Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | FAT-3 protein | 0.0201 | 0.0796 | 0.0761 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0201 | 0.0796 | 1 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0201 | 0.0796 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.205 | 0.9097 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0796 | 0.0761 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0201 | 0.0796 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0201 | 0.0796 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0201 | 0.0796 | 0.5 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0201 | 0.0796 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.0201 | 0.0796 | 0.0875 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.205 | 0.9097 | 0.9019 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0201 | 0.0796 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0113 | 0.0124 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0201 | 0.0796 | 0.5 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0201 | 0.0796 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2252 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0163 | 0.1201 |
Schistosoma mansoni | fatty acid desaturase | 0.0201 | 0.0796 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.0077 | 0.0966 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0201 | 0.0796 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0201 | 0.0796 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0201 | 0.0796 | 0.0875 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0201 | 0.0796 | 0.0761 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0201 | 0.0796 | 0.0761 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.2252 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0143 | 0.1792 |
Onchocerca volvulus | 0.2252 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0163 | 0.0056 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0201 | 0.0796 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0163 | 0.1201 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0201 | 0.0796 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.205 | 0.9097 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.205 | 0.9097 | 0.9019 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0201 | 0.0796 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0201 | 0.0796 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0092 | 0.0101 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0201 | 0.0796 | 0.0875 |
Mycobacterium ulcerans | hypothetical protein | 0.0201 | 0.0796 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.2252 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.205 | 0.9097 | 1 |
Onchocerca volvulus | 0.2252 | 1 | 1 | |
Brugia malayi | acyl-CoA desaturase | 0.205 | 0.9097 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 7.94 | Positive allosteric modulation of human mGlu4 receptor expressed in human HEK293 cells assessed as potentiation of glutamate-induced calcium mobilization after 1 hr by FLIPR assay | ChEMBL. | 21295468 |
EC50 (binding) | = 11.5 nM | Positive allosteric modulation of human mGlu4 receptor expressed in human HEK293 cells assessed as potentiation of glutamate-induced calcium mobilization after 1 hr by FLIPR assay | ChEMBL. | 21295468 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.