypothetical protein 0.0034 0.0039 0.0107
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0469 0.1408 0.1396
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0038 0.0038
Echinococcus multilocularis disintegrin and metalloproteinase 0.0074 0.0165 0.0165
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0139 0.0369 0.1011
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0038 0.0024
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.3195 1 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0234 0.0668 0.0972
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0203 0.0572 0.0833
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0105 0.0287
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0032
Loa Loa (eye worm) hypothetical protein 0.0863 0.2651 0.3859
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0208 0.0587 0.0855
Loa Loa (eye worm) hypothetical protein 0.0275 0.0798 0.1162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0105 0.0287
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0076 0.0361
Schistosoma mansoni hypothetical protein 0.0072 0.0157 0.0431
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0038 0.0038
Echinococcus granulosus adam 17 protease 0.0821 0.2519 0.2509
Loa Loa (eye worm) aminopeptidase N 0.0034 0.0038 0.0055
Loa Loa (eye worm) hypothetical protein 0.0063 0.0128 0.0187
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.0038 0.018
Echinococcus multilocularis endothelin converting enzyme 1 0.0275 0.0798 0.0798
Schistosoma mansoni hypothetical protein 0.0072 0.0157 0.0431
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0041 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0008 0.0038
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0993 0.3061 0.4449
Loa Loa (eye worm) peptidase family M13 containing protein 0.0203 0.0572 0.0833
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0038 0.0038
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.0038 0.018
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0038 0.0024
Onchocerca volvulus 0.0115 0.0294 0.0415
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0273 0.0387
Schistosoma mansoni hypothetical protein 0.1023 0.3154 0.8649
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0013 0.0019
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0261 0.0337
Onchocerca volvulus Papilin homolog 0.0063 0.0128 0.017
Trypanosoma cruzi Peptide deformylase 2, putative 0.0685 0.2089 1
Brugia malayi Peptidase family M13 containing protein 0.0275 0.0798 0.1152
Trichomonas vaginalis set domain proteins, putative 0.023 0.0656 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0008 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0568 0.0827
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0103 0.0254 0.1182
Treponema pallidum polypeptide deformylase (def) 0.1795 0.5588 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0039 0.0026
Echinococcus multilocularis musashi 0.0026 0.0013 0.0013
Onchocerca volvulus Matrix metalloproteinase homolog 0.1857 0.5782 0.8529
Brugia malayi hypothetical protein 0.0034 0.0038 0.0043
Plasmodium falciparum peptide deformylase 0.1795 0.5588 1
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0353 0.1042 0.1507
Schistosoma mansoni hypothetical protein 0.0122 0.0316 0.0867
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0298 0.0403
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0101 0.025 0.0686
Echinococcus multilocularis aminopeptidase N 0.0115 0.0294 0.0294
Echinococcus multilocularis geminin 0.0165 0.045 0.045
Brugia malayi angiogenesis inhibito 0.0116 0.0297 0.0422
Chlamydia trachomatis peptide deformylase 0.1795 0.5588 1
Brugia malayi hypothetical protein 0.0035 0.0041 0.0048
Brugia malayi peptidase family M13 containing protein 0.0067 0.0142 0.0196
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.0038 0.0038
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0076 0.011
Schistosoma mansoni hypothetical protein 0.0165 0.045 0.1233
Echinococcus multilocularis GPCR, family 2 0.0034 0.0039 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0105 0.0092
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0298 0.0403
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0038 0.0143
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0275 0.0798 0.1162
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0038 0.0043
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0103 0.0254 0.1215
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0038 0.0024
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0103 0.0254 0.0441
Brugia malayi Hemopexin family protein 0.1023 0.3154 0.4585
Brugia malayi Pre-SET motif family protein 0.0029 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0017
Brugia malayi Matrixin family protein 0.0863 0.2651 0.3852
Echinococcus granulosus geminin 0.0165 0.045 0.0437
Brugia malayi Pax transcription factor protein 2 0.0234 0.0668 0.0962
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0993 0.3061 0.5415
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0316 0.0316
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.1179 0.3647 1
Entamoeba histolytica hypothetical protein 0.0035 0.0041 1
Entamoeba histolytica hypothetical protein 0.0035 0.0041 1
Loa Loa (eye worm) metalloprotease 0.0027 0.0015 0.0023
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0067 0.0142 0.039
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0101 0.025 0.0237
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0316 0.0303
Brugia malayi Pre-SET motif family protein 0.0202 0.0568 0.0817
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0187 0.0519 0.1424
Brugia malayi Matrixin family protein 0.2202 0.687 1
Loa Loa (eye worm) hypothetical protein 0.0208 0.0587 0.0855
Onchocerca volvulus 0.023 0.0656 0.0951
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0275 0.0798 0.1311
Onchocerca volvulus 0.0029 0.0022 0.0013
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.1795 0.5588 1
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0103 0.0254 0.0324
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0298 0.0403
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0261 0.0013
Toxoplasma gondii thioredoxin reductase 0.0046 0.0076 0.0121
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.1795 0.5588 1
Brugia malayi hypothetical protein 0.0187 0.0519 0.0745
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0022 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0347 0.0952
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0072 0.0157 0.0431
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0747 0.2285 0.6265
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.0038 0.0103
Loa Loa (eye worm) hypothetical protein 0.0203 0.0572 0.0833
Schistosoma mansoni hypothetical protein 0.0072 0.0157 0.0431
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.1795 0.5588 1
Toxoplasma gondii peptidase family M13 protein 0.0275 0.0798 0.1417
Loa Loa (eye worm) hypothetical protein 0.0208 0.0587 0.0855
Brugia malayi Matrixin family protein 0.0863 0.2651 0.3852
Loa Loa (eye worm) hypothetical protein 0.0993 0.3061 0.4456
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.0038 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0022 0.0061
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0039 0.0045
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0012
Onchocerca volvulus Matrilysin homolog 0.0863 0.2651 0.39
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0101 0.025 0.0686
Entamoeba histolytica hypothetical protein 0.0035 0.0041 1
Loa Loa (eye worm) matrixin family protein 0.1857 0.5782 0.8416
Loa Loa (eye worm) hypothetical protein 0.0208 0.0587 0.0855
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0105 0.0287
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.0038 0.018
Schistosoma mansoni hypothetical protein 0.0074 0.0165 0.0452
Schistosoma mansoni lamin 0.0026 0.0013 0.0036
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0139 0.0369 0.1011
Mycobacterium ulcerans hydrolase 0.0993 0.3061 0.5447
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0434 0.1299 0.3562
Mycobacterium leprae probable zinc metalloprotease 0.0275 0.0798 0.1021
Onchocerca volvulus 0.1023 0.3154 0.4644
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0067 0.0142 0.039
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0041 0.0112
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0347 0.0952
Brugia malayi Matrixin family protein 0.0863 0.2651 0.3852
Toxoplasma gondii hypothetical protein 0.1795 0.5588 1
Schistosoma mansoni hypothetical protein 0.0034 0.0039 0.0107
Mycobacterium ulcerans peptide deformylase 0.1795 0.5588 1
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0103 0.0254 0.1215
Brugia malayi Thioredoxin reductase 0.0046 0.0076 0.0099
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0019 0.0005
Onchocerca volvulus 0.0034 0.0038 0.0036
Plasmodium falciparum thioredoxin reductase 0.0046 0.0076 0.0121
Onchocerca volvulus 0.0234 0.0668 0.0968
Echinococcus granulosus aminopeptidase N 0.0115 0.0294 0.0281
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0436 0.1304 0.3575
Plasmodium vivax glutathione reductase, putative 0.0046 0.0076 0.0121
Echinococcus granulosus endothelin converting enzyme 1 0.0275 0.0798 0.0786
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0469 0.1408 0.1408
Schistosoma mansoni hypothetical protein 0.0035 0.0041 0.0112
Loa Loa (eye worm) hypothetical protein 0.0074 0.0165 0.024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3017 0.3017
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0022 0.0022
Schistosoma mansoni intermediate filament proteins 0.0026 0.0013 0.0036
Brugia malayi Peptidase family M1 containing protein 0.0115 0.0294 0.0417
Leishmania major trypanothione reductase 0.0046 0.0076 0.0325
Leishmania major polypeptide deformylase-like protein, putative 0.0685 0.2089 1
Brugia malayi Matrixin family protein 0.0863 0.2651 0.3852
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0039 0.0039
Loa Loa (eye worm) peptidase family M13 containing protein 0.0203 0.0572 0.0833

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.3183 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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