Detailed information for compound 1508713

Basic information

Technical information
  • TDR Targets ID: 1508713
  • Name: (5Z)-2-(dimethylaminomethyl)-5-pentylidenecyc lopentan-1-one
  • MW: 209.328 | Formula: C13H23NO
  • H donors: 0 H acceptors: 1 LogP: 2.78 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC/C=C\1/CCC(C1=O)CN(C)C
  • InChi: 1S/C13H23NO/c1-4-5-6-7-11-8-9-12(13(11)15)10-14(2)3/h7,12H,4-6,8-10H2,1-3H3/b11-7-
  • InChiKey: DGFOGZAJBWCFAR-XFFZJAGNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z)-2-(dimethylaminomethyl)-5-pentylidene-cyclopentan-1-one
  • (5Z)-2-(dimethylaminomethyl)-5-pentylidene-1-cyclopentanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0389 0.0294 0.0961
Echinococcus granulosus dUTP pyrophosphatase 0.3349 0.2685 0.2685
Schistosoma mansoni microtubule-associated protein tau 0.0717 0.0559 0.1825
Schistosoma mansoni kinase 0.005 0.0021 0.0067
Brugia malayi heat shock protein 90 0.0081 0.0046 0.0043
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.1397 0.1108 0.4105
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Trypanosoma brucei heat shock protein, putative 0.0081 0.0046 0.0322
Echinococcus multilocularis dUTP pyrophosphatase 0.3349 0.2685 0.2685
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0389 0.0294 0.0961
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.006 0.0446
Trichomonas vaginalis conserved hypothetical protein 0.1008 0.0794 0.293
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0294 0.1061
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0389 0.0294 0.0294
Toxoplasma gondii hypothetical protein 0.1008 0.0794 0.2565
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Trichomonas vaginalis heat shock protein, putative 0.0068 0.0035 0.0091
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0389 0.0294 0.2585
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1397 0.1108 0.4105
Plasmodium falciparum endoplasmin, putative 0.0055 0.0025 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0021 0.007
Plasmodium vivax heat shock protein 86, putative 0.0081 0.0046 0.0114
Trypanosoma brucei polo-like protein kinase 0.0098 0.006 0.0446
Trypanosoma brucei heat shock protein, putative 0.0081 0.0046 0.0322
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1397 0.1108 0.4105
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1397 0.1108 0.4105
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Schistosoma mansoni hypothetical protein 0.005 0.0021 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.1397 0.1108 0.4105
Loa Loa (eye worm) hypothetical protein 1.1009 0.8872 0.9159
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.382 0.3066 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0024 0.0122
Loa Loa (eye worm) RNA binding protein 0.0066 0.0034 0.0032
Onchocerca volvulus Huntingtin homolog 0.0127 0.0083 0.7696
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.1022 0.0805 0.8708
Echinococcus multilocularis musashi 0.0028 0.0003 0.0003
Schistosoma mansoni lamin 0.0028 0.0003 0.001
Entamoeba histolytica heat shock protein 90, putative 0.0081 0.0046 0.0132
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0022 0.002
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0389 0.0294 0.0294
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.0117 0.0118
Trypanosoma cruzi heat shock protein 90, putative 0.0081 0.0046 0.0322
Loa Loa (eye worm) hypothetical protein 0.0389 0.0294 0.0301
Brugia malayi hypothetical protein 0.0127 0.0083 0.008
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.3349 0.2685 0.8754
Leishmania major hypothetical protein, conserved 0.0389 0.0294 0.2585
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.1163 0.0919 0.3398
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0389 0.0294 0.0928
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.1022 0.0805 0.8708
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0389 0.0294 0.0294
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Plasmodium vivax heat shock protein, putative 0.0194 0.0137 0.0413
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.3349 0.2685 1
Entamoeba histolytica hypothetical protein 0.2186 0.1746 0.6489
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0034 0.0109
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0034 0.0032
Toxoplasma gondii heat shock protein 75, putative 0.0045 0.0017 0.0021
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0045 0.0017 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.002 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.1008 0.0794 0.293
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Brugia malayi hypothetical protein 0.0035 0.0009 0.0006
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0038 0.0011 0.0011
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.1008 0.0794 0.293
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.0117 0.0114
Brugia malayi hypothetical protein 0.0054 0.0024 0.0021
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0068 0.0035 0.0035
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0389 0.0294 0.0294
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0007
Toxoplasma gondii heat shock protein 90, putative 0.0081 0.0046 0.0116
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.1163 0.0919 0.3329
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.1449 0.1151 0.3732
Plasmodium vivax heat shock protein 90, putative 0.0045 0.0017 0.0019
Brugia malayi Endoplasmin precursor 0.0081 0.0046 0.0043
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1397 0.1108 1
Schistosoma mansoni alpha-glucosidase 0.0146 0.0098 0.032
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0014 0.0012
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Loa Loa (eye worm) hypothetical protein 0.0052 0.0022 0.002
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.382 0.3066 1
Entamoeba histolytica hypothetical protein 0.2186 0.1746 0.6489
Trichomonas vaginalis endoplasmin, putative 0.0055 0.0025 0.0053
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Trypanosoma cruzi heat shock protein 85, putative 0.0081 0.0046 0.0322
Trypanosoma brucei heat shock protein 90, putative 0.0081 0.0046 0.0322
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0045 0.0017 0.0024
Plasmodium falciparum heat shock protein 90, putative 0.0194 0.0137 0.0413
Loa Loa (eye worm) hypothetical protein 0.0054 0.0024 0.0022
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0389 0.0294 0.0928
Trypanosoma cruzi Heat shock protein 83, putative 0.0081 0.0046 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.1008 0.0794 0.293
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0389 0.0294 0.0928
Trypanosoma brucei heat shock protein, putative 0.0081 0.0046 0.0322
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0035 0.0221
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.006 0.5437
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0389 0.0294 0.2585
Schistosoma mansoni heat shock protein 0.0081 0.0046 0.015
Schistosoma mansoni endoplasmin 0.0081 0.0046 0.015
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.382 0.3066 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.1397 0.1108 0.3616
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.1163 0.0919 0.3398
Schistosoma mansoni lipoxygenase 0.0057 0.0027 0.0087
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0117 0.0117
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0389 0.0294 0.0961
Entamoeba histolytica heat shock protein 90, putative 0.0081 0.0046 0.0132
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.3349 0.2685 0.8758
Trichomonas vaginalis heat shock protein, putative 0.0072 0.0038 0.0103
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.1397 0.1108 0.1108
Echinococcus granulosus intermediate filament protein 0.0028 0.0003 0.0003
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0389 0.0294 0.0856
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Plasmodium vivax phosphodiesterase gamma, putative 0.0389 0.0294 0.0928
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0011 0.0008
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0389 0.0294 0.0294
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0011 0.0008
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Loa Loa (eye worm) hypothetical protein 1.2016 0.9686 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.0117 0.0117
Trypanosoma brucei hypothetical protein, conserved 0.0389 0.0294 0.2585
Brugia malayi hypothetical protein 0.0246 0.0179 0.0176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0021 0.007
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1397 0.1108 0.4105
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.0011 0.0004
Mycobacterium leprae conserved hypothetical protein 0.1008 0.0794 0.8581
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.3349 0.2685 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0389 0.0294 0.1061
Echinococcus multilocularis heat shock protein 90 0.0081 0.0046 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.006 0.0183
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0389 0.0294 0.1061
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Giardia lamblia Grp94/Hsp90 0.0072 0.0038 0.0011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Trypanosoma cruzi hypothetical protein, conserved 0.0389 0.0294 0.2585
Giardia lamblia Kinase, PLK 0.0098 0.006 0.0081
Schistosoma mansoni heat shock protein 0.0045 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0127 0.0083 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.006 0.0183
Trypanosoma cruzi heat shock protein, putative 0.0045 0.0017 0.0058
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0389 0.0294 0.1061
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.1022 0.0805 0.8708
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.1163 0.0919 1
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.3349 0.2685 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.382 0.3066 1
Toxoplasma gondii hypothetical protein 0.1008 0.0794 0.2565
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0389 0.0294 0.2585
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Leishmania major hypothetical protein, conserved 0.0038 0.0011 0.0004
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0389 0.0294 0.0301
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0013 0.0017
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Trypanosoma brucei heat shock protein, putative 0.0081 0.0046 0.0322
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.006 0.0183
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.0179 0.0179
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0034 0.0031
Plasmodium vivax endoplasmin, putative 0.0081 0.0046 0.0114
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0389 0.0294 0.1061
Plasmodium falciparum phosphodiesterase gamma, putative 0.0389 0.0294 0.0928
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Schistosoma mansoni lamin 0.0028 0.0003 0.001
Brugia malayi RNA binding protein 0.0066 0.0034 0.0031
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.1449 0.1151 0.3732
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0842 0.0661 0.0661
Entamoeba histolytica hypothetical protein 0.3349 0.2685 1
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0045 0.0017 0.1353
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0045 0.0017 0.0017
Schistosoma mansoni survival motor neuron protein 0.005 0.0021 0.0068
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0389 0.0294 0.1061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0021 0.0021
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0389 0.0294 0.1061
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0389 0.0294 0.2585
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.006 0.0183
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0009 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0081 0.0081
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0389 0.0294 0.0961
Plasmodium falciparum phosphodiesterase delta, putative 0.0389 0.0294 0.0928
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1397 0.1108 0.4105
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.006 0.0183
Trypanosoma brucei cAMP-specific phosphodiesterase 0.1397 0.1108 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0389 0.0294 0.1061
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.1397 0.1108 0.3616
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.3349 0.2685 0.8754
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0389 0.0294 0.2585
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.0179 0.0179
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.006 0.0057
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.006 0.0195
Loa Loa (eye worm) hypothetical protein 0.0246 0.0179 0.0182
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.006 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0034 0.0109
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0389 0.0294 0.0292
Plasmodium falciparum GAF domain-related protein, putative 0.1008 0.0794 0.2564
Trypanosoma brucei heat shock protein, putative 0.0081 0.0046 0.0322
Leishmania major hypothetical protein, conserved 0.0389 0.0294 0.2585
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0389 0.0294 0.0928
Echinococcus granulosus heat shock protein 0.0081 0.0046 0.0046
Trypanosoma brucei Heat shock protein 83, putative 0.0081 0.0046 0.0322
Loa Loa (eye worm) hypothetical protein 0.0127 0.0083 0.0083
Onchocerca volvulus 0.005 0.0021 0.1713
Brugia malayi MH2 domain containing protein 0.0124 0.0081 0.0078
Echinococcus multilocularis heat shock protein 0.0081 0.0046 0.0046
Trypanosoma cruzi heat shock protein 90, putative 0.0068 0.0035 0.0221
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0389 0.0294 0.0928
Echinococcus multilocularis lamin dm0 0.0028 0.0003 0.0003
Echinococcus multilocularis endoplasmin 0.0072 0.0038 0.0038
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0389 0.0294 0.0928
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0389 0.0294 0.2585
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1397 0.1108 0.4105
Leishmania major hypothetical protein, conserved 0.0054 0.0024 0.0122
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.006 0.0446
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.0011 0.0004
Giardia lamblia Heat shock protein HSP 90-alpha 0.0081 0.0046 0.0037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Trypanosoma cruzi hypothetical protein, conserved 0.0389 0.0294 0.2585
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0034 0.0032
Onchocerca volvulus 0.0098 0.0059 0.5418
Mycobacterium ulcerans putative regulatory protein 0.1008 0.0794 0.8581
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.0011 0.0004
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0389 0.0294 0.0961
Giardia lamblia Encystation-specific protease 0.1449 0.1151 0.3683
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0025 0.0053
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.3349 0.2685 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1397 0.1108 1
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0024 0.0044
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Toxoplasma gondii GAF domain-containing protein 0.1008 0.0794 0.2565
Trypanosoma brucei cAMP-specific phosphodiesterase 0.1397 0.1108 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.1449 0.1151 0.3683
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0389 0.0294 0.0928
Schistosoma mansoni alpha-glucosidase 0.0146 0.0098 0.032
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0389 0.0294 0.0294
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.3349 0.2685 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1397 0.1108 0.4105
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.1163 0.0919 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1397 0.1108 0.4105
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.1163 0.0919 1
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0081 0.0081
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0294 0.1061
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.0011 0.0001
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.0011 0.0001
Echinococcus granulosus heat shock protein 90 0.0068 0.0035 0.0035
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0389 0.0294 0.2585
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0021 0.0021
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.006 0.0059
Echinococcus multilocularis heat shock protein 90 0.0068 0.0035 0.0035
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0389 0.0294 0.0961
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1397 0.1108 0.4105
Trypanosoma brucei heat shock protein 90, putative 0.0081 0.0046 0.0322
Entamoeba histolytica hypothetical protein 0.1163 0.0919 0.3398
Leishmania major cAMP-specific phosphodiesterase, putative 0.0389 0.0294 0.2585
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.006 0.0446
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0389 0.0294 0.2585
Echinococcus granulosus endoplasmin 0.0072 0.0038 0.0038
Loa Loa (eye worm) hepatopoietin HPO2 0.0038 0.0011 0.0009
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0038 0.0011 0.0011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0021 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0389 0.0294 0.2585
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0011 0.0011
Mycobacterium ulcerans putative regulatory protein 0.1008 0.0794 0.8581
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Giardia lamblia hypothetical protein 0.0389 0.0294 0.0856
Echinococcus granulosus lamin dm0 0.0028 0.0003 0.0003
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0389 0.0294 0.0294
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0389 0.0294 0.1061
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0034 0.0109
Plasmodium vivax hypothetical protein, conserved 0.1008 0.0794 0.2564
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0389 0.0294 0.2585
Trichomonas vaginalis heat shock protein, putative 0.0072 0.0038 0.0103
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.3349 0.2685 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0003 0.001
Loa Loa (eye worm) PDE1B protein 0.0389 0.0294 0.0301
Loa Loa (eye worm) hypothetical protein 0.0389 0.0294 0.0301
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0389 0.0294 0.0294
Leishmania major heat shock protein, putative 0.0045 0.0017 0.0058
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.0011 0.0004
Onchocerca volvulus Huntingtin homolog 0.0127 0.0083 0.7696
Trypanosoma cruzi hypothetical protein, conserved 0.0389 0.0294 0.2585
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0389 0.0294 0.2585
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.002 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.2371 0.1895 0.7046
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.382 0.3066 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.1397 0.1108 0.1108
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0034 0.0109
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0027 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Loa Loa (eye worm) heat shock protein 90 0.0081 0.0046 0.0045
Schistosoma mansoni alpha glucosidase 0.0038 0.0011 0.0035
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0389 0.0294 0.0961
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.006 0.0183
Brugia malayi TAR-binding protein 0.0066 0.0034 0.0031
Echinococcus multilocularis geminin 0.0364 0.0275 0.0275
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0389 0.0294 0.0961
Wolbachia endosymbiont of Brugia malayi dUTPase 0.3349 0.2685 1
Trypanosoma brucei heat shock protein, putative 0.0081 0.0046 0.0322
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Toxoplasma gondii hypothetical protein 0.1008 0.0794 0.2565
Brugia malayi dUTP diphosphatase 0.3349 0.2685 0.2683
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.006 0.006
Brugia malayi Hsp90 protein 0.0045 0.0017 0.0014
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1397 0.1108 0.1106
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0022 0.0019
Echinococcus granulosus geminin 0.0364 0.0275 0.0275
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.3349 0.2685 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0389 0.0294 0.0961
Loa Loa (eye worm) hypothetical protein 0.0389 0.0294 0.0301
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0389 0.0294 0.0292
Echinococcus multilocularis microtubule associated protein 2 0.0717 0.0559 0.0559
Loa Loa (eye worm) dUTP diphosphatase 0.3349 0.2685 0.277
Trypanosoma cruzi heat shock protein 85, putative 0.0081 0.0046 0.0322
Echinococcus granulosus microtubule associated protein 2 0.0717 0.0559 0.0559
Trypanosoma brucei heat shock protein, putative 0.0081 0.0046 0.0322
Plasmodium falciparum heat shock protein 90, putative 0.0042 0.0014 0.0009
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0024 0.0122
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0389 0.0294 0.0294
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0024 0.0043
Loa Loa (eye worm) endoplasmin 0.0081 0.0046 0.0045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0022 0.0019
Trypanosoma brucei heat shock protein, putative 0.0081 0.0046 0.0322
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0024 0.0122
Giardia lamblia Dipeptidyl-peptidase I precursor 0.1449 0.1151 0.3683
Plasmodium falciparum heat shock protein 90 0.0081 0.0046 0.0114
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0389 0.0294 0.0294
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0027 0.0027
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0389 0.0294 0.1061
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0024 0.0043
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.382 0.3066 1
Schistosoma mansoni hypothetical protein 0.0035 0.0009 0.0029
Toxoplasma gondii cathepsin CPC1 0.382 0.3066 1
Onchocerca volvulus 0.0157 0.0107 1
Loa Loa (eye worm) heat shock protein 75 0.0045 0.0017 0.0015
Toxoplasma gondii preprocathepsin c precursor, putative 0.382 0.3066 1
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0024 0.0043
Echinococcus granulosus heat shock protein 90 0.0081 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0157 0.0107 0.0108
Echinococcus granulosus lamin 0.0028 0.0003 0.0003
Toxoplasma gondii cathepsin CPC2 0.1449 0.1151 0.3733
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0389 0.0294 0.0294
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0021 0.0018
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0389 0.0294 0.1061
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0034 0.0109
Loa Loa (eye worm) hypothetical protein 0.1397 0.1108 0.1142
Schistosoma mansoni heat shock protein 0.0081 0.0046 0.015
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0389 0.0294 0.0292
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0021 0.0018
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1397 0.1108 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0072 0.0038 0.025
Trichomonas vaginalis heat shock protein, putative 0.0081 0.0046 0.0132
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.3349 0.2685 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0389 0.0294 0.1061
Brugia malayi Augmenter of liver regeneration 0.0038 0.0011 0.0008
Brugia malayi hypothetical protein 0.0157 0.0107 0.0104
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Giardia lamblia Hypothetical protein 0.0389 0.0294 0.0856
Echinococcus granulosus tar DNA binding protein 0.0066 0.0034 0.0034
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1397 0.1108 0.4105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0021 0.007
Toxoplasma gondii Hsp90 domain-containing protein 0.0194 0.0137 0.0414
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0389 0.0294 0.0929
Leishmania major heat shock protein 83-1 0.0081 0.0046 0.0322
Trypanosoma brucei heat shock protein 84, putative 0.0045 0.0017 0.0058
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0389 0.0294 0.2585
Schistosoma mansoni hypothetical protein 0.0364 0.0275 0.0896
Echinococcus multilocularis lamin 0.0028 0.0003 0.0003
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0389 0.0294 0.0292
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1163 0.0919 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1397 0.1108 0.4105
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.3349 0.2685 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0389 0.0294 0.0294
Schistosoma mansoni hypothetical protein 0.0364 0.0275 0.0896
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.006 0.006
Toxoplasma gondii heat shock protein HSP90 0.0081 0.0046 0.0116
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.3349 0.2685 0.8754
Trypanosoma cruzi heat shock protein 85, putative 0.0081 0.0046 0.0322
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.3349 0.2685 1
Schistosoma mansoni endoplasmin 0.0081 0.0046 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.006 0.0183
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0389 0.0294 0.1061
Trypanosoma cruzi hypothetical protein, conserved 0.0389 0.0294 0.2585
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0011 0.0011
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1397 0.1108 0.4105

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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