TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 359.486 | Formula: C19H25N3O2S
H donors: 0 H acceptors: 3 LogP: 4.26 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCC(CC1)c1onc(n1)c1cccs1)CC1CCCCC1
InChi: 1S/C19H25N3O2S/c23-17(13-14-5-2-1-3-6-14)22-10-8-15(9-11-22)19-20-18(21-24-19)16-7-4-12-25-16/h4,7,12,14-15H,1-3,5-6,8-11,13H2
InChiKey: CTZIYDCKRRFLFJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	Get druggable targets OG5_191427	All targets in OG5_191427
Mycobacterium leprae	Probable transcriptional regulatory repressor protein (TetR-family) EthR	Get druggable targets OG5_191427	All targets in OG5_191427
Mycobacterium ulcerans	TetR family transcriptional regulator	Get druggable targets OG5_191427	All targets in OG5_191427
Mycobacterium ulcerans	AcrR family transcriptional regulator	Get druggable targets OG5_191427	All targets in OG5_191427
Mycobacterium ulcerans	transcriptional regulator	Get druggable targets OG5_191427	All targets in OG5_191427

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0039	0.0114	0.0437
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0039	0.0114	0.0619
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0039	0.0114	0.0984
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0039	0.0114	0.015
Loa Loa (eye worm)	hypothetical protein	0.0034	0.008	0.0108
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0039	0.0114	0.0701
Trypanosoma cruzi	3-phosphoglycerate kinase, glycosomal	0.0067	0.0283	0.1531
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0142	0.0735	0.0976
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0154	0.0808	0.4142
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0071	0.0306	0.0418
Loa Loa (eye worm)	PEK/PEK protein kinase	0.0182	0.0983	0.135
Echinococcus multilocularis	pyruvate kinase	0.0036	0.0093	0.0121
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0039	0.0114	0.0619
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0093	0.0125
Loa Loa (eye worm)	RNA binding protein	0.0068	0.0288	0.0394
Toxoplasma gondii	hypothetical protein	0.0102	0.0496	0.4515
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0091	0.012
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0039	0.0114	0.0619
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0051	0.0184	0.1644
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0091	0.0785
Plasmodium falciparum	heat shock protein 90, putative	0.0187	0.1008	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0039	0.0114	0.0984
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0288	0.2504
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0039	0.0114	0.0684
Plasmodium vivax	pyruvate kinase, putative	0.0036	0.0093	0.0204
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0042	0.0131	0.0427
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0067	0.0283	0.1531
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0067	0.0283	0.1531
Brugia malayi	Phosphoglycerate kinase	0.0067	0.0283	0.0374
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0067	0.0283	0.118
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0106	0.0144
Treponema pallidum	phosphoglycerate kinase	0.0183	0.0986	1
Leishmania major	pyruvate kinase	0.0036	0.0093	0.0107
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0093	0.0001
Giardia lamblia	Hypothetical protein	0.0039	0.0114	0.0244
Trichomonas vaginalis	heat shock protein, putative	0.0046	0.0155	0.114
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0106	0.0144
Echinococcus granulosus	Niemann Pick C1 protein	0.0106	0.0517	0.0686
Trypanosoma cruzi	heat shock protein 85, putative	0.0049	0.0174	0.0942
Echinococcus multilocularis	protein dispatched 1	0.0052	0.019	0.025
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0039	0.0114	0.015
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0114	0.0619
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0036	0.0093	0.0121
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.1258	0.7515	1
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0184	0.0243
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Plasmodium falciparum	endoplasmin, putative	0.0036	0.0092	0.045
Echinococcus granulosus	heat shock protein	0.0049	0.0174	0.0229
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0039	0.0114	0.023
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0114	0.023
Loa Loa (eye worm)	hypothetical protein	0.0476	0.2766	0.38
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0306	0.131
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0039	0.0114	0.0684
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0184	0.0625
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0051	0.0184	0.0093
Brugia malayi	TAR-binding protein	0.0068	0.0288	0.0381
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.0124	0.0163
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0039	0.0114	0.015
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Toxoplasma gondii	GAF domain-containing protein	0.0102	0.0496	0.4515
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0093	0.0329
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0114	0.0619
Plasmodium vivax	endoplasmin, putative	0.0049	0.0174	0.1074
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0107	0.0527	0.4592
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0039	0.0114	0.015
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0038	0.0106	0.0014
Entamoeba histolytica	hypothetical protein	0.0036	0.0091	0.0676
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0039	0.0114	0.0984
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0067	0.0283	0.1531
Trichomonas vaginalis	endoplasmin, putative	0.0036	0.0092	0.0461
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0184	0.0251
Echinococcus granulosus	eukaryotic translation initiation factor 2 alpha	0.0031	0.0062	0.0081
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Loa Loa (eye worm)	PDE1B protein	0.0039	0.0114	0.0155
Brugia malayi	RNA binding protein	0.0068	0.0288	0.0381
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0184	0.0093
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Toxoplasma gondii	pyruvate kinase PyK1	0.0036	0.0093	0.0204
Mycobacterium ulcerans	heat shock protein 90	0.0046	0.0155	0.0064
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Onchocerca volvulus		0.0476	0.2766	1
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0183	0.0986	0.0901
Chlamydia trachomatis	phosphoglycerate kinase	0.0183	0.0986	1
Mycobacterium leprae	conserved hypothetical protein	0.0102	0.0496	0.0407
Plasmodium falciparum	acyl-CoA synthetase	0.0038	0.0106	0.0598
Trichomonas vaginalis	heat shock protein, putative	0.0046	0.0155	0.114
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0046	0.0155	0.0463
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0142	0.0735	0.7326
Leishmania major	hypothetical protein, conserved	0.0039	0.0114	0.023
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Echinococcus multilocularis	Niemann Pick C1 protein	0.0106	0.0517	0.0686
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0183	0.0986	0.9758
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0142	0.0735	0.6407
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Echinococcus granulosus	raf serine:threonine protein kinase	0.0209	0.1146	0.1523
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0496	0.477
Plasmodium vivax	heat shock protein 86, putative	0.0049	0.0174	0.1074
Echinococcus multilocularis	heat shock protein 90	0.0042	0.0131	0.0172
Trypanosoma cruzi	heat shock protein 85, putative	0.0042	0.0131	0.0708
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.0735	0.7326
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0114	0.0619
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Giardia lamblia	Phosphoglycerate kinase	0.0183	0.0986	1
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0184	0.0243
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0039	0.0114	0.015
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0039	0.0114	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0106	0.0144
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0039	0.0114	0.0701
Mycobacterium ulcerans	putative regulatory protein	0.0102	0.0496	0.0407
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0039	0.0114	0.015
Schistosoma mansoni	phosphoglycerate kinase	0.0183	0.0986	0.8596
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0517	0.0709
Echinococcus multilocularis	eukaryotic translation initiation factor 2 alpha	0.0031	0.0062	0.0081
Brugia malayi	heat shock protein 90	0.0049	0.0174	0.0229
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0039	0.0114	0.023
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.029
Trypanosoma brucei	pyruvate kinase 1, putative	0.0036	0.0093	0.0107
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0175	0.0231
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0071	0.0306	0.0405
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Giardia lamblia	hypothetical protein	0.0039	0.0114	0.0244
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0183	0.0986	0.131
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0152	0.0823
Echinococcus granulosus	tar DNA binding protein	0.0068	0.0288	0.0381
Plasmodium falciparum	phosphoglycerate kinase	0.0183	0.0986	0.9764
Mycobacterium ulcerans	phosphoglycerate kinase	0.0183	0.0986	0.0901
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0306	0.1656
Plasmodium vivax	phosphoglycerate kinase, putative	0.0183	0.0986	0.9758
Trypanosoma cruzi	heat shock protein 85, putative	0.0049	0.0174	0.0942
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0039	0.0114	0.0701
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0033	0.0073	0.0488
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0036	0.0093	0.0501
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0038	0.0106	0.0014
Schistosoma mansoni	heat shock protein	0.0033	0.0073	0.0628
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0071	0.0306	0.2656
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0175	0.0231
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0152	0.0443
Entamoeba histolytica	heat shock protein 90, putative	0.0049	0.0174	0.1535
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0184	0.0243
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0114	0.0619
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0142	0.0735	0.7326
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0039	0.0114	0.015
Entamoeba histolytica	hypothetical protein	0.0036	0.0091	0.0676
Trypanosoma brucei	heat shock protein 90, putative	0.0049	0.0174	0.0566
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0039	0.0114	0.0984
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0288	0.2504
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.0735	0.7326
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0071	0.0306	0.0405
Brugia malayi	RWD domain containing protein	0.0031	0.0062	0.0081
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0093	0.0001
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.0288	0.0394
Echinococcus multilocularis	neuropeptide receptor A26	0.0458	0.266	0.3538
Trypanosoma brucei	heat shock protein, putative	0.0049	0.0174	0.0566
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0151	0.0198
Schistosoma mansoni	hypothetical protein	0.0044	0.0141	0.1214
Brugia malayi	Raf kinase	0.0202	0.1102	0.1464
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0152	0.0823
Trypanosoma brucei	heat shock protein 90, putative	0.0049	0.0174	0.0566
Plasmodium vivax	heat shock protein, putative	0.0187	0.1008	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Trypanosoma brucei	pyruvate kinase 1	0.0036	0.0093	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0106	0.0144
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0288	0.2504
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0071	0.0306	0.0405
Schistosoma mansoni	hypothetical protein	0.0034	0.008	0.0685
Echinococcus multilocularis	Niemann Pick C1 protein	0.0151	0.0793	0.1053
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0324	0.1846	1
Trichomonas vaginalis	heat shock protein, putative	0.0042	0.0131	0.0875
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0142	0.0735	0.6407
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Schistosoma mansoni	protein kinase	0.0182	0.0983	0.8576
Schistosoma mansoni	endoplasmin	0.0049	0.0174	0.1505
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0039	0.0114	0.0984
Loa Loa (eye worm)	runx1	0.006	0.0237	0.0324
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0306	0.1656
Loa Loa (eye worm)	raf kinase	0.0208	0.114	0.1565
Schistosoma mansoni	protein kinase	0.0031	0.0064	0.0549
Trypanosoma brucei	heat shock protein, putative	0.0049	0.0174	0.0566
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0142	0.0735	0.3733
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0119	0.0596	0.0817
Schistosoma mansoni	serine/threonine protein kinase	0.0209	0.1146	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0151	0.0198
Trypanosoma brucei	heat shock protein, putative	0.0049	0.0174	0.0566
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.008	0.0104
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0142	0.0735	0.7326
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0114	0.0155
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0039	0.0114	0.0984
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Toxoplasma gondii	heat shock protein HSP90	0.0049	0.0174	0.1074
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0288	0.2504
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0184	0.0251
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0039	0.0114	0.0619
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0183	0.0986	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Trichomonas vaginalis	pyruvate kinase, putative	0.0036	0.0093	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0476	0.2766	0.38
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Echinococcus multilocularis	expressed conserved protein	0.0099	0.0478	0.0635
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0039	0.0114	0.0619
Entamoeba histolytica	hypothetical protein	0.0036	0.0091	0.0676
Plasmodium falciparum	GAF domain-related protein, putative	0.0102	0.0496	0.4657
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0093	0.0329
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0175	0.0238
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.1667	1	1
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0093	0.0125
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0036	0.0093	0.0501
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.1258	0.7515	1
Echinococcus granulosus	heat shock protein 90	0.0049	0.0174	0.0229
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0039	0.0114	0.0684
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0039	0.0114	0.0984
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Schistosoma mansoni	pyruvate kinase	0.0036	0.0093	0.0794
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0036	0.0093	0.0121
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0183	0.0986	0.5339
Brugia malayi	CHE-14 protein	0.0045	0.0151	0.0198
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0288	0.2504
Leishmania major	pyruvate kinase	0.0036	0.0093	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0114	0.0155
Brugia malayi	Niemann-Pick C1 protein precursor	0.0106	0.0517	0.0686
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0033	0.0073	0.026
Brugia malayi	Protein kinase domain containing protein	0.0182	0.0983	0.1307
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0109	0.0539	0.045
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.0735	0.7326
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.0288	0.0381
Toxoplasma gondii	hypothetical protein	0.0102	0.0496	0.4515
Echinococcus multilocularis	heat shock protein 90	0.0049	0.0174	0.0229
Echinococcus granulosus	Niemann Pick C1 protein	0.0151	0.0793	0.1053
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0039	0.0114	0.0155
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0183	0.0986	0.9758
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0114	0.0619
Brugia malayi	hypothetical protein	0.0036	0.0091	0.012
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0183	0.0986	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0093	0.0001
Brugia malayi	hypothetical protein	0.0476	0.2766	0.3679
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Loa Loa (eye worm)	pyruvate kinase-PB	0.0025	0.0027	0.0034
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0039	0.0114	0.0701
Trypanosoma brucei	heat shock protein, putative	0.0049	0.0174	0.0566
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0142	0.0735	0.3982
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0039	0.0114	0.015
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0039	0.0114	0.015
Loa Loa (eye worm)	hypothetical protein	0.003	0.0058	0.0078
Schistosoma mansoni	pyruvate kinase	0.0036	0.0093	0.0794
Trypanosoma cruzi	heat shock protein, putative	0.0033	0.0073	0.0398
Echinococcus multilocularis	pyruvate kinase	0.0028	0.0047	0.006
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0154	0.0808	0.4375
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0735	0.1008
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0093	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0027	0.0034
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0184	0.0093
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0039	0.0114	0.015
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0039	0.0114	0.0701
Loa Loa (eye worm)	endoplasmin	0.0049	0.0174	0.0237
Schistosoma mansoni	hypothetical protein	0.0044	0.0141	0.1214
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Echinococcus granulosus	pyruvate kinase	0.0036	0.0093	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0175	0.0238
Trypanosoma brucei	phosphoglycerate kinase	0.0183	0.0986	0.5146
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0039	0.0114	0.0701
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0183	0.0986	1
Schistosoma mansoni	patched 1	0.0045	0.0151	0.1301
Echinococcus granulosus	endoplasmin	0.0046	0.0155	0.0205
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0039	0.0114	0.0701
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0039	0.0114	0.015
Trypanosoma cruzi	Heat shock protein 83, putative	0.0049	0.0174	0.0942
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0183	0.0986	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0039	0.0114	0.0701
Trypanosoma brucei	heat shock protein, putative	0.0049	0.0174	0.0566
Mycobacterium ulcerans	transcriptional regulator	0.1667	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0151	0.1088
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Echinococcus multilocularis	endoplasmin	0.0046	0.0155	0.0205
Echinococcus multilocularis	protein patched	0.0045	0.0151	0.0198
Mycobacterium ulcerans	hypothetical protein	0.0171	0.0913	0.0828
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0142	0.0735	0.7326
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0324	0.1846	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0106	0.0517	0.5117
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0051	0.0184	0.0093
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0183	0.0986	0.0901
Schistosoma mansoni	protein kinase	0.0182	0.0983	0.8576
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0046	0.0155	0.0064
Plasmodium vivax	phosphodiesterase gamma, putative	0.0039	0.0114	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0406	0.0555
Echinococcus granulosus	neuropeptide s receptor	0.0458	0.266	0.3538
Brugia malayi	Hsp90 protein	0.0033	0.0073	0.0096
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0114	0.0619
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0142	0.0735	0.7326
Echinococcus granulosus	phosphoglycerate kinase 1	0.0183	0.0986	0.131
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Plasmodium vivax	hypothetical protein, conserved	0.0102	0.0496	0.4515
Echinococcus granulosus	expressed conserved protein	0.0099	0.0478	0.0635
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Trichomonas vaginalis	pyruvate kinase, putative	0.0036	0.0093	0.0468
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0171	0.0913	0.0828
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0039	0.0114	0.023
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0067	0.0283	0.118
Echinococcus granulosus	heat shock protein 90	0.0042	0.0131	0.0172
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0039	0.0114	0.015
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0039	0.0114	0.0984
Trypanosoma cruzi	heat shock protein 90, putative	0.0042	0.0131	0.0708
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0151	0.0205
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0051	0.0184	0.0093
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0093	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0184	0.0251
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0142	0.0735	0.0976
Mycobacterium ulcerans	TetR family transcriptional regulator	0.1667	1	1
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0183	0.0986	0.5146
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0039	0.0114	0.0437
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0039	0.0114	0.023
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0039	0.0114	0.0701
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.1258	0.7515	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0093	0.0329
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0091	0.012
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.0735	0.7326
Toxoplasma gondii	heat shock protein 90, putative	0.0049	0.0174	0.1074
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.0124	0.0163
Echinococcus granulosus	pyruvate kinase	0.0036	0.0093	0.0121
Echinococcus multilocularis	neuropeptide s receptor	0.0458	0.266	0.3538
Trypanosoma cruzi	heat shock protein 90, putative	0.0049	0.0174	0.0942
Schistosoma mansoni	hypothetical protein	0.0044	0.0141	0.1214
Echinococcus multilocularis	Protein lozenge	0.006	0.0237	0.0314
Mycobacterium ulcerans	hypothetical protein	0.0051	0.0184	0.0093
Loa Loa (eye worm)	heat shock protein 90	0.0049	0.0174	0.0237
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0114	0.0701
Loa Loa (eye worm)	hypothetical protein	0.1116	0.6655	0.9147
Echinococcus granulosus	neuropeptide receptor A26	0.0458	0.266	0.3538
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0142	0.0735	0.3733
Entamoeba histolytica	hypothetical protein	0.0036	0.0091	0.0676
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0051	0.0184	0.0093
Toxoplasma gondii	hypothetical protein	0.0052	0.0193	0.1276
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.0735	0.7326
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0033	0.0073	0.0096
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0067	0.0283	0.1531
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0114	0.0701
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0051	0.0184	0.0093
Schistosoma mansoni	hypothetical protein	0.0044	0.0141	0.1214
Leishmania major	hypothetical protein, conserved	0.0039	0.0114	0.023
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0042	0.0131	0.0172
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0183	0.0986	0.5146
Trypanosoma brucei	heat shock protein, putative	0.0049	0.0174	0.0566
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0184	0.0093
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0184	0.0093
Toxoplasma gondii	hypothetical protein	0.0102	0.0496	0.4515
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0039	0.0114	0.015
Schistosoma mansoni	hypothetical protein	0.0036	0.0091	0.0785
Schistosoma mansoni	eyes absent homolog	0.0087	0.0406	0.3529
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0039	0.0114	0.0244
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0039	0.0114	0.0437
Leishmania major	mitochondrial DNA polymerase beta	0.0324	0.1846	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0142	0.0735	0.3982
Loa Loa (eye worm)	hypothetical protein	0.0183	0.0986	0.1353
Loa Loa (eye worm)	heat shock protein 75	0.0033	0.0073	0.0099
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0056	0.0213	0.1152
Trichomonas vaginalis	STE family protein kinase	0.003	0.0058	0.0103
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0039	0.0114	0.0684
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Trypanosoma brucei	phosphoglycerate kinase	0.0067	0.0283	0.118
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Plasmodium falciparum	pyruvate kinase	0.0036	0.0093	0.0457
Onchocerca volvulus		0.0051	0.0184	0.0661
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0109	0.0539	0.045
Trypanosoma cruzi	heat shock protein 85, putative	0.0049	0.0174	0.0942
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0142	0.0735	0.3982
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Brugia malayi	Phosphoglycerate kinase	0.0183	0.0986	0.131
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0071	0.0306	0.2909
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Trichomonas vaginalis	heat shock protein, putative	0.0036	0.0092	0.0461
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0184	0.0625
Trypanosoma brucei	heat shock protein, putative	0.0049	0.0174	0.0566
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0039	0.0114	0.0437
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0324	0.1846	1
Schistosoma mansoni	lozenge	0.006	0.0237	0.206
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0154	0.0808	0.4142
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.0735	0.7326
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0039	0.0114	0.0701
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.0288	0.0394
Trypanosoma brucei	heat shock protein, putative	0.0049	0.0174	0.0566
Schistosoma mansoni	endoplasmin	0.0049	0.0174	0.1505
Trypanosoma brucei	Heat shock protein 83, putative	0.0049	0.0174	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0114	0.0155
Entamoeba histolytica	heat shock protein 90, putative	0.0049	0.0174	0.1535
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0039	0.0114	0.015
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0496	0.477
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0033	0.0073	0.0096
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0051	0.0184	0.0093
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0151	0.0198
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.0735	0.7326
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0051	0.0184	0.0093
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0039	0.0114	0.023
Giardia lamblia	Grp94/Hsp90	0.0046	0.0155	0.0705
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0046	0.0155	0.0064
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0152	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0093	0.0125
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0039	0.0114	0.023
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0049	0.0174	0.0911
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0142	0.0735	0.7326
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0183	0.0986	0.5339
Loa Loa (eye worm)	hypothetical protein	0.1218	0.7276	1
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0039	0.0114	0.0684
Toxoplasma gondii	Hsp90 domain-containing protein	0.0187	0.1008	1
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0039	0.0114	0.015
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0406	0.0555
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0184	0.0625
Entamoeba histolytica	acyl-coA synthetase, putative	0.0051	0.0184	0.1644
Mycobacterium ulcerans	putative regulatory protein	0.0102	0.0496	0.0407
Plasmodium vivax	acyl-CoA synthetase, putative	0.0038	0.0106	0.0348
Echinococcus multilocularis	pyruvate kinase	0.0036	0.0093	0.0121
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0496	0.477
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0142	0.0735	0.0976
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.0288	0.0381
Echinococcus multilocularis	heat shock protein	0.0049	0.0174	0.0229
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.1667	1	1
Schistosoma mansoni	phosphoglycerate kinase	0.0183	0.0986	0.8596
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0038	0.0106	0.0151
Trichomonas vaginalis	heat shock protein, putative	0.0049	0.0174	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0106	0.0144
Trypanosoma brucei	phosphoglycerate kinase	0.0183	0.0986	0.5146
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0039	0.0114	0.0984
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0209	0.1146	0.1523
Brugia malayi	Endoplasmin precursor	0.0049	0.0174	0.0229
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0496	0.477
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0735	0.7326
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0151	0.0205
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0109	0.0539	0.045
Plasmodium falciparum	heat shock protein 90	0.0049	0.0174	0.1305
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0051	0.0184	0.1644
Plasmodium falciparum	phosphodiesterase delta, putative	0.0039	0.0114	0.0684
Brugia malayi	hypothetical protein	0.0087	0.0406	0.0538
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0039	0.0114	0.015
Schistosoma mansoni	heat shock protein	0.0049	0.0174	0.1505
Schistosoma mansoni	heat shock protein	0.0049	0.0174	0.1505
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0039	0.0114	0.0701
Leishmania major	heat shock protein 83-1	0.0049	0.0174	0.0566
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0071	0.0306	0.131

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.5 uM	Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assay	ChEMBL.	21417236

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1773962

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1526938