Detailed information for compound 1505327

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 634.588 | Formula: C35H26N2O10
  • H donors: 0 H acceptors: 5 LogP: 5.55 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(COc1cc(OC(=O)C)c2c(c1)oc(cc2=O)c1ccccc1)OCc1cccc(c1)OCc1[n+]([O-])onc1c1ccccc1
  • InChi: 1S/C35H26N2O10/c1-22(38)45-31-16-27(17-32-34(31)29(39)18-30(46-32)24-10-4-2-5-11-24)43-21-33(40)44-19-23-9-8-14-26(15-23)42-20-28-35(36-47-37(28)41)25-12-6-3-7-13-25/h2-18H,19-21H2,1H3
  • InChiKey: LSCHLGLZRJDCHN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Conserved protein aldo-keto reductase family 1, member B1 (aldose reductase) 316 aa 325 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.027 0.027
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.027 0.027
Echinococcus granulosus hypothetical protein 0.0038 0.027 0.027
Onchocerca volvulus 0.0038 0.027 0.3076
Loa Loa (eye worm) oxidoreductase 0.0038 0.027 0.027
Onchocerca volvulus 0.0038 0.027 0.3076
Echinococcus granulosus SPRY domain containing protein 0.0053 0.0879 0.0879
Entamoeba histolytica aldose reductase, putative 0.0038 0.027 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.027 0.027
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0108 0.3062 0.3062
Brugia malayi GRP1 binding protein 0.0053 0.0879 0.0879
Schistosoma mansoni Band 4.1-like protein 0.0053 0.0879 0.0879
Schistosoma mansoni hypothetical protein 0.004 0.0342 0.0342
Onchocerca volvulus 0.0053 0.0879 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.027 0.5
Loa Loa (eye worm) oxidoreductase 0.0038 0.027 0.027
Schistosoma mansoni Radixin 0.0035 0.0153 0.0153
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0053 0.0879 0.0879
Echinococcus granulosus radixin 0.0155 0.495 0.495
Brugia malayi hypothetical protein 0.0053 0.0879 0.0879
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.027 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.027 0.027
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5
Echinococcus multilocularis radixin 0.0155 0.495 0.495
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5
Schistosoma mansoni aldo-keto reductase 0.0038 0.027 0.027
Echinococcus multilocularis protein tyrosine phosphatase, non receptor type 0.0035 0.0153 0.0153
Onchocerca volvulus 0.0038 0.027 0.3076
Onchocerca volvulus 0.0038 0.027 0.3076
Giardia lamblia Aldose reductase 0.0038 0.027 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0879 0.0879
Echinococcus multilocularis aldo keto reductase 0.0038 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0038 0.027 0.027
Echinococcus granulosus protein 4.1 0.0053 0.0879 0.0879
Loa Loa (eye worm) hypothetical protein 0.0053 0.0879 0.0879
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.027 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5
Echinococcus multilocularis FERM domain containing protein 5 0.0035 0.0153 0.0153
Echinococcus granulosus FERM domain containing protein 3 0.0053 0.0879 0.0879
Loa Loa (eye worm) oxidoreductase 0.0038 0.027 0.027
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.027 0.027
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.027 0.027
Brugia malayi Ferm domain (protein4.1-ezrin-radixin-moesin) family protein 4-like 0.0035 0.0153 0.0153
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0053 0.0879 0.0879
Echinococcus granulosus Ezrin radixin moesin ERM 0.0053 0.0879 0.0879
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.027 0.5
Echinococcus multilocularis aldo keto reductase 0.0038 0.027 0.027
Echinococcus multilocularis merlin:moesin:ezrin:radixin 0.0053 0.0879 0.0879
Onchocerca volvulus 0.0038 0.027 0.3076
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0053 0.0879 0.0879
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.027 0.027
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.027 0.027
Schistosoma mansoni pol-related 0.0038 0.027 0.027
Brugia malayi protein-tyrosine-phosphatase 0.0035 0.0153 0.0153
Brugia malayi FERM domain 0.0053 0.0879 0.0879
Leishmania major prostaglandin f synthase, putative 0.0038 0.027 0.5
Schistosoma mansoni hypothetical protein 0.0053 0.0879 0.0879
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.027 0.027
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0053 0.0879 0.0879
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0879 0.0879
Echinococcus multilocularis 0.0053 0.0879 0.0879
Echinococcus multilocularis FERM central domain 0.0035 0.0153 0.0153
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.027 0.027
Brugia malayi hypothetical protein 0.0035 0.0153 0.0153
Onchocerca volvulus 0.0053 0.0879 1
Brugia malayi neurofibromatosis homolog protein 1 0.0161 0.5203 0.5203
Echinococcus granulosus aldo keto reductase 0.0038 0.027 0.027
Echinococcus multilocularis FERM domain containing protein 5 0.0053 0.0879 0.0879
Toxoplasma gondii aldose reductase, putative 0.0038 0.027 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.027 0.027
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0053 0.0879 0.0879
Echinococcus granulosus FERM domain containing protein 3 0.0035 0.0153 0.0153
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0035 0.0153 0.0153
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5
Echinococcus multilocularis FERM domain containing protein 3 0.0035 0.0153 0.0153
Schistosoma mansoni aldo-keto reductase 0.0038 0.027 0.027
Brugia malayi hypothetical protein 0.0108 0.3062 0.3062
Echinococcus granulosus aldo keto reductase 0.0038 0.027 0.027
Schistosoma mansoni hypothetical protein 0.0053 0.0879 0.0879
Onchocerca volvulus 0.0038 0.027 0.3076
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.027 1
Echinococcus granulosus SPRY domain containing protein 0.0053 0.0879 0.0879
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.027 0.027
Echinococcus multilocularis SPRY domain containing protein 0.0053 0.0879 0.0879
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.025 0.8737 0.8737
Loa Loa (eye worm) hypothetical protein 0.0035 0.0153 0.0153
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.027 0.027
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.027 0.027
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.027 0.027
Echinococcus granulosus FERM domain containing protein 5 0.0035 0.0153 0.0153
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.027 0.5
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.027 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5
Echinococcus granulosus FERM central domain 0.0035 0.0153 0.0153
Onchocerca volvulus 0.0053 0.0879 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.027 0.027
Echinococcus multilocularis Ezrin radixin moesin ERM 0.0053 0.0879 0.0879
Schistosoma mansoni hypothetical protein 0.0035 0.0153 0.0153
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.027 0.027
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.027 0.027
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5
Echinococcus multilocularis SPRY domain containing protein 0.0053 0.0879 0.0879
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.027 0.5
Leishmania major aldo-keto reductase-like protein 0.0038 0.027 0.5
Loa Loa (eye worm) oxidoreductase 0.0038 0.027 0.027
Loa Loa (eye worm) oxidoreductase 0.0038 0.027 0.027
Trypanosoma cruzi aldo-keto reductase 0.0038 0.027 1
Echinococcus multilocularis Pleckstrin y 0.0053 0.0879 0.0879
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0053 0.0879 0.0879
Brugia malayi Ferm domain 0.0053 0.0879 0.0879
Echinococcus granulosus Pleckstrin y 0.0053 0.0879 0.0879
Echinococcus multilocularis ezrin 0.0155 0.495 0.495
Echinococcus granulosus SPRY domain containing protein 0.0053 0.0879 0.0879
Loa Loa (eye worm) hypothetical protein 0.0108 0.3062 0.3062
Mycobacterium ulcerans oxidoreductase 0.0038 0.027 0.5
Echinococcus granulosus ezrin 0.0155 0.495 0.495
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.027 0.027
Onchocerca volvulus Putative 4.1 G protein 0.0053 0.0879 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5
Echinococcus multilocularis aldo keto reductase 0.0038 0.027 0.027
Echinococcus granulosus protein tyrosine phosphatase non receptor type 0.0035 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0053 0.0879 0.0879
Schistosoma mansoni hypothetical protein 0.004 0.0342 0.0342
Entamoeba histolytica aldose reductase, putative 0.0038 0.027 1
Echinococcus granulosus aldo keto reductase 0.0038 0.027 0.027
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.027 0.5
Loa Loa (eye worm) GRP1 binding protein 0.004 0.0342 0.0342
Trypanosoma brucei prostaglandin f synthase 0.0038 0.027 0.5
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.027 0.027
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.027 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0879 0.0879
Echinococcus granulosus merlin:moesin:ezrin:radixin 0.0053 0.0879 0.0879
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0173 0.5676 0.5676
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.027 0.027
Echinococcus multilocularis aldo keto reductase 0.0038 0.027 0.027
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.027 0.027
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.027 0.5
Entamoeba histolytica aldose reductase, putative 0.0038 0.027 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.027 0.5
Giardia lamblia Aldose reductase 0.0038 0.027 0.5
Brugia malayi Ferm domain 0.0053 0.0879 0.0879
Schistosoma mansoni hypothetical protein 0.0053 0.0879 0.0879
Echinococcus granulosus FERM domain containing protein 5 0.0053 0.0879 0.0879
Echinococcus multilocularis FERM domain containing protein 3 0.0053 0.0879 0.0879
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.027 0.027
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.027 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.62 umol/L Inhibition of aldose reductase by spectrophotometric analysis ChEMBL. 21256748

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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