Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | heat shock protein 90 | 0.0033 | 0.0054 | 0.0153 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.008 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0102 | 0.0503 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.0162 | 0.0364 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0102 | 0.0114 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0102 | 0.1554 |
Echinococcus multilocularis | lamin | 0.0053 | 0.0173 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0523 | 0.259 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0035 | 0.0061 | 0.0017 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0037 | 0.0075 | 0.1778 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0149 | 0.0738 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0716 | 0.1567 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0061 | 0.0017 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0041 | 0.0102 | 0.0089 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0033 | 0.0054 | 0.1182 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.0102 | 0.0089 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0264 | 0.1455 | 0.1445 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0041 | 0.0102 | 0.0089 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0078 | 0.0326 | 0.0645 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0053 | 0.0173 | 0.075 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0061 | 0.0017 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.0326 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0037 | 0.0075 | 0.1778 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0326 | 0.0645 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.0326 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0173 | 0.0855 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0102 | 0.0089 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0102 | 0.2553 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.0162 | 0.0695 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0142 | 0.0716 | 0.3547 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0037 | 0.0075 | 0.0369 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0037 | 0.0075 | 0.0258 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.0326 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0727 | 0.428 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0102 | 0.0592 |
Echinococcus granulosus | endoplasmin | 0.0027 | 0.0012 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0102 | 0.0503 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0033 | 0.0054 | 0.1182 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0241 | 0.1318 | 0.653 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.0075 | 0.0676 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0037 | 0.0075 | 0.0765 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0102 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0102 | 0.0503 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.0162 | 0.0364 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0038 | 0.008 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0362 | 0.1795 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Brugia malayi | intermediate filament protein | 0.0053 | 0.0173 | 0.075 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.0061 | 0.0129 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0162 | 0.0256 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0037 | 0.0075 | 0.0161 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.0716 | 0.1661 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0162 | 0.0256 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.0326 | 1 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0027 | 0.0012 | 0.0015 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0084 | 0.0362 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0041 | 0.0102 | 0.0089 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0037 | 0.0075 | 0.0062 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0102 | 0.0224 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0037 | 0.0075 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0102 | 0.0089 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.0075 | 0.0676 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0102 | 0.0503 |
Echinococcus multilocularis | tumor protein p63 | 0.0335 | 0.1891 | 0.4409 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.0102 | 0.0089 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0033 | 0.0054 | 0.6648 |
Onchocerca volvulus | 0.0041 | 0.0102 | 0.0279 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0102 | 0.0592 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0084 | 0.0362 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0061 | 0.0129 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Onchocerca volvulus | 0.0274 | 0.1521 | 1 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0102 | 0.1554 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0033 | 0.0054 | 0.1182 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0162 | 0.0256 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0041 | 0.0102 | 0.0089 |
Echinococcus multilocularis | lamin dm0 | 0.0053 | 0.0173 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0102 | 0.0503 |
Echinococcus granulosus | tumor protein p63 | 0.0335 | 0.1891 | 0.4409 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.0162 | 0.0364 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.0162 | 0.0364 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Echinococcus multilocularis | heat shock protein 90 | 0.0033 | 0.0054 | 0.0112 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0102 | 0.0089 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0102 | 0.0592 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0142 | 0.0716 | 0.3473 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0102 | 0.0503 |
Trichomonas vaginalis | set domain proteins, putative | 0.0274 | 0.1521 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0028 | 0.0023 | 0.0114 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0041 | 0.0102 | 0.0089 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.0716 | 0.1661 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0326 | 0.152 |
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.0075 | 0.0049 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0033 | 0.0054 | 0.1182 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Echinococcus granulosus | heat shock protein | 0.0033 | 0.0054 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0167 | 0.0826 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Loa Loa (eye worm) | endoplasmin | 0.0033 | 0.0054 | 0.0266 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0037 | 0.0075 | 0.0161 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0102 | 0.0089 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0084 | 0.0362 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.011 | 0.0523 | 0.2505 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0149 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0834 | 0.4132 |
Mycobacterium ulcerans | transcriptional regulator | 0.1667 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.0162 | 0.0364 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.0716 | 0.1661 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0302 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0037 | 0.0075 | 1 |
Onchocerca volvulus | 0.0053 | 0.0173 | 0.0765 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0053 | 0.0173 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0102 | 0.0503 |
Brugia malayi | Endoplasmin precursor | 0.0033 | 0.0054 | 0.0153 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0162 | 0.0256 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0727 | 0.428 | 1 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.0523 | 0.111 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0084 | 0.0362 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0035 | 0.0061 | 0.0129 |
Brugia malayi | Pre-SET motif family protein | 0.0241 | 0.1318 | 0.649 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0102 | 0.0592 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0356 | 0.2019 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0102 | 0.0394 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0102 | 0.0089 |
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.0075 | 0.0049 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0102 | 0.0089 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Echinococcus granulosus | heat shock protein 90 | 0.0027 | 0.0012 | 0.0015 |
Brugia malayi | Pre-SET motif family protein | 0.0035 | 0.0061 | 0.019 |
Mycobacterium ulcerans | TetR family transcriptional regulator | 0.1667 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0053 | 0.0173 | 0.039 |
Mycobacterium tuberculosis | Transcriptional regulatory repressor protein (TetR-family) EthR | 0.1667 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0356 | 0.2019 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.0053 | 0.0111 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0041 | 0.0102 | 0.0089 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0102 | 0.0089 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.0061 | 0.0236 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Echinococcus multilocularis | heat shock protein 90 | 0.0027 | 0.0012 | 0.0015 |
Trichomonas vaginalis | heat shock protein, putative | 0.0033 | 0.0054 | 0.0274 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0033 | 0.0054 | 0.1182 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0102 | 0.0503 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0033 | 0.0054 | 0.0266 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0162 | 0.0834 | 0.4065 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0037 | 0.0075 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0037 | 0.0075 | 0.0062 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0078 | 0.0326 | 0.075 |
Echinococcus granulosus | geminin | 0.0194 | 0.1033 | 0.2402 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.0061 | 0.0236 |
Brugia malayi | MH2 domain containing protein | 0.0356 | 0.2019 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.0716 | 0.1661 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0102 | 0.0394 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0102 | 0.0394 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0078 | 0.0326 | 0.075 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.0162 | 0.0695 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.1033 | 0.2317 |
Onchocerca volvulus | 0.0049 | 0.0149 | 0.0603 | |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.0075 | 0.1778 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0084 | 0.0362 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0162 | 0.0834 | 0.4065 |
Echinococcus multilocularis | geminin | 0.0194 | 0.1033 | 0.2402 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0038 | 0.008 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0006 | 0.0029 |
Echinococcus granulosus | intermediate filament protein | 0.0053 | 0.0173 | 0.039 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0362 | 0.17 |
Mycobacterium ulcerans | AcrR family transcriptional regulator | 0.1667 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.0075 | 0.0676 |
Schistosoma mansoni | intermediate filament proteins | 0.0053 | 0.0173 | 0.0281 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.0075 | 0.0413 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.1033 | 0.2317 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0061 | 0.0017 |
Leishmania major | hypothetical protein, conserved | 0.0084 | 0.0362 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0084 | 0.0362 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0162 | 0.0834 | 0.4132 |
Echinococcus granulosus | lamin dm0 | 0.0053 | 0.0173 | 0.039 |
Loa Loa (eye worm) | intermediate filament protein | 0.0053 | 0.0173 | 0.0855 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0181 | 0.0791 |
Echinococcus multilocularis | endoplasmin | 0.0027 | 0.0012 | 0.0015 |
Onchocerca volvulus | 0.0053 | 0.0173 | 0.0765 | |
Schistosoma mansoni | lamin | 0.0053 | 0.0173 | 0.0281 |
Schistosoma mansoni | lamin | 0.0053 | 0.0173 | 0.0281 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0102 | 0.1554 |
Echinococcus multilocularis | heat shock protein | 0.0033 | 0.0054 | 0.0112 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0102 | 0.0114 |
Toxoplasma gondii | exonuclease III APE | 0.0037 | 0.0075 | 0.0676 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0727 | 0.428 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0102 | 0.2553 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0102 | 0.0394 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0716 | 0.1567 |
Onchocerca volvulus | 0.0041 | 0.0102 | 0.0279 | |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0102 | 0.0089 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0102 | 0.0224 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.0075 | 0.0413 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0102 | 0.2553 |
Echinococcus granulosus | lamin | 0.0053 | 0.0173 | 0.039 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.0162 | 0.0364 |
Echinococcus granulosus | heat shock protein 90 | 0.0033 | 0.0054 | 0.0112 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0162 | 0.0801 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0102 | 0.0592 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0084 | 0.0362 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.0162 | 0.0801 |
Onchocerca volvulus | 0.0041 | 0.0102 | 0.0279 | |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.0054 | 0.1182 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0716 | 0.1567 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0041 | 0.0102 | 0.0089 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.