Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0015 | 0.0218 | 0.0218 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0042 | 0.3015 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0473 | 0.0591 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0042 | 0.3015 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0473 | 0.0146 |
Plasmodium vivax | polyprenol reductase, putative | 0.0042 | 0.3015 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0083 | 0.7063 | 0.8827 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0473 | 0.0146 |
Brugia malayi | Protein kinase c protein 2 | 0.0095 | 0.8295 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0473 | 0.0146 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0042 | 0.3015 | 0.3015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.3015 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0042 | 0.3015 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.0473 | 0.0473 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0017 | 0.0473 | 0.0473 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0017 | 0.0473 | 0.0591 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0042 | 0.3015 | 0.3015 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0017 | 0.0473 | 0.0473 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0473 | 0.0146 |
Echinococcus multilocularis | protein kinase c iota type | 0.0029 | 0.1705 | 0.1705 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.008 | 0.6769 | 0.6769 |
Echinococcus granulosus | protein kinase C gamma type | 0.0099 | 0.8768 | 0.8768 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0017 | 0.0473 | 0.0473 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.8001 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3015 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0042 | 0.3015 | 0.5 |
Brugia malayi | protein kinase C II. | 0.0032 | 0.1961 | 0.2364 |
Schistosoma mansoni | unc-13 (munc13) | 0.0015 | 0.0218 | 0.0218 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0042 | 0.3015 | 0.3015 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.008 | 0.6769 | 0.6769 |
Brugia malayi | Protein kinase domain containing protein | 0.0017 | 0.0473 | 0.057 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0032 | 0.1961 | 0.1961 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0032 | 0.1961 | 0.2451 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0042 | 0.3015 | 1 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0015 | 0.0218 | 0.0218 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0015 | 0.0218 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3015 | 0.3768 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.6769 | 0.846 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0017 | 0.0473 | 0.0591 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0032 | 0.1961 | 0.1961 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0042 | 0.3015 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.3015 | 1 | |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0017 | 0.0473 | 0.057 |
Schistosoma mansoni | serine/threonine kinase | 0.0017 | 0.0473 | 0.0473 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0042 | 0.3015 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0473 | 0.0146 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0473 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3015 | 0.3768 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0042 | 0.3015 | 0.3634 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0218 | 0.0273 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.0042 | 0.3015 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.0473 | 0.0473 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0473 | 0.0146 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.0042 | 0.3015 | 1 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0042 | 0.3015 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0042 | 0.3015 | 0.5 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0042 | 0.3015 | 0.3015 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0042 | 0.3015 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0017 | 0.0473 | 0.0591 |
Schistosoma mansoni | protein kinase C | 0.0015 | 0.0218 | 0.0218 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0042 | 0.3015 | 0.3015 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0042 | 0.3015 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0017 | 0.0473 | 0.0591 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0042 | 0.3015 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0017 | 0.0473 | 0.0591 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0017 | 0.0473 | 0.0473 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0032 | 0.1961 | 0.1961 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0042 | 0.3015 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0042 | 0.3015 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0042 | 0.3015 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0042 | 0.3015 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.0473 | 0.0473 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0017 | 0.0473 | 0.0473 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0042 | 0.3015 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0099 | 0.8768 | 0.8768 |
Brugia malayi | Protein kinase domain containing protein | 0.0017 | 0.0473 | 0.057 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.008 | 0.6769 | 0.6769 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0017 | 0.0473 | 0.0473 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0017 | 0.0473 | 0.0473 |
Echinococcus granulosus | protein kinase c iota type | 0.0029 | 0.1705 | 0.1705 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0042 | 0.3015 | 0.5 |
Echinococcus granulosus | NDR protein kinase | 0.0017 | 0.0473 | 0.0473 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0017 | 0.0473 | 0.0591 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.3015 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0473 | 0.0146 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0042 | 0.3015 | 0.3015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.3015 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0015 | 0.0218 | 0.0218 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.0473 | 0.0473 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0017 | 0.0473 | 0.0473 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0042 | 0.3015 | 0.5 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0042 | 0.3015 | 0.3634 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0017 | 0.0473 | 0.0591 |
Echinococcus granulosus | unc 13 munc13 | 0.0015 | 0.0218 | 0.0218 |
Brugia malayi | Protein kinase domain containing protein | 0.0017 | 0.0473 | 0.057 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0473 | 0.0146 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0042 | 0.3015 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0473 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3015 | 0.3768 |
Brugia malayi | Hr1 repeat family protein | 0.0017 | 0.0473 | 0.057 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0473 | 0.0146 |
Schistosoma mansoni | atypical protein kinase C | 0.0029 | 0.1705 | 0.1705 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0017 | 0.0473 | 0.0473 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0017 | 0.0473 | 0.0473 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0042 | 0.3015 | 0.5 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21115212 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.