TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 258.276 | Formula: C13H14N4O2
H donors: 1 H acceptors: 3 LogP: 1.66 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC2C(N1c1nc3c(o1)cccn3)CCCC2
InChi: 1S/C13H14N4O2/c18-12-15-8-4-1-2-5-9(8)17(12)13-16-11-10(19-13)6-3-7-14-11/h3,6-9H,1-2,4-5H2,(H,15,18)
InChiKey: TVQBBUXMWAXFBW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0018	0.0538	0.0538
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.1157	0.1157
Leishmania major	cysteine peptidase A (CPA)	0.0022	0.1157	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0002	0.0002
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0002	0.0002
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0022	0.1157	0.1157
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0015	0.0002	0.0002
Loa Loa (eye worm)	CYP4Cod1	0.0028	0.1965	0.1965
Onchocerca volvulus		0.0022	0.1157	0.1157
Schistosoma mansoni	nAChR subunit	0.0015	0.0002	0.0002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.1157	0.0654
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Leishmania major	cathepsin L-like protease	0.0022	0.1157	0.0654
Leishmania major	cathepsin L-like protease	0.0022	0.1157	0.0654
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0015	0.0002	0.0002
Mycobacterium leprae	Conserved hypothetical protein	0.0018	0.0538	0.5
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0079	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.1157	0.1157
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0079	1	1
Brugia malayi	cytochrome P450	0.0018	0.0538	0.0538
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0002	0.0002
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0015	0.0002	0.0002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.1157	0.0654
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.1157	0.1157
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0015	0.0002	0.0002
Onchocerca volvulus		0.0022	0.1157	0.1157
Leishmania major	cathepsin L-like protease	0.0022	0.1157	0.0654
Onchocerca volvulus		0.0022	0.1157	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0079	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.1157	0.1157
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0015	0.0002	0.0002
Loa Loa (eye worm)	LGC-31 protein	0.0015	0.0002	0.0002
Onchocerca volvulus	Cathepsin F homolog	0.0022	0.1157	0.1157
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.1157	0.0654
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0002	0.0002
Leishmania major	cathepsin L-like protease	0.0022	0.1157	0.0654
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.1965	0.1965
Onchocerca volvulus		0.0022	0.1157	0.1157
Echinococcus multilocularis		0.0018	0.0538	0.0536
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0079	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.1157	0.1157
Brugia malayi	Cytochrome P450 family protein	0.0028	0.1965	0.1965
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.1157	0.1157
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0015	0.0002	0.0002
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0002	0.0002
Toxoplasma gondii	cathepsin CPL	0.0022	0.1157	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0015	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Schistosoma mansoni	cytochrome P450	0.0018	0.0538	0.0538
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.1157	0.1157
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0002	0.0002
Leishmania major	cathepsin L-like protease	0.0022	0.1157	0.0654
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0015	0.0002	0.0002
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0002	0.0002
Onchocerca volvulus		0.0022	0.1157	0.1157
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.1157	0.1157
Onchocerca volvulus		0.0015	0.0002	0.0002
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0015	0.0002	0.0002
Loa Loa (eye worm)	cysteine protease	0.0022	0.1157	0.1157
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.1157	0.1157
Schistosoma mansoni	hypothetical protein	0.0018	0.0538	0.0538
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0079	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0002	0.0002
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.1965	0.1965
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0002	0.0002
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0022	0.1157	0.1157
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.1157	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Onchocerca volvulus		0.0015	0.0002	0.0002
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0002	0.0002
Brugia malayi	Cathepsin L-like precursor	0.0022	0.1157	0.1157
Trypanosoma brucei	cytochrome P450, putative	0.0028	0.1965	0.1508
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0002	0.0002
Brugia malayi	Cathepsin L-like precursor	0.0022	0.1157	0.1157
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0015	0.0002	0.0002
Schistosoma mansoni	nAChR subunit	0.0015	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0002	0.0002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.1157	0.0654
Onchocerca volvulus		0.0022	0.1157	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0079	1	1
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0079	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.1157	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Schistosoma mansoni	nAChR subunit	0.0015	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0002	0.0002
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0002	0.0002
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.1157	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.1157	0.1155
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0022	0.1157	0.1157
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.1157	0.1157
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Echinococcus granulosus	nAChR subunit	0.0015	0.0002	0.0002
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0015	0.0002	0.0002
Onchocerca volvulus		0.0015	0.0002	0.0002
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0079	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.1157	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0079	1	1
Echinococcus granulosus	cathepsin l1	0.0022	0.1157	0.1157
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0079	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.1157	0.1157
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.1157	0.0654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0015	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0079	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.1157	0.1157
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0079	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.1157	0.0654
Onchocerca volvulus		0.0022	0.1157	0.1157
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.1157	0.1157
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.1157	0.1157
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0015	0.0002	0.0002
Leishmania major	eukaryotic initiation factor 4a, putative	0.0079	1	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0018	0.0538	0.0538
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0538	0.0538
Schistosoma mansoni	nAChR subunit	0.0015	0.0002	0.0002
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0002	0.0002
Onchocerca volvulus		0.0015	0.0002	0.0002
Loa Loa (eye worm)	fibroinase	0.0022	0.1157	0.1157
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.1157	0.1155
Leishmania major	cytochrome p450-like protein	0.0028	0.1965	0.1508
Brugia malayi	Cathepsin L-like precursor	0.0022	0.1157	0.1157
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0002	0.0002
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0022	0.1157	0.1157
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.1157	0.1157
Schistosoma mansoni	nAChR subunit	0.0015	0.0002	0.0002
Mycobacterium leprae	putative cytochrome p450	0.0018	0.0538	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.1157	0.0654
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0015	0.0002	0.0002
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0015	0.0002	0.0002
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.1157	0.1157
Leishmania major	cathepsin L-like protease	0.0022	0.1157	0.0654
Brugia malayi	Cathepsin L-like precursor	0.0022	0.1157	0.1157
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0002	0.0002
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0028	0.1965	1
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.1157	0.1157
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.1965	0.1965
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0015	0.0002	0.0002
Leishmania major	cathepsin L-like protease	0.0022	0.1157	0.0654
Entamoeba histolytica	cysteine protease, putative	0.0022	0.1157	0.1157
Onchocerca volvulus		0.0015	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.1157	0.1157
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0079	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0058	0.6751	0.6751
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.1965	0.1965
Echinococcus multilocularis	cysteine protease	0.0022	0.1157	0.1155
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.1157	0.1155
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0079	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.1157	0.0654
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.1157	0.1157
Brugia malayi	Cathepsin L-like precursor	0.0022	0.1157	0.1157
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.1157	0.0654
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0002	0.0002
Echinococcus multilocularis	cysteine protease	0.0022	0.1157	0.1155
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0079	1	1
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0018	0.0538	0.0538
Loa Loa (eye worm)	ctsf protein	0.0022	0.1157	0.1157
Brugia malayi	Cation transporter family protein	0.0015	0.0002	0.0002
Treponema pallidum	ATP-dependent RNA helicase	0.0079	1	0.5
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0015	0.0002	0.0002
Onchocerca volvulus		0.0015	0.0002	0.0002
Plasmodium vivax	RNA helicase-1, putative	0.0079	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.1157	0.0654
Leishmania major	eukaryotic initiation factor 4a, putative	0.0079	1	1
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0079	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.1157	0.1155
Brugia malayi	Cation transporter family protein	0.0015	0.0002	0.0002
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0015	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Schistosoma mansoni	nAChR subunit	0.0015	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Onchocerca volvulus	Putative nachr subunit	0.0015	0.0002	0.0002
Brugia malayi	Cathepsin L-like precursor	0.0022	0.1157	0.1157
Loa Loa (eye worm)	cytochrome P450	0.0018	0.0538	0.0538
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0002	0.0002
Brugia malayi	Cytochrome P450 family protein	0.0058	0.6751	0.6751
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0015	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Brugia malayi	excitatory GABA receptor EXP-1A	0.0015	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Schistosoma mansoni	nAChR subunit	0.0015	0.0002	0.0002
Trypanosoma cruzi	cruzipain precursor, putative	0.0022	0.1157	0.1157
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0079	1	1
Brugia malayi	Cytochrome P450 family protein	0.0028	0.1965	0.1965
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0015	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0002	0.0002
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0079	1	1
Leishmania major	cathepsin L-like protease	0.0022	0.1157	0.0654
Brugia malayi	Cation transporter family protein	0.0015	0.0002	0.0002
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0079	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.1157	0.0654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.1157	0.1157
Echinococcus granulosus	cytochrome P450 2K1	0.0018	0.0538	0.0538

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 1000 nM	Binding affinity against GABA-A benzodiazepine receptor	ChEMBL.	11133077
Ki (binding)	> 1000 nM	Binding affinity against GABA-A benzodiazepine receptor	ChEMBL.	11133077

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 151992