Detailed information for compound 1525084

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.229 | Formula: C14H12Cl2N2OS
  • H donors: 1 H acceptors: 2 LogP: 5.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1nc(c(s1)C(=O)/C=C/c1ccc(cc1Cl)Cl)C
  • InChi: 1S/C14H12Cl2N2OS/c1-8-13(20-14(17-2)18-8)12(19)6-4-9-3-5-10(15)7-11(9)16/h3-7H,1-2H3,(H,17,18)/b6-4+
  • InChiKey: JPIHSLFKWSZWBK-GQCTYLIASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0565
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0055 0.0376 0.1032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0381 0.1046
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0019 0.0019
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0115 0.3308
Brugia malayi glutaminase DH11.1 0.0306 0.3206 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.031 0.0913
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0329 0.1026
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0019 0.0614
Schistosoma mansoni hypothetical protein 0.0046 0.0272 0.0746
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.1531 0.3808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0329 0.0903
Trypanosoma brucei metacaspase 0.005 0.031 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0476 0.0997
Trichomonas vaginalis conserved hypothetical protein 0.005 0.031 0.0913
Plasmodium vivax hypothetical protein, conserved 0.005 0.031 1
Schistosoma mansoni caspase-7 (C14 family) 0.0131 0.1229 0.3375
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.031 0.0913
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0206 0.0512
Echinococcus granulosus caspase 0.0131 0.1229 0.3056
Entamoeba histolytica hypothetical protein 0.004 0.0206 0.8266
Entamoeba histolytica hypothetical protein 0.004 0.0206 0.8266
Brugia malayi RNA, U transporter 1 0.0092 0.0787 0.2455
Mycobacterium leprae conserved hypothetical protein 0.004 0.0206 0.0364
Mycobacterium ulcerans glutaminase 0.0306 0.3206 0.7394
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0218 0.6847
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0206 0.0364
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0218 0.0543
Onchocerca volvulus 0.0054 0.036 0.4339
Echinococcus granulosus tumor protein p63 0.0378 0.4022 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0272 0.0746
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0115 0.0115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0329 0.0818
Leishmania major hypothetical protein, conserved 0.004 0.0206 0.409
Echinococcus granulosus importin subunit beta 1 0.0032 0.0115 0.0287
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0115 0.3308
Schistosoma mansoni hypothetical protein 0.0345 0.3641 1
Onchocerca volvulus 0.004 0.0206 0.2478
Schistosoma mansoni caspase-3 (C14 family) 0.0131 0.1229 0.3375
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0476 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0206 0.0364
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0206 0.0642
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0599
Trypanosoma cruzi metacaspase 5, putative 0.005 0.031 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0206 0.0364
Plasmodium falciparum metacaspase-like protein 0.005 0.031 1
Trypanosoma cruzi metacaspase, putative 0.005 0.031 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0329 0.0329
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0206 0.0565
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.031 0.0913
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0218 0.8828
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0329 0.0903
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.005 0.1393
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0132 0.1241 0.1241
Brugia malayi beta-lactamase family protein 0.004 0.0206 0.0642
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.2658 0.611
Trichomonas vaginalis conserved hypothetical protein 0.005 0.031 0.0913
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0019 0.0059
Trypanosoma brucei Metacaspase-4 0.005 0.031 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.036 0.1124
Brugia malayi beta-lactamase 0.004 0.0206 0.0642
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0019 0.0614
Trichomonas vaginalis esterase, putative 0.004 0.0206 0.0586
Brugia malayi AMP-binding enzyme family protein 0.0027 0.005 0.0157
Schistosoma mansoni glutaminase 0.0306 0.3206 0.8804
Schistosoma mansoni hypothetical protein 0.004 0.0206 0.0564
Echinococcus granulosus caspase 2 0.0096 0.0831 0.2065
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0476 0.0997
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0245 1
Plasmodium falciparum importin beta, putative 0.0032 0.0115 0.3719
Entamoeba histolytica hypothetical protein 0.004 0.0206 0.8266
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0381 0.1188
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0206 0.6423
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.1583 0.1583
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0206 0.0586
Loa Loa (eye worm) hypothetical protein 0.0265 0.274 0.7523
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0206 0.0586
Trypanosoma brucei metacaspase MCA3 0.005 0.031 1
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0206 0.0364
Schistosoma mansoni hypothetical protein 0.0054 0.036 0.099
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.031 0.0913
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0206 0.0364
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.031 0.0913
Brugia malayi hypothetical protein 0.0046 0.0272 0.0847
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0218 0.0599
Schistosoma mansoni hypothetical protein 0.0038 0.0182 0.0498
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0498
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0132 0.1241 0.3087
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0046 0.0086
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0218 0.0218
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0206 0.0586
Brugia malayi beta-lactamase family protein 0.004 0.0206 0.0642
Brugia malayi hypothetical protein 0.0265 0.274 0.8545
Loa Loa (eye worm) glutaminase 2 0.0306 0.3206 0.8804
Mycobacterium tuberculosis Conserved hypothetical protein 0.0404 0.4318 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0206 0.0364
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0218 0.0218
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0476 0.1183
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.029 0.0849
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0218 0.0681
Loa Loa (eye worm) hypothetical protein 0.0096 0.0831 0.2281
Mycobacterium ulcerans beta-lactamase 0.004 0.0206 0.0364
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.031 0.0913
Plasmodium vivax hypothetical protein, conserved 0.004 0.0206 0.6643
Mycobacterium leprae Probable lipase LipE 0.004 0.0206 0.0364
Plasmodium falciparum metacaspase 1 0.005 0.031 1
Leishmania major importin beta-1 subunit, putative 0.0026 0.0046 0.0597
Echinococcus granulosus caspase 3 0.0081 0.067 0.1666
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0182 0.0566
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0131 0.1229 0.1229
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0206 0.0364
Mycobacterium leprae Conserved hypothetical protein 0.0404 0.4318 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0139
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0218 0.0599
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0046 0.0938
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0115 0.3308
Loa Loa (eye worm) acetyltransferase 0.0162 0.1583 0.4346
Trypanosoma cruzi metacaspase, putative 0.005 0.031 1
Schistosoma mansoni lipoxygenase 0.0132 0.1241 0.3409
Trypanosoma cruzi metacaspase, putative 0.005 0.031 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0218 0.0625
Schistosoma mansoni ran 0.0024 0.0019 0.0052
Entamoeba histolytica hypothetical protein 0.004 0.0206 0.8266
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0032 0.0115 0.0316
Schistosoma mansoni caspase-7 (C14 family) 0.0096 0.0831 0.2281
Trichomonas vaginalis conserved hypothetical protein 0.005 0.031 0.0913
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0565
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0476 0.1484
Trypanosoma cruzi metacaspase, putative 0.005 0.031 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.029 0.072
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0218 0.0543
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0476 0.0476
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0218 0.0543
Onchocerca volvulus 0.0027 0.005 0.0607
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0206 0.0586
Schistosoma mansoni importin beta-1 0.0032 0.0115 0.0316
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0245 0.7894
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.005 0.1393
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0046 0.0086
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0476 0.1307
Echinococcus multilocularis caspase 8 0.005 0.031 0.031
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.005 0.0688
Brugia malayi Importin beta-1 subunit 0.0032 0.0115 0.0359
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0206 0.0511
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0131 0.1229 0.3056
Mycobacterium ulcerans hypothetical protein 0.004 0.0206 0.0364
Echinococcus multilocularis geminin 0.019 0.1893 0.1893
Leishmania major metacaspase, putative 0.005 0.031 0.6367
Schistosoma mansoni ran 0.0024 0.0019 0.0052
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0218 0.436
Brugia malayi AMP-binding enzyme family protein 0.0027 0.005 0.0157
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.274 0.6812
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0329 0.0903
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.005 0.031 0.0913
Schistosoma mansoni lipoxygenase 0.0092 0.0793 0.2177
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.031 1
Brugia malayi Cell death protein 3 precursor 0.0096 0.0831 0.2591
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.031 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.1583 0.4346
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.1583 0.4937
Echinococcus granulosus geminin 0.019 0.1893 0.4706
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0206 0.0564
Loa Loa (eye worm) hypothetical protein 0.005 0.031 0.0851
Onchocerca volvulus 0.004 0.0206 0.2478
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0218 0.6847
Mycobacterium ulcerans hypothetical protein 0.0404 0.4318 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0427 0.1173
Plasmodium vivax importin-beta 2, putative 0.0032 0.0115 0.3719
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0206 0.0364
Echinococcus multilocularis tumor protein p63 0.0378 0.4022 0.4022
Trichomonas vaginalis conserved hypothetical protein 0.005 0.031 0.0913
Echinococcus multilocularis caspase 2 0.0096 0.0831 0.0831
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0476 0.0997
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.029 0.0849
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.3641 1
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0206 0.0586
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.031 0.0913
Echinococcus granulosus caspase 8 0.005 0.031 0.0771
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0206 0.0565
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.005 0.0688
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.031 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0218 0.8828
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0381 0.1188
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0565
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0139
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.029 0.9342
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.005 0.0688
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.029 0.9299
Onchocerca volvulus 0.0055 0.0376 0.4525
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.005 0.031 0.0967
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0218 0.6847
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0218 0.0625
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0206 0.0364
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0046 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0329 0.0903
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0565
Echinococcus granulosus apoptotic protease activating factor 1 0.0046 0.0272 0.0675
Mycobacterium tuberculosis Conserved protein 0.004 0.0206 0.0364
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.274 0.274
Schistosoma mansoni hypothetical protein 0.019 0.1893 0.5197
Loa Loa (eye worm) beta-lactamase 0.004 0.0206 0.0565
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0019 0.0052
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0139
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0245 1
Echinococcus multilocularis caspase 3 0.0081 0.067 0.067
Echinococcus multilocularis apoptotic protease activating factor 1 0.0046 0.0272 0.0272
Echinococcus multilocularis snurportin 1 0.0345 0.3641 0.3641
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0206 0.0206
Onchocerca volvulus 0.0046 0.0272 0.3269
Trypanosoma brucei metacaspase MCA2 0.005 0.031 1
Onchocerca volvulus 0.004 0.0206 0.2478
Mycobacterium tuberculosis Conserved protein 0.004 0.0206 0.0364
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0329 0.0818
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.031 0.0913
Trypanosoma brucei metacaspase 5, putative 0.005 0.031 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.005 0.031 0.0851
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.031 0.0913
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.005 0.1393
Mycobacterium tuberculosis Conserved protein 0.004 0.0206 0.0364
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0218 0.0625
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0019 0.0047
Schistosoma mansoni survival motor neuron protein 0.0054 0.036 0.099
Brugia malayi hypothetical protein 0.004 0.0206 0.0641
Loa Loa (eye worm) hypothetical protein 0.0056 0.0381 0.1046
Onchocerca volvulus Cell death protein 3 homolog 0.0096 0.0831 1
Trypanosoma cruzi metacaspase 5, putative 0.005 0.031 1
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0206 0.6423
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0206 0.0206
Trichomonas vaginalis glutaminase, putative 0.0306 0.3206 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0206 0.0565
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.029 0.9299
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0565
Brugia malayi AMP-binding enzyme family protein 0.0027 0.005 0.0157
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.031 0.0913
Echinococcus granulosus snurportin 1 0.0345 0.3641 0.9055
Schistosoma mansoni hypothetical protein 0.019 0.1893 0.5197
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0376 0.1032
Entamoeba histolytica hypothetical protein 0.0026 0.0046 0.121
Mycobacterium ulcerans lipase LipD 0.004 0.0206 0.0364
Echinococcus multilocularis caspase 0.0131 0.1229 0.1229
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0206 0.6423
Toxoplasma gondii ABC1 family protein 0.004 0.0206 0.6423
Plasmodium vivax metacaspase 1, putative 0.005 0.031 1
Loa Loa (eye worm) glutaminase 0.0306 0.3206 0.8804

Activities

Activity type Activity value Assay description Source Reference
MBC (functional) = 45.87 10'-2 umol/ml Bactericidal activity against Escherichia coli ATCC 35210 after 24 hrs ChEMBL. 21524583
MIC (functional) = 30.58 10'-2 umol/ml Antibacterial activity against Escherichia coli ATCC 35210 after 24 hrs by microdilution method ChEMBL. 21524583

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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