TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 359.367 | Formula: C15H16F3N3O2S
H donors: 0 H acceptors: 3 LogP: 3 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCC(CC1)c1onc(n1)c1cccs1)CCC(F)(F)F
InChi: 1S/C15H16F3N3O2S/c16-15(17,18)6-3-12(22)21-7-4-10(5-8-21)14-19-13(20-23-14)11-2-1-9-24-11/h1-2,9-10H,3-8H2
InChiKey: HWEFEZJVFIOBJA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	TetR family transcriptional regulator	Get druggable targets OG5_191427	All targets in OG5_191427
Mycobacterium ulcerans	transcriptional regulator	Get druggable targets OG5_191427	All targets in OG5_191427
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	Get druggable targets OG5_191427	All targets in OG5_191427
Mycobacterium leprae	Probable transcriptional regulatory repressor protein (TetR-family) EthR	Get druggable targets OG5_191427	All targets in OG5_191427
Mycobacterium ulcerans	AcrR family transcriptional regulator	Get druggable targets OG5_191427	All targets in OG5_191427

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0054	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.0503
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0241	0.1318	0.653
Echinococcus multilocularis	microtubule associated protein 2	0.0727	0.428	1
Echinococcus granulosus	endoplasmin	0.0027	0.0012	0.0015
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0102	0.0592
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.0075	0.0258
Entamoeba histolytica	hypothetical protein	0.0078	0.0326	1
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Brugia malayi	Latrophilin receptor protein 2	0.0051	0.0162	0.0695
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.0075	0.0369
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0142	0.0716	0.3547
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0102	0.0089
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0102	0.2553
Schistosoma mansoni	hypothetical protein	0.0078	0.0326	0.0645
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Entamoeba histolytica	hypothetical protein	0.0078	0.0326	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0173	0.0855
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Brugia malayi	intermediate filament protein	0.0053	0.0173	0.075
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0362	0.1795
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0038	0.008	0.0173
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0051	0.0162	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.0503
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0075	0.0676
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0102	0.0592
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.0075	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0149	0.0738
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0061	0.0017
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.0075	0.1778
Loa Loa (eye worm)	hypothetical protein	0.011	0.0523	0.259
Echinococcus multilocularis	lamin	0.0053	0.0173	0.039
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0102	0.0114
Toxoplasma gondii	ABC1 family protein	0.0041	0.0102	0.1554
Brugia malayi	heat shock protein 90	0.0033	0.0054	0.0153
Schistosoma mansoni	hypothetical protein	0.0038	0.008	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.0503
Echinococcus multilocularis	GPCR, family 2	0.0051	0.0162	0.0364
Entamoeba histolytica	hypothetical protein	0.0078	0.0326	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.0075	0.1778
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0061	0.0017
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.0173	0.075
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0102	0.0089
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0264	0.1455	0.1445
Schistosoma mansoni	transcription factor LCR-F1	0.0078	0.0326	0.0645
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0102	0.0089
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0102	0.0089
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0054	0.1182
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.0716	0.1567
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0061	0.0017
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0142	0.0716	0.1661
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0102	0.0089
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0028	0.0023	0.0114
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0142	0.0716	0.3473
Trichomonas vaginalis	set domain proteins, putative	0.0274	0.1521	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0102	0.0503
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0102	0.0089
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0102	0.0592
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0051	0.0162	0.0364
Echinococcus multilocularis	heat shock protein 90	0.0033	0.0054	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.0503
Echinococcus granulosus	tumor protein p63	0.0335	0.1891	0.4409
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0051	0.0162	0.0364
Echinococcus multilocularis	lamin dm0	0.0053	0.0173	0.039
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.0075	0.0161
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0102	0.0089
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Loa Loa (eye worm)	endoplasmin	0.0033	0.0054	0.0266
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0167	0.0826
Schistosoma mansoni	ap endonuclease	0.0037	0.0075	0.0049
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Echinococcus granulosus	heat shock protein	0.0033	0.0054	0.0112
Trypanosoma cruzi	heat shock protein 90, putative	0.0033	0.0054	0.1182
Brugia malayi	hypothetical protein	0.0078	0.0326	0.152
Onchocerca volvulus		0.0041	0.0102	0.0279
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0033	0.0054	0.6648
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0102	0.0503
Echinococcus multilocularis	tumor protein p63	0.0335	0.1891	0.4409
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0102	0.0089
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0075	0.0676
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0102	0.0089
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0037	0.0075	1
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0102	0.0089
Plasmodium vivax	ataxin-2 like protein, putative	0.0084	0.0362	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0037	0.0075	0.0062
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0102	0.0224
Schistosoma mansoni	hypothetical protein	0.0051	0.0162	0.0256
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0027	0.0012	0.0015
Entamoeba histolytica	hypothetical protein	0.0078	0.0326	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0061	0.0129
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.0075	0.0161
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0142	0.0716	0.1661
Schistosoma mansoni	hypothetical protein	0.0051	0.0162	0.0256
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0102	0.0089
Schistosoma mansoni	hypothetical protein	0.0051	0.0162	0.0256
Trypanosoma cruzi	Heat shock protein 83, putative	0.0033	0.0054	0.1182
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0102	0.1554
Onchocerca volvulus		0.0274	0.1521	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0061	0.0129
Toxoplasma gondii	LsmAD domain-containing protein	0.0084	0.0362	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0102	0.0592
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0037	0.0075	0.0062
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0037	0.0075	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0078	0.0326	0.075
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0162	0.0834	0.4065
Loa Loa (eye worm)	heat shock protein 90	0.0033	0.0054	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.0503
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0054	0.1182
Trichomonas vaginalis	heat shock protein, putative	0.0033	0.0054	0.0274
Echinococcus multilocularis	heat shock protein 90	0.0027	0.0012	0.0015
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0102	0.0089
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0061	0.0236
Mycobacterium ulcerans	lipase LipD	0.0041	0.0102	0.0089
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0053	0.0111
Schistosoma mansoni	hypothetical protein	0.0194	0.1033	0.2317
Onchocerca volvulus		0.0049	0.0149	0.0603
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0075	0.1778
Brugia malayi	beta-lactamase	0.0041	0.0102	0.0394
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0051	0.0162	0.0695
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0078	0.0326	0.075
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0102	0.0394
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0142	0.0716	0.1661
Brugia malayi	MH2 domain containing protein	0.0356	0.2019	1
Plasmodium vivax	SET domain protein, putative	0.0035	0.0061	0.0236
Echinococcus granulosus	geminin	0.0194	0.1033	0.2402
Schistosoma mansoni	hypothetical protein	0.011	0.0523	0.111
Schistosoma mansoni	microtubule-associated protein tau	0.0727	0.428	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0084	0.0362	1
Schistosoma mansoni	hypothetical protein	0.0051	0.0162	0.0256
Brugia malayi	Endoplasmin precursor	0.0033	0.0054	0.0153
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.0173	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.0503
Onchocerca volvulus		0.0053	0.0173	0.0765
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0037	0.0075	1
Echinococcus granulosus	GPCR family 2	0.0051	0.0162	0.0364
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0142	0.0716	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0061	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0834	0.4132
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0149	0.0226
Brugia malayi	latrophilin 2 splice variant baaae	0.011	0.0523	0.2505
Mycobacterium ulcerans	transcriptional regulator	0.1667	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0084	0.0362	1
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.1667	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0356	0.2019	1
Brugia malayi	Pre-SET motif family protein	0.0035	0.0061	0.019
Mycobacterium ulcerans	TetR family transcriptional regulator	0.1667	1	1
Echinococcus granulosus	heat shock protein 90	0.0027	0.0012	0.0015
Echinococcus multilocularis	musashi	0.0053	0.0173	0.039
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Schistosoma mansoni	ap endonuclease	0.0037	0.0075	0.0049
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0102	0.0089
Brugia malayi	beta-lactamase family protein	0.0041	0.0102	0.0394
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0102	0.0089
Trichomonas vaginalis	esterase, putative	0.0041	0.0102	0.0592
Loa Loa (eye worm)	MH2 domain-containing protein	0.0356	0.2019	1
Brugia malayi	Pre-SET motif family protein	0.0241	0.1318	0.649
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0061	0.0129
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0051	0.0162	0.0364
Echinococcus granulosus	lamin	0.0053	0.0173	0.039
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0075	0.0413
Leishmania major	hypothetical protein, conserved	0.0041	0.0102	0.2553
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0102	0.0224
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0102	0.0089
Onchocerca volvulus		0.0041	0.0102	0.0279
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.0716	0.1567
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0102	0.0089
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Onchocerca volvulus		0.0041	0.0102	0.0279
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.0716	0.1567
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0051	0.0162	0.0801
Trypanosoma brucei	PAB1-binding protein , putative	0.0084	0.0362	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0102	0.0592
Leishmania major	heat shock protein 83-1	0.0033	0.0054	0.1182
Echinococcus granulosus	heat shock protein 90	0.0033	0.0054	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0162	0.0801
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.0173	0.0855
Echinococcus granulosus	lamin dm0	0.0053	0.0173	0.039
Plasmodium falciparum	ataxin-2 like protein, putative	0.0084	0.0362	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0162	0.0834	0.4132
Schistosoma mansoni	hypothetical protein	0.0194	0.1033	0.2317
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0075	0.0413
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0061	0.0017
Leishmania major	hypothetical protein, conserved	0.0084	0.0362	1
Schistosoma mansoni	intermediate filament proteins	0.0053	0.0173	0.0281
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.1667	1	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0075	0.0676
Echinococcus granulosus	intermediate filament protein	0.0053	0.0173	0.039
Brugia malayi	hypothetical protein	0.0084	0.0362	0.17
Plasmodium falciparum	ataxin-2 like protein, putative	0.0084	0.0362	1
Echinococcus multilocularis	geminin	0.0194	0.1033	0.2402
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0162	0.0834	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0006	0.0029
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0038	0.008	0.0173
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0102	0.2553
Brugia malayi	beta-lactamase family protein	0.0041	0.0102	0.0394
Echinococcus granulosus	microtubule associated protein 2	0.0727	0.428	1
Toxoplasma gondii	exonuclease III APE	0.0037	0.0075	0.0676
Echinococcus multilocularis	heat shock protein	0.0033	0.0054	0.0112
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0102	0.0114
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0102	0.1554
Schistosoma mansoni	lamin	0.0053	0.0173	0.0281
Echinococcus multilocularis	endoplasmin	0.0027	0.0012	0.0015
Schistosoma mansoni	lamin	0.0053	0.0173	0.0281
Onchocerca volvulus		0.0053	0.0173	0.0765
Brugia malayi	hypothetical protein	0.0054	0.0181	0.0791

Activities

Activity type	Activity value	Assay description	Source	Reference
CL (ADMET)	= 213 microL/min/mg	Intrinsic clearance in CD1 mouse liver microsomes by LC-MS-MS analysis	ChEMBL.	21417236
CL (ADMET)	= 213 microL/min/mg	Intrinsic clearance in CD-1 mouse liver microsomes at 1 uM by LC-MS/MS analysis	ChEMBL.	22098589
EC50 (binding)	= 0.1 uM	Inhibition of Mycobacterium tuberculosis H37Rv EthR in Mycobacterium tuberculosis H37Rv expressing GFP infected mouse in RAW264.7 cells assessed as potentiation of ethionamide-induced antitubercular activity after 5 days by SYTO60-based fluorescence microscopy	ChEMBL.	22098589
IC50 (binding)	= 1.6 uM	Inhibition of EthR binding to ethA promoter in 106-bp biotinylated DNA preincubated for 5 mins measured for 3 mins by surface plasmon resonance assay	ChEMBL.	22098589
IC50 (binding)	= 1.6 uM	Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assay	ChEMBL.	21417236
Inhibition (binding)		Inhibition of EthR binding to ethA promoter in 106-bp biotinylated DNA preincubated for 5 mins measured for 3 mins by surface plasmon resonance assay	ChEMBL.	22098589
T1/2 (ADMET)	= 5 min	Half life in CD1 mouse liver microsomes by LC-MS-MS analysis	ChEMBL.	21417236
T1/2 (ADMET)	= 5 min	Half life in CD-1 mouse liver microsomes at 1 uM by LC-MS/MS analysis	ChEMBL.	22098589

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1773966

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1527302