TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 276.332 | Formula: C18H16N2O
H donors: 0 H acceptors: 1 LogP: 4.5 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCN(c1ccc(cc1)C=C1C=Cc2c1cccc2)N=O
InChi: 1S/C18H16N2O/c1-2-20(19-21)17-11-7-14(8-12-17)13-16-10-9-15-5-3-4-6-18(15)16/h3-13H,2H2,1H3
InChiKey: YIMHZKNXDQIPKK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	breast cancer 1, early onset	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0531	0.0531
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.037	0.037
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.003	0.003
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.003	0.003
Onchocerca volvulus		0.0054	0.0531	0.0967
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.003	0.003
Schistosoma mansoni	thyroid hormone receptor	0.0151	0.1982	0.1982
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0095	0.0095
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.003	0.003
Echinococcus multilocularis	lamin dm0	0.0054	0.0531	0.0531
Schistosoma mansoni	m-phase inducer phosphatase(cdc25)	0.0059	0.0601	0.0601
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.1469	0.1469
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.003	0.003
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0531	0.0531
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.1469	0.1469
Echinococcus multilocularis	lamin	0.0054	0.0531	0.0531
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0038	0.029	0.029
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.003	0.003
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0365	0.5205	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.003	0.003
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.003	0.003
Schistosoma mansoni	lamin	0.0054	0.0531	0.0531
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0021	0.003	0.003
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0151	0.1982	0.1982
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0038	0.029	0.029
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.081	0.081
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.011	0.011
Entamoeba histolytica	hypothetical protein	0.0043	0.037	0.0711
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0021	0.003	0.003
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.003	0.003
Echinococcus granulosus	intermediate filament protein	0.0054	0.0531	0.0531
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0246	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.003	0.003
Onchocerca volvulus		0.0059	0.0601	0.1102
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.003	0.003
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.003	0.003
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0531	0.0531
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.003	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.003	0.003
Echinococcus granulosus	m phase inducer phosphatasecdc25	0.0059	0.0601	0.0601
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0038	0.029	0.029
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.003	0.003
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.145	0.145
Brugia malayi	ecdysteroid receptor	0.0021	0.003	0.003
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.003	0.003
Entamoeba histolytica	hypothetical protein	0.0043	0.037	0.0711
Brugia malayi	Rhodanese-like domain containing protein	0.0059	0.0601	0.0601
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0365	0.5205	1
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0365	0.5205	0.5205
Entamoeba histolytica	hypothetical protein	0.0043	0.037	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0601	0.0601
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0059	0.0601	0.1154
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.003	0.003
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0038	0.029	0.0557
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.011	0.011
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.003	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.003	0.003
Leishmania major	hypothetical protein, conserved	0.0113	0.1409	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0038	0.029	0.029
Echinococcus granulosus	ubiquitin specific protease 41	0.0038	0.029	0.029
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.013	0.1669	0.1669
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0246	0.5
Entamoeba histolytica	rodhanase-like domain containing protein	0.0059	0.0601	0.1154
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0365	0.5205	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0684	1	1
Onchocerca volvulus		0.0059	0.0601	0.1102
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.003	0.003
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0684	1	1
Giardia lamblia	PHD finger protein 15	0.0035	0.0246	0.0473
Schistosoma mansoni	lamin	0.0054	0.0531	0.0531
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0365	0.5205	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0021	0.003	0.003
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0246	0.0246
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0153	0.0153
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0246	0.0246
Brugia malayi	jmjC domain containing protein	0.0115	0.145	0.145
Loa Loa (eye worm)	hypothetical protein	0.006	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0026	0.011	0.011
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0365	0.5205	0.5205
Onchocerca volvulus		0.0059	0.0601	0.1102
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.003	0.003
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.003	0.003
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.037	0.037
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0531	0.0531
Schistosoma mansoni	hypothetical protein	0.013	0.1669	0.1669
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.029	0.206
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0038	0.029	0.029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.003	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.003	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.003	0.003
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.003	0.003
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0038	0.029	0.0557
Brugia malayi	MH2 domain containing protein	0.0117	0.1469	0.1469
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0246	0.0246
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0059	0.0601	0.1154
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0038	0.029	0.206
Schistosoma mansoni	thyroid hormone receptor	0.0151	0.1982	0.1982
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.003	0.003
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0059	0.0601	0.1154
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0365	0.5205	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0113	0.1409	0.2706
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0684	1	1
Trichomonas vaginalis	cdc25c, putative	0.0059	0.0601	0.1154
Trypanosoma cruzi	hypothetical protein, conserved	0.0113	0.1409	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.003	0.003
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0516	0.0516
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0365	0.5205	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.003	0.003
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0246	0.0246
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.003	0.003
Trypanosoma cruzi	hypothetical protein, conserved	0.0113	0.1409	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.037	0.037
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0021	0.003	0.003
Echinococcus granulosus	lamin	0.0054	0.0531	0.0531
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.003	0.003
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.003	0.003
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.003	0.003
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.145	0.145
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0021	0.003	0.003
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0357	0.0357
Brugia malayi	jmjC domain containing protein	0.0043	0.0357	0.0357
Echinococcus multilocularis	peregrin	0.0035	0.0246	0.0246
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.003	0.003
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0113	0.1409	0.2706
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0365	0.5205	1
Brugia malayi	nuclear receptor NHR-88	0.0021	0.003	0.003
Trichomonas vaginalis	cdc25b, putative	0.0059	0.0601	0.1154
Trichomonas vaginalis	cdc25b, putative	0.0059	0.0601	0.1154
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0531	0.0531
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0038	0.029	0.0557
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0531	0.0531
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.003	0.003
Brugia malayi	Bromodomain containing protein	0.0035	0.0246	0.0246
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.003	0.003
Entamoeba histolytica	hypothetical protein	0.0043	0.037	0.0711
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.0357	0.0357
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.029	0.206
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.003	0.003
Schistosoma mansoni	coup transcription factor	0.0021	0.003	0.003
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0357	0.0357
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.003	0.003
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0365	0.5205	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.003	0.003
Brugia malayi	PHD-finger family protein	0.0035	0.0246	0.0246
Onchocerca volvulus		0.0059	0.0601	0.1102
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0246	0.5
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0357	0.0357
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.003	0.003
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0365	0.5205	1
Schistosoma mansoni	hypothetical protein	0.0043	0.037	0.037
Brugia malayi	hypothetical protein	0.0043	0.037	0.037
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0059	0.0601	0.1154
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0059	0.0601	0.1154
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0684	1	1
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0453	0.0453
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0246	0.0246
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.013	0.1669	0.1669
Echinococcus multilocularis	musashi	0.0054	0.0531	0.0531
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.1094	0.1094
Echinococcus granulosus	lamin dm0	0.0054	0.0531	0.0531
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.029	0.0557
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.003	0.003
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0246	0.5
Brugia malayi	steroid hormone receptor	0.0021	0.003	0.003
Onchocerca volvulus		0.0054	0.0531	0.0967
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0531	0.0531
Brugia malayi	intermediate filament protein	0.0054	0.0531	0.0531
Onchocerca volvulus		0.0365	0.5205	1
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0113	0.1409	1
Brugia malayi	Rhodanese-like domain containing protein	0.0059	0.0601	0.0601
Echinococcus granulosus	peregrin	0.0035	0.0246	0.0246
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.029	0.206
Brugia malayi	nuclear hormone receptor	0.0021	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0021	0.003	0.003
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.003	0.003
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.003	0.003
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.003	0.003
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0453	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0601	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0038	0.029	0.029
Schistosoma mansoni	hypothetical protein	0.0035	0.0246	0.0246
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0038	0.029	0.029
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0153	0.0153
Onchocerca volvulus	Alhambra homolog	0.0035	0.0246	0.0417
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0038	0.029	0.029
Entamoeba histolytica	rodhanase-like domain containing protein	0.0059	0.0601	0.1154
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0365	0.5205	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0095	0.0095
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.003	0.003
Echinococcus multilocularis	m phase inducer phosphatase(cdc25)	0.0059	0.0601	0.0601
Entamoeba histolytica	rodhanase-like domain containing protein	0.0059	0.0601	0.1154
Loa Loa (eye worm)	hypothetical protein	0.0021	0.003	0.003
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0038	0.029	0.0557
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.003	0.003
Echinococcus multilocularis	ubiquitin specific protease 41	0.0038	0.029	0.029
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.003	0.003
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0253	0.3513	1

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)	= 68.858 uM	PUBCHEM_BIOASSAY: MITF Act Counter Assay: HeLa CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-08_Activator_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540328]	ChEMBL.	No reference
Potency (functional)	1.636 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	4.4668 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1713366

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1500766