Detailed information for compound 151264

Basic information

Technical information
  • TDR Targets ID: 151264
  • Name: [(E)-1-[3-(trifluoromethyl)phenyl]ethylidenea mino]thiourea
  • MW: 261.267 | Formula: C10H10F3N3S
  • H donors: 1 H acceptors: 0 LogP: 2.74 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N/C(=N/N=C(/c1cccc(c1)C(F)(F)F)\C)/S
  • InChi: 1S/C10H10F3N3S/c1-6(15-16-9(14)17)7-3-2-4-8(5-7)10(11,12)13/h2-5H,1H3,(H3,14,16,17)/b15-6+
  • InChiKey: TZKDKVOAUCBYJK-GIDUJCDVSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[(E)-1-[3-(trifluoromethyl)phenyl]ethylideneamino]thiourea
  • [1-[3-(trifluoromethyl)phenyl]ethylideneamino]thiourea
  • NSC118182

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0027 0.0053 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0295 0.0438
Loa Loa (eye worm) oxidoreductase 0.0033 0.009 0.012
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0368 1
Plasmodium falciparum carbonic anhydrase 0.0029 0.0065 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0053 0.0062
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0295 0.0438
Brugia malayi hypothetical protein 0.0027 0.0053 0.0083
Onchocerca volvulus 0.0027 0.0053 0.5218
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Trypanosoma brucei prostaglandin f synthase 0.0033 0.009 0.117
Onchocerca volvulus 0.0027 0.0053 0.5218
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0027 0.0053 0.0062
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0062 0.9377
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.009 0.012
Loa Loa (eye worm) hypothetical protein 0.0033 0.009 0.012
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0368 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1051 0.6449 1
Entamoeba histolytica aldose reductase, putative 0.0033 0.009 0.6229
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0062 0.1375
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0062 0.0274
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.009 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0368 1
Onchocerca volvulus 0.0027 0.0053 0.5218
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0027 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0027 0.0053 0.0062
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0053 0.0062
Echinococcus multilocularis hypothetical protein 0.0027 0.0053 0.0062
Echinococcus granulosus protein tyrosine phosphatase n9 0.0027 0.0053 0.0062
Schistosoma mansoni carbonic anhydrase 0.0029 0.0065 0.0081
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.009 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Echinococcus multilocularis aldo keto reductase 0.0033 0.009 0.012
Onchocerca volvulus 0.0027 0.0053 0.5218
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0295 0.0438
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.009 0.012
Loa Loa (eye worm) carbonic anhydrase 3 0.0029 0.0065 0.0081
Onchocerca volvulus 0.0027 0.0053 0.5218
Onchocerca volvulus 0.0033 0.009 1
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0062 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0013 0.0021
Brugia malayi hypothetical protein 0.0028 0.0062 0.0096
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0065 0.0101
Onchocerca volvulus 0.0027 0.0053 0.5218
Echinococcus granulosus carbonic anhydrase 0.0029 0.0065 0.0081
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0027 0.0053 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0368 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Schistosoma mansoni pcd6 interacting protein-related 0.0027 0.0053 0.0062
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0053 0.0062
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1051 0.6449 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0295 0.0438
Loa Loa (eye worm) oxidoreductase 0.0033 0.009 0.012
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0027 0.0053 0.0062
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0033 0.009 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.0053 0.1132
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0027 0.0053 0.0062
Onchocerca volvulus 0.0027 0.0053 0.5218
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0033 0.009 0.2169
Trichomonas vaginalis pten, drome, putative 0.0027 0.0053 0.5218
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0053 0.0062
Leishmania major carbonic anhydrase-like protein 0.0029 0.0065 0.1466
Onchocerca volvulus 0.0027 0.0053 0.5218
Brugia malayi Protein-tyrosine phosphatase 0.0027 0.0053 0.0083
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Echinococcus granulosus carbonic anhydrase 0.0029 0.0065 0.0081
Trichomonas vaginalis aldo/keto reductase, putative 0.0033 0.009 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0368 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0053 0.0062
Leishmania major prostaglandin f synthase, putative 0.0033 0.009 0.2169
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.009 0.012
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Entamoeba histolytica hypothetical protein 0.004 0.0137 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0033 0.009 0.0059
Onchocerca volvulus 0.0033 0.009 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0137 0.0192
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.162 1 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0027 0.0053 0.0062
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0065 0.0081
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.009 0.012
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Echinococcus granulosus aldo keto reductase 0.0033 0.009 0.012
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Schistosoma mansoni pol-related 0.0033 0.009 0.012
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0027 0.0053 0.0062
Mycobacterium leprae Isocitrate lyase 0.0759 0.4627 0.4611
Leishmania major cathepsin L-like protease 0.0077 0.0368 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0295 0.0438
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0027 0.0053 0.325
Schistosoma mansoni hypothetical protein 0.0029 0.0065 0.0081
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.009 0.012
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.009 0.012
Trypanosoma cruzi aldo-keto reductase 0.0033 0.009 0.2169
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Brugia malayi Cathepsin L-like precursor 0.002 0.0013 0.0021
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.162 1 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0027 0.0053 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0368 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0027 0.0053 0.0062
Schistosoma mansoni aldo-keto reductase 0.0033 0.009 0.012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0027 0.0053 0.0062
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0295 0.0438
Entamoeba histolytica hypothetical protein 0.004 0.0137 1
Onchocerca volvulus 0.0027 0.0053 0.5218
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0053 0.0062
Echinococcus granulosus aldehyde reductase 0.0023 0.0031 0.0028
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0053 0.0062
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0033 0.009 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Echinococcus granulosus aldo keto reductase 0.0033 0.009 0.012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0029 0.0065 0.1466
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Schistosoma mansoni aldo-keto reductase 0.0033 0.009 0.012
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0027 0.0053 0.0062
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.009 0.014
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.009 0.014
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Schistosoma mansoni hypothetical protein 0.0188 0.1063 0.1632
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0081
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Entamoeba histolytica hypothetical protein 0.004 0.0137 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1
Leishmania major aldo-keto reductase-like protein 0.0033 0.009 0.2169
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0368 1
Onchocerca volvulus 0.0033 0.009 1
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0027 0.0053 0.0062
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0137 0.0192
Echinococcus granulosus aldo keto reductase 0.0033 0.009 0.012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Brugia malayi Cathepsin L-like precursor 0.002 0.0013 0.0021
Onchocerca volvulus 0.0027 0.0053 0.5218
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.0053 0.1132
Brugia malayi hypothetical protein 0.0027 0.0053 0.0083
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0062 0.9377
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Schistosoma mansoni hypothetical protein 0.0188 0.1063 0.1632
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0053 0.0062
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1051 0.6449 1
Loa Loa (eye worm) protein tyrosine phosphatase 0.0027 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.009 0.012
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Onchocerca volvulus 0.0027 0.0053 0.5218
Entamoeba histolytica hypothetical protein 0.004 0.0137 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.162 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Brugia malayi hypothetical protein 0.0027 0.0053 0.0083
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.009 0.012
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0065 0.0101
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0029 0.0065 0.0081
Loa Loa (eye worm) oxidoreductase 0.0033 0.009 0.012
Onchocerca volvulus 0.0027 0.0053 0.5218
Echinococcus granulosus carbonic anhydrase 0.0029 0.0065 0.0081
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0053 0.0062
Echinococcus multilocularis aldo keto reductase 0.0033 0.009 0.012
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0027 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0027 0.0053 0.0062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0137 0.0192
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.0053 0.0062
Echinococcus multilocularis carbonic anhydrase II 0.0029 0.0065 0.0081
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.009 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Brugia malayi Protein-tyrosine phosphatase 0.0027 0.0053 0.0083
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0265 0.7098
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0065 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0368 1
Echinococcus granulosus carbonic anhydrase II 0.0029 0.0065 0.0081
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0029 0.0065 0.1466
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.009 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0368 1
Leishmania major tyrosine specific protein phosphatase, putative 0.0027 0.0053 0.1132
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.009 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0368 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0053 0.0062
Onchocerca volvulus 0.0027 0.0053 0.5218
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0065 0.0081
Leishmania major cathepsin L-like protease 0.0077 0.0368 1
Brugia malayi hypothetical protein 0.0027 0.0053 0.0083
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0053 0.0062
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0295 0.0438
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0027 0.0053 0.0062
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Toxoplasma gondii hypothetical protein 0.0029 0.0065 0.6758
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0013 0.0021
Onchocerca volvulus 0.0027 0.0053 0.5218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0368 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0081
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0062 0.6337
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.009 0.012
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.0053 0.1132
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.009 0.012
Onchocerca volvulus 0.0033 0.009 1
Leishmania major cathepsin L-like protease 0.0077 0.0368 1
Brugia malayi hypothetical protein 0.0027 0.0053 0.0083
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0368 1
Giardia lamblia Aldose reductase 0.0033 0.009 1
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.0053 0.0062
Brugia malayi Cathepsin L-like precursor 0.002 0.0013 0.0021
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.009 0.012
Brugia malayi Protein-tyrosine phosphatase 1 0.0027 0.0053 0.0083
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0065 0.0081
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.009 0.012
Brugia malayi Cathepsin L-like precursor 0.002 0.0013 0.0021
Trypanosoma cruzi aldo/keto reductase, putative 0.0033 0.009 0.2169
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0027 0.0053 0.325
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0326 0.8824
Mycobacterium ulcerans isocitrate lyase AceAb 0.162 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0053 0.0062
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.0053 0.0062
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0053 0.0062
Echinococcus multilocularis aldehyde reductase 0.0023 0.0031 0.0028
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1051 0.6449 1
Onchocerca volvulus 0.0033 0.009 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0053 0.0062
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0053 0.0062
Toxoplasma gondii aldose reductase, putative 0.0033 0.009 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1051 0.6449 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0368 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0081
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0065 0.0081
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0029 0.0065 0.0081
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.009 0.014
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0065 0.0081
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0053 0.0062
Echinococcus multilocularis 0.0027 0.0053 0.0062
Entamoeba histolytica aldose reductase, putative 0.0033 0.009 0.6229
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Entamoeba histolytica aldose reductase, putative 0.0033 0.009 0.6229
Echinococcus granulosus hypothetical protein 0.0033 0.009 0.012
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0029 0.0065 0.0101
Echinococcus multilocularis aldo keto reductase 0.0033 0.009 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Brugia malayi Cathepsin L-like precursor 0.002 0.0013 0.0021
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0029 0.0065 0.0081
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0029 0.0065 0.0101
Echinococcus multilocularis geminin 0.0188 0.1063 0.1632
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0027 0.0053 0.0062
Onchocerca volvulus 4.1 G protein, putative homolog 0.0027 0.0053 0.5218
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0027 0.0053 0.325
Onchocerca volvulus 0.0027 0.0053 0.5218
Mycobacterium ulcerans isocitrate lyase Icl 0.162 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0033 0.009 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0027 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0028 0.0062 0.0076
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0053 0.0062
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0027 0.0053 0.0083
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.009 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Onchocerca volvulus 0.0027 0.0053 0.5218
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0065 0.0081
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0065 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0368 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1
Leishmania major hypothetical protein, conserved 0.0028 0.0062 0.1375
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0027 0.0053 0.0062
Onchocerca volvulus 0.0027 0.0053 0.5218
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0027 0.0053 0.0062
Onchocerca volvulus 0.0027 0.0053 0.5218
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0027 0.0053 0.0062
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0029 0.0065 0.0101
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0027 0.0053 0.0062
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.009 0.014
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Onchocerca volvulus 0.0033 0.009 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Onchocerca volvulus 0.0027 0.0053 0.5218
Onchocerca volvulus 0.0027 0.0053 0.5218
Trypanosoma brucei carbonic anhydrase-like protein 0.0029 0.0065 0.0377
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Onchocerca volvulus 0.0027 0.0053 0.5218
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0027 0.0053 0.1132
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0033 0.009 0.2169
Schistosoma mansoni hypothetical protein 0.004 0.0137 0.0192
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Loa Loa (eye worm) oxidoreductase 0.0033 0.009 0.012
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0029 0.0065 0.0081
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0027 0.0053 0.0062
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0062 0.1375
Brugia malayi jmjC domain containing protein 0.0065 0.0295 0.0458
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1
Loa Loa (eye worm) oxidoreductase 0.0033 0.009 0.012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Onchocerca volvulus 0.0027 0.0053 0.5218
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.009 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1
Giardia lamblia Aldose reductase 0.0033 0.009 1
Brugia malayi jmjC domain containing protein 0.0065 0.0295 0.0458
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.009 0.012
Onchocerca volvulus 0.0027 0.0053 0.5218
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0062
Trypanosoma brucei aldo-keto reductase, putative 0.0033 0.009 0.117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0368 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0033 0.009 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0053 0.0083
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0053 0.0062
Echinococcus multilocularis aldo keto reductase 0.0033 0.009 0.012
Brugia malayi hypothetical protein 0.004 0.0137 0.0212
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0295 0.0438
Echinococcus granulosus geminin 0.0188 0.1063 0.1632
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0053 0.0062
Trichomonas vaginalis aldo/keto reductase, putative 0.0033 0.009 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0053 0.0062
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.009 1

Activities

Activity type Activity value Assay description Source Reference
Cell survived (functional) = 15 day Trypanocidal activity in infected host cells ChEMBL. 12061873
Cell survived (functional) = 15 day Trypanocidal activity in infected host cells ChEMBL. 12061873
IC50 (binding) = 170 nM Inhibitory activity against Trypanosoma cruzi cathepsin L-like protease (cruzain) was determined using purified recombinant protein ChEMBL. 12061873
IC50 (binding) = 170 nM Inhibitory activity against Trypanosoma cruzi cathepsin L-like protease (cruzain) was determined using purified recombinant protein ChEMBL. 12061873

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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