Detailed information for compound 1520039

Basic information

Technical information
  • TDR Targets ID: 1520039
  • Name: N'-[2-(3,4-dimethoxyphenyl)acetyl]furan-2-car bohydrazide
  • MW: 304.298 | Formula: C15H16N2O5
  • H donors: 2 H acceptors: 2 LogP: 1.64 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)CC(=O)NNC(=O)c1ccco1
  • InChi: 1S/C15H16N2O5/c1-20-11-6-5-10(8-13(11)21-2)9-14(18)16-17-15(19)12-4-3-7-22-12/h3-8H,9H2,1-2H3,(H,16,18)(H,17,19)
  • InChiKey: KOBCQXCSRDZGIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N'-[2-(3,4-dimethoxyphenyl)-1-oxoethyl]-2-furancarbohydrazide
  • N'-[2-(3,4-dimethoxyphenyl)ethanoyl]furan-2-carbohydrazide
  • CBMicro_032227
  • STK324564
  • ZINC00260062
  • BIM-0032185.P001
  • MixCom6_001891
  • BAS 01188876
  • Furan-2-carboxylic acid N'-[2-(3,4-dimethoxy-phenyl)-acetyl]-hydrazide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GPCR family 2 0.0032 0.003 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0053 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0073 0.0362 0.0362
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0505 0.092
Loa Loa (eye worm) nuclear receptor NHR-67 0.0035 0.0053 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0362 0.0658
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0266 0.0484
Echinococcus granulosus heat shock protein 90 0.0038 0.008 0.0145
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Brugia malayi Protein kinase domain containing protein 0.0093 0.0517 0.0517
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0362 0.0658
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0073 0.0362 0.0658
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Brugia malayi nuclear receptor NHR-67 0.0035 0.0053 0.0053
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0053 0.0053
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0039 0.0086 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0073 0.0362 0.0362
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0055
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0073 0.0362 0.0658
Brugia malayi photoreceptor-specific nuclear receptor 0.0073 0.0362 0.0362
Echinococcus granulosus dual specificity 0.0093 0.0517 0.0941
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0039 0.0086 0.0157
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0362 0.0658
Brugia malayi nuclear hormone receptor 0.0035 0.0053 0.0053
Plasmodium vivax heat shock protein, putative 0.0168 0.1115 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0362 0.0362
Echinococcus granulosus FTZ F1 alpha 0.0073 0.0362 0.0658
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0035 0.0053 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0073 0.0362 0.0362
Schistosoma mansoni zinc finger protein 0.0035 0.0053 0.0097
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0012 0.0029
Brugia malayi RNA, U transporter 1 0.0079 0.0409 0.0409
Echinococcus multilocularis snurportin 1 0.0298 0.2147 0.391
Loa Loa (eye worm) hypothetical protein 0.01 0.0574 0.0574
Schistosoma mansoni RAR-like nuclear receptor 0.0073 0.0362 0.0658
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0362 0.0658
Trypanosoma brucei heat shock protein, putative 0.0044 0.0131 0.0311
Schistosoma mansoni nuclear hormone receptor 0.0073 0.0362 0.0658
Trichomonas vaginalis heat shock protein, putative 0.0038 0.008 0.4732
Schistosoma mansoni heat shock protein 0.0044 0.0131 0.0238
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.003 0.003
Giardia lamblia Heat shock protein HSP 90-alpha 0.0044 0.0131 1
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.008 0.0161
Echinococcus multilocularis peregrin 0.0035 0.0058 0.0105
Loa Loa (eye worm) hypothetical protein 0.0073 0.0362 0.0362
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0131 0.0282
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0053 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0362 0.0658
Echinococcus multilocularis nuclear receptor nhr 48 0.0035 0.0053 0.0097
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0058 0.0516
Loa Loa (eye worm) hypothetical protein 0.0073 0.0362 0.0362
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0035 0.0053 0.0053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0086 0.0157
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0086 0.0086
Echinococcus granulosus heat shock protein 0.0044 0.0131 0.0238
Toxoplasma gondii heat shock protein 90, putative 0.0044 0.0131 0.1173
Brugia malayi heat shock protein 90 0.0044 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Loa Loa (eye worm) RNA binding protein 0.0061 0.0266 0.0266
Schistosoma mansoni hypothetical protein 0.0205 0.1402 0.2554
Brugia malayi nuclear receptor RXR 0.0035 0.0053 0.0053
Echinococcus multilocularis heat shock protein 90 0.0038 0.008 0.0145
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.003 0.0055
Trypanosoma brucei heat shock protein 90, putative 0.0044 0.0131 0.0311
Trypanosoma cruzi squalene monooxygenase, putative 0.0557 0.4203 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0073 0.0362 0.0658
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0012 0.0023
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0012 0.0111
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Echinococcus granulosus nuclear receptor nhr 48 0.0035 0.0053 0.0097
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0073 0.0362 0.0362
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) endoplasmin 0.0044 0.0131 0.0131
Entamoeba histolytica heat shock protein 90, putative 0.0044 0.0131 0.2346
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0693 0.1263
Brugia malayi hypothetical protein 0.0147 0.0945 0.0945
Loa Loa (eye worm) heat shock protein 90 0.0044 0.0131 0.0131
Entamoeba histolytica heat shock protein 90, putative 0.0044 0.0131 0.2346
Brugia malayi orphan nuclear receptor NR2E1 0.0035 0.0053 0.0053
Trypanosoma brucei heat shock protein, putative 0.0044 0.0131 0.0311
Loa Loa (eye worm) hypothetical protein 0.0073 0.0362 0.0362
Trypanosoma brucei heat shock protein, putative 0.0044 0.0131 0.0311
Echinococcus multilocularis GPCR, family 2 0.0032 0.003 0.0055
Schistosoma mansoni endoplasmin 0.0044 0.0131 0.0238
Loa Loa (eye worm) hypothetical protein 0.0073 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Brugia malayi hypothetical protein 0.0078 0.0399 0.0399
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0362 0.0362
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0399 0.0726
Brugia malayi TAR-binding protein 0.0061 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Echinococcus multilocularis heat shock protein 0.0044 0.0131 0.0238
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0035 0.0053 0.0097
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0167 0.0304
Schistosoma mansoni hypothetical protein 0.0078 0.0399 0.0726
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.003 0.003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0073 0.0362 0.0658
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0574 0.0574
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0109 0.0231
Echinococcus multilocularis microtubule associated protein 2 0.072 0.5491 1
Trypanosoma brucei squalene monooxygenase, putative 0.0557 0.4203 1
Echinococcus multilocularis endoplasmin 0.0042 0.0109 0.0199
Brugia malayi Bromodomain containing protein 0.0035 0.0058 0.0058
Brugia malayi steroid hormone receptor 0.0073 0.0362 0.0362
Schistosoma mansoni heat shock protein 0.003 0.0012 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0073 0.0362 0.0658
Echinococcus granulosus snurportin 1 0.0298 0.2147 0.391
Brugia malayi ecdysone receptor 0.0035 0.0053 0.0053
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0093 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Trypanosoma cruzi heat shock protein 90, putative 0.0044 0.0131 0.0282
Trypanosoma brucei heat shock protein, putative 0.0044 0.0131 0.0311
Brugia malayi Hsp90 protein 0.003 0.0012 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0058 0.0516
Trypanosoma brucei heat shock protein, putative 0.0044 0.0131 0.0311
Toxoplasma gondii Hsp90 domain-containing protein 0.0168 0.1115 1
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0266 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0073 0.0362 0.0362
Trypanosoma brucei heat shock protein 90, putative 0.0044 0.0131 0.0311
Loa Loa (eye worm) hypothetical protein 0.0182 0.1223 0.1223
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0073 0.0362 0.0658
Brugia malayi tailless protein 0.0035 0.0053 0.0053
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0073 0.0362 0.3743
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0073 0.0362 0.0362
Echinococcus multilocularis jun protein 0.0187 0.1264 0.2302
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0058 0.0105
Entamoeba histolytica hypothetical protein 0.0078 0.0399 0.766
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0266 0.0484
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0266 0.0484
Schistosoma mansoni coup transcription factor 0.0073 0.0362 0.0658
Onchocerca volvulus 0.0035 0.0053 0.0439
Schistosoma mansoni jun-related protein 0.0152 0.0986 0.1795
Echinococcus granulosus peregrin 0.0035 0.0058 0.0105
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0362 0.0658
Schistosoma mansoni hypothetical protein 0.0152 0.0986 0.1795
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0053 0.0439
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.008 0.3037
Trypanosoma brucei heat shock protein, putative 0.0044 0.0131 0.0311
Echinococcus multilocularis geminin 0.0205 0.1402 0.2554
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0058 0.0105
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0116 0.0212
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0073 0.0362 0.0658
Echinococcus granulosus heat shock protein 90 0.0044 0.0131 0.0238
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0116 0.0116
Echinococcus granulosus tar DNA binding protein 0.0061 0.0266 0.0484
Echinococcus granulosus ecdysone induced protein 78C 0.0073 0.0362 0.0658
Echinococcus granulosus endoplasmin 0.0042 0.0109 0.0199
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0266 0.0266
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0058 0.0105
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0073 0.0362 0.0658
Brugia malayi Latrophilin receptor protein 2 0.0032 0.003 0.003
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0109 0.5
Schistosoma mansoni endoplasmin 0.0044 0.0131 0.0238
Onchocerca volvulus 0.0035 0.0053 0.0439
Echinococcus multilocularis dual specificity 0.0093 0.0517 0.0941
Schistosoma mansoni nuclear receptor nhr-48 0.0035 0.0053 0.0097
Loa Loa (eye worm) hypothetical protein 0.006 0.0257 0.0257
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0399 0.0726
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.0517 0.1204
Brugia malayi nuclear receptor NHR-88 0.0035 0.0053 0.0053
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0053 0.0097
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0693 0.1263
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0109 0.5
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0058 0.0058
Brugia malayi hypothetical protein 0.0039 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0205 0.1402 0.2554
Leishmania major squalene monooxygenase-like protein 0.0557 0.4203 1
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0055
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Onchocerca volvulus Bile acid receptor homolog 0.0073 0.0362 0.3743
Schistosoma mansoni retinoic acid receptor RXR 0.0073 0.0362 0.0658
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0131 0.0282
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0093 0.0517 0.123
Schistosoma mansoni microtubule-associated protein tau 0.072 0.5491 1
Brugia malayi hypothetical protein 0.0035 0.0053 0.0053
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0035 0.0053 0.0053
Schistosoma mansoni nuclear receptor 0.0035 0.0053 0.0097
Loa Loa (eye worm) hypothetical protein 0.0073 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Brugia malayi Endoplasmin precursor 0.0044 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0078 0.0399 0.766
Loa Loa (eye worm) heat shock protein 75 0.003 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0073 0.0362 0.0362
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0362 0.0362
Brugia malayi nuclear receptor NHR-88 0.0073 0.0362 0.0362
Brugia malayi hypothetical protein 0.0035 0.0053 0.0053
Echinococcus granulosus geminin 0.0205 0.1402 0.2554
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0266 0.0484
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0517 0.0941
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0035 0.0053 0.0097
Brugia malayi nuclear hormone receptor 0.0073 0.0362 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0073 0.0362 0.0362
Echinococcus granulosus jun protein 0.0187 0.1264 0.2302
Onchocerca volvulus 0.0073 0.0362 0.3743
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0053 0.0097
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0399 0.0726
Entamoeba histolytica hypothetical protein 0.0078 0.0399 0.766
Schistosoma mansoni heat shock protein 0.0044 0.0131 0.0238
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0053 0.0097
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Echinococcus granulosus microtubule associated protein 2 0.072 0.5491 1
Plasmodium vivax heat shock protein 90, putative 0.003 0.0012 0.0111
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0574 0.0574
Entamoeba histolytica hypothetical protein 0.0078 0.0399 0.766
Schistosoma mansoni hypothetical protein 0.0035 0.0058 0.0105
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0035 0.0053 0.0097
Onchocerca volvulus Alhambra homolog 0.0035 0.0058 0.0485
Schistosoma mansoni nuclear receptor 0.0035 0.0053 0.0097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0093 0.0513 0.0513
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0039 0.0086 0.0086
Brugia malayi nuclear hormone receptor family member nhr-6 0.0035 0.0053 0.0053
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0109 0.776
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0058 0.0516
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Treponema pallidum heat shock protein 90 0.0042 0.0109 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0073 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Brugia malayi ecdysteroid receptor 0.0073 0.0362 0.0362
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0073 0.0362 0.0658
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0073 0.0362 0.0362
Trypanosoma brucei heat shock protein, putative 0.0044 0.0131 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0362 0.0362
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0109 0.5
Schistosoma mansoni hypothetical protein 0.0298 0.2147 0.391
Brugia malayi jmjC domain containing protein 0.0115 0.0693 0.0693
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0055
Loa Loa (eye worm) hypothetical protein 0.0093 0.0513 0.0513
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.003 0.0055
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0073 0.0362 0.0658
Brugia malayi RNA binding protein 0.0061 0.0266 0.0266
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0362 0.0362
Echinococcus multilocularis FTZ F1 alpha 0.0073 0.0362 0.0658
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Trypanosoma brucei Heat shock protein 83, putative 0.0044 0.0131 0.0311
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Brugia malayi nuclear receptor RXR 0.0039 0.0086 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0053 0.0097
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0073 0.0362 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0362 0.0362
Plasmodium falciparum heat shock protein 90, putative 0.0168 0.1115 1
Loa Loa (eye worm) DR-78 0.0035 0.0053 0.0053
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0035 0.0053 0.0097
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0053 0.0097
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0073 0.0362 0.0658
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0116 0.0212
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.0517 0.1204
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0073 0.0362 0.0658
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0073 0.0362 0.0362
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0073 0.0362 0.0362
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0131 0.0282
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0093 0.0517 0.1204
Loa Loa (eye worm) hypothetical protein 0.1288 1 1
Giardia lamblia Grp94/Hsp90 0.0042 0.0109 0.7039
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0131 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0322 0.0322
Onchocerca volvulus 0.0147 0.0945 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Brugia malayi PHD-finger family protein 0.0035 0.0058 0.0058
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0053 0.0097
Plasmodium falciparum phd finger protein, putative 0.0035 0.0058 0.0516
Trypanosoma cruzi squalene monooxygenase, putative 0.0557 0.4203 1
Entamoeba histolytica protein kinase domain containing protein 0.0093 0.0517 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0073 0.0362 0.0658
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0109 0.776
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0012 0.0023
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0053 0.0097
Echinococcus multilocularis ecdysone induced protein 78C 0.0073 0.0362 0.0658
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0053 0.0439
Brugia malayi nuclear hormone receptor family member odr-7 0.0035 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0109 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0073 0.0362 0.0362
Plasmodium falciparum heat shock protein 90 0.0044 0.0131 0.1173
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0187 0.1264 0.2302
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0073 0.0362 0.0362
Brugia malayi jmjC domain containing protein 0.0043 0.0116 0.0116
Plasmodium vivax heat shock protein 86, putative 0.0044 0.0131 0.1173
Echinococcus granulosus thyroid hormone receptor alpha 0.0035 0.0053 0.0097
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0116 0.0212
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.003 0.0055
Brugia malayi hypothetical protein 0.0039 0.0086 0.0086
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.008 0.0145
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0167 0.0304
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0355 0.0355
Brugia malayi conserved hypotetical protein 0.0035 0.0053 0.0053
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0362 0.0658
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.008 0.0161
Entamoeba histolytica protein kinase, putative 0.0093 0.0517 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0073 0.0362 0.0362
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0266 0.0484
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Echinococcus multilocularis thyroid hormone receptor alpha 0.0073 0.0362 0.0658
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Echinococcus multilocularis heat shock protein 90 0.0044 0.0131 0.0238
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0086 0.0086
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.003 0.0055
Entamoeba histolytica protein kinase, putative 0.0093 0.0517 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0073 0.0362 0.3743
Brugia malayi bZIP transcription factor family protein 0.0187 0.1264 0.1264
Schistosoma mansoni hypothetical protein 0.0069 0.0322 0.0587
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0116 0.0212
Entamoeba histolytica hypothetical protein 0.0093 0.0517 1
Loa Loa (eye worm) nuclear hormone receptor 0.0035 0.0053 0.0053
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0039 0.0086 0.0157
Plasmodium falciparum endoplasmin, putative 0.0032 0.0034 0.0305
Toxoplasma gondii heat shock protein HSP90 0.0044 0.0131 0.1173
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Loa Loa (eye worm) steroid hormone receptor 0.0073 0.0362 0.0362
Trypanosoma cruzi Heat shock protein 83, putative 0.0044 0.0131 0.0282
Plasmodium vivax endoplasmin, putative 0.0044 0.0131 0.1173
Trypanosoma brucei heat shock protein, putative 0.0044 0.0131 0.0311
Schistosoma mansoni steroid hormone receptor ad4bp 0.0073 0.0362 0.0658
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0073 0.0362 0.0362
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0073 0.0362 0.0658
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0187 0.1264 0.2302
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.2147 0.2147
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0362 0.0362
Leishmania major heat shock protein 83-1 0.0044 0.0131 0.0282

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1122 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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