TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 489.52 | Formula: C27H27N3O6
H donors: 3 H acceptors: 4 LogP: 3.04 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCC1(OCCc2c1[nH]c1c2c(C#N)cc(c1C)C(=O)NCc1ccc2c(c1)OCO2)CC(=O)O
InChi: 1S/C27H27N3O6/c1-3-7-27(11-22(31)32)25-18(6-8-36-27)23-17(12-28)10-19(15(2)24(23)30-25)26(33)29-13-16-4-5-20-21(9-16)35-14-34-20/h4-5,9-10,30H,3,6-8,11,13-14H2,1-2H3,(H,29,33)(H,31,32)
InChiKey: NIWFPORMVLNOEI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	loxhd1	0.0057	0.0338	0.0338
Trichomonas vaginalis	heat shock protein, putative	0.0887	1	1
Brugia malayi	hypothetical protein	0.0227	0.2317	0.2317
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0011	0.0011
Plasmodium falciparum	heat shock protein 90	0.0887	1	1
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0177	0.1736	0.1835
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0295	0.3107	0.3107
Plasmodium falciparum	endoplasmin, putative	0.055	0.6076	0.6076
Onchocerca volvulus		0.0057	0.0338	0.0693
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0177	0.1736	0.0686
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.028	0.294	0.2882
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0055	0.0318	0.0318
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.028	0.294	0.2882
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1736	0.1736
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0177	0.1736	0.3657
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.028	0.294	0.2882
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0153	0.1454	0.1469
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0063	0.0415	0.0415
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0295	0.3107	0.3107
Plasmodium falciparum	heat shock protein 90, putative	0.0425	0.4623	0.4623
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0177	0.1736	0.1736
Loa Loa (eye worm)	endoplasmin	0.0887	1	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.028	0.294	0.1457
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0177	0.1736	0.1835
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.029	0.3049	0.3049
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0063	0.0415	0.0336
Trypanosoma brucei	heat shock protein, putative	0.0887	1	1
Schistosoma mansoni	alkaline phosphatase	0.0156	0.1493	0.1493
Trichomonas vaginalis	receptor histidine kinase, putative	0.0177	0.1736	0.1668
Trichomonas vaginalis	endoplasmin, putative	0.055	0.6076	0.6044
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0156	0.1493	0.1493
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0887	1	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0156	0.1497	0.1497
Schistosoma mansoni	alpha glucosidase	0.0035	0.0082	0.0082
Plasmodium vivax	SET domain protein, putative	0.0029	0.0011	0.0011
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0177	0.1736	0.1835
Schistosoma mansoni	microtubule-associated protein tau	0.0662	0.738	0.738
Leishmania major	heat shock protein 83-1	0.0887	1	1
Trypanosoma brucei	heat shock protein, putative	0.0887	1	1
Schistosoma mansoni	heat shock protein	0.0887	1	1
Schistosoma mansoni	alkaline phosphatase	0.0156	0.1493	0.1493
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0177	0.1736	0.3657
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0177	0.1736	0.1835
Trypanosoma brucei	glucosidase, putative	0.0035	0.0082	0.0082
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0177	0.1736	0.1736
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0382	0.4122	0.4073
Echinococcus granulosus	heat shock protein 90	0.0887	1	1
Trypanosoma brucei	heat shock protein 90, putative	0.0887	1	1
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0177	0.1736	0.1835
Echinococcus granulosus	alkaline phosphatase	0.0156	0.1493	0.1493
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0063	0.0415	0.0415
Leishmania major	DNA topoisomerase ii	0.0177	0.1736	0.1668
Leishmania major	heat shock protein 83-1	0.0887	1	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0227	0.2317	0.2317
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.028	0.294	0.2882
Schistosoma mansoni	hypothetical protein	0.0046	0.0216	0.0216
Plasmodium falciparum	DNA gyrase subunit B	0.0177	0.1736	0.1736
Leishmania major	heat shock protein 83-1	0.0887	1	1
Leishmania major	heat shock protein 83-1	0.0887	1	1
Echinococcus granulosus	endoplasmin	0.0719	0.8046	0.8046
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0137	0.1273	0.1202
Brugia malayi	jmjC domain containing protein	0.0056	0.0335	0.0335
Trichomonas vaginalis	heat shock protein, putative	0.0719	0.8046	0.803
Plasmodium vivax	hypothetical protein, conserved	0.0177	0.1736	0.1736
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0055	0.0318	0.0239
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.028	0.294	0.2882
Entamoeba histolytica	heat shock protein 90, putative	0.0887	1	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0887	1	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.0082	0.0082
Plasmodium vivax	DNA topoisomerase II, putative	0.0177	0.1736	0.1736
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0057	0.0338	0.0338
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0152	0.0071
Plasmodium falciparum	LCCL domain-containing protein	0.0057	0.0338	0.0338
Loa Loa (eye worm)	doublecortin family protein	0.0057	0.0338	0.0338
Echinococcus multilocularis	lysine specific demethylase 5A	0.0056	0.0335	0.0335
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0046	0.0216	0.0216
Echinococcus granulosus	microtubule associated protein 2	0.0662	0.738	0.738
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0035	0.0082	0.0082
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0295	0.3107	0.3107
Trichomonas vaginalis	sensor histidine kinase, putative	0.0177	0.1736	0.1668
Brugia malayi	hypothetical protein	0.0057	0.0338	0.0338
Trichomonas vaginalis	receptor histidine kinase, putative	0.0177	0.1736	0.1668
Mycobacterium ulcerans	heat shock protein 90	0.0719	0.8046	1
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0177	0.1736	0.1835
Trypanosoma brucei	heat shock protein, putative	0.0887	1	1
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0177	0.1736	0.1668
Leishmania major	heat shock protein 83-1	0.0887	1	1
Brugia malayi	RNA, U transporter 1	0.0079	0.0593	0.0593
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0177	0.1736	0.1835
Entamoeba histolytica	DNA topoisomerase II, putative	0.0177	0.1736	0.1668
Echinococcus multilocularis	Polycystic kidney disease protein	0.0057	0.0338	0.0338
Trypanosoma brucei	heat shock protein, putative	0.0887	1	1
Schistosoma mansoni	hypothetical protein	0.0295	0.3114	0.3114
Trichomonas vaginalis	heat shock protein, putative	0.0373	0.4018	0.3969
Giardia lamblia	Grp94/Hsp90	0.0719	0.8046	0.7635
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.029	0.3049	0.2992
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0063	0.0415	0.0415
Schistosoma mansoni	hypothetical protein	0.0163	0.1569	0.1569
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0177	0.1736	0.1835
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0177	0.1736	0.3657
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0055	0.0318	0.0318
Echinococcus granulosus	lysine specific demethylase 5A	0.0056	0.0335	0.0335
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0156	0.1497	0.1497
Trypanosoma brucei	Heat shock protein 83, putative	0.0887	1	1
Brugia malayi	Probable DNA topoisomerase II	0.0177	0.1736	0.1736
Schistosoma mansoni	hypothetical protein	0.0081	0.0621	0.0621
Leishmania major	hypothetical protein, conserved	0.0177	0.1736	0.1668
Echinococcus multilocularis	snurportin 1	0.0295	0.3114	0.3114
Loa Loa (eye worm)	hypothetical protein	0.0295	0.3107	0.3107
Echinococcus multilocularis	geminin	0.0163	0.1569	0.1569
Trypanosoma brucei	heat shock protein 90, putative	0.0887	1	1
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0177	0.1736	0.1835
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0055	0.0318	0.0318
Chlamydia trachomatis	DNA gyrase subunit B	0.0177	0.1736	0.5
Plasmodium vivax	heat shock protein 86, putative	0.0887	1	1
Echinococcus granulosus	survival motor neuron protein 1	0.0227	0.2317	0.2317
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0011	0.0011
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0295	0.3107	0.305
Leishmania major	heat shock protein 83-1	0.0887	1	1
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0177	0.1736	0.1668
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0177	0.1736	0.1736
Onchocerca volvulus		0.0057	0.0338	0.0693
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0177	0.1736	0.0686
Leishmania major	heat shock protein 83-1	0.0887	1	1
Plasmodium vivax	heat shock protein 90, putative	0.0434	0.4727	0.4727
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0177	0.1736	0.1736
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0152	0.0152
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0719	0.8046	1
Mycobacterium ulcerans	DNA gyrase subunit B	0.0177	0.1736	0.1835
Echinococcus multilocularis	alkaline phosphatase	0.0156	0.1493	0.1493
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0177	0.1736	0.1736
Loa Loa (eye worm)	heat shock protein 90	0.0887	1	1
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0177	0.1736	0.1736
Toxoplasma gondii	heat shock protein 90, putative	0.0887	1	1
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0177	0.1736	0.1835
Brugia malayi	jmjC domain containing protein	0.0056	0.0335	0.0335
Schistosoma mansoni	lipoxygenase	0.0117	0.1038	0.1038
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0219	0.2227	0.2227
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0063	0.0415	0.0415
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0177	0.1736	0.1668
Loa Loa (eye worm)	TOPoisomerase family member	0.0177	0.1736	0.1736
Mycobacterium ulcerans	two component sensor kinase MprB	0.0177	0.1736	0.1835
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0056	0.0335	0.0335
Treponema pallidum	fructose-bisphosphate aldolase	0.028	0.294	0.1908
Trypanosoma brucei	heat shock protein, putative	0.0887	1	1
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0177	0.1736	0.1835
Trypanosoma cruzi	heat shock protein 90, putative	0.0514	0.566	0.5624
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0082	0.0082
Leishmania major	heat shock protein 83-1	0.0887	1	1
Brugia malayi	heat shock protein 90	0.0887	1	1
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0177	0.1736	0.1736
Loa Loa (eye worm)	jmjC domain-containing protein	0.0056	0.0335	0.0335
Mycobacterium ulcerans	putative regultory protein	0.0177	0.1736	0.1835
Echinococcus granulosus	lysosomal alpha glucosidase	0.0156	0.1497	0.1497
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0177	0.1736	0.1668
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.0044	0.0186	0.0186
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0177	0.1736	0.1736
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0177	0.1736	0.1835
Toxoplasma gondii	heat shock protein 75, putative	0.0434	0.4727	0.4727
Leishmania major	heat shock protein 83-1	0.0887	1	1
Loa Loa (eye worm)	heat shock protein 75	0.0434	0.4727	0.4727
Schistosoma mansoni	DNA topoisomerase II	0.0177	0.1736	0.1736
Mycobacterium leprae	Probable two-component sensor kinase	0.0177	0.1736	0.0686
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0295	0.3107	0.305
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0177	0.1736	0.1835
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0063	0.0415	0.0336
Leishmania major	heat shock protein 83-1	0.0887	1	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0011	0.0011
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0177	0.1736	0.1835
Brugia malayi	Doublecortin family protein	0.0057	0.0338	0.0338
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0044	0.0186	0.0105
Echinococcus multilocularis	RUN	0.0057	0.0338	0.0338
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0177	0.1736	0.1835
Trypanosoma brucei	DNA topoisomerase ii	0.0177	0.1736	0.1736
Leishmania major	heat shock protein 83-1	0.0887	1	1
Schistosoma mansoni	polycystin 1-related	0.0057	0.0338	0.0338
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.028	0.294	0.2882
Chlamydia trachomatis	DNA gyrase subunit B	0.0177	0.1736	0.5
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0156	0.1493	0.1493
Schistosoma mansoni	survival motor neuron protein	0.0046	0.0216	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0338	0.0338
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0434	0.4727	1
Trypanosoma cruzi	heat shock protein, putative	0.0434	0.4727	0.4684
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.022	0.2243	0.2243
Trypanosoma cruzi	heat shock protein 85, putative	0.0887	1	1
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0177	0.1736	0.1835
Onchocerca volvulus		0.0046	0.0216	0.0435
Schistosoma mansoni	pyruvate dehydrogenase	0.0118	0.1049	0.1049
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0177	0.1736	0.1668
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0177	0.1736	0.1736
Trichomonas vaginalis	heat shock protein, putative	0.071	0.7942	0.7925
Brugia malayi	Hsp90 protein	0.0434	0.4727	0.4727
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0156	0.1497	0.1497
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0177	0.1736	0.1835
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0177	0.1736	0.1668
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0177	0.1736	0.5
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0219	0.2227	0.2227
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0177	0.1736	0.1668
Plasmodium falciparum	heat shock protein 90, putative	0.0382	0.4122	0.4122
Trypanosoma cruzi	Heat shock protein 83, putative	0.0887	1	1
Brugia malayi	kinase, mitochondrial precursor	0.0295	0.3107	0.3107
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0156	0.1493	0.1493
Schistosoma mansoni	endoplasmin	0.0887	1	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0051	0.0275	0.0275
Treponema pallidum	heat shock protein 90	0.0719	0.8046	1
Plasmodium vivax	heat shock protein, putative	0.0382	0.4122	0.4122
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0177	0.1736	0.1668
Echinococcus granulosus	intestinal type alkaline phosphatase	0.0156	0.1493	0.1493
Plasmodium vivax	endoplasmin, putative	0.0887	1	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0063	0.0415	0.0415
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0105	0.0105
Trypanosoma brucei	heat shock protein, putative	0.0887	1	1
Trichomonas vaginalis	heat shock protein, putative	0.0719	0.8046	0.803
Mycobacterium ulcerans	hypothetical protein	0.0153	0.1454	0.1469
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0156	0.1497	0.1497
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0152	0.0071
Echinococcus granulosus	lipoxygenase domain containing protein	0.0057	0.0338	0.0338
Trypanosoma brucei	heat shock protein, putative	0.0887	1	1
Leishmania major	heat shock protein 83-1	0.0887	1	1
Schistosoma mansoni	rab6-interacting	0.0057	0.0338	0.0338
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.028	0.294	0.2882
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0055	0.0318	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0011	0.0011
Echinococcus granulosus	Polycystic kidney disease protein	0.0057	0.0338	0.0338
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0063	0.0415	0.0415
Leishmania major	heat shock protein 83-1	0.0887	1	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.029	0.3049	0.2992
Trypanosoma cruzi	heat shock protein 90, putative	0.071	0.7942	0.7925
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0177	0.1736	0.0686
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0156	0.1493	0.1493
Leishmania major	heat shock protein 83-1	0.0887	1	1
Leishmania major	heat shock protein 83-1	0.0887	1	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0137	0.1273	0.1202
Echinococcus multilocularis	heat shock protein	0.0887	1	1
Trypanosoma cruzi	heat shock protein 85, putative	0.071	0.7942	0.7925
Echinococcus multilocularis	endoplasmin	0.0719	0.8046	0.8046
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0082	0.0082
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0137	0.1273	0.1273
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0719	0.8046	1
Schistosoma mansoni	alpha-glucosidase	0.0135	0.1243	0.1243
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0177	0.1736	0.1835
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0177	0.1736	0.1835
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0177	0.1736	0.1835
Onchocerca volvulus		0.0227	0.2322	0.49
Trypanosoma cruzi	heat shock protein 85, putative	0.0887	1	1
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0295	0.3107	0.3107
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0063	0.0415	0.0336
Giardia lamblia	Heat shock protein HSP 90-alpha	0.071	0.7942	0.751
Schistosoma mansoni	rab6-interacting	0.0057	0.0338	0.0338
Echinococcus granulosus	heat shock protein	0.0887	1	1
Toxoplasma gondii	heat shock protein HSP90	0.0887	1	1
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0156	0.1493	0.1493
Onchocerca volvulus		0.009	0.073	0.1524
Trichomonas vaginalis	set domain proteins, putative	0.0227	0.2322	0.2259
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0256	0.0176
Schistosoma mansoni	lipoxygenase	0.0219	0.2227	0.2227
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0011	0.0011
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0011	0.0011
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0011	0.0011
Echinococcus multilocularis	heat shock protein 90	0.0887	1	1
Mycobacterium tuberculosis	Conserved protein	0.0177	0.1736	0.1835
Schistosoma mansoni	hypothetical protein	0.0163	0.1569	0.1569
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.028	0.294	0.2882
Brugia malayi	Pre-SET motif family protein	0.0029	0.0011	0.0011
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0152	0.0071
Entamoeba histolytica	heat shock protein 90, putative	0.0887	1	1
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2317	0.2317
Schistosoma mansoni	endoplasmin	0.0887	1	1
Trypanosoma brucei	heat shock protein 84, putative	0.0434	0.4727	0.4727
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0044	0.0186	0.0186
Echinococcus granulosus	lipoxygenase domain containing protein	0.0057	0.0338	0.0338
Echinococcus granulosus	heat shock protein 90	0.071	0.7942	0.7942
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1736	0.1736
Schistosoma mansoni	alpha-glucosidase	0.0135	0.1243	0.1243
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0295	0.3114	0.3114
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0434	0.4727	0.4727
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0105	0.0105
Leishmania major	mitochondrial DNA topoisomerase II	0.0177	0.1736	0.1668
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0011	0.0011
Plasmodium vivax	multidomain scavenger receptor, putative	0.0057	0.0338	0.0338
Schistosoma mansoni	heat shock protein	0.0887	1	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0056	0.0335	0.0335
Schistosoma mansoni	heat shock protein	0.0434	0.4727	0.4727
Echinococcus multilocularis	heat shock protein 90	0.071	0.7942	0.7942
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.028	0.294	0.2882
Trypanosoma cruzi	heat shock protein 90, putative	0.0887	1	1
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0177	0.1736	0.1736
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0177	0.1736	0.1835
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0338	0.0338
Plasmodium vivax	DNA gyrase subunit B, putative	0.0177	0.1736	0.1736
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0719	0.8046	0.803
Schistosoma mansoni	pyruvate dehydrogenase	0.0295	0.3107	0.3107
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.028	0.294	0.2882
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0434	0.4727	0.4727
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0011	0.0011
Plasmodium falciparum	DNA topoisomerase 2	0.0177	0.1736	0.1736
Echinococcus multilocularis	microtubule associated protein 2	0.0662	0.738	0.738
Leishmania major	mitochondrial DNA polymerase beta	0.029	0.3049	0.2992
Echinococcus granulosus	geminin	0.0163	0.1569	0.1569
Trypanosoma brucei	heat shock protein, putative	0.0887	1	1
Leishmania major	heat shock protein, putative	0.0434	0.4727	0.4684
Schistosoma mansoni	hypothetical protein	0.0057	0.0338	0.0338
Toxoplasma gondii	Hsp90 domain-containing protein	0.0382	0.4122	0.4122
Echinococcus granulosus	RUN	0.0057	0.0338	0.0338
Echinococcus granulosus	snurportin 1	0.0295	0.3114	0.3114
Leishmania major	heat shock protein 83-1	0.0887	1	1
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0177	0.1736	0.1668
Brugia malayi	Pre-SET motif family protein	0.02	0.2001	0.2001
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0719	0.8046	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0057	0.0338	0.0338
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.071	0.7942	0.7942
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0177	0.1736	0.1668
Leishmania major	heat shock protein 83-1	0.0887	1	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0137	0.1272	0.1234
Trichomonas vaginalis	heat shock protein, putative	0.055	0.6076	0.6044
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0063	0.0415	0.0336
Brugia malayi	hypothetical protein	0.0057	0.0338	0.0338
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0177	0.1736	0.1835
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0082	0.0082
Toxoplasma gondii	hypothetical protein	0.0047	0.0222	0.0222
Schistosoma mansoni	jumonji domain containing protein	0.0056	0.0335	0.0335
Schistosoma mansoni	pyruvate dehydrogenase	0.0118	0.1049	0.1049
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0056	0.0335	0.0335
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0137	0.1272	0.1234
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0177	0.1736	0.1668
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.02	0.2001	0.2001
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0177	0.1736	0.1736
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0044	0.0186	0.0105
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0056	0.0335	0.0335

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1778565

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1525467